Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(3 products)
- Caspase(153 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(93 products)
- PDK(9 products)
- PERK(26 products)
- Serine/threonin kinase(18 products)
- Survivin(14 products)
- TNF(49 products)
- c-RET(60 products)
- p53(63 products)
Show 6 more subcategories
Found 6033 products of "Apoptosis"
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LSD1-IN-21
LSD1-IN-21: potent LSD1 inhibitor, crosses blood-brain barrier, IC50 of 0.956 μM; lowers TNF-α, anti-cancer, anti-inflammatory.Formula:C24H25N5O2SColor and Shape:SolidMolecular weight:447.55Cetzole
CAS:Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 μM in NCI-H522, 10.31 μM in NCI-H522 GFP-SCL7A11 #8, 2.71 μM in NCI-H522 RV-GFP, 3.07 μM in HT-1080, 14.9 μM in NARF2, and 6.28 μM in MDA-MB-231. This highlights Cetzole's potential for research in cancer therapeutics.Formula:C11H11NOSColor and Shape:SolidMolecular weight:205.28EGFR/HER2-IN-6
EGFR/HER2-IN-6 is a dual inhibitor of EGFR, HER2, and DHFR with IC50s: 0.122, 0.078, and 0.585 μM, showing anticancer potential and selectivity.Formula:C18H21N5O3SColor and Shape:SolidMolecular weight:387.46Antitumor agent-58
Antitumor agent-58 suppresses tumor growth, colony formation, cell migration, and induces mitochondrial dysfunction in MGC-803 cells.Formula:C27H28F3N9SColor and Shape:SolidMolecular weight:567.63HER2-IN-11
HER2-IN-11 is a psoralen derivative that induces apoptosis. HER2-IN-11 shows light-activated cytotoxicity and also exhibits anti-breast cancer activity [1].Formula:C17H11NO6Color and Shape:SolidMolecular weight:325.27STAT3-IN-9
STAT3-IN-9 hinders STAT3 at Tyr705, doesn't affect STAT1 Tyr701, induces apoptosis, and arrests cells in G2/M phase.Formula:C22H21N3O4Color and Shape:SolidMolecular weight:391.42eIF4E-IN-4
CAS:eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.
Formula:C20H19ClN5O5PColor and Shape:SolidMolecular weight:475.822LL-Z 1640-4
CAS:A signal-specific JNK/p38 pathway and TAK 1 inhibitorFormula:C19H24O7Purity:98%Color and Shape:SolidMolecular weight:364.39UR-AK49
CAS:UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.Formula:C16H27N5OColor and Shape:SolidMolecular weight:305.42SILA-123
CAS:SILA-123, an inhibitor of FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM), induces cell apoptosis by hindering the cell cycle progression at the G0/G1 phase through the suppression of FLT3 phosphorylation and its downstream signaling pathways. This compound is utilized in the study of acute myeloid leukemia.Formula:C24H25N5O2Color and Shape:SolidMolecular weight:415.49TP-030-1
CAS:TP-030-1, RIPK1 inhibitor: K(i) hRIPK1 at 3.9nM, IC50 mRIPK1 at 4.2μM; targets inflammation, neurodegeneration research.Formula:C23H22N4O3Color and Shape:SolidMolecular weight:402.45Triphen diol
CAS:Triphen diol, a phenol diol, fights pancreatic cancer & cholangiocarcinoma, inducing apoptosis via caspase-dependent & -independent paths.Formula:C22H20O4Color and Shape:SolidMolecular weight:348.39GIC-20
CAS:GIC-20, a dual inducer of apoptosis and ferroptosis, exhibits antitumor efficacy against fibrosarcoma [1].Formula:C38H37ClN4O5SColor and Shape:SolidMolecular weight:697.24Scytonemin
CAS:Scytonemin, a cyanobacterial pigment, inhibits cancer cell growth by decreasing Plk1 activity, especially effective on U266 myeloma cells.Formula:C36H20N2O4Color and Shape:SolidMolecular weight:544.55Thalidomide-NH-amido-PEG2-C2-NH2
CAS:Thalidomide-NH-amido-PEG2-C2-NH2 is a synthetic E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. It is utilized in the synthesis of PROTACs.Formula:C21H27N5O7Molecular weight:461.47EGFR-IN-62
EGFR-IN-62: IC50 of 10-242 nM for various EGFR mutations, blocks A549/H1975 cell cycle, induces apoptosis, and inhibits cell motility and proliferation.Formula:C30H33N9O2Color and Shape:SolidMolecular weight:551.64Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride
CAS:Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, comprised of a cereblon ligand based on Thalidomide and a linker, utilized in the synthesis of PROTACs.
Formula:C21H28ClN5O7Molecular weight:497.93Thalidomide-NH-C5-NH2
CAS:Thalidomide-NH-C5-NH2 is a synthetic E3 ligase ligand-linker conjugate, consisting of a Thalidomide-based cereblon ligand and a linker, used in the synthesis of PROTACs.Formula:C18H22N4O4Molecular weight:358.39Tubulin polymerization-IN-9
CAS:Tubulin-IN-9 inhibits tubulin (IC50: 1.82 μM), halts K562 cells in G2/M, induces apoptosis, and has anti-cancer effects.Formula:C19H19NO5SeColor and Shape:SolidMolecular weight:420.32CDK2/9-IN-1
CAS:CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.004 μM and 0.009 μM for CDK2 and CDK9, respectively. It induces apoptosis by regulating G2/M cell cycle arrest and exhibits antitumor activity.Formula:C14H14N6O2S2Color and Shape:SolidMolecular weight:362.43
