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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 6039 products of "Apoptosis"

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  • Tubulin inhibitor 41
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    Tubulin inhibitor 41

    CAS:
    Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].
    Formula:C20H15N3O
    Color and Shape:Solid
    Molecular weight:313.35

    Ref: TM-T87573

  • HAC-Y6
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    HAC-Y6

    CAS:
    HAC-Y6 exerts its anticancer effects by inducing cell cycle arrest. It prompts apoptosis in COLO 205 cells with an IC50 of 0.52 µM.
    Formula:C23H22N2O4
    Color and Shape:Solid
    Molecular weight:390.43

    Ref: TM-T200179

  • (S)-JDQ-443
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    (S)-JDQ-443

    CAS:
    <p>(S)-JDQ-443, an isomer of JDQ-443, is a selective, potent oral KRAS G12C inhibitor with antitumor properties.</p>
    Formula:C29H28ClN7O
    Color and Shape:Solid
    Molecular weight:526.03

    Ref: TM-T72971

  • Top/HDAC-IN-3
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    Top/HDAC-IN-3

    CAS:
    Top/HDAC-IN-3 (Compound 31) is a dual inhibitor of Topoisomerase and HDAC with oral activity. It induces DNA damage by elevating reactive oxygen species (ROS) levels, consequently inhibiting the clonal formation and migration of cancer cells, and triggering apoptosis (Apoptosis) and cell cycle arrest. Top/HDAC-IN-3 demonstrates a significant antitumor effect in NSCLC models, exhibiting a tumor growth inhibition (TGI = 77.5%, 100 mg/kg) superior to that of the HDAC inhibitor SAHA and the combination of SAHA with the topoisomerase inhibitor Irinotecan.
    Formula:C24H25N3O5
    Color and Shape:Solid
    Molecular weight:435.47

    Ref: TM-T201842

  • Autophagy inducer 7
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    Autophagy inducer 7

    CAS:
    <p>Autophagyinducer 7 (Compound SSA) serves as an inducer of autophagy (Autophagy) and apoptosis (Apoptosis). It stimulates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Additionally, Autophagyinducer 7 suppresses DNA synthesis and causes G0-G1 cell cycle arrest, ultimately inhibiting the growth of tumor cells.</p>
    Formula:C24H27FN2OS
    Color and Shape:Solid
    Molecular weight:410.547

    Ref: TM-T204882

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    LSD1-IN-21

    LSD1-IN-21: potent LSD1 inhibitor, crosses blood-brain barrier, IC50 of 0.956 μM; lowers TNF-α, anti-cancer, anti-inflammatory.
    Formula:C24H25N5O2S
    Color and Shape:Solid
    Molecular weight:447.55

    Ref: TM-T62674

  • FTO-IN-13
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    FTO-IN-13

    CAS:
    <p>FTO-IN-13 (compound 8t) is a potent FTO inhibitor with antiproliferative properties. It induces apoptosis (cell apoptosis) and reduces the expression of Bcl-2 and Caspase 3 active proteins. Additionally, FTO-IN-13 lowers the expression of MYC and CEBPA genes and demonstrates anticancer activity.</p>
    Formula:C18H12Br2N2O4
    Color and Shape:Solid
    Molecular weight:480.107

    Ref: TM-T204333

  • GP130-IN-1
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    GP130-IN-1

    CAS:
    GP130-IN-1 (compound 49) is an effective inhibitor of GP130, demonstrating significant in vitro anti-tumor activity and higher selectivity compared to Bazedoxifene. It induces ultrastructural changes in cells, leading to a time-dependent arrest of the cell cycle at the G0/G1 phase, and triggers both apoptosis and autophagy. GP130-IN-1 is useful for research on triple-negative breast cancer.
    Formula:C21H10F5NO3
    Color and Shape:Solid
    Molecular weight:419.30

    Ref: TM-T200607

  • Mcl-1 inhibitor 21
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    Mcl-1 inhibitor 21

    CAS:
    Mcl-1 inhibitor21 (Example 1-36) is an Mcl-1 inhibitor with an IC50 of 328 nM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it applicable for cancer research.
    Formula:C32H33N3O4
    Color and Shape:Solid
    Molecular weight:523.622

    Ref: TM-T204659

  • 06:0 PE
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    06:0 PE

    CAS:
    06:0 PE (PE(6:0/6:0)) is a water-soluble phospholipid characterized by its short acyl chains. It possesses notable antitumor activity and can inhibit tumor progression in the body. Additionally, it exhibits antiproliferative and pro-apoptotic properties, and serves as a precursor for phosphatidylcholine and phosphatidylethanolamine.
    Formula:C17H34NO8P
    Color and Shape:Solid
    Molecular weight:411.43

    Ref: TM-T200930

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    HDAC-IN-9

    HDAC-IN-9, a dual tubulin/HDAC inhibitor, impedes A549 cell invasion/migration and shows strong anti-tumor/angiogenic effects.
    Formula:C33H38N2O4
    Color and Shape:Solid
    Molecular weight:526.67

    Ref: TM-T63696

  • HR-19011
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    HR-19011

    CAS:
    HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.
    Formula:C25H19F6N3O3
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:523.43

    Ref: TM-T63665

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    ZLHQ-5f

    ZLHQ-5f inhibits CDK2/Topo I, with IC50 of 0.145μM for CDK2/CycA2, and promotes apoptosis by arresting HCT116 cells in S phase.
    Formula:C28H25N5O2
    Color and Shape:Solid
    Molecular weight:463.53

    Ref: TM-T62934

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    STAT3-IN-9

    STAT3-IN-9 hinders STAT3 at Tyr705, doesn't affect STAT1 Tyr701, induces apoptosis, and arrests cells in G2/M phase.
    Formula:C22H21N3O4
    Color and Shape:Solid
    Molecular weight:391.42

    Ref: TM-T61779

  • RET-IN-10
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    RET-IN-10

    CAS:
    RET-IN-10: Potent RET inhibitor, may treat congenital megacolon and tumors (Patent WO2021135938A1, compound 18).
    Formula:C29H28N8OS
    Color and Shape:Solid
    Molecular weight:536.65

    Ref: TM-T63782

  • RIP3 activator 1
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    RIP3 activator 1

    CAS:
    RIP3 Activator 1 (compound C8) is an effective RIP3 activator that inhibits cell growth and induces necroptotic cell death (necroptosis) and autophagy through the RIP3/p62/Keap1 signaling pathway. Additionally, this compound enhances the expression of p-MLKL and promotes the accumulation of LC3-II and p62 proteins.
    Formula:C26H50N4O3
    Color and Shape:Solid
    Molecular weight:466.7

    Ref: TM-T201677

  • Sampangine
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    Sampangine

    CAS:
    Sampangine, an alkaloid, induces apoptosis by causing cell cycle arrest at the G0/G1 phase and inhibits the biosynthesis of heme.
    Formula:C15H8N2O
    Color and Shape:Solid
    Molecular weight:232.24

    Ref: TM-T200281

  • GNE684
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    GNE684

    CAS:
    GNE684 inhibits RIP1; Ki app: 21 nM (human), 189 nM (mouse), 691 nM (rat).
    Formula:C23H24N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:432.48

    Ref: TM-T11442

  • Urease-IN-20
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    Urease-IN-20

    CAS:
    <p>Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori), with an IC50 of 0.14 μM for H. pylori inhibition. It effectively decreases apoptosis in GES-1 cells infected with H. pylori and reduces levels of ROS and γH2AX. Urease-IN-20 also demonstrates significant gastric mucosal protective effects, making it suitable for H. pylori research.</p>
    Formula:C14H8FNO2Se
    Color and Shape:Solid
    Molecular weight:320.18

    Ref: TM-T205707

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    HDAC6/HSP90-IN-2

    HDAC6/HSP90-IN-2, a cancer research chemical, inhibits HDAC6 & Hsp90 with IC50s of 105.7 & 61 nM.
    Formula:C19H22N2O5
    Color and Shape:Solid
    Molecular weight:358.39

    Ref: TM-T61315