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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3480 products of "Cell Cycle/Checkpoint"

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  • CDK5-IN-2

    CAS:
    <p>CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor that acts on CDK5/p25 (IC50: 0.2 nM) and CDK2/CycA (IC50: 23 nM).</p>
    Formula:C29H28FN5O
    Color and Shape:Solid
    Molecular weight:481.56
  • DYRKs-IN-1 hydrochloride

    CAS:
    <p>DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) &amp; DYRK1B (8 nM IC50) with antitumor properties.</p>
    Formula:C30H31Cl2N7O4
    Color and Shape:Solid
    Molecular weight:624.52
  • CDK4/6-IN-13

    CAS:
    <p>Compounds 10B and 10C: potent cdk4/6 inhibitors with low nM activity, great antiproliferative effects, excellent metabolism, and good pharmacokinetics.</p>
    Formula:C25H29N7O
    Color and Shape:Solid
    Molecular weight:443.54
  • CDK4/6-IN-24

    CAS:
    <p>CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.</p>
    Formula:C32H41N7O3
    Color and Shape:Solid
    Molecular weight:571.713
  • Des-ethyl-carafiban

    CAS:
    <p>Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.</p>
    Formula:C22H23N5O5
    Color and Shape:Solid
    Molecular weight:437.448
  • Galidesivir

    CAS:
    <p>Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.</p>
    Formula:C11H15N5O3
    Purity:96.73% - 99.13%
    Color and Shape:Solid
    Molecular weight:265.27
  • Werner syndrome RecQ helicase-IN-2

    CAS:
    <p>Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.</p>
    Formula:C32H34F3N9O5
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:681.67
  • Aurora B inhibitor 1

    CAS:
    <p>Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki &lt;0.010 uM) with potential anticancer activity for cancer research.</p>
    Formula:C25H26ClF2N7O2
    Purity:98.37%
    Color and Shape:Solid
    Molecular weight:529.97
  • LY309887

    CAS:
    <p>LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.</p>
    Formula:C19H23N5O6S
    Color and Shape:Solid
    Molecular weight:449.48
  • GSK_WRN4

    CAS:
    <p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>
    Formula:C16H20N2O4S
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:336.41
  • Fradafiban

    CAS:
    <p>Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.</p>
    Formula:C20H21N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:367.40
  • 4,5'-Dimethylangelicin-NHS


    <p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity &amp; photosensitivity.</p>
    Formula:C21H19NO7S
    Color and Shape:Solid
    Molecular weight:429.44
  • KWR095

    CAS:
    <p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>
    Formula:C33H31ClF3N9O4
    Color and Shape:Solid
    Molecular weight:710.105
  • 2′-O-MOE-AMP

    CAS:
    <p>2′-O-MOE-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Formula:C13H20N5O8P
    Color and Shape:Solid
    Molecular weight:405.30
  • CDK4-IN-1

    CAS:
    <p>CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50&gt;15 uM) and CDK2/Cyclin A (IC50</p>
    Formula:C22H29ClN8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:440.97
  • DNA Gyrase-IN-16

    CAS:
    <p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>
    Formula:C17H15N3O3
    Color and Shape:Solid
    Molecular weight:309.319
  • 2'-F-UMP

    CAS:
    <p>2'-F-UMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Formula:C9H12FN2O8P
    Molecular weight:326.17
  • GR 83895

    CAS:
    <p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>
    Formula:C29H39N9O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:673.74
  • BBI-355

    CAS:
    <p>BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.</p>
    Formula:C19H19N7O2
    Color and Shape:Solid
    Molecular weight:377.40
  • 2-Amino-2'-fluoro-2'-deoxyadenosine

    CAS:
    <p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>
    Formula:C10H13FN6O3
    Color and Shape:Solid
    Molecular weight:284.25
  • BRD4 Inhibitor-40

    CAS:
    <p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>
    Formula:C27H32N8O
    Color and Shape:Solid
    Molecular weight:484.596
  • KI-CDK9d-32

    CAS:
    <p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>
    Formula:C39H45N9O4
    Color and Shape:Solid
    Molecular weight:703.83
  • 5'-DMT-5-F-2'-dU Phosphoramidite

    CAS:
    <p>5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.</p>
    Formula:C39H46FN4O8P
    Color and Shape:Solid
    Molecular weight:748.777
  • Haspin-IN-2

    CAS:
    <p>Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).</p>
    Formula:C12H8N4O3
    Color and Shape:Solid
    Molecular weight:256.22
  • Terpendole E

    CAS:
    <p>Terpendole E is an atypical L5 site inhibitor.</p>
    Formula:C28H39NO3
    Color and Shape:Solid
    Molecular weight:437.61
  • 6-B345TTQ

    CAS:
    <p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>
    Formula:C22H20BrNO4
    Color and Shape:Solid
    Molecular weight:442.303
  • Glycyl H-1152 hydrochloride

    CAS:
    <p>Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.</p>
    Formula:C18H26Cl2N4O3S
    Color and Shape:Solid
    Molecular weight:449.39
  • Anticancer agent 29


    <p>Compound E/Z-6f, anticancer, IC50: CDK2 (0.054 μM), CDK1 (0.127 μM), CDK4 (0.129 μM), CDK6 (0.396 μM).</p>
    Formula:C22H15ClFNO
    Color and Shape:Solid
    Molecular weight:363.81
  • Dyrk1A/α-synuclein-IN-2


    <p>Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).</p>
    Formula:C21H16N4O4S
    Color and Shape:Solid
    Molecular weight:420.44
  • BET/Aurora kinase-IN-1

    CAS:
    <p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>
    Formula:C25H30FN7O
    Color and Shape:Solid
    Molecular weight:463.55
  • Polθ-IN-6

    CAS:
    <p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>
    Formula:C25H23N3O3S
    Color and Shape:Solid
    Molecular weight:445.53
  • HNC-1664

    CAS:
    <p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>
    Formula:C12H13FIN3O3
    Color and Shape:Solid
    Molecular weight:393.153
  • CDK9 autophagic degrader 1

    CAS:
    <p>CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.</p>
    Formula:C34H39N7O4S2
    Color and Shape:Solid
    Molecular weight:673.848
  • LNA-GMP

    CAS:
    <p>LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.</p>
    Formula:C11H14N5O8P
    Color and Shape:Solid
    Molecular weight:375.23
  • CIB-L43

    CAS:
    <p>CIB-L43 is a oral TRBP inhibitor, inhibit miR-21, increase PTEN and Smad7, and block the AKT and TGF-β,inhibit proliferation and migration.</p>
    Formula:C15H16N2O3S
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:304.36
  • IXA62

    CAS:
    <p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>
    Formula:C24H23N3O3
    Color and Shape:Solid
    Molecular weight:401.458
  • CDK2-IN-31

    CAS:
    <p>CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.</p>
    Formula:C37H52N6O5
    Color and Shape:Solid
    Molecular weight:660.85
  • IRE1α kinase-IN-5


    <p>IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.</p>
    Formula:C28H30N6O3S
    Color and Shape:Solid
    Molecular weight:530.64
  • KL-50

    CAS:
    <p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>
    Formula:C7H7FN6O2
    Color and Shape:Solid
    Molecular weight:226.17
  • DNA Gyrase-IN-1


    <p>DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.</p>
    Formula:C24H24FN7O6
    Color and Shape:Solid
    Molecular weight:525.49
  • LNA-GDP

    CAS:
    <p>LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Formula:C11H15N5O11P2
    Color and Shape:Solid
    Molecular weight:455.21
  • MtTMPK-IN-2

    CAS:
    <p>MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).</p>
    Formula:C23H24ClN3O3
    Color and Shape:Solid
    Molecular weight:425.91
  • MtTMPK-IN-7


    <p>MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.</p>
    Formula:C27H29ClN6O3
    Color and Shape:Solid
    Molecular weight:521.01
  • Cdc7-IN-10

    CAS:
    <p>Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.</p>
    Formula:C20H22F2N4O2S
    Color and Shape:Solid
    Molecular weight:420.48
  • DHX9-IN-19

    CAS:
    <p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>
    Formula:C20H21ClN4O4S2
    Color and Shape:Solid
    Molecular weight:480.988
  • SR121566A

    CAS:
    <p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>
    Formula:C20H25N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.51
  • 3'-Deoxy-GTP

    CAS:
    <p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.</p>
    Formula:C10H16N5O13P3
    Color and Shape:Solid
    Molecular weight:507.181
  • Metesind Glucuronate

    CAS:
    <p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>
    Formula:C29H34N4O10S
    Color and Shape:Solid
    Molecular weight:630.67
  • AB25583

    CAS:
    <p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>
    Formula:C22H17ClN4O3S
    Color and Shape:Solid
    Molecular weight:452.91
  • 2′-O-MOE-CMP

    CAS:
    <p>2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.</p>
    Formula:C12H20N3O9P
    Color and Shape:Solid
    Molecular weight:381.28