CAS 25122-46-7: Clobetasol propionate

Description: Clobetasol propionate is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties, primarily used in dermatology for the treatment of various skin conditions, including psoriasis and eczema. It is classified as a class I corticosteroid, indicating its high potency. The chemical structure features a 21-carbon steroid backbone with a propionate ester at the 17-position, which enhances its skin penetration and efficacy. Clobetasol propionate is typically formulated as topical creams, ointments, or solutions, allowing for localized treatment with minimal systemic absorption. Its mechanism of action involves the inhibition of inflammatory mediators and the modulation of immune responses, leading to reduced redness, swelling, and itching. While effective, prolonged use can lead to side effects such as skin thinning, striae, and potential systemic effects if absorbed in significant amounts. Therefore, it is recommended for short-term use under medical supervision. The substance is listed under the CAS number 25122-46-7, which uniquely identifies it in chemical databases.

Formula: C₂₅H₃₂ClFO₅

InChI: InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1

InChI key: InChIKey=CBGUOGMQLZIXBE-XGQKBEPLSA-N

SMILES: O=C1C=CC2(C(=C1)CCC3C4CC(C)C(OC(=O)CC)(C(=O)CCl)C4(C)CC(O)C32F)C

Synonyms:

• (11Beta,16Beta)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate
• (11β,16β)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
• (8Xi,11Beta,14Xi,16Beta)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate
• 17-Propionate De 21-Chloro-9-Fluoro-11Β,17-Dihydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione
• 17-Propionato De 21-Cloro-9-Fluoro-11Β,17-Dihidroxi-16Β-Metilpregna-1,4-Dieno-3,20-Diona
• 21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
• 21-Chloro-21-deoxybetamethasone 17-propionate
• 21-Chloro-9-Fluoro-11Β,17-Dihydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate
• CCl 4725
• Cgp 9555
• Clobederm
• Clobesol
• Clobetasol 17-propionate
• Clobetasole Propionate
• Clobetazol Propiorate
• Clobex
• Dermoval
• Dermovate
• Dermoxin
• Dermoxinale
• Gr 2/925
• Karison
• Olux-E
• Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-
• Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate
• Skin Cap
• Temovate
• Tenovate

Clobetasol 17-Propionate

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 466.97

Clobetasol propionate

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Purity: 99.5%
• Color and Shape: Off White Solid
• Molecular weight: 466.19223

Clobetasol propionate CRS

CAS: 25122-46-7

• Color and Shape: Added Modified

Clobetasol propionate for peak identification CRS

CAS: 25122-46-7

• Color and Shape: Added Modified

Clobetasol Propionate

CAS: 25122-46-7

Halogenated derivatives of adrenal cortical hormones

• Formula: C₂₅H₃₂ClFO₅
• Color and Shape: White Cream Powder
• Molecular weight: 466.19223

Clobetasol propionate

CAS: 25122-46-7

Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates …

• Formula: C₂₅H₃₂ClFO₅
• Purity: 98.44%
• Color and Shape: White Crystalline Powder
• Molecular weight: 466.97

Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 466.97

Clobetasol Propionate

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 466.98

Clobetasol propionate, USP grade

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Purity: ≤ 1.0%
• Color and Shape: White to almost white crystalline powder
• Molecular weight: 466.97

Clobetasol propionate

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: White to off-white powder
• Molecular weight: 466.97

Clobetasol propionate, Ph. Eur. grade

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Purity: ≤ 0.1%
• Color and Shape: White or almost white crystalline powder
• Molecular weight: 466.97

Clobetasol Propionate-d5

CAS: 25122-46-7

• Formula: C₂₅H₂₇D₅ClFO₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 472.00

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

CAS: 105102-22-5 1177-87-3 124-94-7 13609-67-1 14484-47-0 1524-88-5 2135-17-3 2152-44-5 25122-46-725122-57-0 3093-35-4 33564-31-7 356-12-7 378-44-9 3801-06-7 3870-07-3 426-13-1 4419-39-0 50-02-2 50-03-3 50-04-4 50-23-7 50-24-8 51022-69-6 51333-22-3 514-36-3 53-06-5 53-36-1 5534-09-8 5593-20-4 57524-89-7 66734-13-2 67-78-7 73771-04-7 76-25-5 80474-14-2 83-43-2 987-24-6

• Color and Shape: Mixture

Clobetasol propionate

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Color and Shape: Neat
• Molecular weight: 466.97

Clobetasol Propionate

CAS: 25122-46-7

• Formula: C₂₅H₃₂ClFO₅
• Color and Shape: Neat
• Molecular weight: 466.97

Clobetasol Propionate RS

CAS: 25122-46-7

• Color and Shape: White To Pale Yellow-White Solid Powder

Clobetasol 17-Propionate

CAS: 25122-46-7

Applications Topical corticosteroid. Glucocorticoid; anti-inflammatory. References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, …

• Formula: C₂₅H₃₂ClFO₅
• Color and Shape: White To Off-White
• Molecular weight: 466.97

Clobetasol 17-Propionate-d5

CAS: 25122-46-7

Applications Clobetasol 17-Propionate-d5 is labelled Clobetasol 17-Propionate (C583500) which is a topical corticosteroid. Clobetasol 17-Propionate …

• Formula: C₂₅H₂₇D₅ClFO₅
• Color and Shape: Neat
• Molecular weight: 472.0

Clobetasol 17-propionate

CAS: 25122-46-7

Clobetasol 17-propionate is a synthetic, long-acting corticosteroid that has been used in the treatment of …

• Formula: C₂₅H₃₂ClFO₅
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 466.97 g/mol