Apoptosis

Compound PDK0035, with CAS No. 119-65-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0035 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Isovalerylcarnitine (3-methylbutyrylcarnitine) is a selective effective calpain activator that can promote cell apoptosis and is related to isovaleric acidemia.

Prexasertib dimesylate is a selective CHK1 inhibitor with K i 0.9 nM, blocks CHK2 & RSK1, induces DNA breakage, and has potent anti-tumor effects.

Propylparaben sodium, a plant-based preservative used in cosmetics, pharma, and food, hinders follicle growth and sperm health.

4-PQBH is a potent Nur77-binding agent with antitumour activity.4-PQBH is used in the study of hepatocellular carcinoma.

Chlorhexidine digluconate is a disinfectant with antibacterial activity that induces apoptosis and can be used to study bacterial infections.

Fenvalerate (Evercide 2362) is a protein phosphatase 2B (calcineurin) inhibitor, a synthetic pyrethroid insecticide, that inhibits PP2B-Aα.

Diuron is an orally active benzoylurea herbicide. Diuron inhibits the production of ATP and NADH,, ROS and cancer.

<p>5-Methoxyuridine (Mo5U) is an antitumor purine analog that inhibits DNA synthesis and induces apoptosis in lymphatic cancers.</p>

<p>Celosin K (compound 8), isolated from Semen Celosiae seeds, effectively inhibits t-BHP-induced neuronal injury.</p>

PETCM is a caspase-3 activator and acts as an cytochrome c (cyto c)-dependent manner.

Zardaverine (BY 290) is a PDE3/4 inhibitor with anti-hepatocarcinogenic activity and is used in the study of acute renal failure and chronic airflow obstruction

Thalidomide-based cereblon ligand linked to PEG-C2-NH2 for use in PROTAC E3 ligase conjugates.

Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methyltransferase (Mtase) with an IC50 of 8.4 μM.

Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Thioridazine: an antipsychotic, anti-anxiety drug, blocks dopamine D2, PI3K-Akt-mTOR; halts angiogenesis, kills cancer cells, targets CSCs.

Citrinin (Standard) is the standard substance of Citrinin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Citrinin is a mycotoxin that causes contamination in the food and is associated with different toxic effects. Citrinin also possesses a broad spectrum of bioactivities, including antifungal, antibacterial, and potential anticancer and neuroprotective effects in vitro.

Tegaserod is a 5-HT4R agonist and 5-HT2B receptor antagonist with antitumor activity used in the treatment of irritable bowel syndrome (IBS).

(E/Z)-E64FC26 is a protein disulfide isomerase (PDI) family inhibitor with affinity for PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6.