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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 5600 products of "Apoptosis"

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  • TrxR1-IN-2
    Targetmol
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    TrxR1-IN-2

    <p>TrxR1-IN-2 (Compound 6a) acts as a TrxR1 inhibitor that covalently bonds with the Cys475 and Sec498 sites of TrxR1. This interaction hampers TrxR1 activity, resulting in a redox homeostasis disruption and inducing apoptosis and ferroptosis.</p>
    Formula:C19H23NO6
    Color and Shape:Solid
    Molecular weight:361.389

    Ref: TM-T204985

  • CymitQuimica logo
    Targetmol
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    PROTAC ROR1 degrader-1

    <p>PROTACROR1degrader-1 (Compound 11d) serves as a PROTAC degrader targeting the pseudokinase ROR1, with the capability of degrading ROR1 in NSCLC cells at a DC50 of 40-80 nM. It induces PARP cleavage and apoptosis in NCI-H23 cells. [Pink: ligand for target protein ROR1 ligand-1; Black: linker; Blue: ligand for VHL E3 ligase (S,R,S)-AHPC]</p>
    Formula:C55H74BrN11O5S
    Color and Shape:Solid
    Molecular weight:1081.22

    Ref: TM-T205060

  • CymitQuimica logo
    Targetmol
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    JAK-IN-40

    <p>JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.</p>
    Formula:C26H32N8O3S
    Color and Shape:Solid
    Molecular weight:536.65

    Ref: TM-T205062

  • XY221
    Targetmol
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    XY221

    <p>XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.</p>
    Formula:C32H34FN3O5
    Color and Shape:Solid
    Molecular weight:559.628

    Ref: TM-T204924

  • AMPK-IN-6
    Targetmol
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    AMPK-IN-6

    <p>AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.</p>
    Formula:C18H20FN5O
    Color and Shape:Solid
    Molecular weight:341.383

    Ref: TM-T204944

  • CQ627
    Targetmol
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    CQ627

    <p>CQ627 is a molecular glue that targets the degradation of RIOK2. It effectively recruits the E3 ubiquitin ligase RNF126, inducing the proteasomal degradation of RIOK2 via the ubiquitin-proteasome system (UPS) in MOLT4 leukemia cell lines, with a DC50 value of 410 nM. Additionally, CQ627 induces apoptosis in a dose-dependent manner in these cells, blocking the cell cycle at the G2/M phase, and exhibits antiproliferative activity across various cancer cell lines. It also demonstrates in vivo anticancer activity in MOLT4 xenograft mouse models.</p>
    Formula:C36H27F4N7O4
    Color and Shape:Solid
    Molecular weight:697.638

    Ref: TM-T204921

  • STEP-IN-1
    Targetmol
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    STEP-IN-1

    <p>STEP-IN-1 (Compound 14b) is a potent and selective inhibitor of STEP, with an IC50 of 5.27 μM. It offers neuroprotective effects by safeguarding neuronal cells from glutamate-induced toxicity, reducing intracellular reactive oxygen species (ROS) accumulation, and inhibiting apoptosis. STEP-IN-1 is applicable in research related to neurodegenerative diseases.</p>
    Formula:C21H10ClNO7
    Color and Shape:Solid
    Molecular weight:423.76

    Ref: TM-T204907

  • PROTAC XPO1 degrader-1
    Targetmol
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    PROTAC XPO1 degrader-1

    <p>PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.</p>
    Formula:C33H35ClF3N7O7
    Color and Shape:Solid
    Molecular weight:734.122

    Ref: TM-T204868

  • VEGFR-2-IN-61
    Targetmol
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    VEGFR-2-IN-61

    <p>VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.</p>
    Formula:C27H25N5O
    Color and Shape:Solid
    Molecular weight:435.52

    Ref: TM-T204905

  • DP-15
    Targetmol
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    DP-15

    CAS:
    <p>DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]</p>
    Formula:C42H44ClN9O5S
    Color and Shape:Solid
    Molecular weight:822.374

    Ref: TM-T205043

  • BC13
    Targetmol
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    BC13

    <p>BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.</p>
    Formula:C37H39N7O5
    Color and Shape:Solid
    Molecular weight:661.75

    Ref: TM-T204938

  • TTQ-SA
    Targetmol
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    TTQ-SA

    <p>TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.</p>
    Formula:C78H53N7S
    Color and Shape:Solid
    Molecular weight:1120.37

    Ref: TM-T204864

  • (+)-Mcl-1 inhibitor 21
    Targetmol
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    (+)-Mcl-1 inhibitor 21

    CAS:
    <p>(+)-Mcl-1 inhibitor 21 (Example 1-37) is a chemical compound that acts as an Mcl-1 inhibitor with an IC50 value of 172 nM. It demonstrates pro-apoptotic and antiproliferative activities in SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.</p>
    Formula:C32H33N3O4
    Color and Shape:Solid
    Molecular weight:523.622

    Ref: TM-T204815

  • Topoisomerase IIα-IN-10
    Targetmol
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    Topoisomerase IIα-IN-10

    <p>TopoisomeraseIIα-IN-10 (Compound 13r) is a topoisomerase IIα inhibitor that binds to the active site of DNA when complexed with topoisomerase IIα. This binding is stabilized through interactions with DNA base pairs and amino acid residues. By intercalating into DNA, TopoisomeraseIIα-IN-10 induces apoptosis and disrupts the mitochondrial membrane potential in HCT116 cells, effectively inhibiting their growth with an IC50 of 4.37 μM. It is applicable for cancer research studies.</p>
    Formula:C32H27N3O3
    Color and Shape:Solid
    Molecular weight:501.575

    Ref: TM-T204899

  • DefNEtTrp
    Targetmol
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    DefNEtTrp

    <p>DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.</p>
    Formula:C30H27N9O3S
    Color and Shape:Solid
    Molecular weight:593.659

    Ref: TM-T204913

  • CDK4/6/HDAC-IN-1
    Targetmol
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    CDK4/6/HDAC-IN-1

    <p>CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.</p>
    Formula:C35H39N9O5
    Color and Shape:Solid
    Molecular weight:665.742

    Ref: TM-T204833

  • Chetomin
    Targetmol
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    Chetomin

    CAS:
    <p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>
    Formula:C31H30N6O6S4
    Purity:98%
    Color and Shape:Off-White To Fawn Solid
    Molecular weight:710.87

    Ref: TM-T6804

  • ZLDI-8
    Targetmol
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    ZLDI-8

    CAS:
    <p>ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.</p>
    Formula:C24H23N3O3S
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:433.52

    Ref: TM-T13410

  • Mcl-1 inhibitor 3
    Targetmol
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    Mcl-1 inhibitor 3

    CAS:
    <p>Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate</p>
    Formula:C40H52ClF2N5O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:820.39

    Ref: TM-T11972

  • HDAC-IN-84
    Targetmol
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    HDAC-IN-84

    <p>HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.</p>
    Formula:C17H21N3O5S
    Color and Shape:Solid
    Molecular weight:379.431

    Ref: TM-T204799