
Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(111 products)
- CDK(522 products)
- Cell Cycle Arrest(4 products)
- Chk(46 products)
- DYRK(49 products)
- Dynamin(26 products)
- Ferroptosis(225 products)
- HSP(180 products)
- Integrin(256 products)
- Kinesin(85 products)
- LIM Kinase(19 products)
- Microtubule Associated(285 products)
- PKC(111 products)
- PLK(25 products)
- ROCK(67 products)
- Rho(2 products)
- Wee1(14 products)
- c-Myc(75 products)
Show 10 more subcategories
Found 3739 products of "Cell Cycle/Checkpoint"
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Bofumustine
CAS:Bofumustine is a chloroethyl nitrosourea with anti tumor properties.Formula:C18H21ClN4O9Color and Shape:SolidMolecular weight:472.83Levoleucovorin disodium
CAS:Levoleucovorin disodium is the sodium salt of the enantiomerically active form of Folinic Acid.Formula:C20H21N7Na2O7Purity:98%Color and Shape:SolidMolecular weight:517.41Nitracrine
CAS:Nitracrine: a 1-nitroacridine, hypoxia-selective, anti-tumor agent; inhibits RNA synthesis, binds DNA reversibly and forms covalent adducts.Formula:C18H20N4O2Purity:98%Color and Shape:SolidMolecular weight:324.38ProTAME
CAS:ProTAME inhibits APC/CFzr & APC/CCdc20, enhances cell death with doxorubicin/etoposide in primary/MM cells, especially after TOPIIα upregulation.Formula:C34H38N4O12SPurity:98%Color and Shape:SolidMolecular weight:726.75DDD100097
CAS:DDD100097 is a N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.Formula:C22H30Cl2F2N4O2SPurity:98.89%Color and Shape:SolidMolecular weight:523.47DHODH-IN-8
CAS:DHODH-IN-8 is a DHODH inhibitor with antimalarial properties, IC50: 0.13 μM (human), 47.4 μM (P. falciparum); Ki: 0.016 μM (human), 5.6 μM (P. falciparum).Formula:C17H13ClN2O2Purity:99.78%Color and Shape:SolidMolecular weight:312.75OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formula:C13H14N4O3SColor and Shape:SolidMolecular weight:306.34VRX-0466617
CAS:VRX-0466617 is a novel selective Chk2 inhibitor.Formula:C19H20BrN5O2SColor and Shape:SolidMolecular weight:462.36CDK2-IN-12
CAS:CDK2-IN-12 (10b), potent CDK2 inhibitor, IC50: 11.6 μM; inhibits hCA I/II/IX/XII, KI: 3534/638.4/44.3/48.8 nM; anti-cancer properties.Formula:C20H17N9O2SColor and Shape:SolidMolecular weight:447.47Dyrk1A-IN-3
CAS:Dyrk1A-IN-3 is a selective DYRK1A inhibitor with an IC50 of 76 nM, useful for neurodegenerative disease research.Formula:C18H16N6Color and Shape:SolidMolecular weight:316.363,6-DMAD dihydrochloride
CAS:3,6-DMAD dihydrochloride: Potent IRE1α-XBP1s inhibitor, affects IL-6 secretion and RNase activity, used in cancer research.Formula:C22H33Cl2N5Color and Shape:SolidMolecular weight:438.44MSC-1186
CAS:MSC-1186 selectively inhibits SRPKs—IC50: 2.7nM (SRPK1), 81nM (SRPK2), 0.6nM (SRPK3)—for cancer research.Formula:C19H17ClFN7O2SColor and Shape:SolidMolecular weight:461.9Bis-Pro-5FU
CAS:Bis-Pro-5FU enhances oral uptake and safety of 5-FU, an anti-cancer drug for colorectal and pancreatic tumors.Formula:C10H7FN2O2Color and Shape:SolidMolecular weight:206.17Fozivudine tidoxil
CAS:Fozivudine tidoxil, a reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.Formula:C35H64N5O8PSColor and Shape:SolidMolecular weight:745.95Aditoprime
CAS:Aditoprime inhibits bacterial growth by blocking DHFR, effective against L.casei and E.coli with IC50 of 520/47 nM.Formula:C15H21N5O2Color and Shape:SolidMolecular weight:303.36PKC-9
CAS:PKC-9 is a PKC-zeta inhibitor 9.Formula:C25H25N7Color and Shape:SolidMolecular weight:423.51L-Guanosine
CAS:L-Guanosine is the L-configuration of Guanosine. Guanosine is a purine nucleoside that has anti-herpesvirus activity [1] [2].Formula:C10H13N5O5Color and Shape:SolidMolecular weight:283.24UIAA-II-232
CAS:UIAA-II-232 (compound 19b) is a potent inhibitor of DNA gyrase catalytic (IC 50= 3.5 μM).Formula:C20H24FN5O3Color and Shape:SolidMolecular weight:401.43Protein kinase D inhibitor 1
CAS:<p>Protein kinase D inhibitor 1 (17m) is a potent pan-PKD suppressant with IC50 of 17-35 nM, targeting cortactin phosphorylation.</p>Formula:C19H21N7Color and Shape:SolidMolecular weight:347.42MK-0668
CAS:<p>MK-0668 is a very potent and orally active very late antigen-4 antagonist.</p>Formula:C31H30Cl2N6O6SColor and Shape:SolidMolecular weight:685.58BI-831266
CAS:BI-831266 is a potent and selective Aurora kinase B inhibitor.Formula:C27H38ClN7O2Color and Shape:SolidMolecular weight:528.09(R)-DRF053 dihydrochloride
CAS:<p>cdk/CK1 inhibitor,potent and ATP-competitive</p>Formula:C23H29Cl2N7OPurity:98%Color and Shape:SolidMolecular weight:490.43Aurora kinase inhibitor-9
CAS:Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.Formula:C19H17Cl2N3O4SColor and Shape:SolidMolecular weight:454.33PV-1019
CAS:PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.Formula:C18H17N7O3Color and Shape:SolidMolecular weight:379.37JTK-101
CAS:JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.Formula:C25H23N3O3Color and Shape:SolidMolecular weight:413.47LDN-209929 dihydrochloride
CAS:LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.Formula:C17H19Cl3N2OSColor and Shape:SolidMolecular weight:405.77DHODH-IN-3
CAS:DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.Formula:C17H13ClN2O2Purity:98%Color and Shape:SolidMolecular weight:312.75Type II topoisomerase inhibitor 1
CAS:Potent E. coli DNA gyrase inhibitor (IC50: 1.7 nM), targets Asp73; weak topoisomerase IV inhibitor (IC50: 0.98 μM).Formula:C18H15N3O4Color and Shape:SolidMolecular weight:337.33Ulecaciclib
CAS:Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).Formula:C25H33FN8SColor and Shape:SolidMolecular weight:496.65Cdc7-IN-13
CAS:<p>Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].</p>Formula:C18H20N4O2SColor and Shape:SolidMolecular weight:356.44DAP-81
CAS:DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.Formula:C25H20N6O4Color and Shape:SolidMolecular weight:468.46CDK4/6-IN-9
CAS:CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.Formula:C22H23FN8Color and Shape:SolidMolecular weight:418.47HBV-IN-16
CAS:HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).Formula:C22H20ClNO4Color and Shape:SolidMolecular weight:397.85CDK7-IN-12
CAS:CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.Formula:C20H19F3N6Color and Shape:SolidMolecular weight:400.4Crisnatol mesylate
CAS:Crisnatol, a potent and selective DNA intercalator, has potential anticancer activity.Formula:C24H27NO5SColor and Shape:SolidMolecular weight:441.54Werner syndrome RecQ helicase-IN-3
CAS:Potent WRN inhibitor, Werner syndrome RecQ helicase-IN-3, is orally active with 0.06 µM IC50; exhibits antiproliferative and anticancer effects.Formula:C31H30ClF3N8O5Color and Shape:SolidMolecular weight:687.07Mps-BAY2b
CAS:Mps-BAY2b is a novel MPS1 inhibitor.Formula:C20H23N5OColor and Shape:SolidMolecular weight:349.43Indirubin-5-sulfonate
CAS:Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.Formula:C16H10N2O5SPurity:98%Color and Shape:SolidMolecular weight:342.33NSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFormula:C26H32N10O4SPurity:98%Color and Shape:SolidMolecular weight:580.6614α-Demethylase/DNA Gyrase-IN-2
CAS:14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formula:C24H22N4O4Color and Shape:SolidMolecular weight:430.46BDM44768
CAS:BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.Formula:C24H22FN5O3Color and Shape:SolidMolecular weight:447.46Mps1-IN-4
CAS:Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.Formula:C26H31F3N6O2Color and Shape:SolidMolecular weight:516.56CDK7-IN-8
CAS:CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.Formula:C25H38N8O3Color and Shape:SolidMolecular weight:498.622'-Deoxy-L-guanosine
CAS:2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death.Formula:C10H13N5O4Color and Shape:SolidMolecular weight:267.24VE-465
CAS:VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formula:C22H28N8OSColor and Shape:SolidMolecular weight:452.58Antitumor agent-85
Antitumor agent-85 stabilizes G4-DNA with potent anti-tumor effects.Formula:C24H33N7Color and Shape:SolidMolecular weight:419.57HBV-IN-15
CAS:HBV-IN-15, a flavone derivative, is a potent cccDNA inhibitor, potentially aiding HBV research.Formula:C24H23ClO6Color and Shape:SolidMolecular weight:442.89LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Formula:C23H23N7O2SColor and Shape:SolidMolecular weight:461.54CB 3717
CAS:CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.Formula:C24H23N5O6Color and Shape:SolidMolecular weight:477.47Sibrafiban
CAS:Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Formula:C20H28N4O6Color and Shape:SolidMolecular weight:420.46
