Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(116 products)
- PDK(9 products)
- PERK(24 products)
- Serine/threonin kinase(18 products)
- Survivin(14 products)
- TNF(65 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6115 products of "Apoptosis"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
JAK-IN-40
JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.Formula:C26H32N8O3SColor and Shape:SolidMolecular weight:536.65TS-IN-5
TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.Formula:C16H17N5OSColor and Shape:SolidMolecular weight:327.404CQ627
CQ627 is a molecular glue that targets the degradation of RIOK2. It effectively recruits the E3 ubiquitin ligase RNF126, inducing the proteasomal degradation of RIOK2 via the ubiquitin-proteasome system (UPS) in MOLT4 leukemia cell lines, with a DC50 value of 410 nM. Additionally, CQ627 induces apoptosis in a dose-dependent manner in these cells, blocking the cell cycle at the G2/M phase, and exhibits antiproliferative activity across various cancer cell lines. It also demonstrates in vivo anticancer activity in MOLT4 xenograft mouse models.Formula:C36H27F4N7O4Color and Shape:SolidMolecular weight:697.638L 683519
CAS:L 683519 is one of the Tacrolimus impurities with immunosuppressant and could restrain the activity of FK-506 binding protein.Formula:C43H67NO12Color and Shape:SolidMolecular weight:789.99Anti-inflammatory agent 74
Anti-inflammatory agent 74 (B5) is known for its ability to inhibit NO, IL-6, and TNF-α, with IC50 values of 10.88 μM and 4.93 μM for NO and IL-6, respectively. It alleviates acute lung injury (ALI) by modulating inflammatory mediators and inhibiting the MAPK and NF-κB signaling pathways.Formula:C41H51NO14Molecular weight:781.33096PD-1-IN-20
PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.Formula:C12H20N6O7Purity:98%Color and Shape:SolidMolecular weight:360.32BC13
BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.Formula:C37H39N7O5Color and Shape:SolidMolecular weight:661.75Tat-ASIC1a (1-20) (mouse, rat)
Tat-ASIC1a (1-20) (mouse, rat) is a competitive ASIC1a transmembrane peptide with significant neuroprotective effects. It alleviates acidotoxic neuronal damage by targeting the ASIC1a-RIPK1 pathway and an auto-inhibition mechanism. This compound effectively safeguards the brain in ischemic stroke mouse models against damage from ischemia and is applicable in research on neurodegenerative diseases, such as Huntington's disease and Parkinson’s disease.Color and Shape:Odour SolidNEP162
CAS:NEP162 is a BRD4 PROTAC degrader with DC50 values of 1.2 μM in SW480 cells and 1.6 μM in U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibiting tumor growth and inducing apoptosis. It is applicable in research on cancers such as osteosarcoma, colorectal cancer, and non-small cell lung cancer.Formula:C50H56ClN11O3SColor and Shape:SolidMolecular weight:926.57PDE4-IN-28
PDE4-IN-28 (Compound G1) is an inhibitor of PDE4D, with an IC50 of 29 nM. It suppresses the production of TNF-α and NO, with IC50 values of 13.32 μM and 2.32 μM, respectively. In a rat pressure ulcer (PU) model, PDE4-IN-28 exhibits anti-inflammatory, antibacterial, and analgesic properties, while promoting HUVEC cell migration to enhance wound healing.Color and Shape:Odour SolidFTI 277 TFA
CAS:FTI 277, a FTI 276 prodrug, blocks farnesyltransferase (IC50 = 0.5 nM), H-Ras/K-Ras processing, and fights tumor cell growth.Formula:C24H30F3N3O5S2Color and Shape:SolidMolecular weight:561.64DefNEtTrp
DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.Formula:C30H27N9O3SColor and Shape:SolidMolecular weight:593.659CDK4/6/HDAC-IN-1
CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.Formula:C35H39N9O5Color and Shape:SolidMolecular weight:665.742Bcl-2-IN-14
Bcl-2-IN-14 (Compound 13c), a BCL-2 inhibitor, exhibits an inhibitory concentration (IC 50) of 0.471 μM, and is applicable in cancer research [1].Color and Shape:Odour SolidSHOC2-RAS PPI-IN-1
SHOC2–RAS PPI-IN-1 (compound 6) is a non-covalent competitive inhibitor that targets the interaction between SHOC2 and RAS proteins. It exhibits an IC50 of 0.048 μM and a KD of 0.065 μM against NRASQ61R. This compound inhibits SMP phosphatase-complex activity, increasing CRAFS259 phosphorylation levels and thus blocking the MAPK signaling pathway (by reducing pMEK and pERK levels). It induces cell cycle arrest and apoptosis in tumor cells. SHOC2–RAS PPI-IN-1 is used in targeting studies for malignancies, such as NRASQ61R-mutant melanoma and colorectal cancer.Color and Shape:Odour SoliddASK1-VHL
dASK1-VHL is an orally active PROTAC degrader targeting ASK1. It effectively binds to VHL, promoting the selective degradation of ASK1. By reducing ASK1 protein levels, dASK1-VHL inhibits the activation of p38 MAPK and decreases liver lipid content, offering new insights for MASH research.Color and Shape:Odour SolidSB-T-1214
CAS:SB-T-1214 (SBT) is a taxane-based drug known for its ability to effectively suppress the expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induce apoptosis in drug-resistant tumorigenic CD133+/CD44+ colon cancer spheroids. In Pgp+ DLD-1 human colon tumor xenograft mouse models, SB-T-1214 successfully inhibits tumor growth. This compound is relevant for anti-tumor research, particularly against drug-resistant tumors such as colon, pancreatic, and renal cancers.Formula:C45H59NO15Color and Shape:SolidMolecular weight:853.95Chetomin
CAS:Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar
Formula:C31H30N6O6S4Purity:98%Color and Shape:Off-White To Fawn SolidMolecular weight:710.87EGFR T790M/L858R-IN-2
EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.Formula:C28H28FN7OColor and Shape:SolidMolecular weight:497.57MB-314
MB-314 is a humanized IgG1 monoclonal antibody (mAb) targeting Lewis Y. This compound enhances antibody-dependent cell-mediated cytotoxicity (ADCC) activity and increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 is applicable in cancer research.Color and Shape:Odour LiquidPROTAC PI3Kδ degrader-1
PROTACPI3Kδ degrader-1 is a covalent PI3Kδ-targeting PROTAC degrader that targets lysine, with a DC50 of 3.98 nM. It exhibits potent antiproliferative activity and selective PI3Kδ inhibition (IC50: 8 nM). Additionally, PROTACPI3Kδ degrader-1 effectively degrades p-AKT, induces cell cycle arrest in the G1 phase, and promotes apoptosis and autophagy. It also significantly suppresses tumor growth in the SU-DHL-6 xenograft mouse model.Color and Shape:Odour SolidHMGB1-IN-2
HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM inFormula:C53H71N3O11Color and Shape:SoildMolecular weight:926.14Insect repellent M 3535
CAS:Insect repellent M 3535 is a bug repellant.Formula:C11H21NO3Color and Shape:Colorless To Slightly Yellowish Liquid SolidMolecular weight:215.29ZLDI-8
CAS:ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
Formula:C24H23N3O3SPurity:98.09%Color and Shape:SolidMolecular weight:433.52ISB2001
ISB2001 is a human trispecific antibody targeting CD38, CD3, and BCMA. It is applicable for research on relapsed/refractory multiple myeloma (RRMM). The recommended isotype control is IgG1-kappa-IgG1-Fab.Color and Shape:Odour LiquidDiafenthiuron
CAS:Diafenthiuron is a widely utilized thiourea-based pesticide that effectively hinders mitochondrial activity in insect pests.Formula:C23H32N2OSColor and Shape:SolidMolecular weight:384.58Tubulin polymerization-IN-79
Tubulin polymerization-IN-79 (Compound C20) acts as an inhibitor of microtubule polymerization. It exhibits significant antiproliferative activity against esophageal cancer cells, such as KYSE450 (IC50=0.36 μM) and EC-109 (IC50=0.63 μM). In esophageal cancer cells, Tubulin polymerization-IN-79 occupies the colchicine binding site, disrupting the microtubule network's integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP, and inducing G2/M phase arrest and apoptosis. This compound shows promise for esophageal cancer research.Color and Shape:Odour SolidRecQ helicase-IN-1
Frangulin B (Compd 11g) exhibits anticancer properties and acts as an effective RecQ helicase inhibitor. It induces apoptosis in both HCT-116 and MDA-MB-231 cells and can arrest HCT-116 cells in the G2/M phase.Formula:C25H21N3O3Molecular weight:411.15829MST3-IN-1
MST3-IN-1 is a selective and orally active MST3 inhibitor with an IC50 of 122.4 nM. It exhibits antiproliferative activity in HepG2 cells, effectively induces apoptosis, and causes cell cycle arrest at the G2/M phase. In HepG2 xenograft mouse models, MST3-IN-1 significantly suppresses tumor growth, making it useful for liver cancer research.Color and Shape:Odour SolidThymocartin
CAS:Thymocartin (RGH 0206) is a fragment 32-35 of the naturally occurring thymic factor (thymopoietin).Thymocartin is used in the study of immunodeficiency diseasesFormula:C21H40N8O7Purity:98%Color and Shape:SolidMolecular weight:516.59TD52 dihydrochloride
TD52 dihydrochloride, an Erlotinib derivative, inhibits protein phosphatase 2A and induces apoptosis in TNBC by disrupting CIP2A/PP2A/p-Akt signaling.Formula:C24H18Cl2N4Purity:97.23%Color and Shape:SoildMolecular weight:433.33AZT triphosphate TEA
AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.Color and Shape:SolidMofarotene
CAS:Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment ofFormula:C29H39NO2Purity:99.96%Color and Shape:SolidMolecular weight:433.63Mcl-1 inhibitor 12
CAS:Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].Formula:C47H45ClFN7O6Color and Shape:SolidMolecular weight:858.35Amino-PEG6-Thalidomide
Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.Formula:C27H39N3O10Purity:98%Color and Shape:SolidMolecular weight:565.61SZUH280
CAS:SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.Formula:C36H34N8O8Color and Shape:SolidMolecular weight:706.7F1324 TFA
F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM.Formula:C85H122N21F3O22SPurity:98%Color and Shape:SolidMolecular weight:1879.06Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.Formula:C10H12FN5Na3O13P3Color and Shape:SolidMolecular weight:591.12PROTAC EGFR degrader 5
CAS:PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formula:C57H72FN13O5SColor and Shape:SolidMolecular weight:1070.33BM-1197
CAS:BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 andFormula:C53H59ClF4N6O7S4Color and Shape:SolidMolecular weight:1131.77ReACp53
ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.Formula:C108H206N52O24Purity:98%Color and Shape:SolidMolecular weight:2617.13PROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).Formula:C76H96ClF3N10O11S3Color and Shape:SolidMolecular weight:1514.28VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Color and Shape:Odour SolidGSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-Formula:C17H16N6OSColor and Shape:SolidMolecular weight:352.41Chalcones A-N-5
CAS:Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.Formula:C21H20N4O4Color and Shape:SolidMolecular weight:392.41Sanggenon G
CAS:Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.Formula:C40H38O11Color and Shape:SolidMolecular weight:694.72Thalidomide-PEG2-C2-NH2
CAS:Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.Formula:C19H24N4O6Purity:98%Color and Shape:SolidMolecular weight:404.42HDAC-IN-57
CAS:HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4Formula:C21H19N3O4Purity:98.62%Color and Shape:SoildMolecular weight:377.395-LOX-IN-8
5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).Color and Shape:Odour Solid
