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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3495 products of "Cell Cycle/Checkpoint"

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  • LN-439A

    CAS:
    <p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>
    Formula:C24H26FN3O4
    Color and Shape:Solid
    Molecular weight:439.48
  • KWR095

    CAS:
    <p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>
    Formula:C33H31ClF3N9O4
    Color and Shape:Solid
    Molecular weight:710.105
  • AR-13324 M1 metabolite

    CAS:
    <p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>
    Formula:C19H19N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:321.37
  • p38α inhibitor 9

    CAS:
    <p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>
    Formula:C27H24FN3O3
    Color and Shape:Solid
    Molecular weight:457.496
  • And1 degrader 1

    CAS:
    <p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>
    Formula:C26H27Cl2N3O
    Color and Shape:Solid
    Molecular weight:468.42
  • DNA Gyrase-IN-16

    CAS:
    <p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>
    Formula:C17H15N3O3
    Color and Shape:Solid
    Molecular weight:309.319
  • BRD4 Inhibitor-40

    CAS:
    <p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>
    Formula:C27H32N8O
    Color and Shape:Solid
    Molecular weight:484.596
  • CDK2/4-IN-2

    CAS:
    <p>CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.</p>
    Formula:C18H20F3N7O3S2
    Color and Shape:Solid
    Molecular weight:503.52
  • BET/Aurora kinase-IN-1

    CAS:
    <p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>
    Formula:C25H30FN7O
    Color and Shape:Solid
    Molecular weight:463.55
  • HNC-1664

    CAS:
    <p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>
    Formula:C12H13FIN3O3
    Color and Shape:Solid
    Molecular weight:393.153
  • IRE1α kinase-IN-5


    <p>IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.</p>
    Formula:C28H30N6O3S
    Color and Shape:Solid
    Molecular weight:530.64
  • L-I-OddU

    CAS:
    <p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>
    Formula:C8H9IN2O5
    Color and Shape:Solid
    Molecular weight:340.07
  • 2′-O-MOE-CMP

    CAS:
    <p>2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.</p>
    Formula:C12H20N3O9P
    Color and Shape:Solid
    Molecular weight:381.28
  • (R)-Atuveciclib

    CAS:
    <p>Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].</p>
    Formula:C18H18FN5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:387.43
  • 7-Methylguanosine 5′-monophosphate

    CAS:
    <p>7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.</p>
    Formula:C11H16N5O8P
    Color and Shape:Solid
    Molecular weight:377.25
  • GR 83895

    CAS:
    <p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>
    Formula:C29H39N9O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:673.74
  • Rhodblock 1a

    CAS:
    <p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>
    Formula:C20H16N2O2
    Color and Shape:Solid
    Molecular weight:316.353
  • (R)-CSN5i-3

    CAS:
    <p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>
    Formula:C28H29F2N5O2
    Purity:99.76% - 99.97%
    Color and Shape:Solid
    Molecular weight:505.56
  • Elacytarabine

    CAS:
    <p>Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.</p>
    Formula:C27H45N3O6
    Purity:97.69%
    Color and Shape:Solid
    Molecular weight:507.66
  • CTPS1-IN-1

    CAS:
    <p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>
    Formula:C21H22N6O4S2
    Purity:99.46%
    Color and Shape:Solid
    Molecular weight:486.57
  • GFB-12811

    CAS:
    <p>GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.</p>
    Formula:C22H23F4N5O
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:449.44
  • HRO761

    CAS:
    <p>HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.</p>
    Formula:C31H31ClF3N9O5
    Purity:98.74% - 99.62%
    Color and Shape:Solid
    Molecular weight:702.08
  • LY3143921 hydrate

    CAS:
    <p>LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].</p>
    Formula:C16H14FN5O2
    Purity:98.43%
    Color and Shape:Solid
    Molecular weight:327.31
  • SR 11302

    CAS:
    <p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>
    Formula:C26H32O2
    Purity:98.65%
    Color and Shape:Solid
    Molecular weight:376.53
  • INCB086550

    CAS:
    <p>INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 &lt;= 10 nM.</p>
    Formula:C41H39N7O4
    Purity:98.49%
    Color and Shape:Solid
    Molecular weight:693.79
  • Bicyclomycin benzoate

    CAS:
    <p>Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.</p>
    Formula:C19H22N2O8
    Color and Shape:Solid
    Molecular weight:406.39

    Ref: TM-T10541

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  • Deoxypseudouridine

    CAS:
    <p>Deoxypseudouridine is a nucleotide analog.</p>
    Formula:C9H12N2O5
    Color and Shape:Solid
    Molecular weight:228.2

    Ref: TM-T13645

    1mg
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  • Troxacitabine

    CAS:
    <p>Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.</p>
    Formula:C8H11N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:213.19

    Ref: TM-T17175

    1mg
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  • GSK-3/CDK5/CDK2-IN-1

    CAS:
    <p>GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].</p>
    Formula:C21H22N4O2
    Color and Shape:Solid
    Molecular weight:362.433

    Ref: TM-T35555

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  • 5'-DMT-3'-TBDMS-ibu-rG

    CAS:
    <p>5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.</p>
    Formula:C41H51N5O8Si
    Color and Shape:Solid
    Molecular weight:769.96

    Ref: TM-T40919

    ne
    Discontinued
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  • Formycin A

    CAS:
    <p>Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.</p>
    Formula:C10H13N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.24

    Ref: TM-T11312

    5mg
    Discontinued
    Discontinued product
  • Ethynylcytidine

    CAS:
    <p>Ethynylcytidine is a nucleoside antimetabolite.</p>
    Formula:C11H13N3O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.24

    Ref: TM-TQ0006

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  • 5'-O-DMT-N6-ibu-dA

    CAS:
    <p>5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.</p>
    Formula:C35H37N5O6
    Color and Shape:Solid
    Molecular weight:623.71

    Ref: TM-T39332

    ne
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  • 2'-Deoxy-2'-fluoro-5-iodouridine

    CAS:
    <p>2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.</p>
    Formula:C9H10FIN2O5
    Color and Shape:Solid
    Molecular weight:372.09

    Ref: TM-TNU0622

    ne
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  • PLK1-IN-6


    <p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>
    Formula:C28H37N9O3
    Color and Shape:Solid
    Molecular weight:547.65

    Ref: TM-T74777

    5mg
    Discontinued
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  • N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine

    CAS:
    <p>N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.</p>
    Formula:C38H35N5O6
    Color and Shape:Solid
    Molecular weight:657.727

    Ref: TM-T66118

    ne
    Discontinued
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  • Tanuxiciclib

    CAS:
    <p>Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.</p>
    Formula:C15H13FN6O
    Color and Shape:Solid
    Molecular weight:312.308

    Ref: TM-T39404

    ne
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  • NSC639828

    CAS:
    <p>NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.</p>
    Formula:C18H13BrClN5O3
    Color and Shape:Solid
    Molecular weight:462.69

    Ref: TM-T38742

    ne
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    Discontinued product
  • 5'-O-TBDMS-dT

    CAS:
    <p>5’-O-TBDMS-dT is a nucleoside with protective and modification effects.</p>
    Formula:C16H28N2O5Si
    Color and Shape:Solid
    Molecular weight:356.49

    Ref: TM-T37145

    1ml*10 (DMSO)
    Discontinued
    Discontinued product
  • MitoE10

    CAS:
    <p>MitoE10 is an effective mitochondrial targeting antioxidant.</p>
    Formula:C42H55O5PS
    Color and Shape:Solid
    Molecular weight:702.92

    Ref: TM-T33406

    25mg
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  • 6-Amino-5-nitropyridin-2-one

    CAS:
    <p>6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.</p>
    Formula:C5H5N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:155.11

    Ref: TM-T19157

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  • Ribocil-C

    CAS:
    <p>Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.</p>
    Formula:C21H21N7OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:419.5

    Ref: TM-T12722L

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  • Tibremciclib

    CAS:
    <p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>
    Formula:C28H32F2N8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:518.6

    Ref: TM-T79863

    ne
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  • PHI-101

    CAS:
    <p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>
    Formula:C19H19FN4O2S
    Purity:99.4%
    Color and Shape:Solid
    Molecular weight:386.44

    Ref: TM-T81490

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  • YK-2168

    CAS:
    <p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>
    Formula:C16H18ClN5
    Color and Shape:Solid
    Molecular weight:315.80

    Ref: TM-T200769

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