DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(18 products)
- DNA Methyltransferase(459 products)
- DNA gyrase(6 products)
- DNA-PK(49 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,422 products)
- Reverse Transcriptase(42 products)
- Sirtuin(86 products)
- Telomerase(34 products)
- Topoisomerase(130 products)
Show 3 more subcategories
Found 923 products of "DNA Damage/DNA Repair"
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VH 032 amide-PEG1-acid
CAS:VHL ligand for PROTAC R&D; E3 ligase with PEG1 linker and carboxylic acid for target conjugation.Formula:C28H38N4O7SColor and Shape:SolidMolecular weight:574.69F44-A13
CAS:F44-A13 is an orally active, highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 μM. It optimizes cholesterol metabolism and reduces activity by inducing CYP7A1 expression, lowering cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) levels in mouse models. F44-A13 is applicable for studying metabolic diseases associated with lipid disorders [1].Formula:C28H40N4O5SMolecular weight:544.71NHC-triphosphate tetrasodium
NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.Formula:C9H12N3Na4O15P3Color and Shape:SolidMolecular weight:587.08SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5FKB04
FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanisms in hepatocellular carcinoma cells. This leads to T-loop defects, inducing telomere shortening and cellular senescence. Additionally, FKB04 inhibits tumor growth in a human liver cancer xenograft mouse model (by implanting Huh-7 cells in BALB/c mice). This compound is utilized in research focused on liver cancer.Color and Shape:Odour SolidDichlorogelignate
CAS:Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].Formula:C32H34O18Color and Shape:SolidMolecular weight:706.69-Nitrooleate
CAS:Nitrated fatty acids like nitrolinoleate and nitrooleate serve as PPARγ ligands and release NO; found in plasma, they aid adipocyte differentiation.
Formula:C18H33NO4Color and Shape:SolidMolecular weight:327.465Corydamine
Corydamine is a useful organic compound for research related to life sciences and the catalog number is T124768.Formula:C20H18N2O4Color and Shape:SolidMolecular weight:350.374AsCas12a Nuclease
AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.Tibesaikosaponin V
CAS:TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.Formula:C42H68O15Color and Shape:SolidMolecular weight:812.98GpC Methyltransferase
GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.Stearolic acid
CAS:Stearolic acid is a useful organic compound for research related to life sciences. The catalog number is T124753 and the CAS number is 506-24-1.Formula:C18H32O2Color and Shape:SolidMolecular weight:280.452Topoisomerase I/II inhibitor 5
TopoisomeraseI/II inhibitor 5 (compound 1) stabilizes G4 structures through binding and concurrently inhibits the relaxation activities of TopoI and II.Color and Shape:Odour SolidTafluposide
CAS:Tafluposide is a DNA topoisomerase inhibitor with anti-tumor activity.Formula:C45H35F10O20PColor and Shape:SolidMolecular weight:1116.713Sulotroban
CAS:sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.Formula:C16H17NO5SPurity:98.86% - 99.98%Color and Shape:SolidMolecular weight:335.37SpCas9 D10A Nickase
SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.Leriglitazone hydrochloride
CAS:Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.Formula:C19H21ClN2O4SColor and Shape:SolidMolecular weight:408.90TUG-499
CAS:TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptorsFormula:C16H11Cl2NO2Purity:99.93%Color and Shape:SoildMolecular weight:320.17TAK1 inhibitor
CAS:TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.
Formula:C22H19ClN6O2SPurity:98%Color and Shape:SoildMolecular weight:466.9423-epi-26-Deoxyactein
CAS:23-epi-26-Deoxyactein is a naturally occurring compound exhibiting anti-obesity and anti-cancer properties when administered orally [1] [2] [3].Formula:C37H56O10Color and Shape:SolidMolecular weight:660.83
