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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 6170 products of "Apoptosis"

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  • RIPK1 ligand-Linker Conjugate-1


    RIPK1ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that consists of a RIPK1 ligand and a PROTAC linker, designed to recruit E3 ligase. It is utilized in the synthesis of PROTACRIPK1Degrader-1.
    Color and Shape:Odour Solid

    Ref: TM-T212290

    10mg
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  • Tilogotamab

    CAS:
    Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).
    Purity:95%
    Color and Shape:Liquid
    Molecular weight:144.88 kDa

    Ref: TM-T80984

    1mg
    241.00€
    5mg
    545.00€
    10mg
    873.00€
    25mg
    1,314.00€
  • Citatuzumab bogatox

    CAS:
    Citatuzumab bogatox is a recombinant immunotoxin targeting EpCAM with the toxin bouganin, inducing apoptosis in EpCAM-positive tumors.
    Color and Shape:Liquid

    Ref: TM-T76799

    5mg
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    50mg
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  • Onercept

    CAS:
    Onercept, a recombinant soluble form of the human tumor necrosis factor-alpha (TNF-α) p55 receptor, is utilized in the study of Crohn's disease [1].
    Color and Shape:Liquid

    Ref: TM-T81606

    1mg
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    5mg
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  • (GalNAc)3-CPT


    (GalNAc)3-CPT is a glycan-conjugated prodrug that targets the asialoglycoprotein receptor (ASGR) overexpressed on liver cells. It demonstrates significant antitumor activity by activating the cGAS-STING pathway and promoting CD8+ T cell infiltration into tumor sites, leading to apoptosis of tumor cells. In HepG2 cells, it shows an IC50 value of 3.07 μM.
    Color and Shape:Odour Solid

    Ref: TM-T212503

    10mg
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    50mg
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  • Finotonlimab


    Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].
    Color and Shape:Odour Liquid

    Ref: TM-T77008

    5mg
    To inquire
  • Pegsunercept

    CAS:
    Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].
    Color and Shape:Liquid

    Ref: TM-T80601

    1mg
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    5mg
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  • (R)-MIK665

    CAS:
    (R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).
    Formula:C47H44ClFN6O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:875.41

    Ref: TM-T12629

    25mg
    9,565.00€
  • dPDL1-4


    dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.
    Color and Shape:Odour Solid

    Ref: TM-T211758

    10mg
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  • PI3Kδ-IN-25


    PI3Kδ-IN-25 is an orally active and selective PI3Kδ inhibitor with an IC50 of 2.1 nM. It exhibits IC50 values of 272, 285, and 1171 nM for PI3Kα, PI3Kγ, and PI3Kβ, respectively. In B16F10 cells, PI3Kδ-IN-25 inhibits the phosphorylation of AKTSer473, suppresses Treg cell proliferation, and downregulates the expression of PD-L1. In mouse models of B16F10 melanoma and Lewis lung cancer, PI3Kδ-IN-25 demonstrates anticancer activity by reducing tumor-infiltrating Treg cells and enhancing immune responses. This compound is applicable for research on cancers such as melanoma and lung cancer.
    Color and Shape:Odour Solid

    Ref: TM-T212311

    10mg
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  • Ac-WEHD-AFC TFA


    Ac-WEHD-AFC TFA: a fluorogenic substrate detecting caspase-1 activity, used in tumor and inflammation research.
    Formula:C40H38F6N8O13
    Color and Shape:Solid
    Molecular weight:952.77

    Ref: TM-T76091

    5mg
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    50mg
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  • VTX-0811


    VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-1683

    1mg
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    5mg
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  • JAK-IN-40


    JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.
    Formula:C26H32N8O3S
    Color and Shape:Solid
    Molecular weight:536.65

    Ref: TM-T205062

    10mg
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  • PROTAC EGFR degrader 14


    PROTACEGFRdegrader 14 is a potent and selective EGFR PROTAC degrader with a DC50 value of approximately 2.9 nM against EGFRL858R/T790M/C797S and a Dmax of 93.1%. It induces the selective degradation of EGFRC797S via a VHL and proteasome-dependent mechanism, downregulating EGFR-related transcriptomes. PROTACEGFRdegrader 14 exhibits high selectivity for EGFRWT, induces cell cycle arrest and apoptosis, and effectively inhibits tumor growth. It is applicable for research on non-small cell lung cancer (NSCLC).
    Color and Shape:Odour Solid

    Ref: TM-T211487

    10mg
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    50mg
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  • XY221


    XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.
    Formula:C32H34FN3O5
    Color and Shape:Solid
    Molecular weight:559.628

    Ref: TM-T204924

    10mg
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    50mg
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  • BCMA72-80

    CAS:
    BCMA72-80: HLA-A2-specific peptide with high affinity; used in multiple myeloma and other BCMA+ tumor research.
    Formula:C59H97N13O11S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1196.55

    Ref: TM-TP1806

    100mg
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    500mg
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  • Ecdysone

    CAS:
    Ecdysone is a major steroid hormone in insects and herbs.
    Formula:C27H44O6
    Purity:99.22%
    Color and Shape:Powder
    Molecular weight:464.63

    Ref: TM-TN3910

    1mg
    96.00€
    5mg
    289.00€
    10mg
    421.00€
    25mg
    675.00€
    50mg
    928.00€
    100mg
    1,251.00€
    200mg
    1,693.00€
  • XmAb-2513


    XmAb-2513 is a humanized monoclonal antibody inhibitor targeting CD30. It demonstrates significant anti-proliferative activity along with excellent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). XmAb-2513 is applicable in research on hematological malignancies such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL).
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-1897

    1mg
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    5mg
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  • CTP-347

    CAS:
    CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.
    Formula:C19H20FNO3
    Color and Shape:Solid
    Molecular weight:331.38

    Ref: TM-T31108

    100mg
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    500mg
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  • HPOB

    CAS:
    HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
    Formula:C17H18N2O4
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:314.34

    Ref: TM-T2430

    5mg
    52.00€
    10mg
    74.00€
    1mL*10mM (DMSO)
    57.00€
  • PIYLGGVFQ


    PIYLGGVFQ is a TNF-α peptide inhibitor. It can suppress TNF-α-mediated apoptosis, nuclear translocation, and activation of NF-κB. In a CIA mouse model, PIYLGGVFQ has demonstrated anti-arthritic activity.
    Formula:C49H72N10O12
    Color and Shape:Solid
    Molecular weight:993.16

    Ref: TM-TP2998

    10mg
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  • Schisandronic acid

    CAS:
    Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua.
    Formula:C30H46O3
    Color and Shape:Solid
    Molecular weight:454.68

    Ref: TM-T34574

    25mg
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    100mg
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  • Zapalog

    CAS:
    Zapalog: photocleavable dimerizer controlling instant protein interactions.
    Formula:C58H73N7O15
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1108.24

    Ref: TM-T19607

    25mg
    1,369.00€
  • NS3694

    CAS:
    NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.
    Formula:C15H10ClF3N2O3
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:358.7

    Ref: TM-T22119

    1mg
    37.00€
    2mg
    52.00€
    5mg
    79.00€
    10mg
    111.00€
    25mg
    227.00€
    50mg
    329.00€
    100mg
    512.00€
    500mg
    1,093.00€
    1mL*10mM (DMSO)
    87.00€
  • MK-1248


    MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. It enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 stimulation and promotes the production of anti-tumor associated regulatory cytokines. MK-1248 is utilized in research on solid tumors.
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-1729

    1mg
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    5mg
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  • Oenothein B

    CAS:
    Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.
    Formula:C68H48O44
    Purity:99.30%
    Color and Shape:Solid
    Molecular weight:1569.08

    Ref: TM-TN6732

    1mg
    109.00€
    5mg
    253.00€
    10mg
    384.00€
  • TQB2916


    TQB2916 is a humanized IgG2 monoclonal antibody agonist that targets CD40. It exhibits significant antitumor activity by occupying CD40 and activating immune function. TQB2916 is applicable for research in advanced solid tumors and lymphomas.
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-1809

    1mg
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    5mg
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  • IBI356


    IBI356 is a humanized monoclonal antibody inhibitor that targets OX40L/CD134L/CD252. It can be utilized in the study of chronic inflammatory skin diseases, such as atopic dermatitis.
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-1813

    1mg
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    5mg
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  • Rasagiline

    CAS:
    Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons
    Formula:C12H13N
    Purity:98% - 99.87%
    Color and Shape:Solid
    Molecular weight:171.24

    Ref: TM-T1119

    25mg
    38.00€
    50mg
    50.00€
    100mg
    78.00€
    1mL*10mM (DMSO)
    44.00€
  • Z-LEHD-fmk

    CAS:
    Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and
    Formula:C32H43FN6O10
    Purity:96.13%
    Color and Shape:Solid
    Molecular weight:690.72

    Ref: TM-T21835

    1mg
    178.00€
    5mg
    557.00€
    10mg
    790.00€
    25mg
    1,153.00€
    50mg
    1,575.00€
  • Human membrane-bound PD-L1 polypeptide

    CAS:
    Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].
    Formula:C85H140N26O36S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2134.24

    Ref: TM-T80209

    1mg
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    5mg
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  • HDAC-IN-77


    HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.
    Formula:C22H26N4O2S
    Color and Shape:Solid
    Molecular weight:410.53

    Ref: TM-T200029

    10mg
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    50mg
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  • ROS inducer 4


    Compound TE3, also known as ROS inducer 4, serves as a mitochondrial inhibitor. This compound induces a variety of mitochondria-related physiological alterations in tumors, including mitochondrial fragmentation, intense generation and accumulation of ROS, reduced mitochondrial membrane potential, and lower ATP content. Additionally, it activates ROS-mediated apoptotic signaling within mitochondria.
    Formula:C49H62BrO4P
    Color and Shape:Solid
    Molecular weight:825.89

    Ref: TM-T89939

    10mg
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    50mg
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  • AB-3PRGD2

    CAS:

    AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.

    Formula:C137H215IN30O45S
    Color and Shape:Solid
    Molecular weight:3161.32

    Ref: TM-T206427

    10mg
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    50mg
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  • Enniatin complex

    CAS:
    Enniatin complex: fungal cyclohexadepsipeptides inhibit enzymes, induce cancer cell apoptosis, and have ionophoric, antibiotic, and hypolipidemic effects.
    Purity:98%
    Color and Shape:Solid

    Ref: TM-T11202

    10mg
    795.00€
    50mg
    2,377.00€
  • RET ligand-1

    CAS:
    RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.
    Formula:C28H24F2N6O3
    Color and Shape:Solid
    Molecular weight:530.525

    Ref: TM-T204842

    10mg
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    50mg
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  • Apoptosis inducer 3

    CAS:
    Apoptosis Inducer 3 (Compound 3), a selective apoptosis triggering agent, induces both apoptosis and late-apoptosis phases, demonstrating cytotoxic effects
    Formula:C49H55ClN2O7
    Color and Shape:Solid
    Molecular weight:819.42

    Ref: TM-T74490

    5mg
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    50mg
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  • BGC4


    BGC4 is a gold(III) complex based on biphenyl. It inhibits human recombinant thioredoxin reductase (TrxR) with an IC50 of 10.7 μM, exhibits cytotoxicity with an IC50 of 5.4 μM in MDA-MB-231 cells, and induces apoptosis. Additionally, BGC4 demonstrates antitumor activity in mouse models.
    Formula:C30H32AuClF3N3
    Color and Shape:Solid
    Molecular weight:724.01

    Ref: TM-T204226

    10mg
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    50mg
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  • ZX782


    ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.
    Formula:C39H48ClN5O8
    Color and Shape:Solid
    Molecular weight:750.28

    Ref: TM-T200295

    10mg
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    50mg
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  • c-Met/HDAC-IN-4


    c-Met/HDAC-IN-4, a dual inhibitor of c-Met/HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 /G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met/HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.
    Formula:C37H36N8O
    Color and Shape:Solid
    Molecular weight:608.73

    Ref: TM-T200367

    10mg
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    50mg
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  • LS-106


    LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.
    Formula:C24H28BrClN5OP
    Color and Shape:Solid
    Molecular weight:548.84

    Ref: TM-T89954

    10mg
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    50mg
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  • Apoptosis inducer 26


    Apoptosisinducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is a mononuclear Ag(I) ligand-based autophagy inducer that exhibits antibacterial and anticancer activities against various bacterial strains and cancer cell lines. This compound facilitates the accumulation of Ag(I) ions in the periphery of bacteria, effectively inhibiting the growth of both Gram-positive (+) and Gram-negative (-) bacteria. Additionally, Apoptosisinducer 26 can intercalate between the base pairs of CT DNA, inducing apoptosis in A549 cells. It also possesses radical scavenging properties, which helps prevent oxidative stress.
    Formula:C40H36AgClN4P2S
    Color and Shape:Solid
    Molecular weight:810.07

    Ref: TM-T200068

    10mg
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    50mg
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  • RIP1-IN-1


    RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.
    Color and Shape:Odour Solid

    Ref: TM-T206258

    10mg
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    50mg
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  • Destruxin B

    CAS:
    Destruxin B: cyclic peptide from Metarhizium fungus, induces apoptosis in lung cancer via mitochondrial pathway.
    Formula:C30H51N5O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:593.766

    Ref: TM-T11009

    1mg
    1,513.00€
    5mg
    5,805.00€
  • rac-CCT-250863 HCl


    rac-CCT-250863 HCl: NEK 2 inhibitor, halts cell cycle, anti-cancer growth, boosts Pomalidomide-induced apoptosis.
    Formula:C24H26ClF3N4O2S
    Purity:98.21%
    Color and Shape:Soild
    Molecular weight:527

    Ref: TM-T28498L

    1mg
    175.00€
    5mg
    396.00€
    50mg
    1,251.00€
    1mL*10mM (DMSO)
    497.00€
  • Bfl-1-IN-6


    Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.
    Formula:C22H24ClFN2O2
    Color and Shape:Solid
    Molecular weight:402.89

    Ref: TM-T204150

    10mg
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    50mg
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  • Bleomycin A5

    CAS:
    Bleomycin A5, or Pingyangmycin, is an oral glycopeptide antibiotic and acts as an antineoplastic and apoptosis inducer.
    Formula:C57H89N19O21S2
    Color and Shape:Solid
    Molecular weight:1440.56

    Ref: TM-T75508

    5mg
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    50mg
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  • Thalidomide-5-PEG2-Cl

    CAS:
    Thalidomide-5-PEG2-Cl is a cereblon ligand that recruits CRBN protein and forms PROTACs through linker conjugation.
    Formula:C17H17ClN2O6
    Color and Shape:Solid
    Molecular weight:380.78

    Ref: TM-T39721

    100mg
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    500mg
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  • AKN-028

    CAS:

    AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.

    Formula:C17H14N6
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:302.33

    Ref: TM-T38562

    5mg
    58.00€
    10mg
    96.00€
    25mg
    177.00€
    50mg
    279.00€
    100mg
    408.00€
  • FGFR1/VEGFR2-IN-2


    FGFR1/VEGFR2-IN-2 (compound 6) is a dual inhibitor targeting both VEGFR2 and FGFR1 with IC50 values of 0.025 µM and 0.026 µM, respectively. This compound also exhibits inhibitory effects on EGFR and PDGFR-β, with IC50 values of 0.106 µM and 0.077 µM, respectively. FGFR1/VEGFR2-IN-2 demonstrates significant anticancer activity in the NCI-60 cell lines, showing a growth inhibition (GI) of 60.38%. In T-47D cell lines, it achieves an IC50 of 8.51 µM, exhibits anti-migratory properties, induces cell cycle arrest in the G1 phase, and promotes both apoptosis and necrosis. Additionally, while it has an IC50 greater than 100 µM in MCF-7 cell lines, it does so with an IC50 of 69.17 µM in MDA-MB-231 cell lines and shows no toxicity to normal cells.
    Formula:C21H15ClF3NO4S
    Color and Shape:Solid
    Molecular weight:469.86

    Ref: TM-T89865

    10mg
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    50mg
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