Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 136 products of "Topoisomerase"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Nifurpirinol
CAS:<p>Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish species.</p>Formula:C12H10N2O4Purity:99.7%Color and Shape:SolidMolecular weight:246.22(4-NH2)-Exatecan
CAS:(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Formula:C23H21N3O4Purity:99.89%Color and Shape:SolidMolecular weight:403.43Daun02
CAS:<p>Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.</p>Formula:C41H44N2O20Purity:98%Color and Shape:SolidMolecular weight:884.79EIDD-1931
CAS:<p>EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Formula:C9H13N3O6Purity:99.14% - 99.73%Color and Shape:SolidMolecular weight:259.22Aurintricarboxylic acid
CAS:Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formula:C22H14O9Purity:97.1%Color and Shape:Deep Red Coarse Crystalline PowderMolecular weight:422.34Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formula:C15H12O3Purity:98.07% - 99.18%Color and Shape:SolidMolecular weight:240.25Marbofloxacin
CAS:<p>Marbofloxacin (Zeniquin) is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.</p>Formula:C17H19FN4O4Purity:99.76% - 99.84%Color and Shape:SolidMolecular weight:362.36Idarubicin hydrochloride
CAS:<p>Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).</p>Formula:C26H27NO9·HClPurity:98.91% - 99.96%Color and Shape:SolidMolecular weight:533.95Voreloxin hydrochloride
CAS:<p>Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.</p>Formula:C18H20ClN5O4SPurity:99.84%Color and Shape:SolidMolecular weight:437.9Rubitecan
CAS:<p>Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.</p>Formula:C20H15N3O6Purity:97.54%Color and Shape:Yellow Amorphous PowderMolecular weight:393.35SN-38
CAS:<p>SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).</p>Formula:C22H20N2O5Purity:98% - 99.97%Color and Shape:Light-Yellow SolidMolecular weight:392.4Betulinic acid
CAS:<p>Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.</p>Formula:C30H48O3Purity:99.12% - 99.7%Color and Shape:White Crystalline PowderMolecular weight:456.7Pixantrone dimaleate
CAS:<p>Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.</p>Formula:C25H27N5O10Purity:98.70% - 99.11%Color and Shape:SolidMolecular weight:557.21Genz-644282
CAS:<p>Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.</p>Formula:C22H21N3O5Purity:97.49%Color and Shape:SolidMolecular weight:407.42Suramin Sodium Salt
CAS:<p>Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.</p>Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15(S)-10-Hydroxycamptothecin
CAS:<p>(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.</p>Formula:C20H16N2O5Purity:99.09% - 99.81%Color and Shape:SolidMolecular weight:364.35Topotecan
CAS:<p>Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.</p>Formula:C23H23N3O5Purity:96.14% - 98.23%Color and Shape:Light Yellow Needle Crystal Or Crystalline PowderMolecular weight:421.45Bisantrene
CAS:<p>Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.</p>Formula:C22H22N8Purity:96.07% - 98.57%Color and Shape:SolidMolecular weight:398.46Gatifloxacin hydrochloride
CAS:<p>Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.</p>Formula:C19H23ClFN3O4Purity:99.85% - 99.89%Color and Shape:SolidMolecular weight:411.86Berberine hydrogen sulphate
CAS:<p>Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.</p>Formula:C20H19NO8SPurity:99% - 99.79%Color and Shape:Yellow Crystals Off-White To Yellow PowderMolecular weight:433.43Belotecan hydrochloride
CAS:Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activityFormula:C25H28ClN3O4Purity:99.63% - ≥95%Color and Shape:SolidMolecular weight:469.96Berberine
CAS:<p>1.</p>Formula:C20H18NO4Purity:95.71% - 99.67%Color and Shape:SolidMolecular weight:336.36Artemisitene
CAS:<p>Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.</p>Formula:C15H20O5Purity:99.58%Color and Shape:SolidMolecular weight:280.329-amino-CPT
CAS:<p>9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.</p>Formula:C20H17N3O4Purity:99.13% - 99.82%Color and Shape:Orange-Yellow PowderMolecular weight:363.379-Hydroxycamptothecin
CAS:<p>9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.</p>Formula:C20H16N2O5Purity:98.28%Color and Shape:SolidMolecular weight:364.35Isosteviol
CAS:<p>Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.</p>Formula:C20H30O3Purity:99.72% - 99.97%Color and Shape:SolidMolecular weight:318.45SW044248
CAS:<p>SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.</p>Formula:C22H23N5O2SPurity:99.56% - 99.87%Color and Shape:SolidMolecular weight:421.52Niranthin
CAS:<p>Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.</p>Formula:C24H32O7Purity:99.8%Color and Shape:SolidMolecular weight:432.51Levofloxacin hydrochloride
CAS:<p>Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Formula:C18H21ClFN3O4Purity:99.78% - 99.98%Color and Shape:SolidMolecular weight:397.8Pirarubicin
CAS:<p>Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.</p>Formula:C32H37NO12Purity:97.80% - 99.15%Color and Shape:Red Crystalline PowderMolecular weight:627.64Indotecan
CAS:<p>Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).</p>Formula:C26H26N2O7Purity:97% - 98%Color and Shape:SolidMolecular weight:478.49Garenoxacin mesylate hydrate
CAS:<p>Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains</p>Formula:C23H20F2N2O4·CH4O3S·H2OPurity:99.56%Color and Shape:SolidMolecular weight:540.53Exatecan Mesylate
CAS:<p>Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).</p>Formula:C25H26FN3O7SPurity:97.32% - 99.9%Color and Shape:SolidMolecular weight:531.55Topovale
CAS:<p>Topovale (ARC111) is a potent inhibitor of topoisomerase I.</p>Formula:C23H23N3O5Purity:99.94%Color and Shape:SolidMolecular weight:421.45Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purity:96.59% - 99.55%Color and Shape:SolidMolecular weight:383.82Prulifloxacin
CAS:<p>Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.</p>Formula:C21H20FN3O6SPurity:99.47%Color and Shape:Yellow Or Slightly Yellow PowerMolecular weight:461.46NU2058
CAS:<p>NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.</p>Formula:C12H17N5OPurity:99.34% - 99.92%Color and Shape:SolidMolecular weight:247.3Rabdosiin
CAS:<p>Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.</p>Formula:C36H30O16Purity:98.64% - 99.49%Color and Shape:SolidMolecular weight:718.619-Methoxycamptothecin
CAS:9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Formula:C21H18N2O5Purity:98.49% - 99.56%Color and Shape:SolidMolecular weight:378.38Mitoxantrone
CAS:<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formula:C22H28N4O6Purity:96.29% - 98.74%Color and Shape:Blue PowderMolecular weight:444.48β-Lapachone
CAS:<p>β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.</p>Formula:C15H14O3Purity:99.76% - 99.88%Color and Shape:SolidMolecular weight:242.27Ellipticine hydrochloride
CAS:<p>Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.</p>Formula:C17H15ClN2Purity:97.18%Color and Shape:SolidMolecular weight:282.76Coralyne chloride
CAS:<p>Coralyne chloride is a protoberberine with strong anticancer activity.</p>Formula:C22H22ClNO4Purity:98.88%Color and Shape:SolidMolecular weight:399.87Amsacrine hydrochloride
CAS:<p>Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.</p>Formula:C21H20ClN3O3SPurity:99.05% - 99.92%Color and Shape:SolidMolecular weight:429.92Amonafide
CAS:<p>Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.</p>Formula:C16H17N3O2Purity:99.39%Color and Shape:SolidMolecular weight:283.33Groenlandicine
CAS:<p>Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.</p>Formula:C19H16NO4Purity:98.59% - 99.77%Color and Shape:SolidMolecular weight:322.34Irinotecan
CAS:<p>Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.</p>Formula:C33H38N4O6Purity:98% - 99.92%Color and Shape:SolidMolecular weight:586.68Dxd
CAS:<p>Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!</p>Formula:C26H24FN3O6Purity:98.21% - ≥98%Color and Shape:SolidMolecular weight:493.48Levofloxacin
CAS:Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.Formula:C18H20FN3O4Purity:98.14% - 99.80%Color and Shape:Off-White To Yellow CrystalsMolecular weight:361.37TAS-103 dihydrochloride
CAS:<p>TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.</p>Formula:C20H21Cl2N3O2Purity:97.78%Color and Shape:SolidMolecular weight:406.31
