HSP

Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding …

Arimoclomol maleate (BRX-220) is a heat shock protein (HSP) co-inducer.

Ethoxyquin is an antioxidant used in animal feeds.

CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 …

Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it …

NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 …

Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal …

Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for …

Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol …

Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a …

Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). …

AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 …

(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine …

KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.

Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate …

AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: …

CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.

p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand …

KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.

XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 …

HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells …

Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

VER-49009 is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).

Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible …

Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce …

Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.

Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a …

Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with …

Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another …

Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic …

MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: …

NVP-BEP800, a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members …

NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).

JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines …

KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.

VER-50589 is a potent HSP90 inhibitor.

TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, …

KNK437, a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).

TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing …

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, …

2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects

Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: …

Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and …

AUY922 (NVP-AUY922) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell …

DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.

17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.

DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in …

HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.

ML346 is a novel activator of Hsp70.

Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.

SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.

Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.

BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).

HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.