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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 6010 products of "Apoptosis"

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  • EGFR-IN-3
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    EGFR-IN-3

    EGFR-IN-3 is an EGFR inhibitor with antitumor activity.EGFR-IN-3 inhibits EGFRwt-TK, induces apoptosis (cell death), and can block cells in the G2/M phase.
    Formula:C24H18F4N6O2S
    Purity:98.1%
    Color and Shape:Solid
    Molecular weight:530.5

    Ref: TM-T63732

  • DPP-21
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    DPP-21

    CAS:
    DPP-21 is an inhibitor of microtubule protein polymerization (IC50: 2.4 μM). It exhibits antiproliferative activity against various cancer cell lines, with IC50 values of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23), and 9.37 nM (HepG2). DPP-21 induces cell cycle arrest at the G2/M phase of mitosis and subsequently triggers apoptosis in tumor cells by decreasing Bcl-2 while increasing pro-apoptotic protein Bax levels.
    Formula:C17H16N4S
    Color and Shape:Solid
    Molecular weight:308.40

    Ref: TM-T200560

  • p53-MDM2-IN-6
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    p53-MDM2-IN-6

    CAS:
    p53-MDM2-IN-6, an LSM-83177 hydrazone analog, acts as an efficacious p53-MDM2 inhibitor with an IC50 of 11.08 µg/mL. This compound inhibits the p53-MDM2 interaction leading to an increase in p-53 levels while concurrently decreasing GST enzyme expression. It halts the cell cycle at the S phase and induces early and late apoptosis (Apoptosis), exhibiting antiproliferative activity against the HT29 cell line with an IC50 of 10.44 µg/mL. p53-MDM2-IN-6 holds promise for research in colorectal cancer.
    Formula:C17H17N3O4
    Color and Shape:Solid
    Molecular weight:327.33

    Ref: TM-T200473

  • Ferroptosis-IN-18
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    Ferroptosis-IN-18

    CAS:
    Ferroptosis-IN-18 (51) is a phenothiazine derivative known for its potent anti-ferroptotic and antioxidant properties. It is useful for research related to intracerebral hemorrhage (ICH).
    Formula:C25H27N3S
    Color and Shape:Solid
    Molecular weight:401.567

    Ref: TM-T206933

  • TRPM7-IN-1
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    TRPM7-IN-1

    CAS:
    TRPM7-IN-1 (compound SUD) is a benzamide-urea derivative and an effective inhibitor of TRPM7. This compound induces cell cycle arrest and apoptosis in MCF-7 and BGC-823 cells, reducing their migration capabilities. It decreases vimentin expression while increasing E-cadherin expression. TRPM7-IN-1 reduces TRPM7-like currents and inhibits TRPM7 expression by activating the PI3K/Akt signaling pathway. This compound shows potential as a therapeutic agent for reducing breast and gastric cancer metastasis by targeting TRPM7 expression and activity.
    Formula:C23H25N5O3
    Color and Shape:Solid
    Molecular weight:419.48

    Ref: TM-T201413

  • NSD2-IN-1
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    NSD2-IN-1

    CAS:
    <p>NSD2-IN-1: potent, selective NSD2-PWWP1 inhibitor, IC50 0.11 μM, induces gene expression changes, apoptosis, cell cycle arrest.</p>
    Formula:C29H31N5
    Color and Shape:Solid
    Molecular weight:449.59

    Ref: TM-T62705

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    PD-1/PD-L1-IN-17

    <p>PD-1/PD-L1-IN-17 (Compound P20) is a potent PD-1/PD-L1 inhibitor (IC50: 26.8 nM).</p>
    Formula:C23H20ClN3O4
    Color and Shape:Solid
    Molecular weight:437.88

    Ref: TM-T62501

  • EGFR/VEGFR2-IN-3
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    EGFR/VEGFR2-IN-3

    CAS:
    EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 µM for EGFR, 0.142 µM for VEGFR-2, and 3.428 µM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.
    Formula:C24H20ClN5O2S2
    Color and Shape:Solid
    Molecular weight:510.03

    Ref: TM-T201562

  • MLS-0053105
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    MLS-0053105

    CAS:
    MLS-0053105, a chloromaleimide, functions as a selective inhibitor of BFL-1, exhibiting an IC50 of 0.4 µM against Bfl-1/F-Bid. Its inhibitory potency is over tenfold lower for Bcl-W, Bcl-2, and Bcl-XL, and it shows no activity against Bcl-B and Mcl-1.
    Formula:C15H14Cl3N3O2
    Color and Shape:Solid
    Molecular weight:374.65

    Ref: TM-T201585

  • ERK1/2 inhibitor 11
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    ERK1/2 inhibitor 11

    ERK1/2 inhibitor 11 (compound L6) is a dual inhibitor of ERK1/2 that promotes the accumulation of DSBs and the degradation of ERK1/2 expression. This compound decreases BCL-2 levels and induces DNA damage by inhibiting PARP and ERK1/2. Additionally, ERK1/2 inhibitor 11 activates caspase 3 to induce apoptosis.
    Formula:C15H19N5O2S
    Color and Shape:Solid
    Molecular weight:333.41

    Ref: TM-T201740

  • CB-184
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    CB-184

    CAS:
    CB-184 is a selective ligand for sigma-2 (σ2) receptors, with Ki values of 7436 nM for sigma-1 (σ1) and 13.4 nM for sigma-2 (σ2), and it promotes apoptosis with antitumor activity.
    Formula:C22H21Cl2NO2
    Color and Shape:Solid
    Molecular weight:402.31

    Ref: TM-T201560

  • SMO-IN-5
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    SMO-IN-5

    SMO-IN-5 (Compound 25(B31)) is an effective inhibitor of smoothened (SMO), which suppresses the Hedgehog (Hh) signaling pathway. This compound inhibits cellular proliferation and induces apoptosis, demonstrating antitumor activity.
    Formula:C25H24N6O
    Color and Shape:Solid
    Molecular weight:424.5

    Ref: TM-T201772

  • Ferrostatin-1 diyne
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    Ferrostatin-1 diyne

    CAS:
    Ferrostatin-1 diyne (Fer-1 diyne) (compound 2) serves as an inhibitor of ferroptosis, accumulating in cellular lysosomes, mitochondria, and the endoplasmic reticulum. It notably inhibits ferroptosis independently of lysosomal and mitochondrial activity.
    Formula:C18H22N2O2
    Color and Shape:Solid
    Molecular weight:298.38

    Ref: TM-T201460

  • PAK4-IN-5
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    PAK4-IN-5

    <p>PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral).</p>
    Formula:C31H28ClN5O
    Color and Shape:Solid
    Molecular weight:522.04

    Ref: TM-T201422

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    Topoisomerase I/II inhibitor 4

    Topoisomerase I/II inhibitor 4 halts cell growth and spread, induces apoptosis, and is used in liver cancer research.
    Formula:C27H21N5O6
    Color and Shape:Solid
    Molecular weight:511.49

    Ref: TM-T63526

  • Tandutinib sulfate
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    Tandutinib sulfate

    CAS:
    Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 μM. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 μM and 0.20 μM respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.
    Formula:C31H44N6O8S
    Color and Shape:Solid
    Molecular weight:660.78

    Ref: TM-T201851

  • Antiangiogenic agent 7
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    Antiangiogenic agent 7

    CAS:
    Antiangiogenic agent 7 (Compound 1) induces apoptosis, elevates Reactive Oxygen Species (Reactive Oxygen Species), and inhibits the intracellular enzyme thioredoxin reductase. It exhibits anticancer activity with IC50 values ranging from 0.08 to 3.5 μM against cervical cancer cells (HeLa), prostate cancer cells (PC-3), and non-small cell lung cancer cells (A549). Additionally, Antiangiogenic agent 7 suppresses tumor growth in a mouse xenograft model.
    Formula:C24H26AuN3P2S
    Color and Shape:Solid
    Molecular weight:647.46

    Ref: TM-T201574

  • CRI9
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    CRI9

    CRI9 effectively inhibits the c-MET/PI3K/Akt/mTOR axis, suppressing the proliferation of hepatocellular carcinoma (HCC) cells. This compound exhibits potent cytotoxicity against HCC cells and induces apoptosis.
    Formula:C26H18N6O4
    Color and Shape:Solid
    Molecular weight:478.46

    Ref: TM-T201493

  • (Rac)-Idroxioleic acid sodium
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    (Rac)-Idroxioleic acid sodium

    CAS:
    (Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic derivative of oleic acid (OA) that binds to the plasma membrane, altering lipid composition. This compound exhibits antitumor properties.
    Formula:C18H33NaO3
    Color and Shape:Solid
    Molecular weight:320.44

    Ref: TM-T201603

  • Top/HDAC-IN-3
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    Top/HDAC-IN-3

    CAS:
    Top/HDAC-IN-3 (Compound 31) is a dual inhibitor of Topoisomerase and HDAC with oral activity. It induces DNA damage by elevating reactive oxygen species (ROS) levels, consequently inhibiting the clonal formation and migration of cancer cells, and triggering apoptosis (Apoptosis) and cell cycle arrest. Top/HDAC-IN-3 demonstrates a significant antitumor effect in NSCLC models, exhibiting a tumor growth inhibition (TGI = 77.5%, 100 mg/kg) superior to that of the HDAC inhibitor SAHA and the combination of SAHA with the topoisomerase inhibitor Irinotecan.
    Formula:C24H25N3O5
    Color and Shape:Solid
    Molecular weight:435.47

    Ref: TM-T201842