Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(6 products)
- BCL(11 products)
- Caspase(125 products)
- FOXO1(3 products)
- IAP(66 products)
- Mdm2(12 products)
- PD-1/PD-L1(125 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(15 products)
- Survivin(13 products)
- TNF(92 products)
- c-RET(51 products)
- p53(62 products)
Show 6 more subcategories
Found 5592 products of "Apoptosis"
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Thalidomide-5,6-Cl
CAS:<p>Thalidomide-5,6-Cl is a cereblon ligand derivative that recruits CRBN protein and forms PROTACs with a linker.</p>Formula:C13H8Cl2N2O4Color and Shape:SolidMolecular weight:327.12ZX782
<p>ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.</p>Formula:C39H48ClN5O8Color and Shape:SolidMolecular weight:750.28P1D-34
<p>P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. It downregulates Pin1 substrate proteins, including Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. Additionally, P1D-34 exhibits antiproliferative activity across various acute myeloid leukemia (AML) cell lines and induces DNA damage and apoptosis by generating reactive oxygen species (ROS).</p>Color and Shape:Odour SolidMEK/PI3K-IN-2
CAS:<p>MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.</p>Formula:C38H41F5IN9O7Color and Shape:SolidMolecular weight:957.68GPX4-IN-5
CAS:<p>GPX4-IN-5 is a GPX4 inhibitor with antitumor activity.GPX4-IN-5 induces iron death and may be used for the treatment of triple negative breast cancer.</p>Formula:C18H17ClFNO5Purity:99.58%Color and Shape:SoildMolecular weight:381.78SRE-II
<p>SRE-II, an amide derivative, serves as an activatable photosensitizer tailored for photodynamic cancer research, exhibiting diminished fluorescence and</p>Formula:C15H9ClINO2Purity:98%Color and Shape:SolidMolecular weight:397.59FKBP12 PROTAC dTAG-7
CAS:<p>dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.</p>Formula:C63H79N5O19Purity:98%Color and Shape:SolidMolecular weight:1210.32Ferroptosis-IN-13
<p>Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.</p>Formula:C32H30F2N4O3Color and Shape:SolidMolecular weight:556.602PKM2-IN-8
<p>PKM2-IN-8 (Compound 9b) is an inhibitor of pyruvate kinase M2 (PKM2) with an IC50 of 0.31 μM. It exhibits potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 induces early apoptosis and reduces lactate levels. This compound is useful for research in glioblastoma.</p>Formula:C19H13N7OColor and Shape:SolidMolecular weight:355.353Anticancer agent 102
CAS:<p>Anticancer Agent 102, a tetracaine derivative, exhibits anti-cancer activity by inducing apoptosis [1].</p>Formula:C20H19F6N3OColor and Shape:SolidMolecular weight:431.37BT44
CAS:<p>BT44, a potent second-gen GDNF mimetic, is a lead for treating neurodegeneration.</p>Formula:C28H27F4N3O4SPurity:99.87%Color and Shape:SoildMolecular weight:577.59Balstilimab
CAS:<p>Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .</p>Color and Shape:LiquidKTX-582
CAS:<p>KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.</p>Formula:C45H51F3N8O7Color and Shape:SolidMolecular weight:872.93Thalidomide-O-amido-C6-NH2
CAS:<p>Thalidomide-O-amido-C6-NH2 is a synthetic E3 ligase used for PROTAC creation, containing cereblon ligand and linker.</p>Formula:C21H26N4O6Color and Shape:SolidMolecular weight:430.45HDSI-18
<p>HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.</p>Formula:C28H28N4O5Color and Shape:SolidMolecular weight:500.20597PAA5
<p>PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.</p>Formula:C14H8Au5B2F8N2Color and Shape:SolidMolecular weight:1348.66Tebentafusp
CAS:<p>Tebentafusp (IMCgp100) is a protein that targets gp100 with potential anti-tumor activity.</p>Purity:97.2% (SDS-PAGE); 100% (SEC-HPLC) - 97.2% (SDS-PAGE); 100% (SEC-HPLC)Color and Shape:LiquidGLP-2(rat)
CAS:<p>intestinal epithelium-specific growth factor</p>Formula:C166H256N44O56SPurity:98%Color and Shape:SolidMolecular weight:3796.17EGFR T790M/L858R-IN-2
<p>EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.</p>Formula:C28H28FN7OColor and Shape:SolidMolecular weight:497.57STAT3-D11-PROTAC-VHL
<p>STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting signal transducer and activator of transcription 3 (STAT3). It demonstrates anti-tumor activity with IC50 values of 1335 nM in HeLa cells and 1973 nM in MCF-7 cells. The compound binds to the DNA binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent proteasomal degradation of STAT3. Additionally, STAT3-D11-PROTAC-VHL inhibits tumor cell growth, induces cell cycle arrest and apoptosis (apoptosis), and suppresses tumor immune evasion.</p>Color and Shape:Odour Solid
