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CAS 53-19-0

:

Mitotane

Description:
Mitotane, with the CAS number 53-19-0, is an organic compound primarily used in the treatment of adrenocortical carcinoma, a rare type of cancer affecting the adrenal glands. It is classified as an antineoplastic agent and functions by inhibiting adrenal steroidogenesis, leading to a reduction in cortisol production. Mitotane is known for its lipophilic nature, which allows it to accumulate in adipose tissue and the adrenal glands, enhancing its therapeutic effects. The compound has a relatively low solubility in water but is soluble in organic solvents. Its mechanism of action involves the destruction of adrenal cortical cells and the alteration of steroid hormone synthesis. Mitotane can have significant side effects, including adrenal insufficiency, gastrointestinal disturbances, and neurotoxicity, necessitating careful monitoring during treatment. Due to its potent effects and potential toxicity, it is typically administered under strict medical supervision. Overall, Mitotane represents a critical option in the management of specific adrenal tumors, highlighting the importance of targeted therapies in oncology.
Formula:C14H10Cl4
InChI:InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
InChI key:InChIKey=JWBOIMRXGHLCPP-UHFFFAOYSA-N
SMILES:C(C(Cl)Cl)(C1=C(Cl)C=CC=C1)C2=CC=C(Cl)C=C2
Synonyms:
  • 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
  • 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichlor
  • 1-(o-Chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane
  • 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
  • 1-Chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene
  • 2,2,O,P-Tetrachloroethylidenebisbenzene
  • 2,4'-Dichlorodiphenyldichloroethane
  • 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane
  • 2-(p-Chlorophenyl)-2-(o-chlorophenyl)-1,1-dichloroethane
  • Benzene, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-
  • See more synonyms
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