Apoptosis

<p>Tegaserod is a 5-HT4R agonist and 5-HT2B receptor antagonist with antitumor activity used in the treatment of irritable bowel syndrome (IBS).</p>

<p>Vitamin E succinate (D-alpha-Tocopherol Succinate) is an antioxidant tocopherol with antitumor activity that induces apoptosis.</p>

<p>RKI 1447 dihydrochloride: selective ROCK inhibitor, inhibits colorectal cancer growth, promotes apoptosis (ROCK1 IC50=14.5 nM, ROCK2 IC50=6.2 nM).</p>

<p>MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.</p>

<p>Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast.</p>

<p>Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.</p>

<p>M47 is a selective CRY1 (Cryptochrome 1) degradator that enhances nuclear degradation of CRY1, thereby extending the lifespan of p53 knockout mice.</p>

<p>Macitentan-d4 (ACT-064992 D4) is a C13-labeled inhibitor of the peptides ETA and ETB used to study diseases mediated by endothelin receptor mediation.</p>

<p>Edaravone, a potent free radical scavenger, prevents MMP-9-induced brain bleeds in rats and has a deuterium variant, Edaravone D5.</p>

<p>Forodesine hydrochloride blocks lymphocyte growth and induces leukemia cell death by inhibiting PNP, effective across species.</p>

<p>Thalidomide-piperazine-Boc is an intermediate utilized for synthesizing BCL6 PROTAC, which targets B-cell lymphoma 6 protein.</p>

<p>Rutin trihydrate is a natural flavonoid with antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer benefits, plus heart and brain protection.</p>

<p>Hydroxy-PP-Me is a CBR1 inhibitor that inhibits apoptosis induced by serum withdrawal.Hydroxy-PP-Me is used in the study of leukemia.</p>

<p>TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.</p>

<p>Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methyltransferase (Mtase) with an IC50 of 8.4 μM.</p>

<p>Tubastatin A is a potent HDAC6 inhibitor with IC50 of 15 nM.</p>

<p>Thioridazine: an antipsychotic, anti-anxiety drug, blocks dopamine D2, PI3K-Akt-mTOR; halts angiogenesis, kills cancer cells, targets CSCs.</p>

<p>Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.</p>

<p>Mardepodect hydrochloride (Mardepodect HCl) is a PDE10A inhibitor.Mardepodect hydrochloride upregulates genes encoding specific growth factors.</p>

<p>Degarelix is a peptide and selective GnRH (human gonadotropin-releasing hormone) receptor antagonist prostate cancer by lowering testosterone levels.</p>

<p>AZT triphosphate is a Nucleoside Triphosphate.</p>

<p>Thalidomide-5,6-F, a cereblon ligand for CRBN protein recruitment, forms PROTACs for targeted protein degradation.</p>

<p>3,4,5-Trihydroxycinnamic acid decyl ester is an anti-obesity agent that inhibits lipid absorption and pancreatic lipase (EC50 ≈ 0.9μM).</p>

<p>(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.</p>

<p>Forodesine inhibits lymphocyte growth and induces apoptosis in leukemic cells; oral purine nucleoside phosphorylase blocker; IC50: 0.48-1.57 nM.</p>

<p>6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase, which induces ROS generation and apoptosis in HL-60 cells.</p>

<p>5-Methoxyuridine (Mo5U) is an antitumor purine analog that inhibits DNA synthesis and induces apoptosis in lymphatic cancers.</p>

<p>Citrinin: a mycotoxin with antifungal, antibacterial, potential anticancer, and neuroprotective properties; contaminates food.</p>

<p>Etoposide Phosphate is a selective and orally active topoisomerase II inhibitor and anticancer chemotherapy drug that apoptosise, the p53, and G2/M</p>

<p>Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.</p>

<p>TZ9 is a Rad6 inhibitor with anticancer activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.</p>

<p>BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.</p>

<p>LG100268 is a selective, and oral RXR agonist，inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.</p>

<p>Pyridoclax is an inhibitor of potential Mcl-1.</p>

<p>Bleximenib oxalate (Menin-MLL inhibitor 24 oxalate) is a menin-MLL inhibitor that blocks the binding of the menin-KMT2A complex to chromatin at gene promoters.</p>

<p>Tubulin inhibitor 1 blocks tubulin polymerization, with strong anti-tumor effects, induces apoptosis and G2/M mitotic arrest.</p>

<p>Bucladesine calcium: PDE inhibitor, boosts cAMP, activates PKA.</p>

<p>Isoscabertopin has anticancer activity.</p>

<p>(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor with neuroprotective activity that induces apoptosis.</p>

<p>Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.</p>

<p>PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).</p>

<p>TDE is an organochlorine insecticide with slightly irritating to the skin.</p>

<p>AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.</p>

<p>DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.</p>

<p>Thalidomide-piperazine HCl may aid leprosy, multiple myeloma research, and developmental biology studies.</p>

<p>Acyclovir-d4 is a deuterated compound of Acyclovir. Acyclovir has a CAS number of 59277-89-3. Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.</p>

<p>SC144 hydrochloride: oral gp130 inhibitor, blocks Stat3 and gene expression, triggers apoptosis in ovarian cancer cells.</p>

<p>N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interaction with potential anticancer activity for cancer research.</p>

<p>Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.</p>

<p>MPPa, a PDT photosensitizer derived from chlorophyll a, absorbs at 667/674 nm with no dark cytotoxicity.</p>

<p>N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL), a quorum-sensing signaling molecule synthesized by P. aeruginosa and specific B. cepacia complex strains [1][2], facilitates bacterial gene expression modulation in response to cell density escalation and triggers IL-8 production in 16HBE human bronchial epithelial cells [3].</p>

<p>Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM.</p>

<p>C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides.</p>

<p>L-Cystine, hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T124989 and the CAS number is 34760-60-6.</p>

<p>Fenobucarb is a broad-spectrum carbamate insecticide and AChE inhibitor. It exhibits neurotoxicity to zebrafish foetal development and induces muscle spasms</p>

<p>PGV-1, an oral Curcumin analog, induces apoptosis by inhibiting COX-2, VEGF, and NF-κB activation.</p>

<p>Prexasertib dimesylate is a selective CHK1 inhibitor with K i 0.9 nM, blocks CHK2 &amp; RSK1, induces DNA breakage, and has potent anti-tumor effects.</p>

<p>Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.</p>

<p>Lestaurtinib (CEP 701) is a FLT3 inhibitor that inhibits the phosphorylation of RPTKs and can be used to study leukemia.</p>

<p>Pevonedistat(MLN4924) hydrochloride is a NEDD8-activating enzyme inhibitor that induces apoptosis and can be used in the study of acute myeloid leukemias.</p>

<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>

<p>Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.</p>

<p>Necrostatin 2 is a RIPK1 inhibitor that can be used to study inner ear disorders such as sudden deafness, dizziness and tinnitus.</p>

<p>Hematoporphyrin monomethyl ether is a porphyrin photosensitizer that can be used in studies of port wine stains.</p>

<p>MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.</p>

<p>Galantamin-d6 is a deuterated compound of Galantamin.</p>

<p>AZD-5991, an antitumor compound, is a highly selective, potent and direct MCL-1 inhibitor, rapid apoptosis by Bak-dependent mitochondrial apoptotic pathway.</p>

<p>Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with</p>

<p>Diuron is an orally active benzoylurea herbicide. Diuron inhibits the production of ATP and NADH,, ROS and cancer.</p>

<p>ML291 triggers UPR, causing apoptosis in solid cancers by activating PERK/eIF2a/CHOP pathway and reducing leukemia cells.</p>

<p>Chlorhexidine digluconate is a disinfectant with antibacterial activity that induces apoptosis and can be used to study bacterial infections.</p>

<p>Methopterin shows the activation and bone resorption function of murine osteoclasts.</p>

<p>4-Benzoyl-L-phenylalanine is an L-phenylalanine derivative and optically active amino acid.</p>

<p>Sodium cyclamate is a carbonic anhydrase inhibitor, artificial sweetener, with anticonvulsant properties, and used in cancer research.</p>

<p>Casein Kinase inhibitor A86 is a highly effective and orally bioavailable inhibitor of casein kinase 1α (CK1α) and also inhibits CDK7 (TFIIH) and CDK9 (P-TEFb). It induces apoptosis in leukemia cells, exhibiting substantial anti-leukemic effects.</p>

<p>7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.</p>

<p>GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.</p>

<p>Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase</p>

<p>VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent.</p>

<p>Alemtuzumab is a humanized monoclonal antibody against CD52 an antigen found on the surface of normal and malignant lymphocytes.</p>

<p>Chlorfenapyr (AC 303630) is a pyrrole insecticide and converts active substances (insecticidal activity) in insects by a multifunctional oxidase</p>

<p>4-Nitroquinoline 1-oxide (4-NQO) is a chemical carcinogen that induces mutations in bacteria, fungi, and animals through the formation of large amounts of</p>

<p>1.</p>

<p>MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα).</p>

<p>Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also</p>

<p>Imipramine HCl: 1st-gen tricyclic antidepressant, inhibits serotonin and norepinephrine uptake, blocks aSMase, reduces MV/exosome secretion.</p>