Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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Trimebutine
CAS:Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioidFormula:C22H29NO5Purity:99.49% - 99.86%Color and Shape:SolidMolecular weight:387.47UAMC-4821
UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.Formula:C15H19N3OColor and Shape:SolidMolecular weight:257.33OA-Br-1
OA-Br-1 is an orally active, selective inhibitor of PTP1B with an IC50 value of 7.08 μM. It induces apoptosis and exhibits broad-spectrum anti-cancer cell proliferation activity. OA-Br-1 exerts anti-breast cancer effects both in vitro and in vivo through the PTP1B/PI3K/AKT signaling pathway.Formula:C43H70BrNO8Color and Shape:SolidMolecular weight:808.92CDK2-IN-41
CDK2-IN-41 (Compound 7a) is a CDK2 inhibitor that impedes the cell cycle by binding to CDK2, leading to cytotoxicity, increased ROS production, and apoptosis (Apoptosis). It exhibits anticancer activity with an IC50 of 10 µM against acute myeloid leukemia (AML) HL-60 cells. CDK2-IN-41 is applicable in research related to AML-associated cancers.Formula:C19H21N3SColor and Shape:SolidMolecular weight:323.46DNMT-IN-4
DNMT-IN-4 (Compound 4d) is a DNMT inhibitor with an IC50 value of 5.78 µM. It induces apoptosis and exhibits anticancer activity.Formula:C22H25ClN4S2Color and Shape:SolidMolecular weight:445.04SDU-071
CAS:SDU-071 is a BRD4-p53 inhibitor, suppressing MDA-MB-231 cell proliferation, inducing cell cycle arrest and apoptosis.Formula:C28H25N3O2Purity:99.54%Color and Shape:SolidMolecular weight:435.52Antitumor agent-198
Antitumor agent-198 (Compound A3) exhibits cytotoxicity in head and neck squamous cell carcinoma (HNSCC) cells, effectively inhibiting the proliferation of CAL27, HN6, HN30, SCC9, and SCC25, with an IC50 ranging from 4 nM to 77 nM. Additionally, Antitumor agent-198 suppresses HNSCC cell migration, arrests the cell cycle, and induces apoptosis.Formula:C32H28O12SColor and Shape:SolidMolecular weight:636.62Scr-IN-1
Scr-IN-1 (Compound 4e) is a tyrosine kinase inhibitor demonstrating inhibitory activity against HCT-116 and MIA-PaCa-2 cells, with IC50 values of 0.16 μM and 1.16 μM, respectively. It shows selectivity towards HCT-116 cells and MIA-PaCa-2 cells, with a selectivity index (SI) greater than 625 and 86. Scr-IN-1 induces apoptosis in HCT-116 colon cancer cells without altering the proportion of necrotic cells and is a potential novel SRC kinase inhibitor for HCT-116 cells. This compound is suitable for cancer research.Formula:C26H16ClF3N2O3Color and Shape:SolidMolecular weight:496.87CDK9-IN-36
CDK9-IN-36 (Compound T7) is a potent, selective, and metabolically stable CDK9 inhibitor with an IC50 value of 1.2 nM. It effectively suppresses the proliferation of Osimertinib-resistant NSCLC cells by downregulating Mcl-1, reducing colony formation, and inducing apoptosis. Additionally, CDK9-IN-36 exhibits antitumor activity in xenograft models.Formula:C30H33F2N5O4Color and Shape:SolidMolecular weight:565.61Tubulin polymerization-IN-73
Tubulin polymerization-IN-73 (Compound 37) is an inhibitor of microtubule polymerization with an IC50 of 1.8 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in A549 cells. The compound inhibits the proliferation of both A549 WT and A549/T resistant cells with IC50 values of 0.023 μM and 0.057 μM, respectively. Additionally, Tubulin polymerization-IN-73 demonstrates antitumor activity in mouse models.Formula:C23H23N3O4Color and Shape:SolidMolecular weight:405.446Enpp/Carbonic anhydrase-IN-1
CAS:Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.Formula:C23H25NO4SPurity:99.96%Color and Shape:SoildMolecular weight:411.51Tubulin polymerization-IN-72
Tubulin polymerization-IN-72 (Compound 4a4) is a microtubule synthesis inhibitor with anticancer properties. By binding to the colchicine site, it disrupts the polymerization of tubulin, resulting in the arrest of cancer cells at the G2/M phase and inducing apoptosis (Apoptosis). The IC50 for its activity against cancer cells is 0.4-2.7 nM.Formula:C19H19FN4OColor and Shape:SolidMolecular weight:338.379TNF-α-IN-6
CAS:TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
Formula:C26H25N9O2Color and Shape:SolidMolecular weight:495.547NS3694
CAS:NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.Formula:C15H10ClF3N2O3Purity:99.83%Color and Shape:SolidMolecular weight:358.7Ref: TM-T22119
1mg37.00€2mg52.00€5mg79.00€10mg111.00€25mg227.00€50mg329.00€100mg512.00€500mg1,093.00€1mL*10mM (DMSO)87.00€PROTAC RIPK degrader-6
CAS:PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linkerFormula:C43H48N6O11S2Color and Shape:SolidMolecular weight:889.01Oenothein B
CAS:Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.Formula:C68H48O44Purity:99.30%Color and Shape:SolidMolecular weight:1569.08PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurity:99.44% - 99.49%Color and Shape:SolidMolecular weight:469.43Rosamultic acid
Rosamultic acid is a useful organic compound for research related to life sciences and the catalog number is T125342.Formula:C30H46O5Color and Shape:SolidMolecular weight:486.693Voreloxin
CAS:Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formula:C18H19N5O4SPurity:98%Color and Shape:SolidMolecular weight:401.44SPOP-IN-6lc
CAS:SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.
Formula:C26H31N7O2SPurity:99.19%Color and Shape:SolidMolecular weight:505.64Monactin
CAS:Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.Formula:C41H66O12Purity:98%Color and Shape:SolidMolecular weight:750.96Cefatrizine
CAS:Cefatrizine inhibits eEF-2 kinase, affecting apoptosis, autophagy, and ER stress in cancers.Formula:C18H18N6O5S2Purity:98%Color and Shape:SolidMolecular weight:462.5PROTAC FLT-3 degrader 1
CAS:PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.Formula:C52H61N9O9S2Purity:98%Color and Shape:SolidMolecular weight:1020.23KB02-SLF
KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein degradation.Formula:C50H65ClN4O12Purity:98%Color and Shape:SolidMolecular weight:949.52Fosbretabulin [free base]
CAS:Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.
Formula:C18H21O8PColor and Shape:SolidMolecular weight:396.33β-Amyloid (1-40) (rat)
CAS:Rat form of the beta-Amyloid (1-40) peptideFormula:C190H291N51O57SPurity:98%Color and Shape:SolidMolecular weight:4233.76HMGB1-IN-1
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/Formula:C57H75N3O15Color and Shape:SolidMolecular weight:1042.22Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.Formula:C56H81N13O10SPurity:99.23%Color and Shape:SolidMolecular weight:1128.39Ref: TM-T75720
1mg49.00€5mg105.00€10mg172.00€25mg268.00€50mg416.00€100mg600.00€1mL*10mM (DMSO)200.00€BIO8898
BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.Formula:C53H64N8O6Color and Shape:SolidMolecular weight:909.13Jacaric Acid
CAS:Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.Formula:C18H30O2Color and Shape:SolidMolecular weight:278.436PK095
CAS:PK095 is a proprietary compound in the guanidine - based F1F0-ATPase inhibitor family.
Formula:C20H18N4O2SPurity:96.84%Color and Shape:SoildMolecular weight:378.45HDAC-IN-57
CAS:HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4Formula:C21H19N3O4Purity:98.62%Color and Shape:SoildMolecular weight:377.39Mcl-1 inhibitor 14
Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potentialFormula:C39H41ClFN5O5SColor and Shape:SolidMolecular weight:746.298-Aminoadenosine
CAS:8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.
Formula:C10H14N6O4Color and Shape:SolidMolecular weight:282.268-hydroxy Efavirenz
CAS:8-hydroxy Efavirenz, a main efavirenz metabolite by CYP2B6, causes apoptosis in rat neurons at 0.01 μM.Formula:C14H9ClF3NO3Color and Shape:SolidMolecular weight:331.68Ferroptosis-IN-17
Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.Formula:C21H26N4O5SColor and Shape:SolidMolecular weight:446.52Topoisomerase II inhibitor 14
CAS:Topoisomerase II inhibitor 14: powerful anticancer agent that induces apoptosis, halts S phase, and lowers GSH, MDA, and NO levels.Formula:C15H11Cl2N5Purity:99.95%Color and Shape:SoildMolecular weight:332.19Platycoside G3
CAS:Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.Formula:C63H102O32Color and Shape:SolidMolecular weight:1371.48Apoptosis inducer 13
Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion.Formula:C59H54ClF6N8O4PRuPurity:98%Color and Shape:SolidMolecular weight:1220.6Thalidomide-PEG2-C2-NH2 hydrochloride
CAS:Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.Formula:C19H25ClN4O6Purity:98%Color and Shape:SolidMolecular weight:440.88Apoptosis inducer 37
Apoptosis inducer37 (Derivative 10) is an agent that induces apoptosis and exhibits anticancer properties by causing cell cycle arrest at the S-G2/M phase and promoting cell apoptosis. It significantly inhibits HCT116, SKOV3, and HepG2 cancer cells with IC50 values of 24.98 μM, 26.15 μM, and 23.09 μM, respectively. Apoptosis inducer37 demonstrates antitumor activity and can be utilized in ovarian cancer research.Formula:C27H37BrN2O4SColor and Shape:SolidMolecular weight:564.16574ZC0109
ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.Formula:C22H20BrFN8O4SColor and Shape:SolidMolecular weight:591.41EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Formula:C25H18N4O3Purity:98%Color and Shape:SolidMolecular weight:422.44Distamycin A
CAS:Distamycin A (NSC-82150), oligopeptide antibiotic, binds A/T rich DNA, affects cleavage sites, enhances apoptosis.Formula:C22H27N9O4Color and Shape:SolidMolecular weight:481.51Pralnacasan
CAS:Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Formula:C26H29N5O7Purity:98%Color and Shape:SolidMolecular weight:523.54Dehydroaltenusin
CAS:Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM).Formula:C15H12O6Purity:98%Color and Shape:SolidMolecular weight:288.255PZ703b TFA
PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound forFormula:C82H103ClF6N10O13S4Purity:98%Color and Shape:SolidMolecular weight:1714.46Halenaquinone
CAS:Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.Formula:C20H12O5Purity:98%Color and Shape:SolidMolecular weight:332.31CALP1
CAS:Cell-permeable CaM agonist; activates phosphodiesterase, binds to Ca2+ channels, inhibits cytotoxicity (IC50=52μM), protects cells, reduces inflammation.Formula:C40H75N9O10Purity:98%Color and Shape:SolidMolecular weight:842.09A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFormula:C27H28N6OPurity:98%Color and Shape:SolidMolecular weight:452.55
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