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HSP

HSP

HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.

Found 169 products of "HSP"

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  • CC-99677

    CAS:
    <p>CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM &amp; EC50=89 nM.</p>
    Formula:C22H20ClN5O3S
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:469.94
  • GRP78-IN-3

    CAS:
    <p>GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.</p>
    Formula:C17H18N4O2S
    Purity:99.11%
    Color and Shape:Soild
    Molecular weight:342.42
  • IPI-493

    CAS:
    <p>IPI-493 is a bioactive chemical.</p>
    Formula:C28H39N3O8
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:545.62
  • Novobiocin Sodium

    CAS:
    <p>Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.</p>
    Formula:C31H35N2NaO11
    Purity:99% - 99.28%
    Color and Shape:Solid
    Molecular weight:634.61
  • Col003

    CAS:
    <p>Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).</p>
    Formula:C14H11NO4
    Purity:98.67% - 99.03%
    Color and Shape:Solid
    Molecular weight:257.24
  • Arimoclomol maleate

    CAS:
    <p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>
    Formula:C18H24ClN3O7
    Purity:99.44% - 99.98%
    Color and Shape:Solid
    Molecular weight:429.85
  • Rifabutin

    CAS:
    <p>Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.</p>
    Formula:C46H62N4O11
    Purity:98.87% - 99.7%
    Color and Shape:Red-Violet Crystalline Powder
    Molecular weight:847
  • Ethoxyquin

    CAS:
    <p>Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.</p>
    Formula:C14H19NO
    Purity:97.15% - 98.73%
    Color and Shape:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)
    Molecular weight:217.31
  • PU-H71 HCl

    CAS:
    <p>PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.</p>
    Formula:C18H22ClIN6O2S
    Purity:98.95%
    Color and Shape:Soild
    Molecular weight:548.83
  • HEMTAC WEE1 degrader-1

    CAS:
    <p>HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.</p>
    Formula:C57H71N15O6
    Color and Shape:Solid
    Molecular weight:1062.27
  • p5 Ligand for Dnak and DnaJ

    CAS:
    <p>P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.</p>
    Formula:C44H81N15O11S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1028.27
  • Gamitrinib TPP

    CAS:
    <p>Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.</p>
    Formula:C52H65N3O8P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:891.078
  • MAL3-101

    CAS:
    <p>MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).</p>
    Formula:C54H66N4O10
    Color and Shape:Solid
    Molecular weight:931.12
  • PROTAC HSP90 degrader BP3

    CAS:
    <p>PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.</p>
    Formula:C32H29ClN8O5
    Color and Shape:Solid
    Molecular weight:641.08
  • HA15-Biotin

    CAS:
    <p>HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.</p>
    Formula:C37H45N7O5S3
    Color and Shape:Solid
    Molecular weight:763.99
  • Alvespimycin TFA


    <p>Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.</p>
    Formula:C34H49F3N4O10
    Color and Shape:Solid
    Molecular weight:730.34008
  • trans-Dehydrocurvularin

    CAS:
    <p>trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.</p>
    Formula:C16H18O5
    Color and Shape:Solid
    Molecular weight:290.315
  • HSP70/SIRT2-IN-1


    <p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>
    Purity:98%
    Color and Shape:Odour Solid
  • 3-Phenyltoxoflavin

    CAS:
    <p>3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.</p>
    Formula:C13H11N5O2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:269.26
  • Shepherdin (79-87)

    CAS:
    <p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>
    Formula:C41H64N12O12S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:949.09