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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 6022 products of "Apoptosis"

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  • BMS 310705
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    BMS 310705

    CAS:
    BMS 310705, an Epothilone B analog, targets ovarian/renal/bladder/lung cancer, inducing apoptosis via mitochondria.
    Formula:C27H42N2O6S
    Color and Shape:Solid
    Molecular weight:522.70

    Ref: TM-T73084

  • NTU281
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    NTU281

    CAS:
    <p>NTU281 inhibits transglutaminase-2, lowers creatinine in diabetic rats, reduces proteinuria, and fights glomerulosclerosis.</p>
    Formula:C25H31N2O6S
    Color and Shape:Solid
    Molecular weight:487.59

    Ref: TM-T63248

  • Bafilomycin C1
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    Bafilomycin C1

    CAS:
    vacuolar H+-ATPases (V-ATPases) inhibitor
    Formula:C39H60O12
    Purity:98%
    Color and Shape:Light Tan Solid
    Molecular weight:720.89

    Ref: TM-T22598

  • AB8939
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    AB8939

    CAS:
    <p>AB8939 is a potent small-molecule inhibitor of microtubule/tubulin polymerization, exhibiting antitumor activity (with tumor cell proliferation inhibition IC50≤10 nM). It effectively circumvents resistance mechanisms mediated by P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis.</p>
    Formula:C22H24N4O3
    Color and Shape:Solid
    Molecular weight:392.451

    Ref: TM-T204846

  • Fosizensertib
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    Fosizensertib

    CAS:
    Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.
    Formula:C22H21F2N4O5P
    Color and Shape:Solid
    Molecular weight:490.397

    Ref: TM-T206552

  • PROTAC FKBP Degrader-3
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    PROTAC FKBP Degrader-3

    CAS:
    PROTAC FKBP Degrader-3, with FKBP and VHL binding groups linked, is a potent FKBP degrader.
    Formula:C68H90N6O17S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1295.54

    Ref: TM-T18610

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    WF-47-JS03

    <p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>
    Formula:C30H38N6O2
    Color and Shape:Solid
    Molecular weight:514.66

    Ref: TM-T63573

  • ASTX295
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    ASTX295

    CAS:
    ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.
    Formula:C33H34Cl2FNO6
    Color and Shape:Solid
    Molecular weight:630.531

    Ref: TM-T206682

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    VEGFR-2-IN-11

    <p>VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.</p>
    Formula:C29H22BrN5S
    Color and Shape:Solid
    Molecular weight:552.49

    Ref: TM-T63900

  • TAI-95
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    TAI-95

    CAS:
    TAI-95 is an inhibitor of highly expressed cancer protein 1 (Hec1).
    Formula:C24H23N5O3S2
    Color and Shape:Solid
    Molecular weight:493.60

    Ref: TM-T70649

  • VDR agonist 1
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    VDR agonist 1

    CAS:
    Compound 28 is a nonsteroidal VDR agonist with 690 nM potency, inducing cell cycle arrest and apoptosis in MCF-7 cells.
    Formula:C32H51N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:509.77

    Ref: TM-T13292

  • PLK1-IN-13
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    PLK1-IN-13

    CAS:
    PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM). PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML).
    Formula:C29H39N9O2S
    Color and Shape:Solid
    Molecular weight:577.744

    Ref: TM-T206596

  • Microtubulin-IN-1
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    Microtubulin-IN-1

    CAS:
    <p>Microtubulin-IN-1 (Compound 8g) is an inhibitor of microtubulin, targeting the colchicine-binding site to disrupt tubulin integrity and induce upregulation of p53 protein expression. It exhibits antiproliferative activity across various cancer cell lines, including NCI-H460, BxPC-3, and HT-29, with IC50 values of 2.4, 1.6, and 2.07 nM, respectively. Additionally, Microtubulin-IN-1 induces cell cycle arrest at the G2/M phase and apoptosis in NCI-H460 cells.</p>
    Formula:C25H21FN4O3
    Color and Shape:Solid
    Molecular weight:444.458

    Ref: TM-T206493

  • SL-176
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    SL-176

    CAS:
    SL-176, a WIP1 inhibitor, when combined with GSK-J4, can induce cell cycle arrest and apoptosis (apoptosis), thereby inhibiting tumor growth both in vitro and in vivo.
    Formula:C24H48O4Si2
    Color and Shape:Solid
    Molecular weight:456.806

    Ref: TM-T206776

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    Antitumor agent-58

    Antitumor agent-58 suppresses tumor growth, colony formation, cell migration, and induces mitochondrial dysfunction in MGC-803 cells.
    Formula:C27H28F3N9S
    Color and Shape:Solid
    Molecular weight:567.63

    Ref: TM-T64014

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    Microtubule inhibitor 2

    <p>Microtubule inhibitor 2: potent, selective, oral, induces ferroptosis, strong antitumor effect.</p>
    Formula:C20H23NO7
    Color and Shape:Solid
    Molecular weight:389.4

    Ref: TM-T61749

  • microRNA-21-IN-1
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    microRNA-21-IN-1

    CAS:
    microRNA-21-IN-1: microRNA inhibitor, curbs HeLa/HCT-116 growth (IC50: 5.5/2.8 μM), induces HeLa apoptosis, elevates PTEN/EGR1/SLIT2, for cancer research.
    Formula:C30H37FN6O3
    Color and Shape:Solid
    Molecular weight:548.65

    Ref: TM-T63879

  • APD-94
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    APD-94

    CAS:
    APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.
    Formula:C18H17N3O4
    Color and Shape:Solid
    Molecular weight:339.345

    Ref: TM-T206828

  • M3258
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    M3258

    CAS:
    LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer, is an inhibitor of
    Formula:C17H20BNO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:329.16

    Ref: TM-T11924

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    STAT3-IN-9

    STAT3-IN-9 hinders STAT3 at Tyr705, doesn't affect STAT1 Tyr701, induces apoptosis, and arrests cells in G2/M phase.
    Formula:C22H21N3O4
    Color and Shape:Solid
    Molecular weight:391.42

    Ref: TM-T61779