Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(91 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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LSD1-IN-27
CAS:LSD1-IN-27 inhibits LSD1 (IC50=13 nM), blocks gastric cancer cell stemness/migration, reduces PD-L1, and boosts T-cell response.Formula:C24H25N3Purity:99.98%Color and Shape:SoildMolecular weight:355.48LP23
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/JurkatFormula:C27H27N3O5SPurity:98%Color and Shape:SolidMolecular weight:505.59D5B
D5B is an effective and selective PD-L1 inhibitor that has been modified with DBCO. It degrades PD-L1 in 4T1 and B16-F10 tumor cells with EC50 values of 5.4 μM and 6.2 μM, respectively. D5B can block the PD-L1/PD-1 interaction and exhibits antitumor activity.Formula:C58H66N2O12Color and Shape:SolidMolecular weight:983.15PD-L1 ligand 1
PD-L1 ligand 1 is classified as a PROTAC-targeted protein ligand, primarily utilized as a degradation agent for PD-L1.Color and Shape:Odour Solid2-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS:2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Formula:C22H17N3O2Color and Shape:SolidMolecular weight:355.39Lon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Formula:C24H28Cl2N2O3S2Color and Shape:SolidMolecular weight:527.53Ac-VDQQD-pNA
CAS:Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Formula:C31H43N9O14Color and Shape:SolidMolecular weight:765.73PROTAC PD-1/PD-L1 degrader-1
CAS:PROTAC PD-1/PD-L1 degrader-1, a Cereblon-based inhibitor, blocks PD-1/PD-L1 with 39.2 nM IC50, boosting immune response and reducing PD-L1 via lysosomes.Formula:C59H58ClN7O11Purity:99.07%Color and Shape:SolidMolecular weight:1076.59RIPK1-IN-27
RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.Formula:C27H28N4O3Color and Shape:SolidMolecular weight:456.54PMT-O9-1A
PMT-O9-1A is an effective PD-L1 degrader that reduces PD-L1 protein expression and exhibits cytotoxic properties. Additionally, PMT-O9-1A possesses anticancer activity.Formula:C22H25ClN2O4Color and Shape:SolidMolecular weight:416.90SACLAC
CAS:SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity used in the study of acute myeloid leukemia and cancer.Formula:C20H40ClNO3Purity:97.03%Color and Shape:SoildMolecular weight:377.99IETD-CHO TFA
IETD-CHO TFA (Caspase-8-IN-1) functions as a potent inhibitor of caspase-8 [1].Formula:C95H162N20O26·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:2000.42 (free acid)Ac-AAVALLPAVLLALLAP-LEHD-CHO
CAS:Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated withFormula:C97H162N22O25Purity:98%Color and Shape:SolidMolecular weight:2036.46COG-1410 acetate
COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.Formula:C66H125N21O16Purity:99.61%Color and Shape:SolidMolecular weight:1468.83RIPK2-IN-5
CAS:RIPK2-IN-5 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with potential anti-inflammatory activity for the study of diseases caused by immune dysfunctions.Formula:C21H14N4SPurity:98.85%Color and Shape:SoildMolecular weight:354.43YL-5092
CAS:YL-5092, YTHDC1 inhibitor (IC50=7.4 nM), induces G0/G1 arrest and apoptosis, used for acute myeloid leukemia (AML).Formula:C22H14F3N3O2SColor and Shape:SolidMolecular weight:441.43YT117R
YT117R is a PROTAC that targets degradation of FKBP12 and BRD4.Formula:C50H52ClN9O7SColor and Shape:SolidMolecular weight:958.52Secalonic acid D
CAS:Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.Formula:C32H30O14Color and Shape:SolidMolecular weight:638.57AFMK
CAS:AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.Formula:C13H16N2O4Purity:98.34% - 99.81%Color and Shape:SolidMolecular weight:264.28Calcimycin hemimagnesium
CAS:Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.Formula:C58H72MgN6O12Color and Shape:SolidMolecular weight:1069.53EMB-02
EMB-02 is a bispecific antibody targeting both PD-1 and LAG-3. It inhibits the downregulation of T cell activation and proliferation mediated by PD-1 and LAG-3, showing potent anti-cancer properties.Color and Shape:Odour LiquidAnti-Mouse PD-1 Antibody (D265A) Antibody (RMP1-14)
Anti-MousePD-1Antibody (D265A) is an antibody inhibitor targeting the PD-1 protein in mice.Color and Shape:Odour LiquidPTD10
CAS:PTD10 is a BTK-targeting PROTAC degradator, induces apoptosis via caspase-dependent and mitochondrial pathways, B-cell dysregulation.Formula:C49H51N11O8Purity:99.12%Color and Shape:SolidMolecular weight:922.99Pegsunercept
CAS:Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].Color and Shape:LiquidFinotonlimab
Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].Color and Shape:Odour LiquidOnercept
CAS:Onercept, a recombinant soluble form of the human tumor necrosis factor-alpha (TNF-α) p55 receptor, is utilized in the study of Crohn's disease [1].Color and Shape:LiquidRanevetmab
CAS:Ranevetmab (NV-01), a caninized anti-NGF mAb, relieves pain in DJD research.Color and Shape:LiquidAtorolimumab
CAS:Atorolimumab (P3x22914G4), a monoclonal antibody, is employed in immunotherapies that target the programmed death-1 (PD-1) receptor [1].Color and Shape:LiquidCofetuzumab
CAS:Cofetuzumab (PF-06523435) is a antibody targeting protein tyrosine kinase 7 (PTK7), which can be used to synthesize ADC compounds like cofetuzumab pelidotin.Purity:>95%Color and Shape:LiquidMolecular weight:146.7 kDaAnti-Mouse TNF α Antibody (TN3-19.12)
Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.Purity:95%Color and Shape:Odour LiquidMolecular weight:150 kDaOnfekafusp alfa
CAS:Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.Color and Shape:LiquidLorigerlimab
CAS:Lorigerlimab (MGD019) is a bispecific IgG4 DART that blocks PD-1/CTLA-4, enhancing T-cells for mCRPC research.Color and Shape:LiquidAnti-ETBR Antibody (DEDN6526A Naked Antibody)
DEDN6526A (RG-7636) is a humanized ADC compound targeting endothelin B receptor (ETBR), which can be used to study melanoma.Color and Shape:LiquidMolecular weight:145.54 kDaAnti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2)
Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) is an IgG2a, κ antibody inhibitor derived from mice, specifically targeting and inhibiting mouse PD-L1/B7-H1.Color and Shape:Odour LiquidAnti-PD-L1/B7-H1 Antibody (29E.2A3)
Anti-PD-L1/B7-H1 Antibody (29E.2A3) represents a chimeric antibody of mouse IgG2b, κ type, specifically targeting human PD-L1/B7-H1. The recommended isotype control for this antibody is Mouse IgG2b kappa, Isotype Control.δ-secretase inhibitor 11
CAS:δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Formula:C10H12N4O2Purity:99.84%Color and Shape:SolidMolecular weight:220.23Sotigalimab
CAS:Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.Purity:98.50% - 98.50%Color and Shape:LiquidMolecular weight:144.35 kDaObexelimab
CAS:ACBI3 is a pan-KRAS degrader with anticancer activity, degrading oncogenic KRAS.Purity:98% (SDS-PAGE); 100% (SEC-HPLC) - 98% (SDS-PAGE); 100% (SEC-HPLC)Color and Shape:LiquidMolecular weight:147.44 kDaSym029
Sym029 is a human IgG monoclonal antibody (mAb) that targets TNFRSF5/CD40. It is applicable for cancer research. The suggested isotype control is Human IgG1 kappa, Isotype Control.Lodapolimab
CAS:Lodapolimab (LY3300054) is an IgGλ anti- PD-1 monoclonal antibody [1] .Color and Shape:LiquidThalidomide-NH-PEG4-COOH
CAS:Thalidomide-NH-PEG4-COOH is a E3 ligase ligand-linker for synthesizing the selective degrader dCBP-1 targeting p300/CBP.Formula:C24H31N3O10Color and Shape:SolidMolecular weight:521.523Besufetamig
CAS:Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Color and Shape:LiquidMoflerafusp alfa
CAS:Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.Color and Shape:LiquidGSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa, utilized for research related to inflammation and psoriasis.Color and Shape:Odour LiquidGB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Color and Shape:Odour LiquidBC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. It enhances the proliferation of CD8+ T cells and depletes Treg cells, resulting in an increased proportion of effector T cells within the tumor microenvironment. BC011 is applicable in the study of tumor immunology.Color and Shape:Odour LiquidARB-272572 hydrochloride
CAS:ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formula:C32H36N6O4·xClHPurity:99.38%Color and Shape:SoildMolecular weight:568.68(Free base）Thalidomide-NH-C8-NH2 hydrochloride
CAS:Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.Formula:C21H29ClN4O4Color and Shape:SolidMolecular weight:436.94KH16
KH16 is an HDAC inhibitor.KH16 stimulates apoptosis and is able to inhibit gene expression patterns in a variety of tumor cells.Formula:C18H20N6O2Purity:98.15%Color and Shape:SolidMolecular weight:352.39W1131 TFA
W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.Formula:C25H20F3N5O6Purity:98.1%Color and Shape:SolidMolecular weight:543.45Ref: TM-T80847
1mg92.00€5mg188.00€10mg311.00€25mg628.00€50mg1,008.00€100mg1,596.00€1mL*10mM (DMSO)To inquireIRF1-IN-1
CAS:IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.Formula:C22H24N4O4SPurity:99.88%Color and Shape:SolidMolecular weight:440.52N-Stearoyltyrosine
CAS:N-Stearoyltyrosine (N-(1-Oxooctadecyl)-L-tyrosine) is an analog of Anandamide. It exhibits neuroprotective effects by safeguarding the CA1 region of the hippocampus in a gerbil ischemia-reperfusion model. Additionally, N-Stearoyltyrosine inhibits free radical generation, enhances antioxidant capacity, and reduces IR-induced apoptosis (cell apoptosis).Formula:C27H45NO4Color and Shape:SolidMolecular weight:447.65F1324 acetate
F1324 acetate is an efficient, high-affinity b-cell lymphoma inhibitor with IC50 of 1 nM.Formula:C85H125N21O22SPurity:98%Color and Shape:SolidMolecular weight:1825.09Pantoprazole Sodium Hydrate
CAS:Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFormula:C16H14F2N3NaO4SH2OPurity:98.32%Color and Shape:SolidMolecular weight:432.37BCL-XL-IN-3
CAS:BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.Formula:C46H55N7O6SColor and Shape:SolidMolecular weight:834.04AM-8553
CAS:AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.Formula:C25H29Cl2NO4Color and Shape:SolidMolecular weight:478.41MI-1061 TFA
CAS:MI-1061 TFA: potent MDM2 inhibitor, orally bioavailable, stable (IC50=4.4 nM, Ki=0.16 nM), activates p53, induces apoptosis in mice tumors.Formula:C32H27Cl2F4N3O6Color and Shape:SolidMolecular weight:696.47AlbA-DCA
AlbA-DCA, a compound of Albiziabioside A and dichloroacetate, boosts ROS and reduces lactic acid in tumors, killing cancer cells and triggering apoptosis.Formula:C43H67Cl2NO12Purity:98%Color and Shape:SolidMolecular weight:860.9CYP51/PD-L1-IN-1
CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).Formula:C20H15N5O2Color and Shape:SolidMolecular weight:357.37MET/PDGFRA-IN-1
MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET.Formula:C26H23N7OPurity:98%Color and Shape:SolidMolecular weight:449.51HJC0416 hydrochloride
CAS:HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.Formula:C18H18Cl2N2O4SColor and Shape:SolidMolecular weight:429.31PZ703b hydrochloride
PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.Formula:C80H103Cl2F3N10O11S4Color and Shape:SolidMolecular weight:1636.9Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.Formula:C10H12FN5Na3O13P3Color and Shape:SolidMolecular weight:591.1284-B10
CAS:84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.Formula:C25H22F3NO5Purity:99.76%Color and Shape:SolidMolecular weight:473.44Ref: TM-T75268
1mg47.00€5mg92.00€10mg152.00€25mg289.00€50mg447.00€100mg670.00€200mg888.00€1mL*10mM (DMSO)92.00€Tasisulam sodium
CAS:Tasisulam triggers apoptosis, halts mitosis, and normalizes blood vessels to combat cancer.Formula:C11H5BrCl2NNaO3S2Color and Shape:SolidMolecular weight:437.09PROTAC EGFR degrader 5
CAS:PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formula:C57H72FN13O5SColor and Shape:SolidMolecular weight:1070.33Thalidomide-O-amido-C8-NH2 hydrochloride
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthetic cereblon ligand-linker for PROTAC synthesis.Formula:C23H31ClN4O6Purity:98%Color and Shape:SolidMolecular weight:494.97BK50164
CAS:BK50164: CD73 inhibitor, IC50=13.089µM; binds CD99, KD=1.5µM; anticancer, induces apoptosis, arrests sub-G1.Formula:C13H13ClFN5O7Color and Shape:SolidMolecular weight:405.72Thalidomide-Piperazine-PEG2-NH2
CAS:Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.Formula:C23H31N5O6Color and Shape:SolidMolecular weight:473.53Bcl-2-IN-2
CAS:Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.Formula:C48H57N7O7SColor and Shape:SolidMolecular weight:876.09RIP1-IN-1
RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.Color and Shape:Odour SolidVallesiachotamine
CAS:Vallesiachotamine, a recognized monoterpene indole alkaloid, exhibits anti-tumor activity [1].Formula:C21H22N2O3Color and Shape:SolidMolecular weight:350.41FLT3-IN-21
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase.Formula:C20H22FN5O2Color and Shape:SolidMolecular weight:383.42hMAO-B-IN-11
hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.Color and Shape:Odour SolidEpisilvestrol
CAS:Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.Formula:C34H38O13Purity:98%Color and Shape:SolidMolecular weight:654.66BM-1197
CAS:BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 andFormula:C53H59ClF4N6O7S4Color and Shape:SolidMolecular weight:1131.77ReACp53
ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.Formula:C108H206N52O24Purity:98%Color and Shape:SolidMolecular weight:2617.13mTOR inhibitor-27
mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.Color and Shape:Odour SolidSTM3006
CAS:STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).Formula:C25H27BrN8Purity:97.16%Color and Shape:SoildMolecular weight:519.44Didocosahexaenoin
CAS:Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.Formula:C25H40O5Color and Shape:SolidMolecular weight:420.58SDH-IN-26
SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.Color and Shape:Odour SolidThalidomide-4-C3-NH2 hydrochloride
CAS:Thalidomide-4-C3-NH2 HCl is a cereblon ligand for CRBN recruitment, used to make PROTACs with a linker.Formula:C16H18ClN3O4Color and Shape:SolidMolecular weight:351.785Deoxynyboquinone
CAS:Deoxynyboquinone is a potent inducer of cancer cell death with IC(50) values between 16 and 210 nM.Formula:C15H12N2O4Purity:98%Color and Shape:SolidMolecular weight:284.27PROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).Formula:C76H96ClF3N10O11S3Color and Shape:SolidMolecular weight:1514.28VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Color and Shape:Odour SolidSBP-0636457
CAS:SBP-0636457: SMAC mimetic, IAP inhibitor, binds BIR-domains (Ki=0.27μM), potential in tumor/cancer research.Formula:C25H36N4O4Color and Shape:SolidMolecular weight:456.587p53-HDM2-IN-1
p53-HDM2-IN-1 is a potent inhibitor of the p53-HDM2 protein-protein interaction, demonstrating an inhibitory concentration (IC 50) of 0.103 μM.Formula:C35H38F6N4O7SColor and Shape:SolidMolecular weight:772.75Borrelidin
CAS:Borrelidin (Treponemycin) is an inhibitor of trehalose-6-phosphate synthase, a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei.Formula:C28H43NO6Purity:98%Color and Shape:White To Off-White PowderMolecular weight:489.64Antitumor agent-61
CAS:Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.Formula:C54H63FN5O10PColor and Shape:SolidMolecular weight:992.08PI3Kα-IN-14
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting inPurity:98%Color and Shape:Odour SolidRosomidnar
CAS:PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.Formula:C227H291O141P23Color and Shape:SolidMolecular weight:7220.63Se-Aspirin
CAS:Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.Formula:C12H12N2O3SePurity:98.07%Color and Shape:SolidMolecular weight:311.2QN523
CAS:QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.Formula:C14H10N4OPurity:99.83%Color and Shape:SolidMolecular weight:250.263-Hydroxykynurenine
CAS:3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.
Formula:C10H12N2O4Purity:98.83% - 99.69%Color and Shape:SolidMolecular weight:224.21Tubulysin B
CAS:Tubulysin B: a potent, cytotoxic microtubule-disrupting peptide from Archangium geophyra and Angiococcus disciformis.Formula:C42H63N5O10SPurity:98%Color and Shape:SolidMolecular weight:830.04Chalcones A-N-5
CAS:Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.Formula:C21H20N4O4Color and Shape:SolidMolecular weight:392.41KHKI-01215
KHKI-01215 is a NUAK2 inhibitor with anticancer activity, inhibiting the proliferation of SW480 cancer cells and inducing apoptosis.Formula:C24H26F3IN6OPurity:98.19%Color and Shape:SolidMolecular weight:598.4Sanggenon G
CAS:Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.Formula:C40H38O11Color and Shape:SolidMolecular weight:694.72SDU-071
CAS:SDU-071 is a BRD4-p53 inhibitor, suppressing MDA-MB-231 cell proliferation, inducing cell cycle arrest and apoptosis.Formula:C28H25N3O2Purity:99.54%Color and Shape:SolidMolecular weight:435.52
