CAS 50-02-2: Dexamethasone

Description: Dexamethasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressant properties, commonly used in the treatment of various conditions such as allergies, autoimmune diseases, and certain types of cancer. Its chemical formula is C22H29FO5, and it features a steroid backbone with a fluorine atom and a ketone group, contributing to its potency. Dexamethasone acts by binding to glucocorticoid receptors, influencing gene expression and modulating the immune response. It is typically administered orally, intravenously, or via injection, and its effects can include reduced inflammation and suppression of the immune system. The substance is known for its relatively long half-life compared to other corticosteroids, allowing for less frequent dosing. Side effects may include weight gain, mood changes, and increased risk of infections, particularly with prolonged use. Dexamethasone is also notable for its role in managing severe cases of COVID-19, where it has been shown to improve outcomes in patients requiring oxygen or mechanical ventilation.

Formula: C₂₂H₂₉FO₅

InChI: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key: InChIKey=UREBDLICKHMUKA-CXSFZGCWSA-N

SMILES: O=C1C=CC2(C(=C1)CCC3C4CC(C)C(O)(C(=O)CO)C4(C)CC(O)C32F)C

Synonyms:

• (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• (8Xi,11Beta,16Alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• 1-Dehydro-16α-methyl-9α-fluorohydrocortisone
• 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 16α-Methyl-9α-fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
• 16α-Methyl-9α-fluoro-Δ1-hydrocortisone
• 16α-Methyl-9α-fluoro-Δ¹-hydrocortisone
• 16α-Methyl-9α-fluoroprednisolone
• 9-Alpha-Fluoro-11-Beta,17-Alpha,21-Trihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
• 9-Alpha-Fluoro-16-Alpha-Methylprednisolone
• 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
• 9α-Fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
• 9α-Fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
• 9α-Fluoro-16α-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione
• 9α-Fluoro-16α-methylprednisolone
• Adexone
• Aeroseb-Dex
• Aphtasolon
• Aphthasolone
• Azium
• Calonat
• Corsone
• Cortisumman
• Decacort
• Decaderm
• Decadron
• Decalix
• Decasone
• Dekacort
• Dekort
• Delipos
• Deltafluorene
• Dergramin
• Deronil
• Desadrene
• Desameton
• Deseronil
• Dexa-Cortidelt
• Dexa-Mamallet
• Dexa-Scheroson
• Dexa-sine
• Dexacort
• Dexacortal
• Dexacortin
• Dexadeltone
• Dexafarma
• Dexalona
• Dexaltin
• Dexametasona
• Dexameth
• Dexamethason
• Dexamonozon
• Dexapolcort
• Dexapos
• Dexaprol
• Dexaratiopharm
• Dexason
• Dexasone
• Dexaven
• Dexinoral
• Dexium
• Dexmethsone
• Dexone
• Dexonium
• Dextelan
• Dinormon
• Diodex
• Etacortilen
• Fluormethylprednisolone
• Fluormone
• Fluorocort
• Gammacorten
• Gentalipos
• HL-Dex
• Hexadecadrol
• Hexadrol
• Isopto-Dex
• Loverine
• Luxazone
• Maxidex
• Millicorten
• Minidex
• Neofordex
• Oftan
• Oradexon
• Ozurdex
• Posurdex
• Superprednol
• Surodex
• Visumetazone
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16α)-
• MK 125

Dexamethasone

CAS: 50-02-2

• Formula: C₂₂H₂₉FO₅
• Purity: >99.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 392.47

Dexamethasone, 98%

CAS: 50-02-2

Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and …

• Formula: C₂₂H₂₉FO₅
• Purity: 98%
• Color and Shape: White, Powder
• Molecular weight: 392.47

Dexamethasone impurity standard

CAS: 50-02-2

• Color and Shape: White

Dexamethasone for system suitability CRS

CAS: 50-02-2

Dexamethasone for peak identification CRS

CAS: 50-02-2

Dexamethasone RS

CAS: 50-02-2

• Formula: C₂₂H₂₉FO₅
• Molecular weight: 392.4611

Dexamethasone

CAS: 50-02-2

• Formula: C₂₂H₂₉FO₅
• Purity: 98.9%
• Color and Shape: White
• Molecular weight: 392.1999

Dexamethasone CRS

CAS: 50-02-2

Dexamethasone

CAS: 50-02-2

Halogenated derivatives of adrenal cortical hormones

• Formula: C₂₂H₂₉FO₅
• Color and Shape: White Powder
• Molecular weight: 392.1999

DEXAMETHASONE

CAS: 50-02-2

• Formula: C₂₂H₂₉FO₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 392.4611

Dexamethasone

CAS: 50-02-2

Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.

• Formula: C₂₂H₂₉FO₅
• Purity: 98% - 99.91%
• Color and Shape: Crystals From Ether (Ntp 1992)
• Molecular weight: 392.46

Dexamethasone

CAS: 50-02-2

• Formula: C₂₂H₂₉FO₅
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: White to off-white crystalline powder
• Molecular weight: 392.47

Dexamethasone-13C3

CAS: 50-02-2

• Formula: C₁₉₁₃C₃H₂₉FO₅
• Molecular weight: 395.44

Dexamethasone-d4

CAS: 50-02-2

• Formula: C₂₂H₂₅D₄FO₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 396.49

Dexamethasone (Dexamethasone Sodium Phosphate EP Impurity A)

CAS: 50-02-2

• Formula: C₂₂H₂₉FO₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 392.47

Dexamethasone-4,6α,21,21-d4

CAS: 2483831-63-4 50-02-2

• Purity: 97 atom % D (also 11% deuterated at position C-2)
• Color and Shape: White Solid
• Molecular weight: 396.49

Dexamethasone

CAS: 50-02-2

• Formula: C₂₂H₂₉FO₅
• Color and Shape: Neat
• Molecular weight: 392.46

Dexamethasone, 96%

CAS: 50-02-2

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₂H₂₉FO₅
• Purity: 96%
• Color and Shape: Crystalline powder, White to almost white
• Molecular weight: 392.47

Dexamethasone

CAS: 50-02-2

• Formula: C₂₂H₂₉FO₅
• Color and Shape: Neat
• Molecular weight: 392.46

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

CAS: 105102-22-5 1177-87-3 124-94-7 13609-67-1 14484-47-0 1524-88-5 2135-17-3 2152-44-5 25122-46-7 25122-57-0 3093-35-4 33564-31-7 356-12-7 378-44-9 3801-06-7 3870-07-3 426-13-1 4419-39-0 50-02-250-03-3 50-04-4 50-23-7 50-24-8 51022-69-6 51333-22-3 514-36-3 53-06-5 53-36-1 5534-09-8 5593-20-4 57524-89-7 66734-13-2 67-78-7 73771-04-7 76-25-5 80474-14-2 83-43-2 987-24-6

• Color and Shape: Mixture