Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(116 products)
- PDK(9 products)
- PERK(24 products)
- Serine/threonin kinase(18 products)
- Survivin(14 products)
- TNF(65 products)
- c-RET(61 products)
- p53(63 products)
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Found 6114 products of "Apoptosis"
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ZX703
ZX703 is a protein hydrolysis-targeting chimera (PROTAC) that mediates the degradation of GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways, with a DC50 of 0.315 µM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby promoting ferroptosis in cancer cells.Calcimycin hemimagnesium
CAS:Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.Formula:C58H72MgN6O12Color and Shape:SolidMolecular weight:1069.53Thalidomide-NH-PEG4-COOH
CAS:Thalidomide-NH-PEG4-COOH is a E3 ligase ligand-linker for synthesizing the selective degrader dCBP-1 targeting p300/CBP.Formula:C24H31N3O10Color and Shape:SolidMolecular weight:521.523Thalidomide-PEG2-C2-NH2 hydrochloride
CAS:Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.Formula:C19H25ClN4O6Purity:98%Color and Shape:SolidMolecular weight:440.88Diprovocim-1
CAS:Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.Formula:C56H56N6O6Color and Shape:SolidMolecular weight:909.1JPS014 TFA
JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDACFormula:C48H60F3N7O9SPurity:98%Color and Shape:SolidMolecular weight:968.09HJC0416 hydrochloride
CAS:HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.Formula:C18H18Cl2N2O4SColor and Shape:SolidMolecular weight:429.31Anticancer agent 133
Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy.Formula:C24H19Cl3N5ORhPurity:98%Color and Shape:SolidMolecular weight:602.71Emavusertib Phosphate
CAS:Emavusertib Phosphate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, exhibiting antitumor activity. In ABC DLBCL and AML cell lines, it demonstrates significant cellular efficacy. Furthermore, CA-4948 shows moderate to high selectivity across a panel of 329 kinases and possesses favorable ADME and PK profiles, including good oral bioavailability in mice, rats, and dogs. It achieves over 90% tumor growth inhibition in relevant tumor models and correlates excellently with in vivo PD modulation.Formula:C24H28N7O9PMolecular weight:589.49Antimycin A2c
Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer.Formula:C28H40N2O9Purity:98%Color and Shape:SolidMolecular weight:548.63Hexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Formula:C36H48N6O7Purity:98%Color and Shape:SolidMolecular weight:676.8SBP-0636457
CAS:SBP-0636457: SMAC mimetic, IAP inhibitor, binds BIR-domains (Ki=0.27μM), potential in tumor/cancer research.Formula:C25H36N4O4Color and Shape:SolidMolecular weight:456.587p53-HDM2-IN-1
p53-HDM2-IN-1 is a potent inhibitor of the p53-HDM2 protein-protein interaction, demonstrating an inhibitory concentration (IC 50) of 0.103 μM.Formula:C35H38F6N4O7SColor and Shape:SolidMolecular weight:772.75Antiproliferative agent-42
Antiproliferative Agent-42 (Compound 7m), a dihydrodipyrrolo compound, exhibits antiproliferative activity against the Panc-1 cell line, with an IC 50 of 12.54Color and Shape:Odour SolidNrf2 activator-9
Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-densityFormula:C26H27N5O4Color and Shape:SolidMolecular weight:473.52Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Color and Shape:Odour Solid3-Hydroxykynurenine
CAS:3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.
Formula:C10H12N2O4Purity:98.83% - 99.69%Color and Shape:SolidMolecular weight:224.21Terrein
CAS:Terrain (NSC 291308), a fungal metabolite, reduces age-related inflammation via Nrf2/ERK1/2/HO-1 and inhibits IL-6 in human fibroblasts.Formula:C8H10O3Color and Shape:SolidMolecular weight:154.16MDM2/4-p53-IN-3
MDM2/4-p53-IN-3 inhibits MDM2/4-p53 PPIs (IC50: 18.5nM MDM2, 14.8nM MDM4), used in cancer research.Formula:C25H24Cl2FN3O3Color and Shape:SolidMolecular weight:504.38MEK/PI3K-IN-1
CAS:MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.Formula:C36H37F5IN9O6Color and Shape:SolidMolecular weight:913.63NLRP3-IN-62
CAS:NLRP3-IN-62 (Compound 1) is an inhibitor of NLRP3. It effectively inhibits pyroptosis in THP-1 cells with an IC50 of 0.7 nM and suppresses IL-β release with an IC50 of 108.5 nM.Formula:C21H15F3N4O3Molecular weight:428.365-HT1AR agonist 2
5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice.Formula:C31H31N5O3Color and Shape:SolidMolecular weight:521.61Anticancer agent 39
CAS:Compound B12, a JOA derivative, collapses MMP to induce apoptosis, inhibits cloning/migration, and has an IC50 of 0.39 μM against HGC-27 cells.Formula:C50H65N5O10Color and Shape:SolidMolecular weight:896.08Thalidomide-O-amido-PEG2-C2-NH2
CAS:Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment.Formula:C21H26N4O8Color and Shape:SolidMolecular weight:462.459Monensin
CAS:Monensin, from Streptomyces cinnamonensis, inhibits Wnt/β-catenin. Potential anticancer agent.
Formula:C36H62O11Purity:98%Color and Shape:Crystals White Or Off-White CrystalsMolecular weight:670.87Amiloride hydrochloride dihydrate
CAS:Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.Formula:C6H8ClN7O·HCl·2H2OPurity:99.07% - >99.99%Color and Shape:SolidMolecular weight:302.12N-methyl Paroxetine
CAS:N-methyl Paroxetine, a potent SSRI derivative with Ki=4.3 nM, blocks serotonin reuptake (IC50=22 nM) and is a precursor/impurity in paroxetine synthesis.Formula:C20H22FNO3Color and Shape:SolidMolecular weight:343.395-LOX-IN-8
5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).Color and Shape:Odour SolidFLT3-IN-28
FLT3-IN-28 (Compound 12y) is an orally active FLT3 inhibitor with antitumor properties. It selectively targets cancer cells with FLT3 internal tandem duplication (ITD) mutations, demonstrating IC50 values of 85, 290, 130, 65, and 220 nM against BaF3-FLT3-ITD, BaF3-TEL-VEGFR2, MV4-11, MOLM-13, and MOLM-14 cell lines, respectively. These lines include acute myeloid leukemia (AML) cells harboring FLT3-ITD mutations such as MV4-11 and MOLM-13/14. The compound also reduces phosphorylation levels of FLT3 and STAT5 in MOLM-13 cells, leading to cell cycle arrest and apoptosis. With an oral bioavailability of 19.2% in SD rats, FLT3-IN-28 extends survival in a dose-dependent manner in MOLM-13 xenografted NSG mouse models. It holds promise for research in FLT3-ITD-related cancer studies.Formula:C23H19FN8O4Color and Shape:SolidMolecular weight:490.447AKT-IN-24
AKT-IN-24 (Compound M17) is an allosteric inhibitor of AKT exhibiting antitumor activity. In combination with Trametinib, it targets the AKT/mTOR and MEK/ERK signaling pathways while inhibiting epithelial-mesenchymal transition, resulting in a synergistic suppression effect on TNBC. This combination promotes apoptosis and inhibits cell proliferation and migration.Formula:C32H28N2O10Color and Shape:SolidMolecular weight:600.572NLRP3-IN-60
NLRP3-IN-60 (Compound 39) is an orally bioavailable inhibitor of NLRP3. It effectively suppresses pyroptosis in THP-1 cells with an IC50 of 13 nM and inhibits IL-1β release in human whole blood, exhibiting an IC50 of 225 nM.
Formula:C23H24F2N4O4SColor and Shape:SolidMolecular weight:490.523Thymidine 3',5'-diphosphate tetrasodium
CAS:Thymidine 3',5'-diphosphate tetrasodium inhibits staphylococcal nuclease, SND1 & tyrosyl nuclease; has anti-tumor properties & catalyzes biochemical reactions.Formula:C10H12N2Na4O11P2Color and Shape:SolidMolecular weight:490.12KT-253
CAS:KT-253 is a p53 stabilizer and a PROTAC degrader of MDM2 (DC50=0.4 nM). It inhibits the proliferation of cancer cells RS4;11 with an IC50 of 0.3 nM, induces cell cycle arrest in the G2/M phase, and triggers apoptosis. In mouse models, KT-253 demonstrates antitumor activity. (Pink: ligand for target protein MDM2 ligand 4; Black: linker; Blue: ligand for E3 ligase cereblon)
Formula:C48H52Cl2FN7O6Color and Shape:SolidMolecular weight:912.874HPCR
CAS:HPCR exhibits antiproliferative activity against various cancer cells and is involved in apoptosis (apoptosis).Formula:C52H40O12Color and Shape:SolidMolecular weight:856.867LD4172
CAS:LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-α, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)Formula:C61H75F3N10O7SColor and Shape:SolidMolecular weight:1149.37M24
CAS:M24 inhibits Mcl-1 (Ki = 0.33μM), blocks HepG2 cell growth, and triggers apoptosis.Formula:C44H40Cl3N5O11SColor and Shape:SolidMolecular weight:953.24Anti-inflammatory agent 45
Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies,Formula:C25H22BrNO6Purity:98%Color and Shape:SolidMolecular weight:512.355-hydroxy Diclofenac
CAS:5-hydroxy Diclofenac, a CYP3A4-formed NSAID diclofenac metabolite, inhibits COX-1/2 with varying IC50 values.Formula:C14H11Cl2NO3Color and Shape:SolidMolecular weight:312.15Tubulin-IN-53
Tubulin-IN-53 is a potent inhibitor of microtubulin (Tubulin) with an IC50 of 6.06 μM. By targeting the colchicine binding site on tubulin, Tubulin-IN-53 hinders tubulin polymerization, disrupting the microtubule network. It induces cell cycle arrest at the G2/M phase and apoptosis (apoptosis) in MCF-7 cells, while inhibiting cell migration. This compound also leads to a reduction in mitochondrial membrane potential and an increase in reactive oxygen species (ROS) accumulation. Additionally, Tubulin-IN-53 disrupts angiogenesis in human umbilical vein endothelial cells and is applicable in research on cancers such as breast and lung cancer.Color and Shape:Odour SolidPRMT5-IN-33
PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.Formula:C25H24BrN5O3SMolecular weight:553.07832RO5353
CAS:RO5353 is a potent and orally active inhibitor of p53-MDM2.Formula:C29H29Cl2FN4O4SPurity:98%Color and Shape:SolidMolecular weight:619.53HSP70-IN-6
HSP70-IN-6 (Compound JL-15) acts as an inhibitor of the Hsp70-Bim protein-protein interactions (PPI) with an IC50 value of 70 nM. It induces apoptosis in chronic myeloid leukemia (CML) cells with EC50 values of 0.43 μM (BV173), 0.88 μM (K562), and 0.19 μM (K562-R3).Color and Shape:Odour SolidMK-0731
CAS:MK-0731 inhibits kinesin spindle protein, disrupting mitosis and triggering apoptosis in KSP-overexpressing tumor cells.Formula:C25H28F3N3O2Color and Shape:SolidMolecular weight:459.5PROTAC NCOA4 degrader-1
PROTACNCOA4 degrader-1 (Compound V3) is a PROTAC-based degrader of NCOA4, exhibiting a DC50 of 3 nM in HeLa cells. Besides acting as a ferroptosis inhibitor, this compound effectively reduces the levels of NCOA4 and decreases intracellular ferrous (Fe2+) levels. Moreover, PROTACNCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model.Color and Shape:Odour SolidKurzipene D
CAS:Kurzipene D: anticancer, induces apoptosis, halts HepG2 at S phase, anti-tumor in zebrafish, inhibits tumor growth and spread.Formula:C26H36O8Color and Shape:SolidMolecular weight:476.56Bim BH3
CAS:Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.Formula:C108H170N32O31SColor and Shape:SolidMolecular weight:2444.77Human PD-L1 inhibitor II
CAS:Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.Formula:C103H151N25O30Color and Shape:SolidMolecular weight:2219.486Human PD-L1 inhibitor I
CAS:Human PD-L1 inhibitor I, a peptide, blocks PD-L1/PD-1 interaction with 3.39 μM affinity.Formula:C110H152N26O32Color and Shape:SolidMolecular weight:2350.576EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Formula:C25H18N4O3Purity:98%Color and Shape:SolidMolecular weight:422.44Thalidomide-O-C2-acid
CAS:Thalidomide-O-C2-acid: E3 ligase ligand-linker for PROTAC, with cereblon-derived Thalidomide component.Formula:C16H14N2O7Color and Shape:SolidMolecular weight:346.2916
