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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3730 products of "Cell Cycle/Checkpoint"

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  • HBV-IN-16
    Targetmol
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    HBV-IN-16

    CAS:
    HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).
    Formula:C22H20ClNO4
    Color and Shape:Solid
    Molecular weight:397.85

    Ref: TM-T61886

  • Crisnatol
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    Crisnatol

    CAS:
    Crisnatol (BWA770U) is an oral anticancer DNA intercalator, toxic to breast cancer cells, not skin fibroblasts.
    Formula:C23H23NO2
    Color and Shape:Solid
    Molecular weight:345.43

    Ref: TM-T73217

  • CDK7-IN-12
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    CDK7-IN-12

    CAS:
    CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.
    Formula:C20H19F3N6
    Color and Shape:Solid
    Molecular weight:400.4

    Ref: TM-T61922

  • αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
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    αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)

    αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
    Formula:C28H35F3N6O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:672.67

    Ref: TM-T13473L

  • Crisnatol mesylate
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    Crisnatol mesylate

    CAS:
    Crisnatol, a potent and selective DNA intercalator, has potential anticancer activity.
    Formula:C24H27NO5S
    Color and Shape:Solid
    Molecular weight:441.54

    Ref: TM-T27085

  • SP-471P
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    SP-471P

    CAS:
    SP-471P inhibits DENV protease; EC50: DENV1-5.9 μM, DENV2-1.4 μM, DENV3-5.1 μM, DENV4-1.7 μM; CC50 >100 μM; lowers viral RNA synthesis.
    Formula:C33H26BrN5O2
    Color and Shape:Solid
    Molecular weight:604.5

    Ref: TM-T73420

  • Werner syndrome RecQ helicase-IN-3
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    Werner syndrome RecQ helicase-IN-3

    CAS:
    Potent WRN inhibitor, Werner syndrome RecQ helicase-IN-3, is orally active with 0.06 µM IC50; exhibits antiproliferative and anticancer effects.
    Formula:C31H30ClF3N8O5
    Color and Shape:Solid
    Molecular weight:687.07

    Ref: TM-T72109

  • Mps-BAY2b
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    Mps-BAY2b

    CAS:
    Mps-BAY2b is a novel MPS1 inhibitor.
    Formula:C20H23N5O
    Color and Shape:Solid
    Molecular weight:349.43

    Ref: TM-T28091

  • CH-1504
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    CH-1504

    CAS:
    <p>CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis.</p>
    Formula:C23H23N5O5
    Color and Shape:Solid
    Molecular weight:449.46

    Ref: TM-T27002

  • NSC666715
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    NSC666715

    CAS:
    NSC666715 is the strand-displacement activity of DNA polymerase inhibitor.
    Formula:C15H13Cl2N5O2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.33

    Ref: TM-T24555

  • Indirubin-5-sulfonate
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    Indirubin-5-sulfonate

    CAS:
    Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.
    Formula:C16H10N2O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:342.33

    Ref: TM-T11653

  • hDHODH-IN-3
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    hDHODH-IN-3

    CAS:
    <p>hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.</p>
    Formula:C18H19BrN4O2
    Purity:99.871%
    Color and Shape:Solid
    Molecular weight:403.27

    Ref: TM-T11025

  • NSC 109555 ditosylate
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    NSC 109555 ditosylate

    CAS:
    Chk2 inhibitor,ATP-competitive
    Formula:C26H32N10O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:580.66

    Ref: TM-T23089

  • Eg5 Inhibitor V, trans-24
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    Eg5 Inhibitor V, trans-24

    CAS:
    Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
    Formula:C26H21N3O3
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:423.46

    Ref: TM-T11155

  • (S)-CR8
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    (S)-CR8

    CAS:
    (S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.
    Formula:C24H29N7O
    Color and Shape:Solid
    Molecular weight:431.53

    Ref: TM-T23577

  • 14α-Demethylase/DNA Gyrase-IN-2
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    14α-Demethylase/DNA Gyrase-IN-2

    CAS:
    14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
    Formula:C24H22N4O4
    Color and Shape:Solid
    Molecular weight:430.46

    Ref: TM-T62389

  • DHODH-IN-8
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    DHODH-IN-8

    CAS:
    DHODH-IN-8 is a DHODH inhibitor with antimalarial properties, IC50: 0.13 μM (human), 47.4 μM (P. falciparum); Ki: 0.016 μM (human), 5.6 μM (P. falciparum).
    Formula:C17H13ClN2O2
    Purity:99.78%
    Color and Shape:Solid
    Molecular weight:312.75

    Ref: TM-T11030

  • BDM44768
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    BDM44768

    CAS:
    BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.
    Formula:C24H22FN5O3
    Color and Shape:Solid
    Molecular weight:447.46

    Ref: TM-T25142

  • AS-136A
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    AS-136A

    CAS:
    <p>AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.</p>
    Formula:C17H19F3N4O3S
    Purity:98.52%
    Color and Shape:Solid
    Molecular weight:416.42

    Ref: TM-T62160

  • Zaurategrast ethyl ester sulfate
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    Zaurategrast ethyl ester sulfate

    CAS:
    Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.
    Formula:C56H60Br2N8O10S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1197.01

    Ref: TM-T13388

  • DHODH-IN-13
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    DHODH-IN-13

    CAS:
    <p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>
    Formula:C10H6F3N3O3
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:273.17

    Ref: TM-T11022

  • DENV-IN-4
    Targetmol
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    DENV-IN-4

    CAS:
    <p>DENV-IN-4: Effective DENV inhibitor (EC50=4.79 μM), low toxicity (CC50&gt;100 μM), and strong selectivity (SI&gt;20.9); suppresses DENV2 and RdRp.</p>
    Formula:C28H32N4O4Si
    Color and Shape:Solid
    Molecular weight:516.66

    Ref: TM-T63598

  • NSC 693868
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    NSC 693868

    CAS:
    CDKs and GSK-3 inhibitor
    Formula:C9H7N5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:185.19

    Ref: TM-T23093

  • Y-9738
    Targetmol
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    Y-9738

    CAS:
    <p>Y-9738 is an agent of hypolipidemic.</p>
    Formula:C15H16ClNO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:309.74

    Ref: TM-T13972

  • CDK5 inhibitor 20-223
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    CDK5 inhibitor 20-223

    CAS:
    CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.
    Formula:C19H19N3O
    Color and Shape:Solid
    Molecular weight:305.37

    Ref: TM-T36742

  • Mps1-IN-4
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    Mps1-IN-4

    CAS:
    Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.
    Formula:C26H31F3N6O2
    Color and Shape:Solid
    Molecular weight:516.56

    Ref: TM-T73229

  • CDK7-IN-8
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    CDK7-IN-8

    CAS:
    CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.
    Formula:C25H38N8O3
    Color and Shape:Solid
    Molecular weight:498.62

    Ref: TM-T63381

  • hDHODH-IN-5
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    hDHODH-IN-5

    CAS:
    <p>hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).</p>
    Formula:C21H21F3N2O2
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:390.4

    Ref: TM-T11029

  • Flurocitabine
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    Flurocitabine

    CAS:
    Flurocitabine is a therapeutic agent with antineoplastic activity.
    Formula:C9H10FN3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:243.19

    Ref: TM-T27342

  • 2'-Deoxy-L-guanosine
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    2'-Deoxy-L-guanosine

    CAS:
    2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death.
    Formula:C10H13N5O4
    Color and Shape:Solid
    Molecular weight:267.24

    Ref: TM-T71892

  • LCAHA
    Targetmol
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    LCAHA

    CAS:
    LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.
    Formula:C24H41NO3
    Color and Shape:Solid
    Molecular weight:391.59

    Ref: TM-T27804

  • VE-465
    Targetmol
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    VE-465

    CAS:
    VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.
    Formula:C22H28N8OS
    Color and Shape:Solid
    Molecular weight:452.58

    Ref: TM-T29101

  • Antitumor agent-85
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    Antitumor agent-85

    Antitumor agent-85 stabilizes G4-DNA with potent anti-tumor effects.
    Formula:C24H33N7
    Color and Shape:Solid
    Molecular weight:419.57

    Ref: TM-T72572

  • DHFR-IN-5
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    DHFR-IN-5

    CAS:
    <p>DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.</p>
    Formula:C18H24N4O4
    Color and Shape:Solid
    Molecular weight:360.41

    Ref: TM-T73328

  • HBV-IN-15
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    HBV-IN-15

    CAS:
    HBV-IN-15, a flavone derivative, is a potent cccDNA inhibitor, potentially aiding HBV research.
    Formula:C24H23ClO6
    Color and Shape:Solid
    Molecular weight:442.89

    Ref: TM-T73249

  • LIMK1 inhibitor BMS-4
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    LIMK1 inhibitor BMS-4

    CAS:
    BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.
    Formula:C23H23N7O2S
    Color and Shape:Solid
    Molecular weight:461.54

    Ref: TM-T72399

  • CB 3717
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    CB 3717

    CAS:
    CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.
    Formula:C24H23N5O6
    Color and Shape:Solid
    Molecular weight:477.47

    Ref: TM-T25208

  • Lysine-methotrexate
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    Lysine-methotrexate

    CAS:
    Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase.
    Formula:C21H27N9O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:453.5

    Ref: TM-T24427

  • HBV-IN-22
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    HBV-IN-22

    CAS:
    HBV-IN-22 (Compound LC5f) is an HBV DNA replication inhibitor that acts on both wild-type HBV (IC50: 0.71 μM) and drug-resistant HBV (IC50: 0.84 μM).
    Formula:C26H29N3O2S2
    Color and Shape:Solid
    Molecular weight:479.66

    Ref: TM-T63162

  • ROCK2-IN-5
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    ROCK2-IN-5

    ROCK2-IN-5, a compound blending fasudil, caffeic, and ferulic acids, shows promise for ALS research involving SOD1 mutations.
    Formula:C23H25N3O5S
    Color and Shape:Solid
    Molecular weight:455.53

    Ref: TM-T73117

  • WNK1-IN-1
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    WNK1-IN-1

    CAS:
    WNK1-IN-1, a WNK1 inhibitor (IC50: 1.6 μM), also inhibits OSR1 phosphorylation (IC50: 4.3 μM), used in blood pressure and cancer research.
    Formula:C13H15BrCl2N2O4S
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:446.14

    Ref: TM-T73295

  • CCT068127
    Targetmol
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    CCT068127

    CAS:
    CCT068127 is a potent CDK2 and CDK9 inhibitor.
    Formula:C19H27N7O
    Color and Shape:Solid
    Molecular weight:369.46

    Ref: TM-T68913

  • KIRA-7
    Targetmol
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    KIRA-7

    CAS:
    KIRA-7: imidazopyrazine, anti-fibrotic, inhibits IRE1α RNase (IC50: 110 nM) allosterically.
    Formula:C27H23FN6O
    Color and Shape:Solid
    Molecular weight:466.51

    Ref: TM-T15664

  • Sibrafiban
    Targetmol
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    Sibrafiban

    CAS:
    Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.
    Formula:C20H28N4O6
    Color and Shape:Solid
    Molecular weight:420.46

    Ref: TM-T28775

  • RSK-IN-1
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    RSK-IN-1

    CAS:
    <p>RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].</p>
    Formula:C22H17NO2
    Color and Shape:Solid
    Molecular weight:327.38

    Ref: TM-T60922

  • IACS-4759
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    IACS-4759

    CAS:
    IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.
    Formula:C10H17N3O2
    Color and Shape:Solid
    Molecular weight:211.26

    Ref: TM-T70091

  • DHFR-IN-2
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    DHFR-IN-2

    CAS:
    DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.
    Formula:C14H13NO2
    Color and Shape:Solid
    Molecular weight:227.26

    Ref: TM-T60286

  • CDK2-IN-12
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    CDK2-IN-12

    CAS:
    CDK2-IN-12 (10b), potent CDK2 inhibitor, IC50: 11.6 μM; inhibits hCA I/II/IX/XII, KI: 3534/638.4/44.3/48.8 nM; anti-cancer properties.
    Formula:C20H17N9O2S
    Color and Shape:Solid
    Molecular weight:447.47

    Ref: TM-T62668

  • FINDY
    Targetmol
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    FINDY

    CAS:
    FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.
    Formula:C16H17NO2S2Si
    Color and Shape:Solid
    Molecular weight:347.53

    Ref: TM-T73551

  • RET-IN-19
    Targetmol
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    RET-IN-19

    CAS:
    <p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>
    Formula:C28H28N6O4S
    Color and Shape:Solid
    Molecular weight:544.62

    Ref: TM-T63837