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Proteases/Proteassoma

Proteases/Proteassoma

Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Proteases/Proteassoma"

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Foram encontrados 1092 produtos de "Proteases/Proteassoma"

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  • Logotipo do CymitQuimica
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    Nostosin G

    Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).
    Fórmula:C25H33N5O6
    Cor e Forma:Solid
    Peso molecular:499.56

    Ref: TM-T75647

  • 6-Acetylnimbandiol
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    6-Acetylnimbandiol

    CAS:
    6-Acetylnimbandiol, a non-toxic agent, inhibits tyrosinase (IC50=69.85 μM), melanin, and MITF; useful in melanoma studies.
    Fórmula:C28H34O8
    Cor e Forma:Solid
    Peso molecular:498.56

    Ref: TM-T75506

  • Ac-Phe-Gly-pNA
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    Ac-Phe-Gly-pNA

    CAS:
    Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .
    Fórmula:C19H20N4O5
    Cor e Forma:Solid
    Peso molecular:384.39

    Ref: TM-T74692

  • α 1(I) Collagen (614-639), human
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    α 1(I) Collagen (614-639), human

    CAS:
    This is a peptide inhibitor of collagen fibrillar matrix assembly.
    Fórmula:C134H189N37O39
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:2942.16

    Ref: TM-TP1643

  • Cyanopeptolin 954
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    Cyanopeptolin 954

    CAS:
    Cyanopeptolin 954 is a chlorine-containing Microcystis aeruginosa NIVA Cya 43 chymotrypsin Inhibitor.
    Fórmula:C46H63ClN8O12
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:955.5

    Ref: TM-T25280

  • BMS-767778
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    BMS-767778

    CAS:
    BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.
    Fórmula:C19H20Cl2N4O2
    Cor e Forma:Solid
    Peso molecular:407.29

    Ref: TM-T26857

  • Histargin
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    Histargin

    CAS:
    Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.
    Fórmula:C14H25N7O4
    Cor e Forma:Solid
    Peso molecular:355.39

    Ref: TM-T25504

  • (-)-Sitagliptin Carbamoyl Glucuronide
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    (-)-Sitagliptin Carbamoyl Glucuronide

    CAS:
    Minor phase II metabolite of DPP-4 inhibitor sitagliptin, found in rat and dog plasma.
    Fórmula:C23H23F6N5O9
    Cor e Forma:Solid
    Peso molecular:627.453

    Ref: TM-T35440

  • Logotipo do CymitQuimica
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    Tyrosinase-IN-38

    Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.
    Cor e Forma:Odour Solid

    Ref: TM-T200602

  • Logotipo do CymitQuimica
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    RJS308

    <p>RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)</p>
    Fórmula:C63H75N13O11S
    Cor e Forma:Solid
    Peso molecular:1222.42

    Ref: TM-T205591

  • Logotipo do CymitQuimica
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    Stevia Powder

    Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.
    Cor e Forma:Odour Solid

    Ref: TM-TN8189

  • Zetomipzomib maleate
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    Zetomipzomib maleate

    CAS:
    Zetomipzomib maleate (KZR-616) selectively targets LMP7/2 in immunoproteasomes, potential for autoimmune research.
    Fórmula:C34H46N4O12
    Cor e Forma:Solid
    Peso molecular:702.758

    Ref: TM-T39653

  • Logotipo do CymitQuimica
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    PROTAC 20S proteasome subunit β5 degrader 2

    PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.
    Cor e Forma:Odour Solid

    Ref: TM-T200540

  • ADAM8-IN-1
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    ADAM8-IN-1

    CAS:
    <p>ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.</p>
    Fórmula:C44H44Br4N6O12S2
    Cor e Forma:Solid
    Peso molecular:1232.6

    Ref: TM-T73998

  • Leptosin D
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    Leptosin D

    CAS:
    Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)
    Fórmula:C25H24N4O3S2
    Cor e Forma:Solid
    Peso molecular:492.61

    Ref: TM-T75472

  • Logotipo do CymitQuimica
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    Ecallantide TFA

    Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of
    Cor e Forma:Odour Solid

    Ref: TM-T82510

  • Logotipo do CymitQuimica
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    Tyrosinase-IN-34

    Tyrosinase-IN-34 (compound 5a), a human tyrosinase inhibitor (IC 50: 3.5 μM), shows promise in regulating melanogenesis and pigmentation.
    Fórmula:C19H14BrClN4O
    Cor e Forma:Solid
    Peso molecular:429.7

    Ref: TM-T89968

  • 6,6′-Dihydroxythiobinupharidine
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    6,6′-Dihydroxythiobinupharidine

    CAS:
    6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold
    Fórmula:C30H42N2O4S
    Cor e Forma:Solid
    Peso molecular:526.73

    Ref: TM-T79978

  • Ac-PAL-AMC
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    Ac-PAL-AMC

    CAS:
    Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.
    Fórmula:C26H34N4O6
    Cor e Forma:Solid
    Peso molecular:498.57

    Ref: TM-T37421

  • Ac-VDQQD-pNA
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    Ac-VDQQD-pNA

    CAS:
    Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).
    Fórmula:C31H43N9O14
    Cor e Forma:Solid
    Peso molecular:765.73

    Ref: TM-TP2849