
Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(94 products)
- CDK(500 products)
- Cell Cycle Arrest(4 products)
- Chk(42 products)
- DYRK(48 products)
- Dynamin(23 products)
- Ferroptosis(215 products)
- HSP(169 products)
- Integrin(224 products)
- Kinesin(66 products)
- LIM Kinase(19 products)
- Microtubule Associated(261 products)
- PKC(102 products)
- PLK(28 products)
- ROCK(70 products)
- Rho(2 products)
- Wee1(15 products)
- c-Myc(69 products)
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Found 3477 products of "Cell Cycle/Checkpoint"
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Polθ-IN-7
CAS:<p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>Formula:C28H35F3N6O2Color and Shape:SolidMolecular weight:544.612Cdc7-IN-10
CAS:<p>Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.</p>Formula:C20H22F2N4O2SColor and Shape:SolidMolecular weight:420.48CDK7-IN-33
CAS:<p>CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.</p>Formula:C29H36N6O4SColor and Shape:SolidMolecular weight:564.699DHX9-IN-19
CAS:<p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>Formula:C20H21ClN4O4S2Color and Shape:SolidMolecular weight:480.988IRE1α kinase-IN-5
<p>IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.</p>Formula:C28H30N6O3SColor and Shape:SolidMolecular weight:530.643'-Deoxy-GTP
CAS:<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.</p>Formula:C10H16N5O13P3Color and Shape:SolidMolecular weight:507.1815-Fluorouridine 5'-phosphate
CAS:<p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>Formula:C9H12FN2O9PColor and Shape:SolidMolecular weight:342.172Norharmine
CAS:<p>Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.</p>Formula:C12H10N2OColor and Shape:SolidMolecular weight:198.221IXA62
CAS:<p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>Formula:C24H23N3O3Color and Shape:SolidMolecular weight:401.458HNC-1664
CAS:<p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>Formula:C12H13FIN3O3Color and Shape:SolidMolecular weight:393.153CDK1-IN-4
<p>CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.</p>Formula:C26H24ClN5SColor and Shape:SolidMolecular weight:474.02Dyrk1A/α-synuclein-IN-2
<p>Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).</p>Formula:C21H16N4O4SColor and Shape:SolidMolecular weight:420.44LNA-GMP
CAS:<p>LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.</p>Formula:C11H14N5O8PColor and Shape:SolidMolecular weight:375.23CDK2-IN-31
CAS:<p>CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.</p>Formula:C37H52N6O5Color and Shape:SolidMolecular weight:660.85Anticancer agent 29
<p>Compound E/Z-6f, anticancer, IC50: CDK2 (0.054 μM), CDK1 (0.127 μM), CDK4 (0.129 μM), CDK6 (0.396 μM).</p>Formula:C22H15ClFNOColor and Shape:SolidMolecular weight:363.81BET/Aurora kinase-IN-1
CAS:<p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>Formula:C25H30FN7OColor and Shape:SolidMolecular weight:463.55RAD51-IN-6
CAS:<p>RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)</p>Formula:C27H40N3O5PSColor and Shape:SolidMolecular weight:549.66Glycyl H-1152 hydrochloride
CAS:<p>Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.</p>Formula:C18H26Cl2N4O3SColor and Shape:SolidMolecular weight:449.39KI-CDK9d-32
CAS:<p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>Formula:C39H45N9O4Color and Shape:SolidMolecular weight:703.83BBI-355
CAS:<p>BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.</p>Formula:C19H19N7O2Color and Shape:SolidMolecular weight:377.40

