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CAS 50-24-8

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Prednisolone

Description:
Prednisolone is a synthetic glucocorticoid, primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by its steroid structure, which includes a cyclopentanoperhydrophenanthrene core, modified with various functional groups that enhance its therapeutic efficacy. Prednisolone is typically administered in the form of tablets, syrups, or injections, and is commonly prescribed for conditions such as asthma, allergies, autoimmune diseases, and certain types of cancer. Its mechanism of action involves binding to glucocorticoid receptors, leading to the modulation of gene expression and a subsequent reduction in inflammation and immune response. Prednisolone exhibits a relatively high bioavailability and is metabolized primarily in the liver, with its effects lasting several hours to days, depending on the dosage and route of administration. While effective, it can also lead to side effects, particularly with long-term use, including weight gain, osteoporosis, and increased susceptibility to infections. As with any medication, it is essential to use prednisolone under medical supervision to manage potential risks and benefits effectively.
Formula:C21H28O5
InChI:InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key:InChIKey=OIGNJSKKLXVSLS-VWUMJDOOSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]
Synonyms:
  • (11Beta)-11,17-Dihydroxy-3,20-Dioxopregna-1,4-Dien-21-Yl Acetate
  • (11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
  • 1,2-Dehydrohydrocortisone
  • 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione
  • 1,4-Pregnadiene-3,20-dione-11β,17α,21-triol
  • 1-Dehydrohydrocortisone
  • 11,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione
  • 11-Beta,17-Alpha,21-Trihydroxypregna-1,4-Diene-3,20-Dione
  • 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione
  • 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione
  • See more synonyms
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