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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

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Found 3904 products of "Cell Cycle/Checkpoint"

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  • PROTAC CDK9 degrader-2

    CAS:
    PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.
    Formula:C39H36N6O10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:748.74

    Ref: TM-T17728

    100mg
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    500mg
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  • N6-Methyl-2'-O-(2-methoxyethyl) adenosine


    N6-Methyl-2’-O-(2-methoxyethyl) adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.
    Formula:C14H21N5O5
    Color and Shape:Solid
    Molecular weight:339.35

    Ref: TM-T75062

    5mg
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    50mg
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  • CDK2/PIM1-IN-1


    CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.
    Color and Shape:Odour Solid

    Ref: TM-T206369

    10mg
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    50mg
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  • Cdk2/Cyclin Inhibitory Peptide I


    CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.
    Formula:C111H196N48O23
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2571.05

    Ref: TM-TP2192

    5mg
    107.00€
    10mg
    170.00€
    25mg
    236.00€
  • CD532 hydrochloride


    CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.
    Color and Shape:Solid

    Ref: TM-T36932

    5mg
    90.00€
    10mg
    155.00€
    25mg
    291.00€
  • KIF2C-IN-1


    KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.
    Formula:C36H39ClN4O9S
    Color and Shape:Solid
    Molecular weight:738.21263

    Ref: TM-T207280

    10mg
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    50mg
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  • Chrexanthomycin C


    Chrexanthomycin C, orally active, binds DNA (G4C2)4 G4, Kd 2.8 mM, potential in ALS research.
    Formula:C31H24O15
    Color and Shape:Solid
    Molecular weight:636.51

    Ref: TM-T75527

    5mg
    To inquire
    50mg
    To inquire
  • Fibronectin CS1 Peptide

    CAS:
    Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.
    Formula:C38H64N8O15
    Purity:98%
    Color and Shape:Solid
    Molecular weight:872.96

    Ref: TM-TP1526

    100mg
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    500mg
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  • 5'-O-TBDMS-N2-ibu-dG

    CAS:
    5'-O-TBDMS-N2-ibu-dG: a nucleoside derivative with strong anti-BVDV activity, useful in lead compound synthesis.
    Formula:C20H33N5O5Si
    Color and Shape:Solid
    Molecular weight:451.59

    Ref: TM-T40949

    100mg
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    500mg
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  • Pyrindamycin A

    CAS:
    Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.
    Formula:C26H26ClN3O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:543.95

    Ref: TM-T12590

    25mg
    3,934.00€
    50mg
    5,203.00€
    100mg
    7,380.00€
  • Emofolin sodium

    CAS:
    Emofolin sodium, a synthetic folate analogue, inhibits DNA/RNA/protein synthesis by blocking dihydrofolate reductase.
    Formula:C21H25N7Na2O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.45

    Ref: TM-T25374

    25mg
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    50mg
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    100mg
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  • PROTAC CDK9 degrader-7

    CAS:
    PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (
    Formula:C43H50Cl2N8O9
    Color and Shape:Soild
    Molecular weight:893.81

    Ref: TM-T74853

    5mg
    To inquire
    50mg
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  • Deoxythymidine-5'-triphosphate

    CAS:
    Deoxythymidine-5'-triphosphate (dTTP) is a nucleoside triphosphate involved in DNA synthesis.
    Formula:C10H17N2O14P3
    Color and Shape:Solid
    Molecular weight:482.167

    Ref: TM-T40467

    25mg
    1,444.00€
  • dUTP trisodium

    CAS:

    dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.

    Formula:C9H12N2Na3O14P3
    Purity:100.00%
    Color and Shape:Solid
    Molecular weight:534.09

    Ref: TM-T38427

    5mg
    47.00€
    10mg
    60.00€
    25mg
    89.00€
    50mg
    131.00€
    100mg
    187.00€
    200mg
    279.00€
  • PAT-LM1


    PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-1103

    1mg
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    5mg
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  • LY2812223

    CAS:
    LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).
    Formula:C10H12N4O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:284.29

    Ref: TM-T15809

    25mg
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    50mg
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    100mg
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  • Flurocitabine HCl

    CAS:
    Fluorocitabine HCl, a cytarabine analog, hydrolyzes into ara-FC and ara-FU, showing antitumor effects in leukemia and solid cancers.
    Formula:C9H11ClFN3O4
    Purity:99.76% - 99.83%
    Color and Shape:Soild
    Molecular weight:279.65

    Ref: TM-T27342L

    5mg
    40.00€
    10mg
    54.00€
    25mg
    92.00€
    50mg
    123.00€
    100mg
    178.00€
    500mg
    424.00€
  • 5'-O-TBDMS-Bz-dA

    CAS:
    5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.
    Formula:C23H31N5O4Si
    Color and Shape:Solid
    Molecular weight:469.617

    Ref: TM-T37142

    50mg
    47.00€
    1mL*10mM (DMSO)
    52.00€
  • MRK-952


    MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.
    Formula:C20H20ClF3N6
    Color and Shape:Solid
    Molecular weight:436.861

    Ref: TM-T205743

    10mg
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    50mg
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  • CDK2-IN-43


    CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC50 value of 6.0 nM. It is applicable to cancer research.
    Formula:C19H27N7O
    Color and Shape:Solid
    Molecular weight:369.464

    Ref: TM-T206067

    10mg
    To inquire
    50mg
    To inquire
  • DHFR-IN-8


    DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.
    Formula:C18H14N6S
    Color and Shape:Solid
    Molecular weight:346.41

    Ref: TM-T79734

    5mg
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    50mg
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  • MYC-IN-2

    CAS:
    MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.
    Formula:C25H17N3O2S
    Color and Shape:Solid
    Molecular weight:423.49

    Ref: TM-T39751

    5mg
    873.00€
  • CDK5-IN-1

    CAS:
    CDK5-IN-1: Potent CDK5 inhibitor (<10 nM) used in kidney disease research.
    Formula:C24H25FN6O3S
    Color and Shape:Solid
    Molecular weight:496.56

    Ref: TM-T40263

    5mg
    873.00€
  • DSPE-PEG5000-cRGD


    DSPE-PEG5000-cRGD is a PEG compound composed of DSPE and an αvβ3 targeting peptide (cRGD). The cRGD peptide has the ability to specifically bind to the αvβ3 present on the surfaces of numerous cancer cells and new vascular cells. DSPE-PEG5000-cRGD is useful for drug delivery applications.
    Color and Shape:Odour Solid

    Ref: TM-TCL-01154

    10mg
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    50mg
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  • Anti-EMMPRIN/CD147 Antibody


    Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-803

    1mg
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    5mg
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  • 5-Caroxy uracil-1-yl acetic acid benzyl ester


    5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.
    Formula:C14H12N2O6
    Color and Shape:Solid
    Molecular weight:304.25

    Ref: TM-T75189

    5mg
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    50mg
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  • K34c hydrochloride

    CAS:
    K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.
    Formula:C26H30ClN3O4
    Purity:99.76% - 99.89%
    Color and Shape:Soild
    Molecular weight:483.99

    Ref: TM-T41151L

    1mg
    190.00€
    5mg
    447.00€
    10mg
    610.00€
    25mg
    858.00€
    1mL*10mM (DMSO)
    505.00€
  • 6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine


    6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue with broad antitumor activity, particularly against
    Formula:C10H15N7O4
    Color and Shape:Solid
    Molecular weight:297.27

    Ref: TM-T75044

    5mg
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    50mg
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  • Isocytosine

    CAS:
    Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.
    Formula:C4H5N3O
    Color and Shape:White To Off-White Solid
    Molecular weight:111.1

    Ref: TM-PDK0016

    200mg
    36.00€
  • Uridine triphosphate 13C9,15N2 sodium

    CAS:
    Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.
    Formula:C9H1415N2NaO15P3
    Color and Shape:Solid
    Molecular weight:517.04

    Ref: TM-T36299

    100mg
    47.00€
  • ROCK-IN-5

    CAS:
    ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.
    Formula:C16H11ClFN3OS
    Purity:99.72% - 99.86%
    Color and Shape:Solid
    Molecular weight:347.79

    Ref: TM-T67748

    10mg
    43.00€
    25mg
    65.00€
    50mg
    94.00€
    100mg
    128.00€
    500mg
    To inquire
    1mL*10mM (DMSO)
    34.00€
  • 1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine


    1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog.
    Formula:C18H21N5O5
    Color and Shape:Solid
    Molecular weight:387.39

    Ref: TM-T75040

    5mg
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    50mg
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  • HDAC-IN-85


    HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.
    Formula:C24H27FN4O5
    Color and Shape:Solid
    Molecular weight:470.49

    Ref: TM-T205411

    10mg
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    50mg
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  • N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine


    N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.
    Formula:C14H22N2O7
    Color and Shape:Solid
    Molecular weight:330.33

    Ref: TM-T75214

    5mg
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    50mg
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  • Stigmatellin

    CAS:
    Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.
    Formula:C30H42O7
    Color and Shape:Solid
    Molecular weight:514.65

    Ref: TM-TN8168

    10mg
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    50mg
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  • Ribonuclease T1

    CAS:

    Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.

    Color and Shape:Solid

    Ref: TM-T73609

    5mg
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    50mg
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  • IRE1α kinase-IN-6

    CAS:
    IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.
    Formula:C25H23Cl2FN6O3S2
    Color and Shape:Solid
    Molecular weight:609.52

    Ref: TM-T40336

    5mg
    873.00€
  • 2'-Chloro-N6-(3-trifluoromethyl)benzyl adenosine


    2’-Chloro-N6-(3-trifluoromethyl)benzyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid
    Formula:C18H17ClF3N5O4
    Color and Shape:Solid
    Molecular weight:459.81

    Ref: TM-T75035

    5mg
    To inquire
    50mg
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  • LDV

    CAS:
    α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.
    Formula:C48H70N10O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:979.13

    Ref: TM-TP2006

    10mg
    502.00€
  • Remdesivir nucleoside monophosphate

    CAS:
    Remdesivir metabolite, antiviral nucleoside analog, effective against SARS-CoV and MERS-CoV.
    Formula:C12H14N5O7P
    Color and Shape:Solid
    Molecular weight:371.24

    Ref: TM-T39334

    5mg
    897.00€
    10mg
    To inquire
    50mg
    To inquire
  • N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium

    CAS:

    N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].

    Formula:C21H35N12O17P3
    Color and Shape:Solid
    Molecular weight:820.49

    Ref: TM-T74135

    5mg
    To inquire
    50mg
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  • Eesperamicin A1

    CAS:
    Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.
    Formula:C59H80N4O22S4
    Color and Shape:Solid
    Molecular weight:1325.54

    Ref: TM-T41140

    25mg
    1,369.00€
  • Pseudouridimycin

    CAS:
    Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.
    Formula:C17H26N8O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:486.44

    Ref: TM-T16673

    10mg
    762.00€
  • 6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine


    6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits broad antitumor activity by
    Formula:C15H17N5O6
    Color and Shape:Solid
    Molecular weight:363.33

    Ref: TM-T75047

    5mg
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    50mg
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  • PKMYT1-IN-3


    PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.
    Formula:C24H26FN5O2
    Color and Shape:Solid
    Molecular weight:435.49

    Ref: TM-T200211

    10mg
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    50mg
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  • DSPE-PEG2000-iRGD


    DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.
    Color and Shape:Odour Solid

    Ref: TM-TCL-01137

    10mg
    To inquire
    50mg
    To inquire
  • 2'-Deoxy-2'-fluoro-l-uridine

    CAS:
    2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.
    Formula:C9H11FN2O5
    Color and Shape:Solid
    Molecular weight:246.19

    Ref: TM-T74652

    5mg
    To inquire
    50mg
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  • Phen-DC3 Trifluoromethanesulfonate

    CAS:
    Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.
    Formula:C36H26F6N6O8S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:848.75

    Ref: TM-T13817L

    50mg
    To inquire
    100mg
    To inquire
  • SP27

    CAS:
    SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].
    Formula:C40H40F2N12O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:806.82

    Ref: TM-T78728

    5mg
    To inquire
    50mg
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  • 5'-O-DMT-N2-DMF-dG

    CAS:
    5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.
    Formula:C34H36N6O6
    Color and Shape:Solid
    Molecular weight:624.698

    Ref: TM-T40500

    100mg
    To inquire
    500mg
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