Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(94 products)
- CDK(500 products)
- Cell Cycle Arrest(4 products)
- Chk(42 products)
- DYRK(48 products)
- Dynamin(23 products)
- Ferroptosis(215 products)
- HSP(169 products)
- Integrin(224 products)
- Kinesin(66 products)
- LIM Kinase(19 products)
- Microtubule Associated(261 products)
- PKC(102 products)
- PLK(28 products)
- ROCK(70 products)
- Rho(2 products)
- Wee1(15 products)
- c-Myc(69 products)
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Found 3477 products of "Cell Cycle/Checkpoint"
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Uridine triphosphate 13C9,15N2 sodium
CAS:<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>Formula:C9H1415N2NaO15P3Color and Shape:SolidMolecular weight:517.04EC0489
CAS:<p>EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (</p>Formula:C111H156N22O43S2Purity:98%Color and Shape:SolidMolecular weight:2550.7PLK1-IN-2
CAS:<p>PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.</p>Formula:C24H27FN8OSColor and Shape:SolidMolecular weight:494.59Cytidine 5'-diphosphate trisodium salt
CAS:<p>CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.</p>Formula:C9H15N3Na3O11P2Purity:99.55%Color and Shape:White Crystalline PowderMolecular weight:472.15Nocarnickelamides B
<p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>Formula:C29H42N6O9Color and Shape:Odour SolidMolecular weight:618.68Etrolizumab
CAS:<p>MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.</p>Purity:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Color and Shape:LiquidDHODH-IN-16
CAS:<p>DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).</p>Formula:C24H25FN4O3Purity:99.64%Color and Shape:SolidMolecular weight:436.48CDK8-IN-12
CAS:<p>CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.</p>Formula:C21H20ClN3O2Purity:99.46% - 99.83%Color and Shape:SoildMolecular weight:381.86PD-1/PD-L1-IN-50
<p>Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.</p>Color and Shape:Odour SolidN3-[(Pyrid-4-yl)methyl]uridine
<p>N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.</p>Formula:C15H17N3O6Color and Shape:SolidMolecular weight:335.31AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formula:C137H215IN30O45SColor and Shape:SolidMolecular weight:3161.32Pyrindamycin A
CAS:<p>Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.</p>Formula:C26H26ClN3O8Purity:98%Color and Shape:SolidMolecular weight:543.95Apcin A HCL
CAS:<p>Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.</p>Formula:C10H15Cl4N5O2Purity:99.59%Color and Shape:SolidMolecular weight:379.073'-Deoxyuridine-5'-triphosphate trisodium
<p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>Formula:C9H12N2Na3O14P3Color and Shape:SoildMolecular weight:534.08CCT241533 dihydrochloride
CAS:<p>Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.</p>Formula:C23H29Cl2FN4O4Color and Shape:SolidMolecular weight:515.41TLR7 agonist 12
CAS:<p>TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>Formula:C14H19N5O8Color and Shape:SolidMolecular weight:385.33N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>Formula:C21H35N12O17P3Color and Shape:SolidMolecular weight:820.49Antibacterial agent 144
<p>Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.</p>Formula:C26H23N7O3Color and Shape:SolidMolecular weight:481.512'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS:<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>Formula:C10H14N5Na2O8PColor and Shape:SolidMolecular weight:409.202dUTP trisodium
CAS:<p>dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.</p>Formula:C9H12N2Na3O14P3Purity:100.00%Color and Shape:SolidMolecular weight:534.09CDK7-IN-5
CAS:<p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>Formula:C34H45N9O2Color and Shape:SolidMolecular weight:611.795PROTAC CDK9 degrader-2
CAS:<p>PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.</p>Formula:C39H36N6O10Purity:98%Color and Shape:SolidMolecular weight:748.745'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
<p>5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.</p>Formula:C44H49F2N4O7PColor and Shape:SolidMolecular weight:814.85CPS2
CAS:<p>CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.</p>Formula:C38H42N12O10S2Color and Shape:SolidMolecular weight:890.94N6-Methyl-2'-O-(2-methoxyethyl) adenosine
<p>N6-Methyl-2’-O-(2-methoxyethyl) adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formula:C14H21N5O5Color and Shape:SolidMolecular weight:339.35CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Color and Shape:SolidLorutengitide
CAS:<p>Lorutengitide is a transcription-regulating peptide with antiproliferative activity.</p>Formula:C30H50N8O12Color and Shape:SolidMolecular weight:714.764ROCK-IN-32
CAS:<p>ROCK-IN-32 is an effective Rho-kinase inhibitor.</p>Formula:C20H17Cl2N3O2Purity:98%Color and Shape:SolidMolecular weight:402.27Anti-EMMPRIN/CD147 Antibody
<p>Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Color and Shape:Odour Liquidwrwycr-NH2 TFA
<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>Color and Shape:Odour Solid5'-O-DMT-PAC-dA
CAS:<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>Formula:C39H37N5O7Color and Shape:SolidMolecular weight:687.74LDV FITC
CAS:<p>fluorescent ligand that binds to the α4β1 integrin (VLA-4)</p>Formula:C69H81N11O17SPurity:98%Color and Shape:SolidMolecular weight:1368.53Erythromycin A dihydrate
CAS:<p>Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.</p>Formula:C37H69NO14Color and Shape:SolidMolecular weight:751.94AV-153
CAS:<p>AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.</p>Formula:C14H19NNaO6Color and Shape:SolidMolecular weight:320.2978-NH2-ATP
CAS:<p>8-NH2-ATP is an inactive derivative of adenosine triphosphate (ATP), synthesized from 8-NH2-Ado.</p>Formula:C10H17N6O13P3Color and Shape:SolidMolecular weight:522.205-Caroxy uracil-1-yl acetic acid benzyl ester
<p>5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.</p>Formula:C14H12N2O6Color and Shape:SolidMolecular weight:304.25Isocytosine
CAS:<p>Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formula:C4H5N3OColor and Shape:White To Off-White SolidMolecular weight:111.1IV-361
CAS:<p>IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1</p>Formula:C23H32FN5O2SiColor and Shape:SolidMolecular weight:457.625Rev 2'-O-MOE-C(Bz)-5'-amidite
<p>'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.</p>Formula:C49H58N5O10PColor and Shape:SolidMolecular weight:907.99Dafsolimab
CAS:<p>Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and is</p>Color and Shape:LiquidSR15006
CAS:<p>SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).</p>Formula:C16H20ClN3O4SPurity:99.87%Color and Shape:SoildMolecular weight:385.87Nogalamycin
CAS:<p>Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.</p>Formula:C39H49NO16Purity:98%Color and Shape:SolidMolecular weight:787.812Chrexanthomycin C
<p>Chrexanthomycin C, orally active, binds DNA (G4C2)4 G4, Kd 2.8 mM, potential in ALS research.</p>Formula:C31H24O15Color and Shape:SolidMolecular weight:636.51Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formula:C25H41N11O8SColor and Shape:SolidMolecular weight:655.727DHFR-IN-8
<p>DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.</p>Formula:C18H14N6SColor and Shape:SolidMolecular weight:346.41N1-Methylpseudouridine-5′-triphosphate tetralithium
<p>N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.</p>Formula:C10H13Li4N2O15P3Color and Shape:SolidMolecular weight:521.9GRGDSP
CAS:<p>Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.</p>Formula:C22H37N9O10Purity:98%Color and Shape:SolidMolecular weight:587.583'-β-C-Methyl-N6-isopentenyl adenosine
<p>3’-Beta-C-Methyl-N6-isopentenyl adenosine is an adenosine analog.</p>Formula:C16H23N5O4Color and Shape:SolidMolecular weight:349.38Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Formula:C21H25FN4O2Color and Shape:SolidMolecular weight:384.453'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Color and Shape:Odour Solid
