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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3675 products of "Cell Cycle/Checkpoint"

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  • DHICA
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    DHICA

    CAS:
    DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.
    Formula:C9H7NO4
    Color and Shape:Solid
    Molecular weight:193.16

    Ref: TM-T201499

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    CDK1-IN-3

    CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.
    Formula:C28H25ClF3N5O2
    Color and Shape:Solid
    Molecular weight:555.98

    Ref: TM-T63933

  • HNC-1664
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    HNC-1664

    CAS:
    <p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>
    Formula:C12H13FIN3O3
    Color and Shape:Solid
    Molecular weight:393.153

    Ref: TM-T205157

  • DIDS
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    DIDS

    CAS:
    <p>DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.</p>
    Formula:C16H10N2O6S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:454.52

    Ref: TM-T20694

  • 2'-O-MOE-GMP
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    2'-O-MOE-GMP

    CAS:
    <p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>
    Formula:C13H20N5O9P
    Color and Shape:Solid
    Molecular weight:421.30

    Ref: TM-TSW-00967

  • BET/Aurora kinase-IN-1
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    BET/Aurora kinase-IN-1

    CAS:
    <p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>
    Formula:C25H30FN7O
    Color and Shape:Solid
    Molecular weight:463.55

    Ref: TM-T205073

  • VPC-80051
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    VPC-80051

    CAS:
    <p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>
    Formula:C16H13F2N3O
    Color and Shape:Solid
    Molecular weight:301.291

    Ref: TM-T204737

  • CLK1/2-IN-1
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    CLK1/2-IN-1

    CAS:
    CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.
    Formula:C21H20F3N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:443.42

    Ref: TM-T23896

  • 2′-OMe-ADP
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    2′-OMe-ADP

    CAS:
    <p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>
    Formula:C11H17N5O10P2
    Color and Shape:Solid
    Molecular weight:441.23

    Ref: TM-TSW-00949

  • DENV-IN-6
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    DENV-IN-6

    CAS:
    <p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>
    Formula:C23H26ClFN4OS
    Color and Shape:Solid
    Molecular weight:461

    Ref: TM-T62908

  • CDK7-IN-26
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    CDK7-IN-26

    CAS:
    CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.
    Formula:C22H22FN6OPS
    Molecular weight:468.49

    Ref: TM-T208352

  • Antimalarial agent 44
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    Antimalarial agent 44

    Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.
    Formula:C37H37N5O7
    Color and Shape:Solid
    Molecular weight:663.72

    Ref: TM-T201453

  • PARG-IN-6
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    PARG-IN-6

    CAS:
    PARG-IN-6 (Compound 2) is an orally bioavailable PARG inhibitor with an IC50 of 0.3 nM. It exhibits significant anticancer activity against cancer cells, with an IC50 of 0.0368 μM for HCC1395 cells. PARG-IN-6 shows potential for research in colon cancer, appendiceal cancer, and pancreatic cancer.
    Formula:C24H25F4N7O4S3
    Color and Shape:Solid
    Molecular weight:647.69

    Ref: TM-T210766

  • FR-145715
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    FR-145715

    CAS:
    FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.
    Formula:C16H21N5O2S
    Color and Shape:Solid
    Molecular weight:347.44

    Ref: TM-T201582

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    Antiangiogenic agent 2

    <p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>
    Formula:C26H26FN3O4
    Color and Shape:Solid
    Molecular weight:463.5

    Ref: TM-T62931

  • PPA-037
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    PPA-037

    CAS:
    <p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>
    Formula:C25H27N7
    Color and Shape:Solid
    Molecular weight:425.53

    Ref: TM-T207610

  • IIP0943
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    IIP0943

    CAS:
    <p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>
    Formula:C26H28N6O3S
    Color and Shape:Solid
    Molecular weight:504.604

    Ref: TM-T206115

  • FT709
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    FT709

    CAS:
    <p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>
    Formula:C23H22N4O7S
    Color and Shape:Solid
    Molecular weight:498.51

    Ref: TM-T63375

  • PNR-3-80
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    PNR-3-80

    CAS:
    PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.
    Formula:C24H14ClN3O3S
    Color and Shape:Solid
    Molecular weight:459.90

    Ref: TM-T212403

  • DNA polymerase-IN-6
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    DNA polymerase-IN-6

    CAS:
    DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.
    Formula:C26H28ClFN8O4
    Color and Shape:Solid
    Molecular weight:571.003

    Ref: TM-T204284