Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(111 products)
- CDK(522 products)
- Cell Cycle Arrest(4 products)
- Chk(46 products)
- DYRK(49 products)
- Dynamin(26 products)
- Ferroptosis(225 products)
- HSP(180 products)
- Integrin(256 products)
- Kinesin(85 products)
- LIM Kinase(19 products)
- Microtubule Associated(285 products)
- PKC(111 products)
- PLK(25 products)
- ROCK(67 products)
- Rho(2 products)
- Wee1(14 products)
- c-Myc(75 products)
Show 10 more subcategories
Found 3739 products of "Cell Cycle/Checkpoint"
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CLK1-IN-2
CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.Formula:C16H12Cl2N2O2SColor and Shape:SolidMolecular weight:367.25BPIC
CAS:BPIC is an agent of anti-tumor that acts by inhibiting inflammation and scavenging free radicals.Formula:C27H20N2O5Color and Shape:SolidMolecular weight:452.46Tenofovir exalidex
CAS:Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistantFormula:C28H52N5O5PPurity:99.83%Color and Shape:SolidMolecular weight:569.72IMB-10
CAS:IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.Formula:C19H15NOS2Color and Shape:SolidMolecular weight:337.46CDK4/6-IN-8
CAS:CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).Formula:C18H18N6O5Color and Shape:SolidMolecular weight:398.37(R)-Filanesib
CAS:(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).Formula:C20H22F2N4O2SColor and Shape:SolidMolecular weight:420.48RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Formula:C28H28N6O4SColor and Shape:SolidMolecular weight:544.62DHFR-IN-2
CAS:DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.Formula:C14H13NO2Color and Shape:SolidMolecular weight:227.26KIRA-7
CAS:KIRA-7: imidazopyrazine, anti-fibrotic, inhibits IRE1α RNase (IC50: 110 nM) allosterically.Formula:C27H23FN6OColor and Shape:SolidMolecular weight:466.51ROCK2-IN-5
ROCK2-IN-5, a compound blending fasudil, caffeic, and ferulic acids, shows promise for ALS research involving SOD1 mutations.Formula:C23H25N3O5SColor and Shape:SolidMolecular weight:455.53HBV-IN-22
CAS:HBV-IN-22 (Compound LC5f) is an HBV DNA replication inhibitor that acts on both wild-type HBV (IC50: 0.71 μM) and drug-resistant HBV (IC50: 0.84 μM).Formula:C26H29N3O2S2Color and Shape:SolidMolecular weight:479.66DHFR-IN-5
CAS:<p>DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.</p>Formula:C18H24N4O4Color and Shape:SolidMolecular weight:360.41LCAHA
CAS:LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.Formula:C24H41NO3Color and Shape:SolidMolecular weight:391.59Flurocitabine
CAS:Flurocitabine is a therapeutic agent with antineoplastic activity.Formula:C9H10FN3O4Purity:98%Color and Shape:SolidMolecular weight:243.19Y-9738
CAS:<p>Y-9738 is an agent of hypolipidemic.</p>Formula:C15H16ClNO4Purity:98%Color and Shape:SolidMolecular weight:309.74NSC 693868
CAS:CDKs and GSK-3 inhibitorFormula:C9H7N5Purity:98%Color and Shape:SolidMolecular weight:185.19Zaurategrast ethyl ester sulfate
CAS:Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.Formula:C56H60Br2N8O10SPurity:98%Color and Shape:SolidMolecular weight:1197.01NSC666715
CAS:NSC666715 is the strand-displacement activity of DNA polymerase inhibitor.Formula:C15H13Cl2N5O2S2Purity:98%Color and Shape:SolidMolecular weight:430.33Aurora A/PKC-IN-1
CAS:Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Formula:C16H14N6OSe2Color and Shape:SolidMolecular weight:464.24DHODH-IN-1
CAS:<p>DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.</p>Formula:C21H20F3N3O2Purity:99.76%Color and Shape:SolidMolecular weight:403.4BRD9185
CAS:BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.Formula:C23H21F6N3O2Purity:98%Color and Shape:SolidMolecular weight:485.42Zaurategrast ethyl ester
CAS:Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.Formula:C28H29BrN4O3Purity:98%Color and Shape:SolidMolecular weight:549.46(E/Z)-BIO-acetoxime
CAS:(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.Formula:C18H12BrN3O3Color and Shape:SolidMolecular weight:398.21Capzimin
CAS:<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Formula:C30H24N6O2S4Purity:98.31% - 99.32%Color and Shape:SolidMolecular weight:628.81A 65281
CAS:A 65281: antibacterial isothiazoloquinolone, inhibits P4-unknotting, induces DNA breakage via topoisomerase II.Formula:C17H16F2N4O2SPurity:98%Color and Shape:SolidMolecular weight:378.4MFH290
CAS:MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.Formula:C26H31N5O3S2Color and Shape:SolidMolecular weight:525.69RHI002-Me
CAS:RHI002-Me is a methylated derivative of RHI002, a selective inhibitor of human RNaseH2.Formula:C18H19N3O2S2Purity:98%Color and Shape:SolidMolecular weight:373.49ROCK-IN-D2
CAS:ROCK-IN-D2 is an effective and selective inhibitor of ROCK.Formula:C22H28N6OPurity:98%Color and Shape:SolidMolecular weight:392.5Apricitabine
CAS:Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-Formula:C8H11N3O3SPurity:99.45%Color and Shape:SolidMolecular weight:229.26PD 130883
CAS:PD 130883 is a potent lipophilic quinazoline antifolate.Formula:C18H15N5O3Purity:98%Color and Shape:SolidMolecular weight:349.34RP-106
CAS:RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.Formula:C17H19N3OPurity:98%Color and Shape:SolidMolecular weight:281.35A 65282
CAS:A 65282: antibacterial isothiazoloquinolone, inhibits P4-unknotting, causes DNA breaks via topoisomerase II.Formula:C17H16F2N4O2SPurity:98%Color and Shape:SolidMolecular weight:378.4CDK8-IN-10
CAS:CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.Formula:C25H15ClF3N5O3Color and Shape:SolidMolecular weight:525.87AnnH31
CAS:AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm theFormula:C15H13N3OPurity:99.99%Color and Shape:SolidMolecular weight:251.28hDHODH-IN-4
CAS:hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.Formula:C21H24N4O2Purity:99.87%Color and Shape:SolidMolecular weight:364.44SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Formula:C15H13N5O2Purity:98%Color and Shape:SolidMolecular weight:295.3Kira8 Hydrochloride
CAS:Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.Formula:C31H30Cl2N6O3SPurity:98%Color and Shape:SolidMolecular weight:637.58CDK4/6-IN-12
CAS:<p>CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.</p>Formula:C12H10N6Color and Shape:SolidMolecular weight:238.25Levofloxacin sodium
CAS:Levofloxacin sodium: synthetic antibacterial, stops DNA replication by inhibiting bacterial DNA gyrase.Formula:C18H20FN3NaO4Purity:98%Color and Shape:SolidMolecular weight:384.363XL-188
CAS:XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Formula:C32H42N6O4Color and Shape:SolidMolecular weight:574.71Nucleoside-Analog-1
CAS:Nucleoside-Analog-1 is a 4′-Azidocytidine analogue, used to against Hepatitis C virus replication.Formula:C9H9N5O5Purity:98%Color and Shape:SolidMolecular weight:267.2L-Fd4A
CAS:L-Fd4A (compound 36) is an adenine derivative with anti-HIV (EC50=1.5μM) and anti-HBV (EC50=1.7μM) effects, low cytotoxicity.Formula:C10H10FN5O2Color and Shape:SolidMolecular weight:251.22CCT068127
CAS:CCT068127 is a potent CDK2 and CDK9 inhibitor.Formula:C19H27N7OColor and Shape:SolidMolecular weight:369.46hDHODH-IN-5
CAS:hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).Formula:C21H21F3N2O2Purity:99.55%Color and Shape:SolidMolecular weight:390.4DHODH-IN-13
CAS:<p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>Formula:C10H6F3N3O3Purity:99.66%Color and Shape:SolidMolecular weight:273.17(S)-CR8
CAS:(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.Formula:C24H29N7OColor and Shape:SolidMolecular weight:431.53hDHODH-IN-3
CAS:<p>hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.</p>Formula:C18H19BrN4O2Purity:99.871%Color and Shape:SolidMolecular weight:403.27BMVC
CAS:BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities.Formula:C28H25I2N3Color and Shape:SolidMolecular weight:657.33CDK2-IN-11
CAS:CDK2-IN-11 inhibits CDK2 (IC50: 6.4 μM) and targets hCA II, IX, XII (Ki: 23.4-56.3 nM); suited for cancer research.Formula:C18H14ClN7O2SColor and Shape:SolidMolecular weight:427.87(S)-LY3177833 hydrate
CAS:(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.Formula:C16H14FN5O2Color and Shape:SolidMolecular weight:327.31
