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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 6039 products of "Apoptosis"

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  • Tubulin inhibitor 41
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    Tubulin inhibitor 41

    CAS:
    Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].
    Formula:C20H15N3O
    Color and Shape:Solid
    Molecular weight:313.35

    Ref: TM-T87573

  • Topo II/HDAC-IN-1
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    Topo II/HDAC-IN-1

    CAS:
    Topo II/HDAC-IN-1 (7d) demonstrates potent dual inhibitory effects on Topo II and HDAC, while Topo II/HDAC-IN-1 (8d) effectively induces apoptosis [1].
    Formula:C15H16N4O3S
    Color and Shape:Solid
    Molecular weight:332.38

    Ref: TM-T87548

  • Tubulin polymerization-IN-61
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    Tubulin polymerization-IN-61

    CAS:
    Tubulin polymerization-IN-61 (Compound 9a), a tubulin polymerization inhibitor, disrupts the microtubule skeleton, arrests the cell cycle at the G2/M phase, induces Apoptosis, and impedes cancer cell migration and colony formation. This compound demonstrates antitumor efficacy in vivo within the 4T1 xenograft model [1].
    Formula:C22H21N3O5
    Color and Shape:Solid
    Molecular weight:407.42

    Ref: TM-T87579

  • VDX-111
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    VDX-111

    CAS:
    <p>VDX-111, an analog of vitamin D, exhibits cytotoxicity in ovarian cancer cells by upregulating the RIPK1/RIPK3 pathway and inducing necroptosis. It also promotes the expression of cytokines and demonstrates antitumor activity in a mouse model [1].</p>
    Formula:C29H45BrO4
    Color and Shape:Solid
    Molecular weight:537.57

    Ref: TM-T87611

  • Minnelide free acid
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    Minnelide free acid

    CAS:
    Minnelide treats pancreatic cancer, hinders androgen-related prostate growth, shrinks tumors, and improves survival.
    Formula:C21H27O10P
    Color and Shape:Solid
    Molecular weight:470.41

    Ref: TM-T71113

  • YK5
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    YK5

    CAS:
    YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.
    Formula:C18H24N8O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:432.50

    Ref: TM-T26343

  • pan-KRAS-IN-5
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    pan-KRAS-IN-5

    CAS:
    <p>Pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor targeting 5′-UTR RNA G-quadruplexes (rG4s). It induces cell cycle arrest and promotes apoptosis in KRAS-driven cancer cells [1].</p>
    Formula:C31H36FIN4O2
    Color and Shape:Solid
    Molecular weight:642.55

    Ref: TM-T87101

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    Tubulin polymerization-IN-4

    CAS:
    Tubulin polymerization-IN-4: inhibits tubulin (IC50=4.6 μM), blocks G2/M phase, induces apoptosis, hinders cell cloning/migration, damages vasculature.
    Formula:C21H21ClN2O4
    Color and Shape:Solid
    Molecular weight:400.86

    Ref: TM-T61940

  • Necrosis inhibitor 3
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    Necrosis inhibitor 3

    CAS:
    Necrosis Inhibitor 3 (compound B3) effectively inhibits necrosis, demonstrating an IC50 of 0.29 nM in HT29 cells [1].
    Formula:C25H26N4O4S
    Color and Shape:Solid
    Molecular weight:478.56

    Ref: TM-T86990

  • GQN-B37-E
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    GQN-B37-E

    CAS:
    GQN-B37-E is an effective selective binder and inhibitor of MCL-1. It binds to the BH3-binding domain of MCL-1. GQN-B37-E demonstrates binding affinity for MCL-1 within the sub-micromolar range (Ki= 0.6 μM), yet shows negligible binding to BCL-2 or BCL-XL.
    Formula:C29H23ClN4O4
    Color and Shape:Solid
    Molecular weight:526.97

    Ref: TM-T88454

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    CDK4/6-IN-10

    CDK4/6-IN-10: Oral CDK4 (IC50: 22 nM) & CDK6 (IC50: 10 nM) inhibitor with anti-cancer potential for MM research.
    Color and Shape:Solid

    Ref: TM-T64244

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    HER2-IN-10

    HER2-IN-10 is a psoralen derivative that induces apoptosis. HER2-IN-10 shows anti-breast cancer activity and light-activated cytotoxicity [1].
    Formula:C15H13NO5
    Color and Shape:Solid
    Molecular weight:287.27

    Ref: TM-T60572

  • AQIM-I
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    AQIM-I

    CAS:
    <p>AQIM-I is a survivin inhibitor that reduces survivin expression and colony formation. It promotes reactive oxygen species (ROS) production, apoptosis, cell cycle arrest, DNA damage, and autophagy. Moreover, AQIM-I effectively inhibits nonsmall cell lung cancer cells A549, with an IC 50 value of 9 nM [1].</p>
    Formula:C17H13IN2O2
    Color and Shape:Solid
    Molecular weight:404.20

    Ref: TM-T85715

  • HBV/HDV-IN-2
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    HBV/HDV-IN-2

    CAS:
    <p>HBV/HDV-IN-2 (Compd 143) functions as an inhibitor for HBV, HDV, and PD-1/PD-L1, demonstrating an EC 50 of 35 nM in T cell activation.</p>
    Formula:C38H44ClN7O5
    Color and Shape:Solid
    Molecular weight:714.25

    Ref: TM-T88316

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    VEGFR-2-IN-18

    VEGFR-2-IN-18 is a potent VEGFR-2 inhibitor with a 60 nM IC50, promoting cell apoptosis and anticancer effects.
    Formula:C20H13ClN4O2
    Color and Shape:Solid
    Molecular weight:376.8

    Ref: TM-T61561

  • Tubulin inhibitor 43
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    Tubulin inhibitor 43

    CAS:
    Tubulin inhibitor 43 exhibits significant antitumor activity by impeding the proliferation and growth of cancer cells through the inhibition of β-microtubulin activity, ultimately inducing apoptosis [1].
    Formula:C20H21NO6
    Color and Shape:Solid
    Molecular weight:371.38

    Ref: TM-T87575

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    AKN-028 acetate

    AKN-028 acetate: an oral TK inhibitor for AML research, targets FLT3 with IC50 of 6 nM, inhibits autophosphorylation, and induces apoptosis.
    Formula:C19H18N6O2
    Color and Shape:Solid
    Molecular weight:362.39

    Ref: TM-T61358

  • WEHI-9625
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    WEHI-9625

    CAS:
    WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
    Formula:C34H27NO5S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:593.71

    Ref: TM-T13338

  • D18
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    D18

    CAS:
    D18: Dual agonist for TLR7/8, boosts PD-L1, aids tumor sensitivity to PD-1/PD-L1 inhibitors, and is a cytotoxin for ADC HE-S2.
    Formula:C21H28N6
    Color and Shape:Solid
    Molecular weight:364.49

    Ref: TM-T61390

  • Ran-IN-1
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    Ran-IN-1

    CAS:
    Ran-IN-1 (Compound M36) is an orally active and selective inhibitor of Ran GTPase. It binds allosterically with high specificity to the switch II pocket of GDP-bound Ran (RanGDP), stabilizing its inactive state and reducing the formation of active Ran-GTP. Ran-IN-1 induces apoptosis in epithelial ovarian cancer (EOC) cells and inhibits DNA repair pathways such as homologous recombination (HR) and non-homologous end joining (NHEJ). This compound shows potential for research in epithelial ovarian cancer, particularly in high-grade serous carcinoma.
    Formula:C27H26F3NO4S
    Color and Shape:Solid
    Molecular weight:517.56

    Ref: TM-T206660