Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(11 products)
- Caspase(141 products)
- FOXO1(3 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(138 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(14 products)
- Survivin(14 products)
- TNF(89 products)
- c-RET(56 products)
- p53(63 products)
Show 6 more subcategories
Found 5887 products of "Apoptosis"
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Anticancer agent 83
CAS:Anticancer agent 83: potent, GI50 0.15 mM against LOX IMVI, reduces mitochondria potential, DNA damage, induces leukemia apoptosis.Formula:C20H19N5OSColor and Shape:SolidMolecular weight:377.46Mcl1-IN-9
CAS:<p>Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.</p>Formula:C37H39ClN4O4Purity:98%Color and Shape:SolidMolecular weight:639.18c-Met-IN-14
CAS:c-Met-IN-14: selective c-Met kinase inhibitor, IC50 2.89 nM, anticancer, stops G2/M phase, induces A549 cell apoptosis.Formula:C34H38ClFN4O7SColor and Shape:SolidMolecular weight:701.2LLP-3
CAS:Survivin inhibitor LLP-3 induces apoptosis in glioma cells by blocking Ran interaction; halts glioblastoma growth. IC50 = 31 μM.Formula:C32H23ClN2O4Color and Shape:SolidMolecular weight:534.99Antioxidant agent-5
CAS:Antioxidant agent-5 (D-6) curbs oxLDL effects, ROS, NF-κB movement, apoptosis in VECs; boosts Nrf2/HO-1; protects endothelium.Formula:C24H24N6OColor and Shape:SolidMolecular weight:412.49LOM612
CAS:LOM612 is a potent and specific FOXO relocator FOXO3a reporter protein endogenous FOXO3a and FOXO1 , down-regulates c-Myc and cyclin D1, anti-proliferative.Formula:C13H10N2O2SColor and Shape:SolidMolecular weight:258.3ZT55
CAS:<p>ZT55: Oral JAK2 inhibitor, IC50: 0.031 μM, hinders JAK2 V617F HEL cell growth, induces apoptosis, arrests cell cycle, effective in mice HEL tumor studies.</p>Formula:C17H16N2O3Color and Shape:SolidMolecular weight:296.32Apoptotic agent-1
CAS:Compound 8a is an apoptotic agent that boosts Fas receptor and Cyto C genes to fight cancer with low toxicity.Formula:C12H6ClN5O2SColor and Shape:SolidMolecular weight:319.73IDO1/TDO-IN-1
CAS:IDO1/TDO-IN-1 (30) inhibits IDO1 (Ki=0.23μM) & TDO (Ki=0.73μM); induces apoptosis via Bcl-2/Bax.Formula:C21H16O6Color and Shape:SolidMolecular weight:364.35BLM-IN-2
BLM-IN-2: BLM inhibitor, IC50=0.8 μM; hinders CRC cell growth, invasion, cycle arrest, and death.Formula:C33H38BrFN4OColor and Shape:SolidMolecular weight:605.58VEGFR-2/BRAF-IN-1
<p>VEGFR-2/BRAF-IN-1 inhibits VEGFR-2, BRAF V600E & BRAF WT with IC50 of 49, 63 and 5 nM, triggers apoptosis, and halts G1/S cell cycle.</p>Formula:C26H20Cl2F3N5O3S2Color and Shape:SolidMolecular weight:642.5SIRT6 activator 12q
CAS:SIRT6 activator 12q: potent, selective, oral; IC50 - SIRT1: 171.20μM, SIRT6: 0.58μM; halts cell growth/migration, induces apoptosis, G2 arrest, anticancer.Formula:C31H22N2O2Color and Shape:SolidMolecular weight:454.52CEP-1612
CAS:CEP-1612 inhibits protein breakdown, regulates cell cycles, apoptosis, boosts p21/p27 expression, and curbs lung cancer growth.Formula:C35H53N7O7Color and Shape:SolidMolecular weight:683.84SKLB0565
CAS:SKLB0565 inhibits tubulin and colorectal cancer growth (IC50: 0.012-0.081 μM), causes G2/M arrest, triggers apoptosis, and prevents HUVEC migration.Formula:C20H25ClN6OColor and Shape:SolidMolecular weight:400.91MI-63
CAS:MI-63 is a potent, specific, non-peptide inhibitor of the MDM2-p53 interaction.Formula:C29H35Cl2FN4O3Color and Shape:SolidMolecular weight:577.52NSC114792
CAS:NSC114792 is a selective JAK3 inhibitor.Formula:C26H32N4O2SPurity:98%Color and Shape:SolidMolecular weight:464.62TACC3 inhibitor 1
Potent TACC3 inhibitor 1 crosses the blood-brain barrier, induces apoptosis, G2/M arrest, ROS, and has anti-tumor effects.Formula:C20H21N5OSColor and Shape:SolidMolecular weight:379.48IM-93
CAS:IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition [1].Formula:C21H28N4O2Color and Shape:SolidMolecular weight:368.47Anti-inflammatory agent 22
CAS:<p>Compound 14a is an oral anti-inflammatory with an IC50 of 14.6 μM for TNF-α, preventing adipogenesis and reducing mouse limb lymphedema.</p>Formula:C22H16O6Color and Shape:SolidMolecular weight:376.36VO-OHPic
CAS:VO-OHPic, a selective PTEN inhibitor (IC50 = 46 nM), reduces apoptosis and inflammation in doxorubicin-induced cardiomyopathy.Formula:C12H10N2O8VColor and Shape:SolidMolecular weight:361.16Anticancer agent 56
CAS:<p>Anticancer agent 56 (4d) has potent action <3μM IC50 on various cancers, causing G2/M arrest and mitochondrial apoptosis via ROS and caspase activation.</p>Formula:C20H18ClN3O3Color and Shape:SolidMolecular weight:383.83(Rac)-Indoximod
CAS:(Rac)-Indoximod, a robust IDO inhibitor, and IFN-γ combo reduce α-SMA hCM activity and boost apoptosis, aiding cardiac fibrosis.Formula:C12H14N2O2Color and Shape:SolidMolecular weight:218.25AG311
CAS:<p>AG311 inhibits complex I; destabilizes HIF-1α; triggers necrosis in cancer cells, mitochondrial depolarization, superoxide, and calcium increase.</p>Formula:C17H15N5SColor and Shape:SolidMolecular weight:321.4Bcl-2/Mcl-1-IN-1
CAS:Bcl-2/Mcl-1-IN-1 is an inhibitor of Bcl-2 (Ki: 4.53 μM) and Mcl-1 (Ki: 1.19 μM).Bcl-2/Mcl-1-IN-1 can be used in cancer research.Formula:C28H23NO3Color and Shape:SolidMolecular weight:421.49AQX-016A
CAS:AQX-016A, a potent SHIP1 agonist, is an oral analog of pelorol, 3x stronger, inhibits PI3K, TNFa, for inflammation research.Formula:C22H32O2Color and Shape:SolidMolecular weight:328.49RET-IN-15
CAS:RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.Formula:C27H28N8O2Color and Shape:SolidMolecular weight:496.56Anticancer agent 71
CAS:Compound 4b, a potent anticancer, halts G2/M cell cycle, triggers apoptosis, alters Bax, Ikb-α, PARP, and Bcl-2 levels.Formula:C18H13ClF3N5OColor and Shape:SolidMolecular weight:407.78CFM 4
CAS:CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosisFormula:C22H16ClN3OSPurity:98.16%Color and Shape:SolidMolecular weight:405.9PERK-IN-5
CAS:PERK-IN-5: oral PERK inhibitor, IC50 of 2 nM; blocks p-eIF2α at 9 nM; hinders tumor growth in renal cancer model.Formula:C25H26F2N4O3Color and Shape:SolidMolecular weight:468.5VU0285655-1
CAS:<p>VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.</p>Formula:C25H27N5O2Purity:99.73%Color and Shape:SolidMolecular weight:429.51Mammea A/BA
CAS:Mammea A/BA combats T. cruzi by causing mitochondrial damage, ROS, DNA fragmentation, and vacuolization, leading to cell death. Useful for Chagas research.Formula:C25H26O5Color and Shape:SolidMolecular weight:406.47Aurora A inhibitor 2
CAS:Aurora A inhibitor 2 (Compound 16h) is a potent inhibitor of Aurora A kinase (IC50: 21.94 nM).Formula:C24H26N6O3Color and Shape:SolidMolecular weight:446.5Antitumor agent-56
CAS:Antitumor-56: Oral triptolide derivative; inhibits melanoma; anti-tumor, anti-inflammatory, NO-releasing properties.Formula:C28H28N2O10SColor and Shape:SolidMolecular weight:584.59CX-5011
CAS:CX-5011, a CK2 inhibitor, induces Rac1 activation and promotes apoptosis, effectively causing cancer cell death [1] [2].Formula:C20H12N4O2Purity:98%Color and Shape:SolidMolecular weight:340.33YH-306
CAS:<p>YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.</p>Formula:C19H18N2O2Purity:98.06%Color and Shape:SolidMolecular weight:306.36HMBPP triammonium
CAS:HMBPP triammonium is a stimulator of gamma delta T cells.Formula:C5H15NO8P2Color and Shape:SolidMolecular weight:279.122c-Met-IN-9
CAS:<p>c-Met-IN-9 is a 4-phenoxypyridine derivative and a c-Met kinase inhibitor (IC50: 12 nM). c-Met-IN-9 induces apoptosis and shows antitumour effects.</p>Formula:C25H19F2N5O3Color and Shape:SolidMolecular weight:475.45Anti-osteoporosis agent-1
CAS:<p>Anti-osteoporosis agent-1 (comp 4aa) is an effective RPA (replication protein A) inhibitor, demonstrating potency with an IC50 value of 18 μM [1].</p>Formula:C20H19ClN2O2Color and Shape:SolidMolecular weight:354.83Anticancer agent 76
CAS:Compound CT2-3 is an anticancer agent that hinders growth, induces arrest, ROS, and apoptosis in NSCLC cells.Formula:C32H33NO5SColor and Shape:SolidMolecular weight:543.67TL02-59 dihydrochloride
CAS:TL02-59 dihydrochloride is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03 nM).Formula:C32H36Cl2F3N5O4Purity:98%Color and Shape:SolidMolecular weight:682.56SD-36
CAS:SD-36: Potent, selective PROTAC STAT3 degrader, Kd ~50 nM, effective on mutants, IC50=10 nM, strong anti-tumor effects, enables mouse tumor regression.Formula:C59H62F2N9O12PPurity:98% - >99.99%Color and Shape:SoildMolecular weight:1158.15Bax activator-1
CAS:Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].Formula:C29H36N4O3Color and Shape:SolidMolecular weight:488.62PD-1-IN-18
CAS:PD-1-IN-18 is a PD1 inhibitor of signaling pathway, and acts as an immunomodulator.Formula:C11H17N5O8Purity:98%Color and Shape:SolidMolecular weight:347.28EGFR/HER2/TS-IN-1
CAS:EGFR/HER2/TS-IN-1 inhibits EGFR (0.203 μM), HER2 (0.088 μM), TS (0.168 μM), and induces apoptosis in MCF7 cells.Formula:C24H15N5O4S2Color and Shape:SolidMolecular weight:501.54Propiomazine
CAS:Propiomazine is an orally active antihistamine compound with sedative properties, useful for controlling insomnia in neurological disorders.Formula:C20H24N2OSPurity:98.5%Color and Shape:SolidMolecular weight:340.48MI-389
CAS:MI-389 is a PROTAC degrader that induces the degradation of receptor tyrosine kinases (RTKs), useful for leukemia research.Formula:C35H35FN6O6Purity:98.12%Color and Shape:SolidMolecular weight:654.69CU-3
CAS:CU-3 inhibits DGKalpha, reducing cancer growth and boosting anti-cancer immunity.Formula:C16H12N2O4S3Purity:98%Color and Shape:SolidMolecular weight:392.47SZM-1209
CAS:<p>SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM.</p>Formula:C31H29F5N4O5S2Purity:98%Color and Shape:SolidMolecular weight:696.71BIM-46174
CAS:<p>BIM-46174 has anticancer activity, inhibits the growth of a large number of human cancer cell lines, and induces caspase-3-dependent cancer cell apoptosis.</p>Formula:C22H30N4OSColor and Shape:SolidMolecular weight:398.57PI3Kδ/γ-IN-3
CAS:PI3Kδ/γ-IN-3 (Compound 58) is an orally active dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 16 nM).Formula:C23H20ClN9OColor and Shape:SolidMolecular weight:473.92
