Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(127 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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Mofarotene
CAS:Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment ofFormula:C29H39NO2Purity:99.96%Color and Shape:SolidMolecular weight:433.63Citatuzumab bogatox
CAS:Citatuzumab bogatox is a recombinant immunotoxin targeting EpCAM with the toxin bouganin, inducing apoptosis in EpCAM-positive tumors.Color and Shape:LiquidMcl-1 inhibitor 12
CAS:Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].Formula:C47H45ClFN7O6Color and Shape:SolidMolecular weight:858.35Amino-PEG6-Thalidomide
Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.Formula:C27H39N3O10Purity:98%Color and Shape:SolidMolecular weight:565.61HPOB
CAS:HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.Formula:C17H18N2O4Purity:99.91%Color and Shape:SolidMolecular weight:314.34HLDA-212
CAS:HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Formula:C70H90BrFN8O19SColor and Shape:SolidMolecular weight:1478.47Onercept
CAS:Onercept, a recombinant soluble form of the human tumor necrosis factor-alpha (TNF-α) p55 receptor, is utilized in the study of Crohn's disease [1].Color and Shape:LiquidAviculin
CAS:Aviculin, a lignan glycoside, exhibits anticancer properties by inducing apoptosis in breast cancer cells with an IC50 of 75.47 μM.Formula:C26H34O10Color and Shape:SolidMolecular weight:506.54(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFormula:C72H99F3N20O23Purity:98%Color and Shape:SolidMolecular weight:1669.67ALK/ROS1 inhibitor 2e HCL
(R)-1-(2-((2-MeO-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(CF3O)benzyl)piperidine-3-carboxamide HCl is anti-apoptotic and anti-cancer.Formula:C30H36ClF3N6O3Purity:98.66%Color and Shape:SoildMolecular weight:621.09Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity andFormula:C19H12ClN3OPurity:97.37%Color and Shape:SolidMolecular weight:333.77Ref: TM-T77526
1mg115.00€2mg169.00€5mg275.00€10mg394.00€25mg615.00€50mg848.00€100mg1,121.00€200mg1,510.00€Finotonlimab
Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].Color and Shape:Odour LiquidAnti-Mouse CD44 Antibody (IM7)
Anti-Mouse CD44 Antibody (IM7) is a monoclonal antibody targeting CD44 in mice.Purity:99%Color and Shape:Odour LiquidMolecular weight:150 kDaBalstilimab
CAS:Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .Color and Shape:Liquid(Iso)-Z-VAD(OMe)-FMK
CAS:(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formula:C22H30FN3O7Purity:97.10%Color and Shape:SoildMolecular weight:467.49Atacicept
CAS:Atacicept (TACI-Ig) is a homodimeric fusion protein that inhibits B cell stimulation.Purity:97.9% (SDS-PAGE); 98.7% (SEC-HPLC) - 97.9% (SDS-PAGE); 98.7% (SEC-HPLC)Color and Shape:LiquidMolecular weight:35.36 kDaZeluvalimab
CAS:Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].Color and Shape:LiquidAsudemotide
CAS:Asudemotide is a bioactive chemical.Formula:C58H80N10O17Purity:98%Color and Shape:SolidMolecular weight:1189.31PI3Kδ-IN-16
CAS:PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.Formula:C22H26N6O2Purity:99.68%Color and Shape:SoildMolecular weight:406.48TNF-α (46-65), human
CAS:Human TNF alpha (46-65) peptide.Formula:C110H172N24O30Purity:98%Color and Shape:SolidMolecular weight:2310.69GPI-1485
CAS:GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.Formula:C12H19NO4Purity:99.80%Color and Shape:SolidMolecular weight:241.28Ref: TM-T9820
1mg58.00€5mg126.00€1mL*10mM (DMSO)141.00€10mg178.00€25mg340.00€50mg505.00€100mg715.00€200mg1,054.00€AM-8553
CAS:AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.Formula:C25H29Cl2NO4Color and Shape:SolidMolecular weight:478.41Diethylnorspermine HCl
CAS:Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFormula:C13H36Cl4N4Purity:99.79% - 99.86%Color and Shape:SolidMolecular weight:390.26HX009
HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).Color and Shape:Odour LiquidYTHDF2-IN-1
YTHDF2-IN-1 (Compound CK-75) is an inhibitor of YT521-B homology domain family 2 (YTHDF2) with a dissociation constant (Kd) of 26.2 μM, and it effectively blocks the interaction between YTHDF2 and m6A RNA. It suppresses colony formation in JAR cells and exhibits antiproliferative activity in various cancer cell lines, with an IC50 in the micromolar range. Additionally, YTHDF2-IN-1 induces apoptosis in K562 cells and causes cell cycle arrest at the G0/G1 phase.Formula:C21H14N2O4Color and Shape:SolidMolecular weight:358.35IDOi-Pt(IV) prodrug-1
IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug that suppresses IDO expression. It induces apoptosis, reduces mitochondrial membrane potential, and inhibits tumor cell migration and invasion. Additionally, IDOi-Pt(IV) prodrug-1 triggers reactive oxygen species-mediated endoplasmic reticulum stress and the secretion of damage-associated molecular patterns (DAMPs), leading to immunogenic cell death (ICD). Compared to cisplatin, IDOi-Pt(IV) prodrug-1 exhibits relatively high efficiency and low toxicity in its antitumor activity.Formula:C21H26Cl3N3O6PtSColor and Shape:SolidMolecular weight:749.96ERK1/2 inhibitor 13
ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.Formula:C36H29BrF6N4OColor and Shape:SolidMolecular weight:727.54PTD10
CAS:PTD10 is a BTK-targeting PROTAC degradator, induces apoptosis via caspase-dependent and mitochondrial pathways, B-cell dysregulation.Formula:C49H51N11O8Purity:99.12%Color and Shape:SolidMolecular weight:922.99Oenothein B
CAS:Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.Formula:C68H48O44Purity:99.30%Color and Shape:SolidMolecular weight:1569.08(E/Z)-10-Hydroxy-2-decenoic acid
CAS:(E/Z)-10-Hydroxy-2-decenoic acid is a useful organic compound for research related to life sciences.Formula:C10H18O3Color and Shape:SolidMolecular weight:186.251Streptonigrin
CAS:Streptonigrin, from Streptomyces flocculus, has anti-tumor and anti-bacterial properties, inhibiting PAD1-4.Formula:C25H22N4O8Purity:98%Color and Shape:SolidMolecular weight:506.46TAT-BH4 (Bcl-xL) (TFA)
"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death.Formula:C159H268N58O45·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:3712.19 (free acid)Topoisomerase I/II inhibitor 6
TopoisomeraseI/II inhibitor 6 (compound 3i) acts as an effective inhibitor of topoisomerase I and II, with IC50 values of 4.77 µM and 15 µM, respectively. Additionally, it exhibits antiproliferative activity against the human melanoma cell line LOX IMVI, demonstrating IC50 values of 26.7 µM and 25.4 µM.Formula:C31H28F2N4O6SColor and Shape:SolidMolecular weight:622.64HTR2A antagonist 1
HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.Formula:C35H43Cl2F2N5O4Color and Shape:SolidMolecular weight:706.65Verdinexor
CAS:Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.Formula:C18H12F6N6OPurity:98% - 99.68%Color and Shape:SolidMolecular weight:442.32Ref: TM-T6123
1mg35.00€5mg111.00€1mL*10mM (DMSO)123.00€10mg187.00€25mg341.00€50mg567.00€100mg905.00€200mg1,216.00€Lodapolimab
CAS:Lodapolimab (LY3300054) is an IgGλ anti- PD-1 monoclonal antibody [1] .Color and Shape:LiquidRozanolixizumab
CAS:Rozanolixizumab (RYSTIGGO) is a humanized IgG4 monoclonal antibody that targets FcRn in newborns for autoimmune research.
Purity:SDS-PAGE:97.2%;SEC-HPLC:95.9%Color and Shape:LiquidMolecular weight:145.19 kDaThalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS:Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.Formula:C21H27ClN4O8Purity:98.09%Color and Shape:SolidMolecular weight:498.914Taltirelin acetate
CAS:Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating anFormula:C19H27N7O7Purity:99.21%Color and Shape:SolidMolecular weight:465.46Ref: TM-T13072
2mg34.00€5mg49.00€1mL*10mM (DMSO)54.00€10mg80.00€25mg141.00€50mg230.00€100mg358.00€200mg530.00€Antitumor agent-113
Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cellFormula:C21H22ClN5O2SPurity:98%Color and Shape:SolidMolecular weight:443.95Ferroptosis-IN-14
Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.Color and Shape:Odour SolidAsunercept
CAS:Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.Color and Shape:LiquidWKYMVM
CAS:WKYMVM is a N-formyl peptide receptor (FPR1) agonist.Formula:C41H61N9O7S2Purity:98%Color and Shape:SolidMolecular weight:856.11MAO-B-IN-30
CAS:MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.Formula:C15H10BrN3O2Purity:98.31%Color and Shape:SoildMolecular weight:344.16Oxatomide
CAS:Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).Formula:C27H30N4OPurity:99.28% - 99.72%Color and Shape:White PowderMolecular weight:426.55Ref: TM-T19839
1mg35.00€5mg75.00€1mL*10mM (DMSO)84.00€10mg114.00€25mg222.00€50mg356.00€100mg557.00€500mg1,153.00€PG-11047 2HCl
PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.Formula:C14H34Cl2N4Purity:99.51%Color and Shape:SolidMolecular weight:329.35TP4 (Nile tilapia piscidin)
CAS:TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterialFormula:C135H226N50O27Purity:98%Color and Shape:SolidMolecular weight:2981.56TAT-NEP1-40 TFA
TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth.Formula:C268H438N88O77·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:6124.89 (free base)APG-1387
CAS:APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.Formula:C60H72N10O10S2Color and Shape:SolidMolecular weight:1157.41δ-secretase inhibitor 11
CAS:δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Formula:C10H12N4O2Purity:99.84%Color and Shape:SolidMolecular weight:220.23
