Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(109 products)
- CDK(522 products)
- Cell Cycle Arrest(4 products)
- Chk(46 products)
- DYRK(49 products)
- Dynamin(26 products)
- Ferroptosis(222 products)
- HSP(179 products)
- Integrin(256 products)
- Kinesin(83 products)
- LIM Kinase(19 products)
- Microtubule Associated(284 products)
- PKC(111 products)
- PLK(25 products)
- ROCK(67 products)
- Rho(2 products)
- Wee1(14 products)
- c-Myc(74 products)
Show 10 more subcategories
Found 3726 products of "Cell Cycle/Checkpoint"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formula:C21H18F3N5OPurity:98.91%Color and Shape:SolidMolecular weight:413.4FOY 251
CAS:<p>FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.</p>Formula:C17H19N3O7SPurity:97.11% - 99.33%Color and Shape:SolidMolecular weight:409.41BMS-1166
CAS:<p>BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.</p>Formula:C36H33ClN2O7Purity:99.22%Color and Shape:SolidMolecular weight:641.11NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formula:C11H17N5O2Purity:98.36%Color and Shape:SolidMolecular weight:251.29SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Formula:C15H18BrN7Purity:96.69% - 99.6%Color and Shape:SolidMolecular weight:376.25CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurity:98.28% - 99.93%Color and Shape:SolidMolecular weight:379.34TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Formula:C24H21Cl2NO5Purity:98.98%Color and Shape:SolidMolecular weight:474.333-Methylcytidine
CAS:<p>3-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.</p>Formula:C10H15N3O5Purity:99.52%Color and Shape:SolidMolecular weight:257.246-AZATHYMINE
CAS:6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.Formula:C4H5N3O2Purity:99.47%Color and Shape:SolidMolecular weight:127.1TAK-960 hydrochloride
CAS:TAK-960 hydrochloride is an oral, potent PLK1 inhibitor with IC50 of 0.8 nM, effective against various tumor cells and xenografts.Formula:C27H35ClF3N7O3Color and Shape:SolidMolecular weight:598.06Fanotaprim
CAS:<p>Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.</p>Formula:C19H22N8OPurity:98.1%Color and Shape:SolidMolecular weight:378.43M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Formula:C19H24N4O4SPurity:99.02% - >99.99%Color and Shape:SolidMolecular weight:404.48Irigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFormula:C18H16O8Purity:99.50% - 99.85%Color and Shape:SolidMolecular weight:360.31ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formula:C19H22O7SPurity:98.27%Color and Shape:SolidMolecular weight:394.44BSJ-03-123
CAS:BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.Formula:C47H56N10O11Purity:97.78% - 99.38%Color and Shape:SolidMolecular weight:937.01Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formula:C32H46O8Purity:97.1% - 99.33%Color and Shape:SolidMolecular weight:558.70Cyclo(RGDyK) trifluoroacetate
CAS:<p>Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.</p>Formula:C31H43F6N9O12Purity:95.28% - ≥95%Color and Shape:SolidMolecular weight:847.72Y16
CAS:Y16 is a G protein-coupled Rho GEFs inhibitor and also a specific inhibitor of LARG with a Kd of 76 nM.Cost-effective and quality-assured.Formula:C24H20N2O3Purity:98.26% - 99.85%Color and Shape:SolidMolecular weight:384.43TH5427 hydrochloride
CAS:TH5427 HCl inhibits NUDT5 with 29 nM IC50; 690x more selective over MTH1; blocks ATP in breast cancer cells, hindering growth.Formula:C20H21Cl3N8O3Color and Shape:SolidMolecular weight:527.79CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Formula:C22H20BrN3O3SPurity:99.66%Color and Shape:SolidMolecular weight:486.38RNase L-IN-2
CAS:RNase L-IN-2 activates RNase L at 22 uM, has antiviral effects on various RNA viruses, non-toxic at effective levels.Formula:C16H14N2O2SPurity:98.81%Color and Shape:SolidMolecular weight:298.36Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Formula:C18H18FN5O2SPurity:98.8%Color and Shape:SolidMolecular weight:387.43Cyclo(-RGDfK)
CAS:Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.Formula:C27H41N9O7Purity:95.29% - >99.99%Color and Shape:SolidMolecular weight:603.67Seliciclib
CAS:Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Formula:C19H26N6OPurity:97.15% - 99.89%Color and Shape:White To Off-White SolidMolecular weight:354.45LDC-4297 HCl (1453834-21-3(free base))
<p>LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.</p>Formula:C23H29ClN8OPurity:100%Color and Shape:SolidMolecular weight:469.02Sarecycline free base
CAS:Sarecycline free base (P005672) is a tetracycline-derived, narrow-spectrum antibiotic.Formula:C24H29N3O8Purity:98%Color and Shape:SolidMolecular weight:487.5STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFormula:C27H28N4O4SPurity:99.64%Color and Shape:SolidMolecular weight:504.6InhA-IN-2
CAS:N-[3-(Aminomethyl)phenyl]-5-chloro-3-methyl-benzo[b]thiophene-2-sulfonamide inhibits InhA without KatG activation.Formula:C16H15ClN2O2S2Purity:98.4%Color and Shape:SolidMolecular weight:366.89Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Formula:C27H32F2N8Purity:99.43% - 99.87%Color and Shape:SolidMolecular weight:506.59MC180295
CAS:<p>MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.</p>Formula:C17H18N4O3SPurity:99.84%Color and Shape:SolidMolecular weight:358.412-Aminofluorene
CAS:<p>2-Aminofluorene (2-Fluorenamine) is a biochemical.</p>Formula:C13H11NPurity:99.9%Color and Shape:Light Yellow CrystallineMolecular weight:181.23360A
CAS:<p>360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).</p>Formula:C27H23N5O2Purity:98.68%Color and Shape:SolidMolecular weight:449.5CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formula:C21H17ClF6N2O2Purity:99.58%Color and Shape:SolidMolecular weight:478.82TH5487
CAS:<p>TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)</p>Formula:C19H18BrIN4O2Purity:98.38% - 98.73%Color and Shape:SolidMolecular weight:541.18Poloxin
CAS:<p>Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).</p>Formula:C18H19NO3Purity:99.19%Color and Shape:SolidMolecular weight:297.35CWHM-12
CAS:<p>CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).</p>Formula:C26H32BrN5O6Purity:98.05% - 99.83%Color and Shape:SolidMolecular weight:590.47Mogroside I E1
CAS:Mogroside I E1 is a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener.Formula:C36H62O9Purity:98.62% - 99.71%Color and Shape:SolidMolecular weight:638.87Datelliptium chloride hydrochloride
CAS:<p>Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.</p>Formula:C23H29Cl2N3OPurity:99.46%Color and Shape:SolidMolecular weight:434.4IRE1α kinase-IN-1
CAS:<p>IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM.</p>Formula:C26H26ClFN8Purity:99.18%Color and Shape:SolidMolecular weight:504.99PfDHODH-IN-1
CAS:PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for DNA and RNA biosynthesis.Formula:C14H11F3N2O2Purity:99.87%Color and Shape:SolidMolecular weight:296.24Cdk5 Substrate acetate
<p>Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.</p>Formula:C55H103N15O14Purity:96.21%Color and Shape:SolidMolecular weight:1198.5Phthalazinone pyrazole
CAS:Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Formula:C18H15N5OPurity:97.03%Color and Shape:SolidMolecular weight:317.34Tirofiban hydrochloride monohydrate
CAS:<p>Tirofiban（MK383） hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.</p>Formula:C22H39ClN2O6SPurity:98.81% - >99.99%Color and Shape:White SolidMolecular weight:495.07EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formula:C25H28Cl2N4O3Purity:99.6%Color and Shape:SolidMolecular weight:503.42Protein kinase inhibitor 6
CAS:<p>Protein kinase inhibitor 6 is a protein kinase inhibitor.</p>Formula:C13H9FN2SPurity:98.01%Color and Shape:SolidMolecular weight:244.29Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formula:C27H40N8O7Purity:98% - 99.8%Color and Shape:SolidMolecular weight:588.66AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Formula:C18H18Cl2F3N5O4Color and Shape:SolidMolecular weight:496.27Fasudil dihydrochloride
CAS:Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Formula:C14H19Cl2N3O2SPurity:99.86%Color and Shape:SolidMolecular weight:364.29Proguanil
CAS:Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the DHFR enzyme .Formula:C11H16ClN5Purity:99.6%Color and Shape:SolidMolecular weight:253.73Senexin B
CAS:Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Formula:C27H26N6OPurity:99.67%Color and Shape:SolidMolecular weight:450.53
