GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(985 produtos)
- Receptor de adenosina(244 produtos)
- Receptor adrenérgico(2.991 produtos)
- Receptor de Bombesina(32 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(153 produtos)
- CaSR(33 produtos)
- Receptor de Canabinóides(209 produtos)
- Receptor de Dopamina(433 produtos)
- Receptor Endotelina(79 produtos)
- Receptor GNRH(77 produtos)
- GPCR19(32 produtos)
- GRK(33 produtos)
- GTPase(22 produtos)
- Receptor Glucagon(181 produtos)
- Hedgehog/Smoothened(46 produtos)
- Receptor de Histamina(380 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(26 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(309 produtos)
- PAFR(12 produtos)
- PKA(51 produtos)
- Receptor S1P(18 produtos)
- SGLT(31 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5696 produtos de "GPCR/Proteína-G"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Fenoldopam
CAS:Fenoldopam is a selective D1-like dopamine receptor partial agonist (EC50 = 57 nM).Fórmula:C16H16ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:305.76ABT-702
CAS:<p>ABT-702 is an orally active, competitive, and reversible non-nucleoside adenosine kinase (AK) inhibitor analgesic and anti-inflammatory.</p>Fórmula:C22H19BrN6OPureza:99.57%Cor e Forma:SoildPeso molecular:463.33CB1R agonist 1
<p>CB1R agonist 1 (Compound '1350) is a potent full agonist of the cannabinoid-1 receptor (CB1R) with a Ki value of 0.95 nM. It demonstrates significant pain-relieving effects in various pain models, including acute thermal pain, inflammatory pain, and neuropathic pain.</p>Fórmula:C20H18F3N3O3SCor e Forma:SolidPeso molecular:437.435ARL 15849XX
CAS:<p>ARL 15849XX, a CCK-8 analog, is a novel anti-obesity agent.</p>Fórmula:C47H60N8O13SPureza:98%Cor e Forma:SolidPeso molecular:977.09(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
CAS:V1A receptor antagonist; blocks vasopressin & oxytocin, lowers Ca²⁺ levels (IC50: 5/30 nM); long-acting antivasopressor; anxiolytic in dorsal hippocampus.Fórmula:C52H74N14O12S2Pureza:98%Cor e Forma:White Lyophilized PowderPeso molecular:1151.38[Leu31,Pro34]-Neuropeptide Y(human,rat)
CAS:<p>High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.</p>Fórmula:C189H284N54O56SPureza:98%Cor e Forma:SolidPeso molecular:4241LY83583
CAS:<p>LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.</p>Fórmula:C15H10N2O2Pureza:99.54% - 99.80%Cor e Forma:SolidPeso molecular:250.25Anti-TSHR Antibody (M22)
Anti-TSHR Antibody (M22) is a humanized IgG1 monoclonal antibody targeting the thyroid-stimulating hormone receptor (TSHR). This antibody is capable of inhibiting the interaction between TSH and TSHR.Cor e Forma:Odour LiquidFabesetron
CAS:<p>Fabesetron (FK1052): oral dual antagonist for 5-HT3/5-HT4 receptors. Aids in managing acute and delayed chemo-induced emesis.</p>Fórmula:C18H19N3OCor e Forma:SolidPeso molecular:293.37Dipivefrin
CAS:<p>Dipivefrin is a prodrug of epinephrine, and is used to treat open-angle glaucoma.</p>Fórmula:C19H29NO5Cor e Forma:SolidPeso molecular:351.44Pellotine
CAS:<p>Pellotine is an alkaloid isolated from Lophophora. It acts as an inverse agonist of the 5-HT7 receptor (5-HT7 receptor), with an EC50 of 291 nM. Pellotine shows strong affinity for the 5-HT1DR and 5-HT6R, with Ki values of 117 nM and 170 nM, respectively. Additionally, Pellotine reduces intracellular cAMP levels, thereby decreasing neuronal excitability and neurotransmitter release.</p>Fórmula:C13H19NO3Cor e Forma:SolidPeso molecular:237.2955-MeO-pyr-T
CAS:<p>5-MeO-pyr-T (5-Methoxy pyrrolidinyltryptamine) acts as a 5-HT1AR agonist, exhibiting Ki values of 0.577 μM and 373 μM for 5-HT1AR and 5-HT2AR, respectively. It inhibits the reuptake of 5-HT and triggers its release. Additionally, 5-MeO-pyr-T can induce reduced motor activity.</p>Fórmula:C15H20N2OCor e Forma:SolidPeso molecular:244.33BA 1
CAS:<p>Potent BB1, BB2, and BB3 agonist; IC50: 0.26, 1.55, 2.52 nM. Boosts glucose transport in myocytes, promotes cancer cell growth in vitro.</p>Fórmula:C57H76N14O11Pureza:98%Cor e Forma:SolidPeso molecular:1133.32G-Protein antagonist peptide
CAS:<p>Peptide inhibits G protein-receptor binding; competitively blocks M2 and β-adrenoceptor-induced Gs/Gi/Go activation.</p>Fórmula:C57H64N12O9SPureza:98%Cor e Forma:SolidPeso molecular:1093.2717-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
CAS:Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis.Fórmula:C27H39NO4Cor e Forma:SolidPeso molecular:441.612Urocortin III, mouse
CAS:<p>Mouse UcnIII, linked to stress behaviors, mainly occurs in the brain and rises in the hypothalamus post-restraint.</p>Fórmula:C186H312N52O52S2Pureza:98%Cor e Forma:SolidPeso molecular:4172.97Orexin A (human, rat, mouse) (TFA)
Endogenous orexin receptor agonist with Ki of 20 nM (OX1) and 38 nM (OX2), promotes feeding, may regulate sleep-wake cycle.Fórmula:C154H244N47F3O46S4Pureza:98%Cor e Forma:SolidPeso molecular:3675.12TRV045
CAS:<p>TRV045 is a selective agonist of the sphingosine-1-phosphate (S1P) subtype 1 receptor and does not impact lymphocyte trafficking. It possesses antiepileptic properties.</p>Fórmula:C18H18N4O3Cor e Forma:SolidPeso molecular:338.36ABT 724 trihydrochloride
CAS:<p>ABT-724 trihydrochloride: selective D4 agonist; EC50=12.4nM(human),14.3nM(rat),23.2nM(ferret); for erectile dysfunction research.</p>Fórmula:C17H22Cl3N5Pureza:99.91%Cor e Forma:SolidPeso molecular:402.75GR231118
CAS:<p>Potent NPY Y1 antagonist & Y4 agonist; inhibits rat appetite; binds to NPFF receptors (Ki: 43-73 nM).</p>Fórmula:C110H170N34O24Pureza:98%Cor e Forma:Lyophilized PowderPeso molecular:2352.77Adrenomedullin (1-50), rat
CAS:Rat adrenomedullin (1-50) is a 50-AA peptide; induces arterial vasodilation by activating CGRP1 receptors.Fórmula:C248H381N77O75S5Pureza:98%Cor e Forma:SolidPeso molecular:5729.5Atrial Natriuretic Peptide (ANP) (1-28), rat
CAS:Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.Fórmula:C128H205N45O39S2Pureza:98%Cor e Forma:SolidPeso molecular:3062.41(Rac)-Norcisapride
CAS:Norcisapride, a 5-HT3 and 5-HT4 agonist, treats GI, orofacial, and ENT disorders.Fórmula:C14H20ClN3O3Pureza:99.32%Cor e Forma:SoildPeso molecular:313.78Glucagon-like peptide 1 (1-37), human TFA
Human Glucagon-like peptide 1 (1-37) TFA is a potent GLP-1 receptor agonist derived from proglucagon.Fórmula:C188H276N51F3O61Pureza:98%Cor e Forma:SolidPeso molecular:4283.55-OMe-UDP trisodium salt
CAS:Potent P2Y6 agonistFórmula:C10H16N2O13P2Pureza:98%Cor e Forma:SolidPeso molecular:434.19Adrenocorticotropic Hormone (ACTH) (1-39), rat
CAS:ACTH (1-39), rat: potent MC2 agonist, forms fragments in vitro, isolated by HPLC, characterized by amino acids and NH2-terminus.Fórmula:C210H315N57O57SPureza:98%Cor e Forma:SolidPeso molecular:4582.23ALEPH hydrochloride
CAS:<p>ALEPH (hydrochloride) acts as a partial agonist of h5-HT2A and h5-HT2B receptors, with EC50 values of 10.3 nM and 19.2 nM, respectively. It can induce head twitch responses in mice, with an ED50 of 0.80 mg/kg.</p>Fórmula:C12H20ClNO2SCor e Forma:SolidPeso molecular:277.8120-hydroxy Prostaglandin F2α
CAS:<p>20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α.</p>Fórmula:C20H34O6Cor e Forma:SolidPeso molecular:370.486IRL-1038 acetate
<p>IRL-1038 acetate is a potent ETB endothelin receptor antagonist.</p>Fórmula:C70H96N14O17S2Pureza:97.51%Cor e Forma:SoildPeso molecular:1469.73Ki16198
CAS:<p>Ki16198, a methyl ester derivative of Ki16425, blocks LPA1/3, weak on LPA2; inactive on LPA4/5/6. Ki values: 0.34 μM (LPA1), 0.93 μM (LPA3).</p>Fórmula:C24H25ClN2O5SPureza:98.09%Cor e Forma:SolidPeso molecular:488.98Antisauvagine-30
CAS:<p>CRF2 receptor antagonist; Kd 1.4 nM (mCRF2β), 153.6 nM (rCRF1). Blocks sauvagine-induced cAMP in cells & stress-related responses in mice.</p>Fórmula:C161H274N48O46SPureza:98%Cor e Forma:SolidPeso molecular:3650.29Neurokinin B
CAS:<p>NKB, a tachykinin peptide, impacts human functions like gonadotropin-releasing hormone secretion.</p>Fórmula:C55H79N13O14S2Pureza:98%Cor e Forma:SolidPeso molecular:1210.42ELA-32(human)
CAS:Potent apelin receptor agonist with IC50 = 0.27 nM; does not bind GPR15/GPR25. Boosts hESC self-renewal and angiogenesis.Fórmula:C170H289N63O39S4Pureza:98%Cor e Forma:SolidPeso molecular:3967.8HDAC6-IN-49
<p>HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.</p>Cor e Forma:Odour Solid[bAla8]-Neurokinin A(4-10)
CAS:[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.Fórmula:C35H56N8O10SPureza:98%Cor e Forma:SolidPeso molecular:780.942-Methyl-N,N-dimethyltryptamine
CAS:<p>2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) exhibits binding affinity for the serotonin (5-HT) receptor, with a pA2 value of 6.04. It plays a significant role in neurological disease research.</p>Fórmula:C13H18N2Cor e Forma:SolidPeso molecular:202.3Hydroxybupropion
CAS:Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).Fórmula:C13H18ClNO2Pureza:99.73%Cor e Forma:Off-White SolidPeso molecular:255.74Flunarizine
CAS:<p>Flunarizine is an orally administered peripheral vasodilator, a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist.</p>Fórmula:C26H26F2N2Pureza:99.9%Cor e Forma:SolidPeso molecular:404.50Glucagon receptor antagonists-1
CAS:<p>Glucagon receptor antagonist -1 is a highly effective glucagon receptor antagonist.</p>Fórmula:C29H34FNO2Pureza:98%Cor e Forma:SolidPeso molecular:447.58Neuromedin N
CAS:<p>Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.</p>Fórmula:C38H63N7O8Pureza:98%Cor e Forma:SolidPeso molecular:745.95Blue FPG-A trisodium
CAS:<p>Blue FPG-A trisodium is a P2X1 & P2Y1 receptor antagonist, IC50: 35.5 μM & 2.6 μM, related to RB2.</p>Fórmula:C29H17ClN7Na3O11S3Cor e Forma:SolidPeso molecular:840.1P2Y6R antagonist 1
<p>P2Y6R antagonist 1 (compound 5ab) is a selective, orally active antagonist of P2Y6R, featuring an IC50 value of 19.6 nM. This compound also exhibits anti-inflammatory properties.</p>Cor e Forma:Odour SolidDulaglutide
CAS:<p>Dulaglutide (LY2189265) is a GLP-1 receptor agonist for studying type 2 diabetes mellitus (T2DM).</p>Cor e Forma:SolidRF9 acetate
RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.Fórmula:C28H42N6O5Pureza:99.77%Cor e Forma:SolidPeso molecular:542.6711-deoxy Prostaglandin E1
CAS:<p>11-deoxy Prostaglandin E1 is a prostaglandin E1 analogue that has bronchodilator activity and can inhibit histamine-induced bronchoconstriction and cause</p>Fórmula:C20H34O4Cor e Forma:SolidPeso molecular:338.48M1145
CAS:Potent GAL2 agonist with EC50 = 38 nM; Ki: 6.55 nM (GAL2), 497 nM (GAL3), 587 nM (GAL1); enhances galanin signaling.Fórmula:C128H205N37O32Pureza:98%Cor e Forma:SolidPeso molecular:2774.26β-CGRP, human
CAS:<p>β-CGRP, human ,a 37-amino acid peptide,is the beta form of Calcitonin-gene-related peptide (β-CGRP), involved extensively in regulation of the cardiovascular</p>Fórmula:C162H267N51O48S3Pureza:98%Cor e Forma:SolidPeso molecular:3793.41Fasitibant chloride
CAS:<p>Fasitibant chloride, a potent B2R blocker, alleviates pain and swelling in arthritis.</p>Fórmula:C36H49Cl3N6O6SCor e Forma:SolidPeso molecular:800.23MK-7246 S enantiomer
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist.Fórmula:C21H21FN2O4SPureza:98%Cor e Forma:SolidPeso molecular:416.47
![[Leu31,Pro34]-Neuropeptide Y(human,rat)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1985.webp&w=3840&q=75)
![[bAla8]-Neurokinin A(4-10)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1100.webp&w=3840&q=75)
