Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(115 products)
- CDK(547 products)
- Cell Cycle Arrest(5 products)
- Chk(48 products)
- DYRK(46 products)
- Dynamin(27 products)
- Ferroptosis(227 products)
- HSP(180 products)
- Integrin(275 products)
- Kinesin(87 products)
- LIM Kinase(21 products)
- Microtubule Associated(273 products)
- PKC(127 products)
- PLK(25 products)
- ROCK(61 products)
- Rho(6 products)
- Wee1(14 products)
- c-Myc(77 products)
Show 10 more subcategories
Found 3920 products of "Cell Cycle/Checkpoint"
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LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Formula:C29H48N12O12S2Purity:>99.99%Color and Shape:SolidMolecular weight:820.89Risdiplam
CAS:Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Formula:C22H23N7OPurity:98.68% - 99.64%Color and Shape:SolidMolecular weight:401.46Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formula:C27H35F2N7O3Purity:97.1% - >99.99%Color and Shape:SolidMolecular weight:543.61SRI-29329
CAS:SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Formula:C20H26ClN7Purity:99.18%Color and Shape:SolidMolecular weight:399.92Sarecycline free base
CAS:Sarecycline free base (P005672) is a tetracycline-derived, narrow-spectrum antibiotic.Formula:C24H29N3O8Purity:98%Color and Shape:SolidMolecular weight:487.5NSC23005
CAS:NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Formula:C13H17NO4SPurity:>99.99%Color and Shape:SolidMolecular weight:283.345-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formula:C8H13N3SPurity:99.03%Color and Shape:SolidMolecular weight:183.27ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Formula:C21H19BrClN5O4S2Purity:96.29% - 99.72%Color and Shape:SolidMolecular weight:584.89Ref: TM-T1855
5mg52.00€10mg74.00€1mL*10mM (DMSO)74.00€25mg129.00€50mg210.00€100mg294.00€200mg470.00€500mg763.00€BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formula:C17H12Cl2F2N4OSPurity:99.31% - 99.81%Color and Shape:SolidMolecular weight:429.27Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.
Formula:C29H24Cl2N2O7SPurity:99.39% - 99.66%Color and Shape:SolidMolecular weight:615.48Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Formula:C14H17N3O3SPurity:98.13%Color and Shape:SolidMolecular weight:307.376-O-Methyl Guanosine
CAS:6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.Formula:C11H15N5O5Purity:97.5%Color and Shape:SolidMolecular weight:297.27HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Formula:C15H15N5OS2Purity:98.11%Color and Shape:SolidMolecular weight:345.44Ref: TM-T9849
1mg43.00€2mg56.00€1mL*10mM (DMSO)90.00€5mg93.00€10mg144.00€25mg319.00€50mg537.00€100mg767.00€500mg1,558.00€WNK463
CAS:WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).Formula:C21H24F3N7O2Purity:>99.99% - ≥95%Color and Shape:SolidMolecular weight:463.46CBFβ Inhibitor
CAS:CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.Formula:C12H14N2OSPurity:96.50%Color and Shape:SolidMolecular weight:234.32AG-636
CAS:AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.Formula:C21H17N3O2Purity:99.19%Color and Shape:SolidMolecular weight:343.38TH287 hydrochloride
CAS:TH287 inhibits MTH1 (IC50: 0.8 nM), causing DNA damage in cancer cells through oxidized dNTP incorporation, leading to cytotoxicity in mouse xenografts.Formula:C11H11Cl3N4Purity:>99.99%Color and Shape:SolidMolecular weight:305.59ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurity:99.69%Color and Shape:SolidMolecular weight:232.24HAMNO
CAS:HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Formula:C17H13NO2Purity:99.96%Color and Shape:SolidMolecular weight:263.29Cyclo(-RGDfK)
CAS:Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.Formula:C27H41N9O7Purity:95.29% - >99.99%Color and Shape:SolidMolecular weight:603.67Ispinesib
CAS:Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic
Formula:C30H33ClN4O2Purity:98% - 99.09%Color and Shape:SolidMolecular weight:517.06CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Formula:C22H20BrN3O3SPurity:99.66%Color and Shape:SolidMolecular weight:486.38Ref: TM-T8930
2mg34.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg85.00€25mg159.00€50mg244.00€100mg359.00€200mg512.00€Saccharin 1-methylimidazole
CAS:Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.Formula:C7H5NO3S·C4H6N2Purity:98.21%Color and Shape:SolidMolecular weight:265.29Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Formula:C27H32F2N8Purity:99.43% - 99.87%Color and Shape:SolidMolecular weight:506.59AZD-5597
CAS:AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent
Formula:C23H28FN7OPurity:98.01%Color and Shape:SolidMolecular weight:437.51SP-146
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).Formula:C25H20FN7OPurity:97.82%Color and Shape:SolidMolecular weight:453.47Ref: TM-T8685
1mg88.00€5mg170.00€1mL*10mM (DMSO)177.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€3-AP
CAS:3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).Formula:C7H9N5SPurity:97.33% - 99.87%Color and Shape:SolidMolecular weight:195.24Ref: TM-T1982
2mg37.00€5mg54.00€1mL*10mM (DMSO)54.00€10mg65.00€25mg142.00€50mg250.00€100mg379.00€500mg862.00€5-BrdU
CAS:5-BrdU (Broxuridine) is a nucleoside analogue, detect proliferating cells and compete with thymidine for incorporation into DNA. High-Quality, Low-Cost!Formula:C9H11BrN2O5Purity:99.54% - 99.87%Color and Shape:Crystals From Absolute Ethanol Physical Description White Crystalline Powder (Ntp 1992)Molecular weight:307.1NITD-2
CAS:NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.Formula:C23H19N3O4SPurity:98.03% - 99.46%Color and Shape:SolidMolecular weight:433.48Ref: TM-T8886
1mg74.00€5mg170.00€1mL*10mM (DMSO)188.00€10mg274.00€25mg472.00€50mg655.00€100mg944.00€200mg1,264.00€ILK-IN-2
CAS:ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.Formula:C30H30F3N5OPurity:99.30%Color and Shape:SolidMolecular weight:533.59Ref: TM-T5488
1mg46.00€5mg92.00€10mg122.00€1mL*10mM (DMSO)130.00€25mg154.00€50mg182.00€100mg266.00€200mg386.00€Fanotaprim
CAS:Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.Formula:C19H22N8OPurity:98.1%Color and Shape:SolidMolecular weight:378.43Ref: TM-T36692
1mg50.00€2mg71.00€5mg110.00€1mL*10mM (DMSO)122.00€10mg170.00€25mg318.00€50mg442.00€100mg627.00€200mg845.00€GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formula:C27H28F3N5O2SPurity:99% - 99.73%Color and Shape:SolidMolecular weight:543.6Ref: TM-T6282
1mg34.00€2mg49.00€5mg71.00€10mg117.00€25mg195.00€50mg354.00€100mg528.00€200mg755.00€500mg1,153.00€FIT-039
CAS:FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Formula:C17H18FN3SPurity:98.61%Color and Shape:SolidMolecular weight:315.41GSK269962A
CAS:GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Formula:C29H30N8O5Purity:99.14% - 99.71%Color and Shape:SolidMolecular weight:570.6NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFormula:C38H43N3O6Purity:99.16% - 99.27%Color and Shape:SolidMolecular weight:637.76IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formula:C20H23N3O2Purity:99.3%Color and Shape:SolidMolecular weight:337.42Ref: TM-T9375
1mg48.00€5mg92.00€1mL*10mM (DMSO)102.00€10mg152.00€25mg301.00€50mg424.00€100mg605.00€200mg845.00€BMH-21
CAS:BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.Formula:C21H20N4O2Purity:99.47% - 99.84%Color and Shape:SolidMolecular weight:360.41K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Formula:C13H15N3O2SPurity:>99.99%Color and Shape:SolidMolecular weight:277.34P18IN011
CAS:P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).
Formula:C15H12N2O5SPurity:97.63%Color and Shape:SolidMolecular weight:332.33Folinic acid calcium hydrate
CAS:Folinic acid (Leucovorin) calcium hydrate is a biofolic acid often used as a rescue agent with methotrexate (MTX) to reduce MTX-induced toxicity.Formula:C20H23CaN7O8Color and Shape:SolidMolecular weight:529.523Trilaciclib
CAS:Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.Formula:C24H30N8OPurity:99.624%Color and Shape:SolidMolecular weight:446.55Netarsudil free base
CAS:Netarsudil (AR-11324), a ROCK inhibitor, treats glaucoma by increasing eye outflow and lowering IOP, with mild hyperemia as a side effect.Formula:C28H27N3O3Color and Shape:SolidMolecular weight:453.53kb-NB77-78
CAS:kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).Formula:C18H25NO3SiPurity:99.54%Color and Shape:SolidMolecular weight:331.48JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Formula:C24H33ClN6O2SPurity:99.96% - 99.96%Color and Shape:SolidMolecular weight:505.08EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Formula:C25H29Cl2F3N2O4SPurity:98.39% - 99.42%Color and Shape:SolidMolecular weight:581.47Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Formula:C28H43N9O7Purity:>99.99%Color and Shape:SolidMolecular weight:617.7DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Formula:C15H9N5OPurity:98.96%Color and Shape:SolidMolecular weight:275.26Ref: TM-T11111
1mg54.00€5mg155.00€1mL*10mM (DMSO)169.00€10mg233.00€25mg467.00€50mg682.00€100mg990.00€2-Aminofluorene
CAS:2-Aminofluorene (2-Fluorenamine) is a biochemical.Formula:C13H11NPurity:99.9%Color and Shape:Light Yellow CrystallineMolecular weight:181.23IMT1B
CAS:IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.Formula:C24H21ClFNO6Purity:98.26% - 99.83%Color and Shape:SolidMolecular weight:473.88Ref: TM-T8842
1mg138.00€5mg295.00€1mL*10mM (DMSO)309.00€10mg505.00€25mg733.00€50mg888.00€100mg1,251.00€AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formula:C16H14Cl2N8OPurity:>99.99%Color and Shape:SolidMolecular weight:405.24Ref: TM-T8378
1mg124.00€2mg170.00€5mg260.00€1mL*10mM (DMSO)286.00€10mg409.00€25mg677.00€50mg954.00€100mg1,288.00€Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Formula:C14H18ClN3O3SPurity:98.05%Color and Shape:SolidMolecular weight:343.83Monastrol
CAS:Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formula:C14H16N2O3SPurity:98.02% - 98.59%Color and Shape:SolidMolecular weight:292.35Ref: TM-T4048
1mg46.00€5mg73.00€10mg92.00€1mL*10mM (DMSO)93.00€25mg178.00€50mg295.00€100mg477.00€500mg1,018.00€Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formula:C27H40N8O7Purity:98% - 99.8%Color and Shape:SolidMolecular weight:588.66AUZ 454
CAS:AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.Formula:C24H26F3N7O2Purity:99.59%Color and Shape:SolidMolecular weight:501.5BRD9876
CAS:BRD9876 is a selective inhibitor of MM1S growth.Formula:C16H14N2Purity:97.81%Color and Shape:SolidMolecular weight:234.3STF-083010
CAS:STF-083010 is a selective inhibitor of the IRE1α endonuclease.Formula:C15H11NO3S2Purity:98.09% - 99.45%Color and Shape:SolidMolecular weight:317.38Ref: TM-T6681
5mg49.00€1mL*10mM (DMSO)55.00€10mg75.00€25mg114.00€50mg193.00€100mg349.00€200mg527.00€500mg767.00€CX-5461
CAS:CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.Formula:C27H27N7O2SPurity:95.44% - 99.4%Color and Shape:SolidMolecular weight:513.61BVDV-IN-1
CAS:BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.Formula:C20H22N4OPurity:98.43%Color and Shape:SolidMolecular weight:334.41Ref: TM-T9103
1mg38.00€5mg86.00€1mL*10mM (DMSO)95.00€10mg124.00€25mg241.00€50mg355.00€100mg507.00€200mg687.00€Ilorasertib
CAS:Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Formula:C25H21FN6O2SPurity:96.17% - 97.49%Color and Shape:SolidMolecular weight:488.54UNC10217938A
CAS:UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.Formula:C26H28N6O2Purity:98%Color and Shape:SolidMolecular weight:456.54NSC23005 Sodium
CAS:NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Formula:C13H16NNaO4SPurity:99.64%Color and Shape:SolidMolecular weight:305.32α2β1 Integrin Ligand Peptide acetate
α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) is a potential antagonist of α2β1 integrin receptor.Formula:C16H26N4O11Purity:98.46%Color and Shape:SolidMolecular weight:450.4LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formula:C19H23N7O2Purity:99.77%Color and Shape:SolidMolecular weight:381.43Cetraxate hydrochloride
CAS:Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect.Formula:C17H24ClNO4Purity:99.75%Color and Shape:SolidMolecular weight:341.83LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Formula:C26H39N7O3Purity:99.66%Color and Shape:SolidMolecular weight:497.63Levoleucovorin Calcium
CAS:Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.Formula:C20H21N7O7·CaPurity:99.07% - ≥98%Color and Shape:White Crystalline PowderMolecular weight:511.5PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Formula:C25H26F3N5O3Purity:99.14% - 99.75%Color and Shape:SolidMolecular weight:501.5IXA4
CAS:IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.Formula:C24H28N4O4Purity:99.8% - 99.85%Color and Shape:SolidMolecular weight:436.5RK33
CAS:"RK33 is a DDX3 inhibitor causing G1 arrest, apoptosis, and radiation sensitization in DDX3-overexpressing cells."Formula:C23H20N6O3Purity:99.04% - 99.72%Color and Shape:SolidMolecular weight:428.44THZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Formula:C31H28ClN7O2Purity:98.28%Color and Shape:SolidMolecular weight:566.05BS-181 dihydrochloride
CAS:BS-181 dihydrochloride: Potent CDK7 inhibitor (IC50: 21 nM), less effective on CDK2/5/9, no impact on CDK1/4/6, halts cancer cell growth, triggers apoptosis.Formula:C22H34Cl2N6Color and Shape:SolidMolecular weight:453.46RCM-1
CAS:RCM-1 is an inhibitor of FOXM1.Formula:C20H12N2OS4Purity:98.08%Color and Shape:SolidMolecular weight:424.58STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFormula:C27H28N4O4SPurity:99.64%Color and Shape:SolidMolecular weight:504.6Ref: TM-T8706
1mg67.00€5mg152.00€1mL*10mM (DMSO)192.00€10mg236.00€25mg507.00€50mg730.00€100mg1,018.00€GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Formula:C19H16FN5O2Purity:98.38% - 98.98%Color and Shape:SolidMolecular weight:365.36Ref: TM-T3513
1mg39.00€2mg50.00€1mL*10mM (DMSO)62.00€5mg70.00€10mg94.00€25mg161.00€50mg290.00€100mg538.00€500mg1,161.00€DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formula:C20H11N5OPurity:98.33% - 98.96%Color and Shape:SolidMolecular weight:337.33Ref: TM-T11110
1mg62.00€5mg110.00€1mL*10mM (DMSO)122.00€10mg173.00€25mg334.00€50mg469.00€100mg618.00€200mg848.00€CX-5461 dihydrochloride
CX-5461 dihydrochloride: Oral Pol I inhibitor, HCT-116 (IC50: 142 nM), A375 (IC50: 113 nM), MIA PaCa-2 (IC50: 54 nM), weak on Pol II (IC50 ≥ 25 μM).Formula:C27H29Cl2N7O2SColor and Shape:SolidMolecular weight:586.54OSU-T315
CAS:OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Formula:C30H30F3N5OPurity:98.69%Color and Shape:SolidMolecular weight:533.59Ref: TM-T5485
1mg88.00€5mg187.00€1mL*10mM (DMSO)220.00€10mg298.00€25mg533.00€50mg755.00€100mg1,008.00€200mg1,359.00€GPRP acetate (67869-62-9 free base)
CAS:GPRP acetate (Pefabloc FG) is fibrinogen-related peptides, which inhibit the interaction of fibrinogen with the platelet membrane glycoprotein IIbIIIa complex.
Formula:C20H35N7O7Purity:>99.99%Color and Shape:SolidMolecular weight:485.53RNase L-IN-2
CAS:RNase L-IN-2 activates RNase L at 22 uM, has antiviral effects on various RNA viruses, non-toxic at effective levels.Formula:C16H14N2O2SPurity:98.81%Color and Shape:SolidMolecular weight:298.36Ref: TM-T8591
1mg120.00€1mL*10mM (DMSO)243.00€5mg264.00€10mg395.00€25mg627.00€50mg890.00€100mg1,198.00€200mg1,603.00€Apcin-A
CAS:Apcin-A is an anaphase-promoting complex (APC) inhibitor.Formula:C10H14Cl3N5O2Color and Shape:SolidMolecular weight:342.61T-5224
CAS:T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcriptionFormula:C29H27NO8Purity:97.88% - 99.29%Color and Shape:SolidMolecular weight:517.53Ref: TM-T5416
1mg48.00€5mg96.00€1mL*10mM (DMSO)107.00€10mg144.00€25mg254.00€50mg424.00€100mg627.00€200mg998.00€TH-263
CAS:TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Formula:C21H20N2O3SPurity:99.54%Color and Shape:SolidMolecular weight:380.46Ref: TM-T19578
2mg34.00€5mg49.00€1mL*10mM (DMSO)54.00€10mg75.00€25mg137.00€50mg192.00€100mg281.00€200mg419.00€HMN-176
CAS:HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Formula:C20H18N2O4SPurity:98.92% - 98.99%Color and Shape:SolidMolecular weight:382.43Ref: TM-T3643
1mg40.00€2mg52.00€1mL*10mM (DMSO)74.00€5mg84.00€10mg113.00€25mg178.00€50mg333.00€100mg495.00€500mg1,071.00€BRD32048
CAS:BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.Formula:C16H22N6OPurity:99.87%Color and Shape:SolidMolecular weight:314.39Ref: TM-T23820
1mL*10mM (DMSO)44.00€2mg50.00€5mg105.00€10mg172.00€25mg304.00€50mg485.00€100mg782.00€200mg1,054.00€AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Formula:C18H18Cl2F3N5O4Color and Shape:SolidMolecular weight:496.27PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Formula:C28H35N7O2Purity:98.2%Color and Shape:SolidMolecular weight:501.62BIO-1211
CAS:BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Formula:C36H48N6O9Purity:99.33%Color and Shape:SolidMolecular weight:708.86-AZATHYMINE
CAS:6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.Formula:C4H5N3O2Purity:99.47%Color and Shape:SolidMolecular weight:127.1AT-9283 HCl
CAS:AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.Formula:C19H24ClN7O2Color and Shape:SolidMolecular weight:417.89Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Formula:C18H18FN5O2SPurity:98.8%Color and Shape:SolidMolecular weight:387.43Ref: TM-T10464L
1mg84.00€2mg114.00€5mg192.00€1mL*10mM (DMSO)212.00€10mg313.00€25mg580.00€50mg773.00€100mg1,063.00€Purvalanol B
CAS:Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)Formula:C20H25ClN6O3Purity:98.95%Color and Shape:SolidMolecular weight:432.9Ref: TM-T7167
1mg34.00€2mg46.00€5mg67.00€1mL*10mM (DMSO)75.00€10mg90.00€25mg130.00€50mg203.00€100mg305.00€200mg447.00€SR18662
SR18662, improved ML264 derivative, inhibits KLF5 at 4.4 nM IC50; curbs colorectal cancer cell growth and triggers apoptosis.Formula:C16H19Cl2N3O4SPurity:98.97% - 99.2%Color and Shape:SolidMolecular weight:420.31Ref: TM-T22429
1mg46.00€5mg90.00€1mL*10mM (DMSO)100.00€10mg152.00€25mg295.00€50mg475.00€100mg680.00€200mg888.00€500mg1,378.00€Pyridostatin TFA
CAS:Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-Formula:C37H35F9N8O11Purity:97.09% - 99.84%Color and Shape:SolidMolecular weight:938.71Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formula:C23H20N4O3Purity:98.66%Color and Shape:SolidMolecular weight:400.43Ref: TM-T9040
1mg63.00€5mg138.00€1mL*10mM (DMSO)150.00€10mg200.00€25mg360.00€50mg532.00€100mg788.00€200mg1,063.00€3-Deazauridine
CAS:3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.Formula:C10H13NO6Purity:99.86%Color and Shape:SolidMolecular weight:243.21Tipiracil
CAS:Tipiracil inhibits thymidine phosphorylase, enhancing trifluridine bioavailability, and is studied in colorectal and gastric cancer treatment.Formula:C9H11ClN4O2Purity:99.815%Color and Shape:SolidMolecular weight:242.66GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formula:C16H21BrClN5OPurity:97.85%Color and Shape:SolidMolecular weight:414.73Ref: TM-T27407
1mg43.00€2mg55.00€5mg80.00€1mL*10mM (DMSO)93.00€10mg103.00€25mg177.00€50mg255.00€100mg356.00€200mg520.00€Afuresertib
CAS:Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFormula:C18H17Cl2FN4OSPurity:97.51% - 99.51%Color and Shape:SolidMolecular weight:427.32Ref: TM-T1911
1mg37.00€2mg52.00€5mg74.00€1mL*10mM (DMSO)74.00€10mg92.00€25mg166.00€50mg259.00€100mg452.00€500mg982.00€Mps1-IN-3 hydrochloride
Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.Formula:C26H32ClN7O4SColor and Shape:SolidMolecular weight:574.09Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formula:C27H20ClFN4O4Purity:98.31% - >99.99%Color and Shape:SolidMolecular weight:518.92Ref: TM-T2241
5mg52.00€1mL*10mM (DMSO)59.00€10mg92.00€25mg146.00€50mg215.00€100mg334.00€200mg430.00€500mg705.00€
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