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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3485 products of "Cell Cycle/Checkpoint"

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  • CDK7-IN-18

    CAS:
    <p>CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.</p>
    Formula:C22H24F3N7OS
    Color and Shape:Solid
    Molecular weight:491.53
  • MU1409

    CAS:
    <p>MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.</p>
    Formula:C20H14BrN3O3S
    Color and Shape:Solid
    Molecular weight:456.312
  • 6K465

    CAS:
    <p>6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.</p>
    Formula:C26H33ClFN9O
    Purity:99.78%
    Color and Shape:Solid
    Molecular weight:542.05
  • CHK1-IN-2

    CAS:
    <p>CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).</p>
    Formula:C20H22N4OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:366.48
  • DENV-IN-6

    CAS:
    <p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>
    Formula:C23H26ClFN4OS
    Color and Shape:Solid
    Molecular weight:461
  • Pol I-IN-1


    <p>Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition</p>
    Formula:C23H22N4O2
    Color and Shape:Solid
    Molecular weight:386.45
  • L-2'-Fd4C

    CAS:
    <p>L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].</p>
    Formula:C9H10FN3O3
    Color and Shape:Solid
    Molecular weight:227.19
  • PKMYT1-IN-9

    CAS:
    <p>PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.</p>
    Formula:C17H14FN5O
    Color and Shape:Solid
    Molecular weight:323.324
  • EFdA-TP tetrasodium

    CAS:
    <p>EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.</p>
    Formula:C12H11FN5Na4O12P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:621.12
  • TREX1-IN-4

    CAS:
    <p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Color and Shape:Solid
    Molecular weight:490.898
  • CDK9/PARP-IN-1

    CAS:
    <p>CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.</p>
    Formula:C38H34F2N8O3
    Color and Shape:Solid
    Molecular weight:688.725
  • MtTMPK-IN-5


    <p>MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.</p>
    Formula:C21H23N5O2
    Color and Shape:Solid
    Molecular weight:377.44
  • GSK_WRN4

    CAS:
    <p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>
    Formula:C16H20N2O4S
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:336.41
  • Mazethramycin

    CAS:
    <p>Mazethramycin is an antitumor antibiotic that exerts its effects by disrupting DNA replication and RNA synthesis within cells. It is utilized in cancer research.</p>
    Formula:C17H19N3O4
    Molecular weight:329.35
  • GHP-88309

    CAS:
    <p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>
    Formula:C16H11FN2O
    Color and Shape:Solid
    Molecular weight:266.27
  • DL-Alanosine

    CAS:
    <p>DL-Alanosine is an amino acid analog with antitumor activity.</p>
    Formula:C3H7N3O4
    Color and Shape:Solid
    Molecular weight:149.105
  • RAD51-IN-5

    CAS:
    <p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>
    Formula:C26H38N4O5S2
    Color and Shape:Solid
    Molecular weight:550.73
  • 2′-OMe-ADP

    CAS:
    <p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>
    Formula:C11H17N5O10P2
    Color and Shape:Solid
    Molecular weight:441.23
  • Aurora A inhibitor 1

    CAS:
    <p>Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)</p>
    Formula:C25H28ClF2N5O2
    Color and Shape:Solid
    Molecular weight:503.97
  • Zorubicin

    CAS:
    <p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>
    Formula:C34H35N3O10
    Color and Shape:Solid
    Molecular weight:645.66