DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(18 products)
- DNA Methyltransferase(459 products)
- DNA gyrase(6 products)
- DNA-PK(49 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,422 products)
- Reverse Transcriptase(42 products)
- Sirtuin(86 products)
- Telomerase(34 products)
- Topoisomerase(131 products)
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Found 924 products of "DNA Damage/DNA Repair"
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SP4e
SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.Formula:C22H17ClN2O2S2Purity:99.79%Color and Shape:SoildMolecular weight:440.97PDPH Crosslinker
CAS:PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.Formula:C8H11N3OS2Color and Shape:SolidMolecular weight:229.32DST Crosslinker
CAS:DST is a cleavable, bifunctional crosslinker; it doesn't disrupt protein disulfides, breaks with oxidizers.Formula:C12H12N2O10Color and Shape:SolidMolecular weight:344.232Colibactin 742
CAS:Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leadsFormula:C37H42N8O5S2Color and Shape:SolidMolecular weight:742.91CH-0793076
CAS:CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).
Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Color and Shape:Odour SolidStearolic acid
CAS:Stearolic acid is a useful organic compound for research related to life sciences. The catalog number is T124753 and the CAS number is 506-24-1.Formula:C18H32O2Color and Shape:SolidMolecular weight:280.452Topoisomerase I/II inhibitor 5
TopoisomeraseI/II inhibitor 5 (compound 1) stabilizes G4 structures through binding and concurrently inhibits the relaxation activities of TopoI and II.Color and Shape:Odour SolidGSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62NHC-diphosphate triammonium
NHC-triphosphate triammonium is a phosphorylated metabolite of NHC, incorporated into HCV RNA by viral polymerase.Color and Shape:SolidBanoxantrone-d12 dihydrochloride
CAS:Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Formula:C22H30Cl2N4O6Purity:98%Color and Shape:SolidMolecular weight:529.48Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Formula:C53H83FN6O15Color and Shape:SolidMolecular weight:1063.26GpC Methyltransferase
GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.GJ071 oxalate
CAS:GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.Formula:C20H29N3O7SPurity:99.97%Color and Shape:SolidMolecular weight:455.53Ref: TM-T31932
1mg73.00€5mg149.00€10mg213.00€25mg319.00€50mg450.00€100mg605.00€200mg802.00€1mL*10mM (DMSO)166.00€25-Hydroxytachysterol3
CAS:25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.Formula:C27H44O2Color and Shape:SolidMolecular weight:400.64Sibiromycin
CAS:Sibiromycin: natural, potent antitumor PBD that binds DNA's minor groove at guanine NH2.Formula:C24H33N3O7Color and Shape:SolidMolecular weight:475.542CUDA disodium
CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.Color and Shape:Odour SolidAnti-obesity agent 1
Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.
Formula:C21H22N2O6Color and Shape:SolidMolecular weight:398.409HDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.Formula:C27H26N4O4Color and Shape:SolidMolecular weight:470.52AZD-5099
CAS:AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.Formula:C21H27Cl2N5O6SColor and Shape:SolidMolecular weight:548.44
