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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 5592 products of "Apoptosis"

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  • EGFR-IN-143
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    EGFR-IN-143

    <p>EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.</p>
    Formula:C20H21ClN6O3
    Color and Shape:Solid
    Molecular weight:428.872

    Ref: TM-T204793

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    Haemanthamine hydrochloride

    <p>Haemanthamine hydrochloride, an alkaloid from Amaryllidaceae, has anticancer, antioxidant, antiviral, antimalarial, and anticonvulsant properties.</p>
    Formula:C17H20ClNO4
    Color and Shape:Solid
    Molecular weight:337.8

    Ref: TM-T73813

  • Thalidomide-PEG2-C2-NH2
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    Thalidomide-PEG2-C2-NH2

    CAS:
    <p>Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.</p>
    Formula:C19H24N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:404.42

    Ref: TM-T18813

  • Ac-LEVD-CHO
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    Ac-LEVD-CHO

    CAS:
    <p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>
    Formula:C22H36N4O9
    Color and Shape:Solid
    Molecular weight:500.54

    Ref: TM-T85585

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    Sudubrilimab

    <p>Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.</p>
    Color and Shape:Odour Liquid

    Ref: TM-T77189

  • TRK-IN-30
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    TRK-IN-30

    <p>TRK-IN-30 (Compound C11) is an inhibitor of tropomyosin receptor kinases (TRK), effectively inhibiting TRKA, TRKB, TRKC, and the resistant mutant TRKAG595R, with IC50 values of 1.8, 0.98, 3.8, and 54 nM, respectively. It also suppresses the activation of downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 hinders colony formation and cell migration of Km-12, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis in Km-12 cells.</p>
    Formula:C24H21N5O3
    Color and Shape:Solid
    Molecular weight:427.455

    Ref: TM-T204692

  • TRF2-IN-1
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    TRF2-IN-1

    <p>TRF2-IN-1 (compound F2) is a potent inhibitor of telomere repeat-binding factor 2 (TRF2). It exhibits antiproliferative activity and induces apoptosis. TRF2-IN-1 binds directly to the TRF2TRFH domain, selectively inhibiting TRF2 protein expression and telomere localization. Additionally, TRF2-IN-1 possesses anticancer properties and shows potential for osteosarcoma research.</p>
    Formula:C18H17BrO4
    Color and Shape:Solid
    Molecular weight:377.229

    Ref: TM-T204175

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    LSD1-IN-26

    <p>LSD1-IN-26 (12u) is a potent LSD1 inhibitor (IC50=25.3 nM), also inhibits MAO-A/B, induces apoptosis in MGC-803, for gastric cancer research.</p>
    Formula:C27H25Cl2F2N3O
    Color and Shape:Solid
    Molecular weight:516.41

    Ref: TM-T74858

  • 4-oxo-27-TBDMS Withaferin A
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    4-oxo-27-TBDMS Withaferin A

    CAS:
    <p>4-oxo-27-TBDMS Withaferin A, a withaferin A derivative, is an anticancer agent cytotoxic to A2780, not A2780/CP70.</p>
    Formula:C34H50O6Si
    Color and Shape:Solid
    Molecular weight:582.853

    Ref: TM-T35647

  • TS-IN-5
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    TS-IN-5

    <p>TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.</p>
    Formula:C16H17N5OS
    Color and Shape:Solid
    Molecular weight:327.404

    Ref: TM-T204796

  • HDAC-IN-84
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    HDAC-IN-84

    <p>HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.</p>
    Formula:C17H21N3O5S
    Color and Shape:Solid
    Molecular weight:379.431

    Ref: TM-T204799

  • TNF-α Antagonist
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    TNF-α Antagonist

    CAS:
    <p>TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with</p>
    Formula:C58H71N11O15S2
    Color and Shape:Solid
    Molecular weight:1226.39

    Ref: TM-T36127

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    NecroIr1

    <p>NecroIr1, an iridium(III) complex, induces necroptosis in Cisplatin-resistant lung cells, targeting mitochondria and disrupting MMP.</p>
    Formula:C40H29ClIrN5O
    Color and Shape:Solid
    Molecular weight:823.36

    Ref: TM-T74680

  • Moracin N
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    Moracin N

    CAS:
    <p>Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].</p>
    Formula:C19H18O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:310.34

    Ref: TM-T79940

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    Peginterferon β-1a

    CAS:
    <p>Peginterferon beta-1a: first pegylated interferon for cancer, RMS research; induces tumor cell apoptosis.</p>
    Color and Shape:Solid

    Ref: TM-T73693

  • Dehydroaltenusin
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    Dehydroaltenusin

    CAS:
    <p>Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM).</p>
    Formula:C15H12O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:288.255

    Ref: TM-T15094

  • ZLDI-8
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    ZLDI-8

    CAS:
    <p>ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.</p>
    Formula:C24H23N3O3S
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:433.52

    Ref: TM-T13410

  • Thrombospondin-1 (1016-1023) (human, bovine, mouse)
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    Thrombospondin-1 (1016-1023) (human, bovine, mouse)

    CAS:
    <p>Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.</p>
    Formula:C56H81N13O10S
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:1128.39

    Ref: TM-T75720

  • CDK4/6/HDAC-IN-1
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    CDK4/6/HDAC-IN-1

    <p>CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.</p>
    Formula:C35H39N9O5
    Color and Shape:Solid
    Molecular weight:665.742

    Ref: TM-T204833

  • Thymidine 3',5'-diphosphate tetrasodium
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    Thymidine 3',5'-diphosphate tetrasodium

    CAS:
    <p>Thymidine 3',5'-diphosphate tetrasodium inhibits staphylococcal nuclease, SND1 &amp; tyrosyl nuclease; has anti-tumor properties &amp; catalyzes biochemical reactions.</p>
    Formula:C10H12N2Na4O11P2
    Color and Shape:Solid
    Molecular weight:490.12

    Ref: TM-T73824