Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(6 products)
- BCL(11 products)
- Caspase(127 products)
- FOXO1(3 products)
- IAP(65 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(24 products)
- Serine/threonin kinase(15 products)
- Survivin(13 products)
- TNF(91 products)
- c-RET(51 products)
- p53(62 products)
Show 6 more subcategories
Found 5622 products of "Apoptosis"
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HDAC-IN-31
CAS:HDAC-IN-31: Oral HDAC inhibitor; targets HDAC1, 2, 3; weak on HDAC8; potential in fighting lymphoma.Formula:C25H24N4O2Color and Shape:SolidMolecular weight:412.48CT-1
CAS:<p>CT-1 is a DNA minor groove ligand and causes p53-dependent breast cancer cell apoptosis.</p>Formula:C29H23F3N4OPurity:99.79%Color and Shape:SolidMolecular weight:500.51Verrucarin J
CAS:<p>Verrucarin J, a Myrothecium fungus metabolite, triggers apoptosis in some cancer cells and fights Candida, Mucor, and JUNV (IC50: 1.2 ng/mL).</p>Formula:C27H32O8Color and Shape:SolidMolecular weight:484.54DC-CPin711
CAS:<p>DC-CPin711: Potent, selective CBP bromodomain inhibitor, IC50=0.0626 μM; arrests G1 cell cycle, induces apoptosis.</p>Formula:C23H22N4O2Color and Shape:SolidMolecular weight:386.45PDK4-IN-1
CAS:<p>PDK4-IN-1 is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM).</p>Formula:C22H19N3O2Purity:98%Color and Shape:SolidMolecular weight:357.41Verticillin A
CAS:<p>Verticillin A, an apoptosis inducer, inhibits Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth.</p>Formula:C30H28N6O6S4Purity:98%Color and Shape:SolidMolecular weight:696.84(Z)-4EGI-1
CAS:<p>(Z)-4EGI-1, a Z-isomer, inhibits eIF4E/eIF4G; binds eIF4E (IC50=43.5 μM, Kd=8.74 μM); anticancer properties.</p>Formula:C18H12Cl2N4O4SColor and Shape:SolidMolecular weight:451.28CB-64D
CAS:<p>CB-64D is a sigma2R selective agonist which releases calcium in human neuroblastoma cells and produces cell death in tumor cell lines.</p>Formula:C22H23NO2Color and Shape:SolidMolecular weight:333.42GZD856
CAS:GZD856 is an orally bioavailable PDGFRα/β inhibitor (IC50s: 68.6 and 136.6 nM) with anti-lung cancer activities.Formula:C29H27F3N6OPurity:98%Color and Shape:SolidMolecular weight:532.56Xanthine oxidase-IN-6
<p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>Formula:C29H34N2O15Color and Shape:SolidMolecular weight:650.58hnRNPK-IN-1
CAS:<p>hnRNPK-IN-1 binds hnRNPK tightly (Kd 4.6-2.6 μM), disrupting c-myc transcription and inducing apoptosis in Hela cells.</p>Formula:C23H21N3O5Color and Shape:SolidMolecular weight:419.43BR102375
CAS:<p>BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes.</p>Formula:C31H34N6O4Purity:98%Color and Shape:SolidMolecular weight:554.64Anticancer agent 58
<p>Anticancer agent 58 targets A549/T24 cell lines; IC50: 0.6/0.7 μM. It triggers apoptosis, ups Ca2+/ROS, and lowers mitochondrial potential.</p>Formula:C39H55NO5Color and Shape:SolidMolecular weight:617.86Casein Kinase inhibitor A51
CAS:Casein Kinase inhibitor A51 is a CK1α inhibitor with anticancer activity used in the study of breast and prostate cancer.Formula:C18H25ClN6Purity:98.42% - 99.88%Color and Shape:SolidMolecular weight:360.88PD-1/PD-L1-IN 5
CAS:<p>PD-1/PD-L1-IN 5 is a potent PD-1/PD-L1 protein/protein interaction inhibitor (IC50 ≤ 100 nM).</p>Formula:C22H18N4O3SColor and Shape:SolidMolecular weight:418.47UCB-6876
CAS:<p>UCB-6876 inhibits TNF signaling, stabilizes trimer asymmetry, shows concentration response, and is selective for TNFR1.</p>Formula:C17H18N2OColor and Shape:SolidMolecular weight:266.34Apogossypolone (ApoG2)
CAS:<p>Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins with K i</p>Formula:C28H26O8Color and Shape:SolidMolecular weight:490.5PARP1/BRD4-IN-1
CAS:<p>PARP1/BRD4-IN-1 selectively inhibits PARP1 (49 nM IC50) and BRD4 (202 nM IC50), hindering pancreatic cancer cell growth.</p>Formula:C29H26N6O3Color and Shape:SolidMolecular weight:506.56Tubulin polymerization-IN-17
CAS:<p>Compound 23g, a potent inhibitor of tubulin aggregation, induces apoptosis, and inhibits cell migration; promising for cancer research.</p>Formula:C26H23NO5Color and Shape:SolidMolecular weight:429.46ADU-S100
CAS:<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Formula:C20H24N10O10P2S2Purity:99.83%Color and Shape:SolidMolecular weight:690.54Ludartin
CAS:<p>Ludartin activates TRPA1, induces DNA damage, and lowers mitochondrial potential, yielding anticancer effects.</p>Formula:C15H18O3Color and Shape:SolidMolecular weight:246.3EGFR-IN-57
CAS:<p>EGFR-IN-57: potent EGFR-TK blocker, IC50 0.054 μM, oral. Halts VEGFR-2, CK2α, topo IIβ, tubulin. Causes G2/M, pre-G1 arrest, cancer cell death.</p>Formula:C22H15N3O2SColor and Shape:SolidMolecular weight:385.44HIOC
CAS:<p>TrkB agonist; shields neurons & retinas; crosses blood-brain & retinal barriers.</p>Formula:C16H19N3O3Color and Shape:SolidMolecular weight:301.34Berubicin HCl
CAS:<p>Berubicin hydrochloride, a brain-penetrating anthracycline, disrupts DNA replication and repair by inhibiting topoisomerase II.</p>Formula:C34H36ClNO11Color and Shape:SolidMolecular weight:670.1RIP1 kinase inhibitor 5
CAS:<p>RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) in</p>Formula:C13H17F2NO2Purity:98%Color and Shape:SolidMolecular weight:257.28VO-OHPic
CAS:<p>VO-OHPic, a selective PTEN inhibitor (IC50 = 46 nM), reduces apoptosis and inflammation in doxorubicin-induced cardiomyopathy.</p>Formula:C12H10N2O8VColor and Shape:SolidMolecular weight:361.16Anti-inflammatory agent 22
CAS:<p>Compound 14a is an oral anti-inflammatory with an IC50 of 14.6 μM for TNF-α, preventing adipogenesis and reducing mouse limb lymphedema.</p>Formula:C22H16O6Color and Shape:SolidMolecular weight:376.36IM-93
CAS:<p>IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition [1].</p>Formula:C21H28N4O2Color and Shape:SolidMolecular weight:368.47Antiproliferative agent-7
CAS:<p>Antiproliferative agent-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative agent-7 can promote ROS production and induce apoptosis.</p>Formula:C28H32N4OColor and Shape:SolidMolecular weight:440.58S-Gem
CAS:<p>S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR.</p>Formula:C13H15F2N3O6S2Purity:98%Color and Shape:SolidMolecular weight:411.4Antitumor agent-44
CAS:<p>Antitumor agent-44 (Compound 5n) elicits potent antitumor effects by inducing disruption of mitochondrial homeostasis, cell cycle arrest, and apoptosis in human</p>Formula:C24H15N3O3Color and Shape:SolidMolecular weight:393.39DMH2
CAS:<p>DMH2 is an antagonist of bone morphogenetic protein (BMP) type I receptor. It acts by decreasing growth and inducing cell death of lung cancer cell lines.</p>Formula:C27H25N5O2Purity:98%Color and Shape:SolidMolecular weight:451.52HLI98C
CAS:<p>HLI98C is a HDM2 ubiquitin ligase inhibitor with anti-tumor activity.</p>Formula:C17H9ClN4O4Color and Shape:SolidMolecular weight:368.73Cl-amidine
CAS:<p>Cl-amidine, an oral PAD inhibitor (IC50: 0.8-6.2 μM for PAD1/3/4), induces apoptosis in cancer cells.</p>Formula:C14H19ClN4O2Purity:98%Color and Shape:SolidMolecular weight:310.78Quinidine polygalacturonate
CAS:Quinidine polygalacturonate: oral cytochrome P450db inhibitor, K+ channel blocker (IC50 19.9 μM), induces apoptosis, anti-arrhythmic, aids malaria research.Formula:C26H34N2O9Color and Shape:SolidMolecular weight:518.22643Caylin-2
CAS:<p>Nutlin-3 activates p53 by blocking MDM2. Caylin-2, a nutlin-3 analog with trifluoromethyl instead of chlorine, is 10x less potent with an 8 μM IC50.</p>Formula:C32H30F6N4O4Color and Shape:SolidMolecular weight:648.6Tolbutamide Sodium
CAS:potassium channel blockerFormula:C12H18N2NaO3SPurity:98%Color and Shape:SolidMolecular weight:293.34MMP2-IN-1
CAS:MMP2-IN-1, an MMP2 inhibitor (IC50 = 6.8μM), halts growth and induces apoptosis in some cancers.Formula:C15H13NO5SColor and Shape:SolidMolecular weight:319.33IZTZ-1
CAS:<p>IZTZ-1: c-MYC G4 stabilizer, reduces expression, blocks cell cycle, induces apoptosis, inhibits B16 melanoma growth.</p>Formula:C32H35N7SColor and Shape:SolidMolecular weight:549.73SAHA-OH
CAS:<p>SAHA-OH selectively inhibits HDAC6 (IC50 = 23 nM) with 10-47x preference over HDACs 1, 2, 3, 8, and reduces inflammation and macrophage apoptosis.</p>Formula:C15H22N2O4Purity:98%Color and Shape:SolidMolecular weight:294.35BMS-566394
CAS:<p>BMS-566394 is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE).</p>Formula:C22H21F3N4O4Color and Shape:SolidMolecular weight:462.42CYD-2-11
CAS:<p>CYD-2-11 is an effective and selective Bax agonist. It acts by targeting the structural pocket proximal to S184 in the C-terminal region of Bax.</p>Formula:C22H18N2O3Color and Shape:SolidMolecular weight:358.39HDAC-IN-36
CAS:<p>HDAC-IN-36: Oral HDAC6 inhibitor, IC50 = 11.68 nM, promotes apoptosis & autophagy, anti-tumor & anti-metastatic, for breast cancer research.</p>Formula:C29H39N5O5Color and Shape:SolidMolecular weight:537.65MR2938
CAS:<p>MR2938: AChE inhibitor (IC50=5.04μM), reduces NO (IC50=3.29μM), blocks MAPK/JNK, NF-κB; for AD research.</p>Formula:C21H24N4O3Color and Shape:SolidMolecular weight:380.44ICG-001
CAS:<p>ICG001 is a β-catenin/TCF-mediated transcription inhibitor that selectively blocks β-catenin/CBP interaction.Cost-effective and quality-assured.</p>Formula:C33H32N4O4Purity:99.55% - 99.62%Color and Shape:SolidMolecular weight:548.63EGFR-IN-88
CAS:<p>EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosis</p>Formula:C22H18Cl2N4O2SPurity:98%Color and Shape:SolidMolecular weight:473.37LG308
CAS:<p>LG308, a synthetic compound, has anti-tumor properties, inducing apoptosis and mitotic arrest, thereby suppressing prostate cancer growth.</p>Formula:C19H17FN2OColor and Shape:SolidMolecular weight:308.35PHA-680626
CAS:<p>PHA-680626 is a PLK inhibitor, effective on resistant leukemia cells, with IC50: Plk1 (0.53 μM), Plk2 (0.07 μM), Plk3 (1.61 μM).</p>Formula:C23H26N6O2SColor and Shape:SolidMolecular weight:450.56Anti-inflammatory agent 47
CAS:<p>Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting</p>Formula:C25H18N2O3Purity:98%Color and Shape:SolidMolecular weight:394.42GW837016X
CAS:<p>GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation.</p>Formula:C25H20ClFN4OSColor and Shape:SolidMolecular weight:478.97
