CAS 66734-13-2

Alclometasone dipropionate

Description:

Alclometasone dipropionate is a synthetic corticosteroid primarily used for its anti-inflammatory and anti-allergic properties in dermatological applications. It is characterized by its potent glucocorticoid activity, which helps in reducing inflammation and suppressing immune responses. The substance is typically formulated as a topical cream or ointment, making it effective for treating various skin conditions such as eczema, dermatitis, and psoriasis. Alclometasone dipropionate exhibits a favorable pharmacokinetic profile, allowing for localized action with minimal systemic absorption when applied to the skin. Its chemical structure includes a dipropionate ester, which enhances its lipophilicity and skin penetration. The compound is generally well-tolerated, although potential side effects may include skin irritation or atrophy with prolonged use. As with other corticosteroids, it is important to use Alclometasone dipropionate as directed to minimize the risk of adverse effects and to ensure effective treatment outcomes.

Formula: C₂₈H₃₇ClO₇

InChI: InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1

InChI key: InChIKey=DJHCCTTVDRAMEH-DUUJBDRPSA-N

SMILES: C(COC(CC)=O)(=O)[C@]1(OC(CC)=O)[C@]2(C)[C@@](C[C@H]1C)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(C[C@H]3Cl)=CC(=O)C=C4)[H])[H])[H]

Synonyms:

• (7Alpha,11Beta,16Alpha)-7-Chloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dipropanoate
• (7Alpha,8Xi,9Xi,10Xi,13Xi,16Alpha)-7-Chloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dipropanoate
• (7α,11β,16α)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
• 17,21-Di(Propionate) De 7Α-Chloro-11Β,17,21-Trihydroxy-16Α-Methylpregna-1,4-Diene-3,20-Dione
• 17,21-Di(Propionato) De 7Α-Cloro-11Β,17,21-Trihidroxi-16Α-Metilpregna-1,4-Dieno-3,20-Diona
• 7Α-Chloro-11Β,17,21-Trihydroxy-16Α-Methylpregna-1,4-Diene-3,20-Dione 17,21-Di(Propionate)
• 7α-Chlor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-17,21-di(propionat)
• Aclovate
• Alclometasone Dipropionate
• Alclometasone-17,21-Dipropionate
• Almeta
• Delonal
• Pregna-1,4-diene-3,20-dione, 7-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (7α,11β,16α)-
• Sch 22219

Alclometasone Dipropionate

CAS: 66734-13-2

Halogenated derivatives of adrenal cortical hormones

Formula: C₂₈H₃₇ClO₇

Color and Shape: Powder

Molecular weight: 520.22278

Ref: 45-1012757

Alclometasone dipropionate

CAS: 66734-13-2

Alclometasone dipropionate (Sch 22219) is a glucocorticoid with antiproliferative and vasoconstrictive properties that is used in the study of skin inflammation

Formula: C₂₈H₃₇ClO₇

Purity: 99.57% - 99.62%

Color and Shape: Solid

Molecular weight: 521.04

Ref: TM-T21361

Alclometasone dipropionate

CAS: 66734-13-2

Alclometasone dipropionate

Purity: ≥98%

Molecular weight: 521.04g/mol

Ref: 54-BUP16427

Alclometasone Dipropionate

CAS: 66734-13-2

Formula: C₂₈H₃₇ClO₇

Color and Shape: White To Off-White Solid

Molecular weight: 521.05

Ref: 4Z-A-190001

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

Controlled Product

CAS: 105102-22-5, 1177-87-3, 124-94-7, 13609-67-1, 14484-47-0, 1524-88-5, 2135-17-3, 2152-44-5, 25122-46-7, 25122-57-0, 3093-35-4, 33564-31-7, 356-12-7, 378-44-9, 3801-06-7, 3870-07-3, 426-13-1, 4419-39-0, 50-02-2, 50-03-3, 50-04-4, 50-23-7, 50-24-8, 51022-69-6, 51333-22-3, 514-36-3, 53-06-5, 5534-09-8, 5593-20-4, 57524-89-7, 66734-13-2, 67-78-7, 73771-04-7, 76-25-5, 80474-14-2, 83-43-2, 987-24-6

Color and Shape: Mixture

Ref: 04-A50000094ME

Alclometasone dipropionate

CAS: 66734-13-2

Formula: C₂₈H₃₇ClO₇

Purity: 97.0 - 102.0 %

Color and Shape: White to off-white crystalline powder

Molecular weight: 521.04

Ref: 7W-GP9293

Alclometasone 17,21-Dipropionate

Controlled Product

CAS: 66734-13-2

Applications Alclometasone-17,21-dipropionate is an synthetic glucocorticoid steroid used for inflammatory skin conditions. Alclometasone-17,21-dipropionate is topically used in dermatology as an anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
References Teraki, Y., et al.: Dermatol., 224, 309 (2012); Yamamoto, Y., et al.: int. J. Pharma., 426. 54 (2012); Aggerwal, A., et al.: J. Int. Med. Res., 10, 414 (1982);

Formula: C₂₈H₃₇ClO₇

Color and Shape: Neat

Molecular weight: 521.04

Ref: TR-A514580

Alclometasone dipropionate

Controlled Product

CAS: 66734-13-2

Alclometasone dipropionate is an anti-inflammatory agent that belongs to the group of corticosteroids. It is a low potency drug with a chemical stability that is similar to that of betamethasone. The monosodium salt form of alclometasone dipropionate is more water soluble than other corticosteroids and thus has better absorption through the skin. Alclometasone dipropionate decreases inflammation by blocking the production of inflammatory mediators, such as prostaglandin E2 and leukotrienes, and also suppresses immune system activity. This drug has been shown to be effective in treating symptoms of bowel disease, including Crohn's disease and ulcerative colitis, in women, as well as the symptoms of inflammatory bowel disease in geriatric patients. Alclometasone dipropionate also has anti-inflammatory effects on rat liver microsomes via intermolecular hydrogen bonding.BR

Formula: C₂₈H₃₇CI₀₇

Purity: Min. 95%

Molecular weight: 1,273.94 g/mol

Ref: 3D-FA35438

Alclometasone Dipropionate

CAS: 66734-13-2

Formula: C₂₈H₃₇ClO₇

Molecular weight: 521.05

Ref: ST-EA-CP-A129000