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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3904 products of "Cell Cycle/Checkpoint"

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  • 12R-LOX-IN-2

    CAS:
    12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.
    Formula:C19H13NO
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:271.31

    Ref: TM-T77677

    5mg
    34.00€
    10mg
    50.00€
    25mg
    94.00€
    50mg
    130.00€
    100mg
    207.00€
    200mg
    305.00€
  • Fibronectin CS1 Peptide

    CAS:
    Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.
    Formula:C38H64N8O15
    Purity:98%
    Color and Shape:Solid
    Molecular weight:872.96

    Ref: TM-TP1526

    100mg
    To inquire
    500mg
    To inquire
  • Cdk2/Cyclin Inhibitory Peptide I


    CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.
    Formula:C111H196N48O23
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2571.05

    Ref: TM-TP2192

    5mg
    107.00€
    10mg
    170.00€
    25mg
    236.00€
  • 5'-O-TBDMS-dG

    CAS:
    5’-O-TBDMS-dG is a modified nucleoside. 5’-O-DMT-2’-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    Formula:C16H27N5O4Si
    Color and Shape:Solid
    Molecular weight:381.50

    Ref: TM-T37144

    50mg
    47.00€
    1mL*10mM (DMSO)
    52.00€
  • CD532 hydrochloride


    CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.
    Color and Shape:Solid

    Ref: TM-T36932

    5mg
    90.00€
    10mg
    155.00€
    25mg
    291.00€
  • KIF2C-IN-1


    KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.
    Formula:C36H39ClN4O9S
    Color and Shape:Solid
    Molecular weight:738.21263

    Ref: TM-T207280

    10mg
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    50mg
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  • Chrexanthomycin C


    Chrexanthomycin C, orally active, binds DNA (G4C2)4 G4, Kd 2.8 mM, potential in ALS research.
    Formula:C31H24O15
    Color and Shape:Solid
    Molecular weight:636.51

    Ref: TM-T75527

    5mg
    To inquire
    50mg
    To inquire
  • N6-Methyl-2'-O-(2-methoxyethyl) adenosine


    N6-Methyl-2’-O-(2-methoxyethyl) adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.
    Formula:C14H21N5O5
    Color and Shape:Solid
    Molecular weight:339.35

    Ref: TM-T75062

    5mg
    To inquire
    50mg
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  • Pyrindamycin A

    CAS:
    Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.
    Formula:C26H26ClN3O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:543.95

    Ref: TM-T12590

    25mg
    3,934.00€
    50mg
    5,203.00€
    100mg
    7,380.00€
  • [pSer2, pSer5, pSer7]-CTD TFA


    Substrate '[pSer2, pSer5, pSer7]-CTD (TFA)' for CDK7 phosphorylates RNA Pol II CTD at ser2, 5, 7.
    Formula:C98H138F3N21O39
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2291.25

    Ref: TM-TP1641

    100mg
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    500mg
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  • PROTAC CDK9 degrader-7

    CAS:
    PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (
    Formula:C43H50Cl2N8O9
    Color and Shape:Soild
    Molecular weight:893.81

    Ref: TM-T74853

    5mg
    To inquire
    50mg
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  • BAY-728


    BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].
    Formula:C24H28F3N5O2S
    Color and Shape:Solid
    Molecular weight:507.57

    Ref: TM-T75101

    2mg
    127.00€
  • MYC-IN-2

    CAS:
    MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.
    Formula:C25H17N3O2S
    Color and Shape:Solid
    Molecular weight:423.49

    Ref: TM-T39751

    5mg
    873.00€
  • CDK2/PIM1-IN-1


    CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.
    Color and Shape:Odour Solid

    Ref: TM-T206369

    10mg
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    50mg
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  • PAT-LM1


    PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-1103

    1mg
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    5mg
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  • DSPE-PEG1000-iRGD


    DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.
    Color and Shape:Odour Solid

    Ref: TM-TCL-01133

    10mg
    To inquire
    50mg
    To inquire
  • BLINK15


    BLINK15 is a blood-brain barrier-permeable Cdk5 inhibitor. It reduces CDK5 activity in CDK5/p35 (IC50= 29.34 nM) and CDK5/p25 (IC50= 12.08 nM) complexes. Additionally, BLINK15 exhibits antidiabetic and neuroprotective effects. It lowers blood glucose levels in type 2 diabetes (T2D) mice, enhances cognitive abilities, and diminishes neurodegenerative lesions.
    Color and Shape:Odour Solid

    Ref: TM-T206737

    10mg
    To inquire
    50mg
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  • Flurocitabine HCl

    CAS:
    Fluorocitabine HCl, a cytarabine analog, hydrolyzes into ara-FC and ara-FU, showing antitumor effects in leukemia and solid cancers.
    Formula:C9H11ClFN3O4
    Purity:99.76% - 99.83%
    Color and Shape:Soild
    Molecular weight:279.65

    Ref: TM-T27342L

    5mg
    40.00€
    10mg
    54.00€
    25mg
    92.00€
    50mg
    123.00€
    100mg
    178.00€
    500mg
    424.00€
  • MRK-952


    MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.
    Formula:C20H20ClF3N6
    Color and Shape:Solid
    Molecular weight:436.861

    Ref: TM-T205743

    10mg
    To inquire
    50mg
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  • THK01

    CAS:
    THK01: ROCK2 inhibitor (IC50=5.7nM), less effective on ROCK1 (923nM). Hinders breast cancer spread via ROCK2-STAT3. For cancer research.
    Formula:C20H13N3O2
    Color and Shape:Solid
    Molecular weight:327.34

    Ref: TM-T74808

    5mg
    To inquire
    50mg
    To inquire
  • DHFR-IN-8


    DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.
    Formula:C18H14N6S
    Color and Shape:Solid
    Molecular weight:346.41

    Ref: TM-T79734

    5mg
    To inquire
    50mg
    To inquire
  • 3'-β-C-Methyl-2-thiouridine


    3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies.
    Formula:C10H14N2O5S
    Color and Shape:Solid
    Molecular weight:274.29

    Ref: TM-T75053

    5mg
    To inquire
    50mg
    To inquire
  • CDK5-IN-1

    CAS:
    CDK5-IN-1: Potent CDK5 inhibitor (<10 nM) used in kidney disease research.
    Formula:C24H25FN6O3S
    Color and Shape:Solid
    Molecular weight:496.56

    Ref: TM-T40263

    5mg
    873.00€
  • DSPE-PEG5000-cRGD


    DSPE-PEG5000-cRGD is a PEG compound composed of DSPE and an αvβ3 targeting peptide (cRGD). The cRGD peptide has the ability to specifically bind to the αvβ3 present on the surfaces of numerous cancer cells and new vascular cells. DSPE-PEG5000-cRGD is useful for drug delivery applications.
    Color and Shape:Odour Solid

    Ref: TM-TCL-01154

    10mg
    To inquire
    50mg
    To inquire
  • Anti-EMMPRIN/CD147 Antibody


    Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-803

    1mg
    To inquire
    5mg
    To inquire
  • GRGDSP

    CAS:
    Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.
    Formula:C22H37N9O10
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:587.58

    Ref: TM-TP1421

    50mg
    To inquire
    100mg
    To inquire
  • dAURK-4

    CAS:
    dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].
    Formula:C52H52ClFN8O12
    Color and Shape:Solid
    Molecular weight:1035.47

    Ref: TM-T74099

    5mg
    To inquire
    50mg
    To inquire
  • K34c hydrochloride

    CAS:
    K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.
    Formula:C26H30ClN3O4
    Purity:99.76% - 99.89%
    Color and Shape:Soild
    Molecular weight:483.99

    Ref: TM-T41151L

    1mg
    190.00€
    5mg
    447.00€
    10mg
    610.00€
    25mg
    858.00€
    1mL*10mM (DMSO)
    505.00€
  • HDAC-IN-85


    HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.
    Formula:C24H27FN4O5
    Color and Shape:Solid
    Molecular weight:470.49

    Ref: TM-T205411

    10mg
    To inquire
    50mg
    To inquire
  • Isocytosine

    CAS:
    Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.
    Formula:C4H5N3O
    Color and Shape:White To Off-White Solid
    Molecular weight:111.1

    Ref: TM-PDK0016

    200mg
    36.00€
  • 7-TFA-ap-7-Deaza-ddA

    CAS:
    Compound 19c is a nucleotide derivative for DNA sequencing dye terminators.
    Formula:C16H16F3N5O3
    Color and Shape:Solid
    Molecular weight:383.331

    Ref: TM-T38534

    100mg
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    500mg
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  • ROCK-IN-5

    CAS:
    ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.
    Formula:C16H11ClFN3OS
    Purity:99.72% - 99.86%
    Color and Shape:Solid
    Molecular weight:347.79

    Ref: TM-T67748

    10mg
    43.00€
    25mg
    65.00€
    50mg
    94.00€
    100mg
    128.00€
    500mg
    To inquire
    1mL*10mM (DMSO)
    34.00€
  • 5-Methylcytidine 5′-triphosphate trisodium


    5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while

    Formula:C10H15N3Na3O14P3
    Color and Shape:Solid
    Molecular weight:563.13

    Ref: TM-T74585

    5mg
    To inquire
    50mg
    To inquire
  • N1-Methylpseudouridine-5′-triphosphate tetralithium


    N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.
    Formula:C10H13Li4N2O15P3
    Color and Shape:Solid
    Molecular weight:521.9

    Ref: TM-T73736

    5mg
    To inquire
    50mg
    To inquire
  • N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine


    N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.
    Formula:C14H22N2O7
    Color and Shape:Solid
    Molecular weight:330.33

    Ref: TM-T75214

    5mg
    To inquire
    50mg
    To inquire
  • Stigmatellin

    CAS:
    Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.
    Formula:C30H42O7
    Color and Shape:Solid
    Molecular weight:514.65

    Ref: TM-TN8168

    10mg
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    50mg
    To inquire
  • DSPE-PEG2000-cRGD


    DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.
    Color and Shape:Odour Solid

    Ref: TM-TCL-01138

    10mg
    To inquire
    50mg
    To inquire
  • 2'-Chloro-N6-(3-trifluoromethyl)benzyl adenosine


    2’-Chloro-N6-(3-trifluoromethyl)benzyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid
    Formula:C18H17ClF3N5O4
    Color and Shape:Solid
    Molecular weight:459.81

    Ref: TM-T75035

    5mg
    To inquire
    50mg
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  • LDV

    CAS:
    α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.
    Formula:C48H70N10O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:979.13

    Ref: TM-TP2006

    10mg
    502.00€
  • Biotin-PEG7-C2-NH-Vidarabine-S-CH3


    Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG linker with Vidarabine, an anti-herpes/zoster antiviral.
    Formula:C37H62N8O12S2
    Color and Shape:Solid
    Molecular weight:875.06

    Ref: TM-T74386

    5mg
    To inquire
    50mg
    To inquire
  • Remdesivir nucleoside monophosphate

    CAS:
    Remdesivir metabolite, antiviral nucleoside analog, effective against SARS-CoV and MERS-CoV.
    Formula:C12H14N5O7P
    Color and Shape:Solid
    Molecular weight:371.24

    Ref: TM-T39334

    5mg
    897.00€
    10mg
    To inquire
    50mg
    To inquire
  • N1-Methylxylo-guanosine


    N1-Methylxylo-guanosine, a purine analog, targets lymphoid cancer via DNA synthesis inhibition and apoptosis.
    Formula:C11H15N5O5
    Color and Shape:Solid
    Molecular weight:297.27

    Ref: TM-T75066

    5mg
    To inquire
    50mg
    To inquire
  • Pseudouridimycin

    CAS:
    Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.
    Formula:C17H26N8O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:486.44

    Ref: TM-T16673

    10mg
    762.00€
  • Eesperamicin A1

    CAS:
    Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.
    Formula:C59H80N4O22S4
    Color and Shape:Solid
    Molecular weight:1325.54

    Ref: TM-T41140

    25mg
    1,369.00€
  • PKMYT1-IN-3


    PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.
    Formula:C24H26FN5O2
    Color and Shape:Solid
    Molecular weight:435.49

    Ref: TM-T200211

    10mg
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    50mg
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  • 2'-Deoxy-2'-fluoro-l-uridine

    CAS:
    2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.
    Formula:C9H11FN2O5
    Color and Shape:Solid
    Molecular weight:246.19

    Ref: TM-T74652

    5mg
    To inquire
    50mg
    To inquire
  • DSPE-PEG2000-iRGD


    DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.
    Color and Shape:Odour Solid

    Ref: TM-TCL-01137

    10mg
    To inquire
    50mg
    To inquire
  • Phen-DC3 Trifluoromethanesulfonate

    CAS:
    Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.
    Formula:C36H26F6N6O8S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:848.75

    Ref: TM-T13817L

    50mg
    To inquire
    100mg
    To inquire
  • AURKA against 1


    Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.
    Formula:C28H32FN9O2
    Color and Shape:Solid
    Molecular weight:545.61

    Ref: TM-T89903

    10mg
    To inquire
    50mg
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  • SP27

    CAS:
    SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].
    Formula:C40H40F2N12O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:806.82

    Ref: TM-T78728

    5mg
    To inquire
    50mg
    To inquire