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CAS 50-02-2

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Dexamethasone

Description:
Dexamethasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressant properties, commonly used in the treatment of various conditions such as allergies, autoimmune diseases, and certain types of cancer. Its chemical formula is C22H29FO5, and it features a steroid backbone with a fluorine atom and a ketone group, contributing to its potency. Dexamethasone acts by binding to glucocorticoid receptors, influencing gene expression and modulating the immune response. It is typically administered orally, intravenously, or via injection, and its effects can include reduced inflammation and suppression of the immune system. The substance is known for its relatively long half-life compared to other corticosteroids, allowing for less frequent dosing. Side effects may include weight gain, mood changes, and increased risk of infections, particularly with prolonged use. Dexamethasone is also notable for its role in managing severe cases of COVID-19, where it has been shown to improve outcomes in patients requiring oxygen or mechanical ventilation.
Formula:C22H29FO5
InChI:InChI=1/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15?,16+,17+,19+,20+,21+,22+/m1/s1
InChI key:InChIKey=UREBDLICKHMUKA-CXSFZGCWSA-N
SMILES:F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]
Synonyms:
  • (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • (8Xi,11Beta,16Alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
  • 1-Dehydro-16α-methyl-9α-fluorohydrocortisone
  • 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
  • 16α-Methyl-9α-fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
  • 16α-Methyl-9α-fluoro-Δ1-hydrocortisone
  • 16α-Methyl-9α-fluoro-Δ<sup>1</sup>-hydrocortisone
  • 16α-Methyl-9α-fluoroprednisolone
  • 9-Alpha-Fluoro-11-Beta,17-Alpha,21-Trihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
  • 9-Alpha-Fluoro-16-Alpha-Methylprednisolone
  • See more synonyms
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