DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(71 products)
- DNA Alkylation(11 products)
- DNA Methyltransferase(422 products)
- DNA gyrase(11 products)
- DNA-PK(51 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,388 products)
- Reverse Transcriptase(43 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(136 products)
Show 3 more subcategories
Found 958 products of "DNA Damage/DNA Repair"
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MN-64
CAS:<p>MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.</p>Formula:C18H16O2Purity:99.5% - 99.93%Color and Shape:SolidMolecular weight:264.32Mavodelpar
CAS:<p>Mavodelpar (REN001), a PPARδ agonist, may treat PMM and LC-FAOD by reducing renal damage.</p>Formula:C31H29FNNaO5Color and Shape:SolidMolecular weight:537.55Furegrelate
CAS:<p>FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.</p>Formula:C15H11NO3Purity:99.71%Color and Shape:SolidMolecular weight:253.25AZ32
CAS:<p>AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.</p>Formula:C20H16N4OPurity:98.68% - 99.68%Color and Shape:SolidMolecular weight:328.37ML216
CAS:<p>ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s > 50 μM).</p>Formula:C15H9F4N5OSPurity:98.12%Color and Shape:SolidMolecular weight:383.32Bendamustine
CAS:<p>Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia</p>Formula:C16H21Cl2N3O2Purity:≥98%Color and Shape:SolidMolecular weight:358.26Zebularine
CAS:<p>Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.</p>Formula:C9H12N2O5Purity:99.04% - >99.99%Color and Shape:SolidMolecular weight:228.2Thymidine
CAS:<p>Thymidine (DThyd) is a cell synchronizing agent and a precursor of deoxyribonucleic acid. Thymidine inhibits DNA synthesis. Cost-effective and quality-assured.</p>Formula:C10H14N2O5Purity:99.64% - 99.86%Color and Shape:White To Off-White Solid CrystallineMolecular weight:242.23GNE-3511
CAS:<p>GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.</p>Formula:C23H26F2N6OPurity:98.3% - 99.51%Color and Shape:SolidMolecular weight:440.49SW-100
CAS:<p>SW-100 is a potent HDAC6 inhibitor with 2.3 nM IC50, highly selective (>1000-fold), can cross blood-brain-barrier.</p>Formula:C17H17ClN2O2Purity:98.34% - 98.47%Color and Shape:SolidMolecular weight:316.78Rucaparib Phosphate
CAS:<p>Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.</p>Formula:C19H18FN3O·H3PO4Purity:99.37%Color and Shape:SolidMolecular weight:421.36L-778123 hydrochloride
CAS:<p>The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.</p>Formula:C22H21Cl2N5OPurity:93.93% - 98.51%Color and Shape:SolidMolecular weight:442.34SCR130
CAS:<p>SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) 是基于 SCR7 的 DNA 非同源末端连接抑制剂，可诱导细胞凋亡并，具有抗癌活性。 它特异性依赖连接酶 IV，抑制 DNA 的末端连接。</p>Formula:C19H13Cl2N3O2SPurity:98.9%Color and Shape:SolidMolecular weight:418.3Garenoxacin mesylate
CAS:<p>Garenoxacin mesylate: potent oral antibiotic for respiratory pathogens, including resistant, Gram-negative, and Gram-positive bacteria.</p>Formula:C24H24F2N2O7SColor and Shape:SolidMolecular weight:522.52Indotecan
CAS:<p>Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).</p>Formula:C26H26N2O7Purity:97% - 98%Color and Shape:SolidMolecular weight:478.49PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formula:C14H16ClN3O4S2Purity:97.72%Color and Shape:SolidMolecular weight:389.88KU-57788
CAS:<p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>Formula:C25H19NO3SPurity:98% - >99.99%Color and Shape:SolidMolecular weight:413.49NU 7026
CAS:<p>NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition</p>Formula:C17H15NO3Purity:99.51% - >99.99%Color and Shape:SolidMolecular weight:281.31E7449
CAS:<p>E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.</p>Formula:C18H15N5OPurity:97.13%Color and Shape:SolidMolecular weight:317.34ACY-775
CAS:<p>ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).</p>Formula:C17H19FN4O2Purity:97.67% - 98.83%Color and Shape:SolidMolecular weight:330.36SRT 1720 dihydrochloride
CAS:<p>SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).</p>Formula:C25H25Cl2N7OSPurity:98.58%Color and Shape:SolidMolecular weight:542.48Prexasertib
CAS:<p>Prexasertib (LY2606368) is a selective checkpoint kinase 1 (CHK1) inhibitor (Ki 0.9 nM, IC50<1 nM). antitumor activity. High-Quality, Low-Cost!</p>Formula:C18H19N7O2Purity:97.3% - 98.23%Color and Shape:SolidMolecular weight:365.39Seladelpar sodium salt
CAS:<p>Seladelpar sodium (MBX-8025) is a potent oral PPARδ agonist, EC50 of 2 nM, >750x selective over PPARα, >2500x over PPARγ.</p>Formula:C21H22F3NaO5SPurity:98%Color and Shape:SolidMolecular weight:466.45Deoxythymidine-5'-triphosphate trisodium
CAS:<p>dTTP trisodium salt, a natural deoxynucleotide for DNA synthesis by DNA polymerase and reverse transcriptase.</p>Formula:C10H14N2Na3O14P3Purity:97.47%Color and Shape:SolidMolecular weight:548.11L755507
CAS:<p>L755507 is an effective, selective agonist of β3-AR（IC50=35 nM）.</p>Formula:C30H40N4O6SPurity:99% - 99.75%Color and Shape:SolidMolecular weight:584.73TMPyP4 tosylate
CAS:<p>TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.</p>Formula:C72H66N8O12S4Purity:98.61% - 99.85%Color and Shape:SolidMolecular weight:1363.6MK-4827 Racemate
CAS:<p>MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for</p>Formula:C19H20N4OPurity:99.86%Color and Shape:SolidMolecular weight:320.39Pixantrone
CAS:<p>Pixantrone has anti-tumor activity that is a DNA intercalator and topoisomerase II inhibitor.</p>Formula:C17H19N5O2Color and Shape:SolidMolecular weight:325.37Gatifloxacin hydrochloride
CAS:<p>Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.</p>Formula:C19H23ClFN3O4Purity:99.85% - 99.89%Color and Shape:SolidMolecular weight:411.86EIDD-1931
CAS:<p>EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Formula:C9H13N3O6Purity:99.14% - 99.73%Color and Shape:SolidMolecular weight:259.22Voxtalisib
CAS:<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formula:C13H14N6OPurity:98.21% - 99.69%Color and Shape:SolidMolecular weight:270.29CXD101
CAS:<p>CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II</p>Formula:C24H29N5OPurity:99.82%Color and Shape:SolidMolecular weight:403.52CM-272
CAS:<p>CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.</p>Formula:C28H38N4O3Purity:97.83%Color and Shape:SolidMolecular weight:478.63LY294002
CAS:<p>LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).</p>Formula:C19H17NO3Purity:98% - 99.96%Color and Shape:Pale Yellow SolidMolecular weight:307.34Tucidinostat
CAS:<p>Tucidinostat is an oral HDAC1/2/3/10 inhibitor (IC50: 67-160 nM), weaker on HDAC8/11, inactive on HDAC4/5/6/7/9.</p>Formula:C22H19FN4O2Purity:97.01% - 99.95%Color and Shape:SolidMolecular weight:390.41IMT1B
CAS:<p>IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.</p>Formula:C24H21ClFNO6Purity:98.26% - 99.83%Color and Shape:SolidMolecular weight:473.88TIQ-A
CAS:<p>TIQ-A blocks PARP1 to prevent excessive DNA damage response, implicated in ischemia, asthma, and atherosclerosis.</p>Formula:C11H7NOSPurity:99.75%Color and Shape:SolidMolecular weight:201.241-Oleoyl lysophosphatidic acid sodium
CAS:<p>1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2</p>Formula:C21H40O7P·NaPurity:98.75% - 99.24%Color and Shape:SolidMolecular weight:458.51Cycloastragenol
CAS:<p>Cycloastragenol, a saponin from Astragalus, could be a new depression treatment.</p>Formula:C30H50O5Purity:99.85% - 99.92%Color and Shape:SolidMolecular weight:490.71RU.521
CAS:<p>RU.521 (RU3205217) is a selective cyclic GMP-AMP synthetase (cGAS) inhibitor (mouse: IC50=0.11 μM), (human: IC50=2.94 μM). High-Quality, Low-Cost!</p>Formula:C19H12Cl2N4O3Purity:98% - 99.78%Color and Shape:SolidMolecular weight:415.23Niraparib hydrochloride
CAS:<p>Niraparib hydrochloride (MK-4827) is a PARP inhibitor with potential cancer treatment effects, causing DNA damage and apoptosis.</p>Formula:C19H21ClN4OPurity:99.26%Color and Shape:SolidMolecular weight:356.85Genz-644282
CAS:<p>Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.</p>Formula:C22H21N3O5Purity:97.49%Color and Shape:SolidMolecular weight:407.42Rubitecan
CAS:<p>Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.</p>Formula:C20H15N3O6Purity:97.54%Color and Shape:Yellow Amorphous PowderMolecular weight:393.35Trifluridine/tipiracil hydrochloride mixture
CAS:<p>Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a</p>Formula:C29H34Cl2F6N8O12Purity:98% - 99.79%Color and Shape:SolidMolecular weight:871.53NPC 15199
CAS:<p>NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.</p>Formula:C21H23NO4Purity:99.93% - 99.94%Color and Shape:White Crystalline PowderMolecular weight:353.41ITSA-1
CAS:<p>ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors.</p>Formula:C13H7Cl2N3OPurity:99.78% - 99.89%Color and Shape:SolidMolecular weight:292.12Remodelin hydrobromide
CAS:<p>Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.</p>Formula:C15H15BrN4SPurity:97.22% - 99.84%Color and Shape:SolidMolecular weight:363.275SRT1720 hydrochloride
CAS:<p>SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).</p>Formula:C25H24ClN7OSPurity:98% - 99.93%Color and Shape:SolidMolecular weight:506.22Tretazicar
CAS:<p>CB1954, an anticancer prodrug, turns into a potent alkylating agent when activated by NQO2 and EP-0152R.</p>Formula:C9H8N4O5Purity:99.41% - 99.7%Color and Shape:SolidMolecular weight:252.18OAC1
CAS:<p>OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.</p>Formula:C14H11N3OPurity:99.49% - 99.65%Color and Shape:SolidMolecular weight:237.26
