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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 5592 products of "Apoptosis"

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  • DNMT1-IN-5
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    DNMT1-IN-5

    CAS:
    <p>DNMT1-IN-5 (Compound 55) is an inhibitor of DNMT, specifically targeting DNMT1 and DNMT3A, with IC50 values of 2.42 μM and 14.4 μM, respectively. It demonstrates antiproliferative effects across various cancer cell lines (TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226, and HCT116) with IC50 values ranging from 0.19 to 2.37 μM. The compound induces G2/M phase cell cycle arrest and apoptosis in TMD-8 and DOHH2 cells. Additionally, DNMT1-IN-5 exhibits antitumor efficacy in a TMD-8 xenograft mouse model.</p>
    Formula:C24H32FN7
    Color and Shape:Solid
    Molecular weight:437.556

    Ref: TM-T205711

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    Top/HDAC-IN-2

    <p>Top/HDAC-IN-2 (45b) is a dual inhibitor of Top and HDAC that induces apoptosis and exhibits significant anti-tumour effects.</p>
    Formula:C30H32N8O4
    Color and Shape:Solid
    Molecular weight:568.63

    Ref: TM-T64025

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    PIM-1/HDAC-IN-1

    <p>PIM-1/HDAC-IN-1 (4d): inhibits PIM-1 (IC50: 343.87nM), HDAC1 (63.65nM), HDAC6 (62.39nM); induces apoptosis in MCF-7 cells.</p>
    Formula:C22H19N3O3
    Color and Shape:Solid
    Molecular weight:373.4

    Ref: TM-T61510

  • Flonoltinib sulfate
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    Flonoltinib sulfate

    CAS:
    <p>Flonoltinib maleate is an orally active dual inhibitor of JAK2/FLT3, with IC50 values of 0.7 nM for JAK2, 4 nM for FLT3, 26 nM for JAK1, and 39 nM for JAK3. It exhibits anticancer properties.</p>
    Formula:C25H36FN7O5S
    Color and Shape:Solid
    Molecular weight:565.661

    Ref: TM-T204180

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    L5-DA

    <p>L5-DA, a G-quadruplex ligand, stabilizes G4s in HeLa cells, induces apoptosis, and is cytotoxic with an IC50 of 4.3 μM.</p>
    Formula:C32H34N6O2
    Color and Shape:Solid
    Molecular weight:534.65

    Ref: TM-T63765

  • HDL-16
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    HDL-16

    CAS:
    <p>HDL-16 is a highly effective P2Y14R antagonist with anti-colitis effects, targeting P2Y14R in intestinal epithelial cells to alleviate ulcerative colitis.</p>
    Formula:C14H11BrN2O
    Purity:97.58%
    Color and Shape:Solid
    Molecular weight:303.15

    Ref: TM-T86565

  • AQX-435
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    AQX-435

    CAS:
    <p>AQX-435 activates SHIP1, inhibits PI3K in BCR signaling, induces apoptosis in B cells, and slows lymphoma growth.</p>
    Formula:C27H34N2O4
    Color and Shape:Solid
    Molecular weight:450.57

    Ref: TM-T62724

  • Aeroplysinin 1
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    Aeroplysinin 1

    CAS:
    <p>Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation.</p>
    Formula:C9H9Br2NO3
    Color and Shape:Solid
    Molecular weight:338.98

    Ref: TM-T23645

  • MDK-3345
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    MDK-3345

    CAS:
    <p>MDK-3345 is a reversible covalent inhibitor for Mcl-1.</p>
    Formula:C36H34BN3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:631.48

    Ref: TM-T27997

  • Fosizensertib
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    Fosizensertib

    CAS:
    <p>Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.</p>
    Formula:C22H21F2N4O5P
    Color and Shape:Solid
    Molecular weight:490.397

    Ref: TM-T206552

  • HC-7366
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    HC-7366

    CAS:
    <p>HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.</p>
    Formula:C20H15ClF2N6O4S
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:508.89

    Ref: TM-T86497

  • TAI-95
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    TAI-95

    CAS:
    <p>TAI-95 is an inhibitor of highly expressed cancer protein 1 (Hec1).</p>
    Formula:C24H23N5O3S2
    Color and Shape:Solid
    Molecular weight:493.60

    Ref: TM-T70649

  • CB-184
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    CB-184

    CAS:
    <p>CB-184 is a selective ligand for sigma-2 (σ2) receptors, with Ki values of 7436 nM for sigma-1 (σ1) and 13.4 nM for sigma-2 (σ2), and it promotes apoptosis with antitumor activity.</p>
    Formula:C22H21Cl2NO2
    Color and Shape:Solid
    Molecular weight:402.31

    Ref: TM-T201560

  • Tandutinib sulfate
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    Tandutinib sulfate

    CAS:
    <p>Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 μM. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 μM and 0.20 μM respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.</p>
    Formula:C31H44N6O8S
    Color and Shape:Solid
    Molecular weight:660.78

    Ref: TM-T201851

  • RIPK1-IN-24
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    RIPK1-IN-24

    CAS:
    <p>RIPK1-IN-24 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1) with an IC50 of 1.3 μM. It is utilized in research on inflammatory diseases.</p>
    Formula:C26H21FN6O2
    Color and Shape:Solid
    Molecular weight:468.48

    Ref: TM-T200682

  • DWP-05195
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    DWP-05195

    CAS:
    <p>DWP-05195 is a TRPV1 antagonist capable of inhibiting pain signal transduction. Additionally, it induces ER stress-dependent apoptosis in human ovarian cancer cells via the ROS-p38-CHOP pathway.</p>
    Formula:C18H10BrF3N4
    Color and Shape:Solid
    Molecular weight:419.2

    Ref: TM-T201755

  • CDK2/9-IN-1
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    CDK2/9-IN-1

    CAS:
    <p>CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.004 μM and 0.009 μM for CDK2 and CDK9, respectively. It induces apoptosis by regulating G2/M cell cycle arrest and exhibits antitumor activity.</p>
    Formula:C14H14N6O2S2
    Color and Shape:Solid
    Molecular weight:362.43

    Ref: TM-T204166

  • Tuvusertib
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    Tuvusertib

    CAS:
    <p>Tuvusertib (M1774), an oral ATR inhibitor (Ki&lt;1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.</p>
    Formula:C16H12F2N8O
    Purity:98.44% - 99.66%
    Color and Shape:Solid
    Molecular weight:370.32

    Ref: TM-T10406

  • UH15-38
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    UH15-38

    CAS:
    <p>UH15-38 is a potent and selective RIPK3 inhibitor that blocks necroptosis in alveolar epithelial cells triggered by IAV, useful for studying lung inflammation.</p>
    Formula:C26H27N5O2
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:441.53

    Ref: TM-T88101

  • HC-5404
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    HC-5404

    CAS:
    <p>HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.</p>
    Formula:C24H24F2N4O3
    Purity:99.33%
    Color and Shape:Solid
    Molecular weight:454.47

    Ref: TM-T86545