Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 136 products of "Topoisomerase"
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DRF-1042 HCl
<p>DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.</p>Formula:C22H21ClN2O6Purity:97.93%Color and Shape:SolidMolecular weight:444.87Moxifloxacin hydrochloride
CAS:<p>Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria and atypical pathogens.</p>Formula:C21H25ClFN3O4Purity:99.91% - >99.99%Color and Shape:SolidMolecular weight:437.89Berberine chloride
CAS:<p>Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.</p>Formula:C20H18ClNO4Purity:99.47% - 99.93%Color and Shape:Yellow Crystalline PowderMolecular weight:371.8Doxorubicin hydrochloride
CAS:<p>Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).</p>Formula:C27H29NO11·HClPurity:98% - 99.52%Color and Shape:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Molecular weight:579.99Lomefloxacin
CAS:<p>Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.</p>Formula:C17H19F2N3O3Purity:98.59%Color and Shape:Off-White To Yellow CrystalsMolecular weight:351.35Epirubicin hydrochloride
CAS:<p>Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.</p>Formula:C27H30ClNO11Purity:98.13% - 99.79%Color and Shape:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Molecular weight:579.98Teniposide
CAS:<p>Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and</p>Formula:C32H32O13SPurity:97.7% - 99.45%Color and Shape:White Or Off-White Crystalline PowderMolecular weight:656.65Levofloxacin hydrate
CAS:<p>Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Formula:C18H20FN3O4H2OPurity:98.26%Color and Shape:Pale Yellow SolidMolecular weight:370.38Ciprofloxacin
CAS:<p>Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!</p>Formula:C17H18FN3O3Purity:98.77% - 99.91%Color and Shape:White PowderMolecular weight:331.34Pefloxacin Mesylate
CAS:<p>Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-</p>Formula:C18H24FN3O6SPurity:99.86%Color and Shape:SolidMolecular weight:429.46Hycanthone
CAS:<p>Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.</p>Formula:C20H24N2O2SPurity:98.78%Color and Shape:Yellow-Orange Powder (Ntp 1992)Molecular weight:356.48Irinotecan hydrochloride trihydrate
CAS:<p>Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.</p>Formula:C33H45ClN4O9Purity:98.22% - >99.99%Color and Shape:Pale Yellow To Yellow Crystalline PowderMolecular weight:677.18Irinotecan Hydrochloride
CAS:<p>Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.</p>Formula:C33H39ClN4O6Purity:98% - 99.94%Color and Shape:Yellow Crystalline PowderMolecular weight:623.14Mitoxantrone dihydrochloride
CAS:<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Formula:C22H30Cl2N4O6Purity:97.05% - >99.99%Color and Shape:Blue-Black Solid From Water Ethanol SolidMolecular weight:517.4Nalidixic acid sodium salt
CAS:<p>Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.</p>Formula:C12H11N2NaO3Purity:99.72% - 99.95%Color and Shape:White To Off-White PowderMolecular weight:254.22Daunorubicin hydrochloride
CAS:<p>Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein</p>Formula:C27H29NO10·HClPurity:96.21% - 99.53%Color and Shape:Cancer DrugMolecular weight:563.99Ledoxantrone trihydrochloride
CAS:<p>Ledoxantrone trihydrochloride is a Top II inhibitor with anticancer activity and is used in the study of digestive disorders and urologic disorders.</p>Formula:C21H30Cl3N5OSPurity:98.13%Color and Shape:SoildMolecular weight:506.92Nalidixic acid
CAS:<p>Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.</p>Formula:C12H12N2O3Purity:99.9% - 99.95%Color and Shape:Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Molecular weight:232.24Topotecan hydrochloride
CAS:<p>Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.</p>Formula:C23H24ClN3O5Purity:97.88% - 99.41%Color and Shape:White Crystalline SolidMolecular weight:457.92Lurtotecan
CAS:<p>Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.</p>Formula:C28H30N4O6Purity:99.18%Color and Shape:SoildMolecular weight:518.56Enoxacin hydrate
CAS:<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>Formula:C15H17FN4O3H2OPurity:99.50%Color and Shape:SolidMolecular weight:347.34Oxaquin TEA
<p>Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and</p>Formula:C37H48F2N5O11PPurity:99.79%Color and Shape:SolidMolecular weight:807.77XR-11576 HCl
<p>XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.</p>Formula:C23H25ClN4O2Purity:98.52%Color and Shape:SoildMolecular weight:424.92Flumequine
CAS:<p>Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.</p>Formula:C14H12FNO3Purity:98.92% - 99.4%Color and Shape:White Crystalline Powder SolidMolecular weight:261.25Enoxacin
CAS:<p>Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.</p>Formula:C15H17FN4O3Purity:98.68% - 99.89%Color and Shape:Off-White To Yellow CrystalsMolecular weight:320.32Etoposide
CAS:<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Formula:C29H32O13Purity:99.19% - 99.94%Color and Shape:Crystals From Methanol SolidMolecular weight:588.56Ciprofloxacin monohydrochloride
CAS:<p>Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.</p>Formula:C17H18FN3O3·HClPurity:99.5% - >99.99%Color and Shape:White Or Light Yellow Crystalline PowderMolecular weight:367.80Gatifloxacin
CAS:<p>Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.</p>Formula:C19H22FN3O4Purity:99.50% - 99.85%Color and Shape:White PowderMolecular weight:375.39AuM1Gly
<p>AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the low</p>Purity:98%Color and Shape:Odour SolidAuM1Phe
<p>AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization.</p>Purity:98%Color and Shape:Odour SolidNH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
<p>Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC)</p>Formula:C26H24ClN3O6Purity:98%Color and Shape:SolidMolecular weight:509.94DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Color and Shape:Odour SolidTopoisomerase I inhibitor 10
<p>Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.</p>Purity:98%Color and Shape:Odour SolidDTS-108
CAS:<p>DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.</p>Formula:C145H233N43O33S2Color and Shape:SolidMolecular weight:3170.8Topoisomerase IIα-IN-9
CAS:Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C14H14O4SColor and Shape:SolidMolecular weight:278.32Voreloxin
CAS:<p>Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.</p>Formula:C18H19N5O4SPurity:98%Color and Shape:SolidMolecular weight:401.44Antitumor agent-102
<p>Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targets</p>Formula:C70H82N8O18SPurity:98%Color and Shape:SolidMolecular weight:1355.51Banoxantrone (D12)
CAS:<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55Dichlorogelignate
CAS:<p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>Formula:C32H34O18Color and Shape:SolidMolecular weight:706.6Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formula:C23H20F2N2O4Purity:98%Color and Shape:SolidMolecular weight:426.41Banoxantrone-d12 dihydrochloride
CAS:<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formula:C22H30Cl2N4O6Purity:98%Color and Shape:SolidMolecular weight:529.48Chimmitecan
CAS:<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formula:C23H20N2O5Purity:98.35%Color and Shape:SoildMolecular weight:404.42Topoisomerase II inhibitor 13
CAS:<p>WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.</p>Formula:C22H23N9Purity:98.4%Color and Shape:SoildMolecular weight:413.48AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formula:C29H50AuCl2N5Color and Shape:SolidMolecular weight:736.61Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formula:C25H26ClN3O5Purity:97.04%Color and Shape:SoildMolecular weight:483.94CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Formula:C53H83FN6O15Color and Shape:SolidMolecular weight:1063.26TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formula:C22H19ClN6O2SPurity:98%Color and Shape:SoildMolecular weight:466.94Topo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Formula:C15H13N3S2Color and Shape:SolidMolecular weight:299.414
