DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(17 products)
- DNA Methyltransferase(459 products)
- DNA gyrase(6 products)
- DNA-PK(49 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,422 products)
- Reverse Transcriptase(42 products)
- Sirtuin(86 products)
- Telomerase(33 products)
- Topoisomerase(132 products)
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Found 929 products of "DNA Damage/DNA Repair"
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DNA gyrase/Topo IV-IN-1
DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV with antibacterial properties. It exhibits IC50 values of 11 and 17 nM against the DNA gyrase of Escherichia coli and methicillin-resistant Staphylococcus aureus, respectively, and IC50 values of 83 and 21 nM against topoisomerase IV of the same organisms. DNA gyrase/Topo IV-IN-1 is applicable in anti-infective research.Formula:C44H59NO8Color and Shape:SolidMolecular weight:729.941MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Color and Shape:Odour SolidFKB04
FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanisms in hepatocellular carcinoma cells. This leads to T-loop defects, inducing telomere shortening and cellular senescence. Additionally, FKB04 inhibits tumor growth in a human liver cancer xenograft mouse model (by implanting Huh-7 cells in BALB/c mice). This compound is utilized in research focused on liver cancer.
Color and Shape:Odour SolidPNU-142586
CAS:PNU-142586 is a bio-active chemical.Formula:C16H20FN3O6Color and Shape:SolidMolecular weight:369.34Murrayanol
Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.Formula:C24H29NO2Color and Shape:SolidMolecular weight:363.501AsCas12a Nuclease
AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.Stearolic acid
CAS:Stearolic acid is a useful organic compound for research related to life sciences. The catalog number is T124753 and the CAS number is 506-24-1.Formula:C18H32O2Color and Shape:SolidMolecular weight:280.45220-carboxy Arachidonic Acid
CAS:20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.Formula:C20H30O4Color and Shape:SolidMolecular weight:334.456Sulotroban
CAS:sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.Formula:C16H17NO5SPurity:98.86% - 99.98%Color and Shape:SolidMolecular weight:335.37DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Color and Shape:Odour Solid1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
CAS:Phospholipid with stearic and docosahexaenoic acids used in membrane studies; decreases in ALS mouse model.Formula:C48H84NO8PColor and Shape:SolidMolecular weight:834.16SpCas9 D10A Nickase
SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.Anticancer agent 177
Anticanceragent 177 (Compound 11b) is an NAMPT inhibitor and DNA alkylating agent with antitumor activity both in vitro and in vivo.Formula:C28H36Cl2N4O2Molecular weight:530.22153Diflomotecan
CAS:Diflomotecan (BN 80915) is a strong oral topoisomerase I inhibitor with high plasma stability and significant preclinical anti-cancer efficacy.Formula:C21H16F2N2O4Color and Shape:SolidMolecular weight:398.36Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41Elomotecan
CAS:Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II.Cost-effective and quality-assured.Formula:C29H32ClN3O4Color and Shape:SolidMolecular weight:522.04PDPH Crosslinker
CAS:PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.Formula:C8H11N3OS2Color and Shape:SolidMolecular weight:229.32Saroglitazar Magnesium
CAS:Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).Formula:C50H56MgN2O8S2Purity:99.40%Color and Shape:SolidMolecular weight:901.43Ref: TM-T12834
1mg54.00€5mg126.00€10mg178.00€25mg309.00€50mg416.00€100mg532.00€1mL*10mM (DMSO)178.00€(±)9-HEPE
CAS:(±)9-HEPE is produced by non-enzymatic oxidation of EPA.Formula:C20H30O3Color and Shape:SolidMolecular weight:318.457GpC Methyltransferase
GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.
