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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3480 products of "Cell Cycle/Checkpoint"

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  • Methyl 3-oxodecanoate

    CAS:
    <p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>
    Formula:C11H20O3
    Color and Shape:Solid
    Molecular weight:200.275
  • NSC 641396

    CAS:
    <p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>
    Formula:C18H13NO3
    Color and Shape:Solid
    Molecular weight:291.301
  • IIP0943

    CAS:
    <p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>
    Formula:C26H28N6O3S
    Color and Shape:Solid
    Molecular weight:504.604
  • DDO-6079

    CAS:
    <p>DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.</p>
    Formula:C18H13ClN2O3
    Color and Shape:Solid
    Molecular weight:340.76
  • JY-3-094

    CAS:
    <p>JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.</p>
    Formula:C13H8N4O5
    Purity:98.72%
    Color and Shape:Solid
    Molecular weight:300.23
  • 12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Formula:C20H32O3
    Color and Shape:Solid
    Molecular weight:320.47
  • Sovesudil hydrochloride


    <p>Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.</p>
    Formula:C23H23ClFN3O3
    Color and Shape:Solid
    Molecular weight:443.9
  • CB 30900

    CAS:
    <p>CB30900 is a novel and effective thymidylate synthase inhibitor.</p>
    Formula:C31H32FN5O9
    Color and Shape:Solid
    Molecular weight:637.61
  • CHK-IN-1

    CAS:
    <p>CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.</p>
    Formula:C18H19ClFN5OS
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:407.89
  • LNA-AMP

    CAS:
    <p>LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.</p>
    Formula:C11H14N5O7P
    Color and Shape:Solid
    Molecular weight:359.23
  • CDK8-IN-9


    <p>CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.</p>
    Color and Shape:Solid
  • PLK1-IN-5

    CAS:
    <p>PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].</p>
    Formula:C28H39N7O3
    Color and Shape:Solid
    Molecular weight:521.65
  • Z4P

    CAS:
    <p>Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.</p>
    Formula:C19H24N2O2
    Purity:98.99%
    Color and Shape:Solid
    Molecular weight:312.41
  • Valopicitabine dihydrochloride

    CAS:
    <p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Formula:C15H25ClN4O6
    Color and Shape:Solid
    Molecular weight:392.84
  • Dyrk1A-IN-8

    CAS:
    <p>Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.</p>
    Formula:C17H21N3O
    Color and Shape:Solid
    Molecular weight:283.37
  • YKL-1-116

    CAS:
    <p>YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.</p>
    Formula:C34H38N8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:606.72
  • p38α inhibitor 9

    CAS:
    <p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>
    Formula:C27H24FN3O3
    Color and Shape:Solid
    Molecular weight:457.496
  • MtTMPK-IN-9


    <p>MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.</p>
    Formula:C25H26N6O7
    Color and Shape:Solid
    Molecular weight:522.51
  • CHK1-IN-11

    CAS:
    <p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>
    Formula:C20H22N8O2
    Color and Shape:Solid
    Molecular weight:406.44
  • BAY-364

    CAS:
    <p>BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+</p>
    Formula:C23H19N3O4
    Color and Shape:Solid
    Molecular weight:401.41