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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3477 products of "Cell Cycle/Checkpoint"

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  • JH-XVI-178

    CAS:
    <p>JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.</p>
    Formula:C22H22ClN7O
    Color and Shape:Solid
    Molecular weight:435.92
  • 3'-Deoxyuridine-5'-triphosphate trisodium


    <p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>
    Formula:C9H12N2Na3O14P3
    Color and Shape:Soild
    Molecular weight:534.08
  • 5'-O-DMT-PAC-dA

    CAS:
    <p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>
    Formula:C39H37N5O7
    Color and Shape:Solid
    Molecular weight:687.74
  • m7GpppCmpG

    CAS:
    <p>m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.</p>
    Formula:C31H43N13O25P4
    Color and Shape:Solid
    Molecular weight:1121.64
  • Phen-DC3 Trifluoromethanesulfonate

    CAS:
    <p>Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.</p>
    Formula:C36H26F6N6O8S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:848.75
  • Heliquinomycin

    CAS:
    <p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>
    Formula:C33H30O17
    Color and Shape:Solid
    Molecular weight:698.586
  • (1S,3R,5R)-PIM447 dihydrochloride


    <p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>
    Formula:C24H25Cl2F3N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:513.38
  • UnyLinker 12 TEA


    <p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>
    Formula:C39H35NO10C6H15N
    Color and Shape:Solid
    Molecular weight:778.34655
  • KWR137


    <p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>
    Formula:C33H31ClF3N9O4
    Color and Shape:Solid
    Molecular weight:710.105
  • Chrysomycin A

    CAS:
    <p>Chrysomycin A is an antibiotic that can be derived from Streptomyces.</p>
    Formula:C28H28O9
    Color and Shape:Solid
    Molecular weight:508.52
  • MYC-IN-2

    CAS:
    <p>MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.</p>
    Formula:C25H17N3O2S
    Color and Shape:Solid
    Molecular weight:423.49
  • XT17


    <p>XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.</p>
    Color and Shape:Odour Solid
  • 5-Aza-xylo-cytidine


    <p>5-Aza-xylo-cytidine, a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>
    Formula:C8H12N4O5
    Color and Shape:Solid
    Molecular weight:244.2
  • JB300

    CAS:
    <p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>
    Formula:C43H45ClFN7O10S
    Color and Shape:Solid
    Molecular weight:906.375
  • Gly-Arg-Gly-Asp-Ser

    CAS:
    <p>Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.</p>
    Formula:C17H30N8O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:490.47
  • 5'-O-TBDMS-dA

    CAS:
    <p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>
    Formula:C16H27N5O3Si
    Color and Shape:Solid
    Molecular weight:365.509
  • WAY-647802

    CAS:
    <p>WAY-647802 is a CDK inhibitor.</p>
    Formula:C11H14N4O3
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:250.25
  • Anticancer agent 263


    <p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>
    Formula:C13H20N2O6
    Color and Shape:Solid
    Molecular weight:300.308
  • Obtustatin


    <p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>
    Formula:C184H284N52O57S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4393.07
  • Fibronectin CS1 Peptide

    CAS:
    <p>Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.</p>
    Formula:C38H64N8O15
    Purity:98%
    Color and Shape:Solid
    Molecular weight:872.96