Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2607 products of "Chromatin/Epigenetics"
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PKC ζ pseudosubstrate acetate
PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide.Formula:C78H132N30O18Purity:98.78%Color and Shape:SolidMolecular weight:1778.10Picolinamide
CAS:Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.Formula:C6H6N2OPurity:99.6%Color and Shape:SolidMolecular weight:122.12MS049
CAS:MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.Formula:C15H24N2OPurity:98.91%Color and Shape:SolidMolecular weight:248.36Ref: TM-T4378
2mg34.00€5mg49.00€10mg80.00€25mg149.00€50mg222.00€100mg334.00€200mg494.00€1mL*10mM (DMSO)52.00€TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formula:C11H6F3NO2SPurity:99.89%Color and Shape:SolidMolecular weight:273.23PTACH
CAS:PTACH (Cpd 51) (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).Formula:C20H26N2O2S2Purity:87.44% - 99.74%Color and Shape:SolidMolecular weight:390.56MS023
CAS:MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Formula:C17H25N3OPurity:98.31% - 99.87%Color and Shape:SolidMolecular weight:287.4Ref: TM-T6900
1mg37.00€2mg49.00€5mg84.00€10mg113.00€25mg230.00€50mg358.00€100mg532.00€500mg1,153.00€1mL*10mM (DMSO)79.00€E1231
CAS:E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.Formula:C21H21N3O3Purity:98.45%Color and Shape:SolidMolecular weight:363.41Ref: TM-T9106
1mg34.00€5mg70.00€10mg99.00€25mg195.00€50mg311.00€100mg449.00€500mg888.00€1mL*10mM (DMSO)94.00€R59949
CAS:R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.Formula:C28H25F2N3OSPurity:97.04%Color and Shape:SolidMolecular weight:489.58Ref: TM-T26019
1mg39.00€2mg52.00€5mg87.00€10mg138.00€25mg281.00€50mg425.00€100mg625.00€200mg883.00€1mL*10mM (DMSO)95.00€EDO-S101
CAS:EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.Formula:C19H28Cl2N4O2Purity:98.02% - 99.44%Color and Shape:SolidMolecular weight:415.36ACY-738
CAS:ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.Formula:C14H14N4O2Purity:98.85% - 99.89%Color and Shape:SolidMolecular weight:270.29Ref: TM-T3509
1mg46.00€2mg62.00€5mg90.00€10mg165.00€25mg268.00€50mg439.00€100mg582.00€1mL*10mM (DMSO)100.00€CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurity:98.92%Color and Shape:SolidMolecular weight:418.44SKLB-23bb
CAS:SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.Formula:C21H24N4O4Purity:97.58%Color and Shape:SolidMolecular weight:396.44Ref: TM-T5830
1mg50.00€5mg133.00€10mg187.00€25mg304.00€50mg424.00€100mg587.00€200mg800.00€1mL*10mM (DMSO)147.00€GSK121
CAS:GSK121 is an inhibitor of selective PAD4.
Formula:C25H26F3N5O3Purity:98.92%Color and Shape:SolidMolecular weight:501.51PJ34
CAS:PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
Formula:C17H17N3O2Purity:95.05% - 99.85%Color and Shape:SolidMolecular weight:295.34TH34
CAS:TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3.Formula:C15H16N2O2Purity:98.32%Color and Shape:SolidMolecular weight:256.3HIF-2α-IN-4
CAS:HIF-2a translation inhibitor is a compound used as a molecular building block.Formula:C9H9N3O4S2Purity:≥98%Color and Shape:SolidMolecular weight:287.32Ref: TM-T50099
5mg37.00€10mg60.00€25mg111.00€50mg200.00€100mg299.00€200mg430.00€1mL*10mM (DMSO)44.00€SP-146
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).Formula:C25H20FN7OPurity:97.82%Color and Shape:SolidMolecular weight:453.47Ref: TM-T8685
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)177.00€SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Formula:C22H20N4OS2Purity:99.52% - 99.75%Color and Shape:SolidMolecular weight:420.55Ref: TM-T6984
1mg37.00€2mg52.00€5mg74.00€10mg102.00€25mg187.00€50mg295.00€100mg477.00€1mL*10mM (DMSO)86.00€Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurity:99.8%Color and Shape:SolidMolecular weight:248.71Ref: TM-T15263
1mg101.00€2mg150.00€5mg245.00€10mg356.00€25mg597.00€50mg835.00€100mg1,108.00€1mL*10mM (DMSO)269.00€Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.Formula:C13H13ClN2OPurity:99.86%Color and Shape:SolidMolecular weight:248.71Ref: TM-T7058
1mg142.00€2mg203.00€5mg314.00€10mg447.00€25mg713.00€50mg1,018.00€1mL*10mM (DMSO)359.00€TPPB
CAS:TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).Formula:C27H30F3N3O3Purity:97.71% - 98.00%Color and Shape:SolidMolecular weight:501.54Piribedil
CAS:Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.Formula:C16H18N4O2Purity:99.79% - 99.82%Color and Shape:SolidMolecular weight:298.34Pep2m, myristoylated acetate
Pep2m, a myristoylated acetate, inhibits GluA2-NSF interaction, reducing AMPA receptor function and expression in neurons.Formula:C65H122N18O16SPurity:99.62%Color and Shape:SolidMolecular weight:1443.96dBET1
CAS:dBET1 fuses (+)-JQ1 with thalidomide, degrades BET proteins via cereblon (EC50: 430 nM), and triggers apoptosis.Formula:C38H37ClN8O7SPurity:98.02% - 99.3%Color and Shape:SolidMolecular weight:785.27Ref: TM-T4495
1mg50.00€5mg99.00€10mg161.00€25mg268.00€50mg427.00€100mg650.00€200mg888.00€1mL*10mM (DMSO)145.00€ZM39923 hydrochloride
CAS:ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formula:C23H25NO·HClPurity:98.05%Color and Shape:SolidMolecular weight:367.91MK-8745
CAS:MK-8745 is a potent and selective Aurora A inhibitor.Formula:C20H19ClFN5OSPurity:99.09% - 99.79%Color and Shape:SolidMolecular weight:431.91JANEX-1
CAS:JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.Formula:C16H15N3O3Purity:98% - 99.81%Color and Shape:SolidMolecular weight:297.31SGC2085
CAS:SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).Formula:C19H24N2O2Purity:99.61% - 99.71%Color and Shape:SolidMolecular weight:312.41Ref: TM-T7089
1mg84.00€2mg113.00€5mg215.00€10mg324.00€25mg533.00€50mg777.00€100mg1,071.00€1mL*10mM (DMSO)152.00€CPI-1205
CAS:CPI-1205 是一种高效的选择性 EZH2 抑制剂（IC50：0.002 μM，EC50：0.032 μM）。Formula:C27H33F3N4O3Purity:98.71% - 99.7%Color and Shape:SolidMolecular weight:518.57DCLX069
CAS:DCLX069: PRMT1 inhibitor, IC50=17.9µM, targets SAM pocket, inhibits breast/liver cancer, and AML cell growth.Formula:C20H25N3O2Purity:97.76%Color and Shape:SolidMolecular weight:339.43Ref: TM-T27133
1mg38.00€2mg49.00€5mg79.00€10mg111.00€25mg187.00€50mg305.00€100mg487.00€500mg1,035.00€1mL*10mM (DMSO)92.00€AZD5305
CAS:AZD5305 is a potent, selective and oral active PARP inhibitor.Formula:C22H26N6O2Purity:98.68% - 99.93%Color and Shape:SolidMolecular weight:406.48Ref: TM-T9165
1mg107.00€5mg222.00€10mg358.00€25mg597.00€50mg850.00€100mg1,153.00€1mL*10mM (DMSO)245.00€Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formula:C18H22N4O2Purity:98.67% - 99.4%Color and Shape:SolidMolecular weight:326.39Ref: TM-T6933
2mg38.00€5mg63.00€10mg99.00€25mg172.00€50mg268.00€100mg416.00€200mg610.00€1mL*10mM (DMSO)70.00€E-7386
CAS:E-7386 is an oral active CBP/ -catenin modulator.Formula:C39H48FN9O4Purity:98.92% - 99.91%Color and Shape:SolidMolecular weight:725.85Ref: TM-T11136
1mg93.00€2mg128.00€5mg219.00€10mg356.00€25mg613.00€50mg873.00€100mg1,161.00€1mL*10mM (DMSO)350.00€Olaparib
CAS:View and buy Olaparib from TargetMol.Olaparib is a small molecule inhibitor of PARP1/PARP2.Cited in 10 publications.Formula:C24H23FN4O3Purity:98% - >99.99%Color and Shape:SolidMolecular weight:434.46TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Formula:C22H25F3N4OPurity:99.8% - 99.95%Color and Shape:SolidMolecular weight:418.46E7449
CAS:E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.Formula:C18H15N5OPurity:97.13%Color and Shape:SolidMolecular weight:317.34Ref: TM-T4471
1mg34.00€5mg88.00€10mg114.00€25mg178.00€50mg269.00€100mg399.00€200mg590.00€1mL*10mM (DMSO)88.00€Protosappanin A
CAS:Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formula:C15H12O5Purity:99.42% - 99.82%Color and Shape:SolidMolecular weight:272.25Ref: TM-TJS1779
1mg88.00€5mg195.00€10mg318.00€25mg523.00€50mg743.00€100mg999.00€1mL*10mM (DMSO)178.00€Molibresib
CAS:Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).Formula:C22H22ClN5O2Purity:97.70% - 99.08%Color and Shape:SolidMolecular weight:423.9Ref: TM-T1906
1mg40.00€2mg54.00€5mg88.00€10mg118.00€25mg205.00€50mg339.00€100mg507.00€200mg712.00€500mg1,108.00€1mL*10mM (DMSO)87.00€(+)-JQ1 PA
CAS:(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).Formula:C22H20ClN5OSPurity:98.36%Color and Shape:SolidMolecular weight:437.95WM-1119
CAS:WM-1119 is a highly potent, selective KAT6A/B inhibitorFormula:C18H13F2N3O3SPurity:96.59% - 99.58%Color and Shape:SolidMolecular weight:389.38XD14
CAS:XD14 inhibits BET bromodomains with Kd: BRD4(1) 160nM, BRD2(1) 170nM, BRD3(1) 380nM, BRD3(2) 490nM, BRD2(2) 830nM, BRD4(2) 850nM.
Formula:C20H27N3O5SPurity:97.46%Color and Shape:SolidMolecular weight:421.51FL-411
CAS:FL-411 (BRD4-IN-1) is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.Formula:C18H19N3O2SPurity:98.19%Color and Shape:SolidMolecular weight:341.43GSK3685032
CAS:GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).
Formula:C22H24N6OSPurity:98.56% - 99.49%Color and Shape:SolidMolecular weight:420.53Daminozide
CAS:Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.Formula:C6H12N2O3Purity:99.86%Color and Shape:White Crystalline Solid Physical Description Odorless White Crystals Or Powder (Ntp 1992)Molecular weight:160.17GSK-5959
CAS:GSK-5959 is a selective BRPF1 inhibitor with IC50 ~80 nM, 100-fold more specific than 35 other bromodomains.Formula:C22H26N4O3Purity:98.35% - 98.65%Color and Shape:SolidMolecular weight:394.47Deucravacitinib
CAS:Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formula:C20H19D3N8O3Purity:98.52% - >99.99%Color and Shape:SolidMolecular weight:425.46Ref: TM-T14687
1mg56.00€5mg137.00€10mg248.00€25mg389.00€50mg575.00€100mg817.00€1mL*10mM (DMSO)149.00€Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formula:C23H22N6O2Purity:97.07% - 99.56%Color and Shape:SolidMolecular weight:414.46Ref: TM-T1849
1mg35.00€2mg50.00€5mg77.00€10mg89.00€25mg158.00€50mg245.00€100mg385.00€200mg592.00€1mL*10mM (DMSO)84.00€MS436
CAS:MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.Formula:C18H17N5O3SPurity:97.95% - 98.92%Color and Shape:SolidMolecular weight:383.42Ref: TM-T1854
2mg42.00€5mg62.00€10mg95.00€25mg172.00€50mg268.00€100mg429.00€200mg615.00€1mL*10mM (DMSO)69.00€SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formula:C18H15ClN6OS2·CH4O3SPurity:99.44% - 99.92%Color and Shape:SolidMolecular weight:527.04BAY-598
CAS:BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.Formula:C22H20Cl2F2N6O3Purity:99.18% - 99.78%Color and Shape:SolidMolecular weight:525.34
