Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
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AGK2
CAS:304896-28-4
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
Formula:
C23H13Cl2N3O2
Purity:
98.68% - 99.17%
Color and Shape:
Solid
Molecular weight:
434.27
Ref: TM-T6371
| 1mg | 36.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 185.00 € | ||
| 50mg | 291.00 € | ||
| 100mg | 458.00 € | ||
| 500mg | 1,034.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Salermide
CAS:1105698-15-4
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
Formula:
C26H22N2O2
Purity:
97.62% - 99.55%
Color and Shape:
Solid
Molecular weight:
394.47
Ref: TM-T3953
| 5mg | 47.00 € | ||
| 10mg | 60.00 € | ||
| 25mg | 102.00 € | ||
| 50mg | 183.00 € | ||
| 100mg | 276.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Inauhzin
CAS:309271-94-1
Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM …
Formula:
C25H19N5OS2
Purity:
97.69% - 99.36%
Color and Shape:
Solid
Molecular weight:
469.58
Ref: TM-T1887
| 2mg | 41.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 146.00 € | ||
| 50mg | 229.00 € | ||
| 100mg | 345.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
UBCS039
CAS:358721-70-7
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
Formula:
C16H13N3
Purity:
99.75%
Color and Shape:
Solid
Molecular weight:
247.29
Ref: TM-T7679
| 1mg | 40.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 113.00 € | ||
| 25mg | 220.00 € | ||
| 50mg | 315.00 € | ||
| 100mg | 440.00 € | ||
| 200mg | 616.00 € | ||
| 1mL*10mM (DMSO) | 98.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SRT 1720
CAS:925434-55-5
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold …
Formula:
C25H23N7OS
Purity:
99.7%
Color and Shape:
Solid
Molecular weight:
469.56
Ref: TM-T5096
| 2mg | 39.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 149.00 € | ||
| 50mg | 254.00 € | ||
| 100mg | 423.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Thiomyristoyl
CAS:1429749-41-6
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: …
Formula:
C34H51N3O3S
Purity:
99.13%
Color and Shape:
Solid
Molecular weight:
581.85
Ref: TM-T3447
| 1mg | 61.00 € | ||
| 2mg | 76.00 € | ||
| 5mg | 100.00 € | ||
| 10mg | 127.00 € | ||
| 25mg | 229.00 € | ||
| 50mg | 378.00 € | ||
| 100mg | 563.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Selisistat S-enantiomer
CAS:848193-68-0
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) …
Formula:
C13H13ClN2O
Purity:
99.69%
Color and Shape:
Solid
Molecular weight:
248.71
Ref: TM-T7058
| 1mg | 147.00 € | ||
| 2mg | 210.00 € | ||
| 5mg | 324.00 € | ||
| 10mg | 462.00 € | ||
| 25mg | 736.00 € | ||
| 50mg | 1,049.00 € | ||
| 1mL*10mM (DMSO) | 376.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Suramin Sodium Salt
CAS:129-46-4
Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the …
Formula:
C51H34N6Na6O23S6
Purity:
97.47% - 99.97%
Color and Shape:
White
Molecular weight:
1429.15
Ref: TM-T2160
| 1mg | 48.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 140.00 € | ||
| 25mg | 231.00 € | ||
| 50mg | 344.00 € | ||
| 100mg | 515.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Tenovin-3
CAS:1011301-27-1
Tenovin-3 acts as a p53 activator.
Formula:
C18H21N3OS
Purity:
100% - ≥95%
Color and Shape:
Solid
Molecular weight:
327.44
Ref: TM-T1873
| 1mg | 61.00 € | ||
| 5mg | 126.00 € | ||
| 10mg | 202.00 € | ||
| 25mg | 432.00 € | ||
| 50mg | 638.00 € | ||
| 100mg | 907.00 € | ||
| 500mg | 1,794.00 € | ||
| 1mL*10mM (DMSO) | 141.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Selisistat R-enantiomer
CAS:848193-69-1
Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer …
Formula:
C13H13ClN2O
Purity:
99.78%
Color and Shape:
Solid
Molecular weight:
248.71
Ref: TM-T15263
| 1mg | 106.00 € | ||
| 2mg | 158.00 € | ||
| 5mg | 257.00 € | ||
| 10mg | 374.00 € | ||
| 25mg | 625.00 € | ||
| 50mg | 874.00 € | ||
| 100mg | 1,159.00 € | ||
| 1mL*10mM (DMSO) | 282.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ophiopogonin D'
CAS:65604-80-0
Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 …
Formula:
C44H70O16
Purity:
99.13%
Color and Shape:
Solid
Molecular weight:
855.02
Ref: TM-TN1071
| 1mg | 117.00 € | ||
| 5mg | 295.00 € | ||
| 10mg | 438.00 € | ||
| 25mg | 703.00 € | ||
| 50mg | 960.00 € | ||
| 100mg | 1,271.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SRT 2104
CAS:1093403-33-8
SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
Formula:
C26H24N6O2S2
Purity:
97.03% - 99.83%
Color and Shape:
Solid
Molecular weight:
516.64
Ref: TM-T6679
| 1g | 1,613.00 € | ||
| 1mg | 45.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 128.00 € | ||
| 25mg | 227.00 € | ||
| 50mg | 369.00 € | ||
| 100mg | 551.00 € | ||
| 200mg | 791.00 € | ||
| 500mg | 1,198.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
OSS_128167
CAS:887686-02-4
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 …
Formula:
C19H14N2O6
Purity:
99.25% - 99.25%
Color and Shape:
Solid
Molecular weight:
366.32
Ref: TM-T4328
| 1mg | 45.00 € | ||
| 2mg | 58.00 € | ||
| 5mg | 92.00 € | ||
| 10mg | 115.00 € | ||
| 25mg | 230.00 € | ||
| 50mg | 423.00 € | ||
| 100mg | 624.00 € | ||
| 500mg | 1,336.00 € | ||
| 1mL*10mM (DMSO) | 93.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AGK7
CAS:304896-21-7
AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM …
Formula:
C23H13Cl2N3O2
Purity:
98.31%
Color and Shape:
Solid
Molecular weight:
434.27
Ref: TM-T22026
| 1mg | 70.00 € | ||
| 5mg | 121.00 € | ||
| 10mg | 201.00 € | ||
| 25mg | 423.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SRT 2183
CAS:1001908-89-9
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
Formula:
C27H24N4O2S
Purity:
97.86%
Color and Shape:
Solid
Molecular weight:
468.57
Ref: TM-T16932
| 1mg | 50.00 € | ||
| 2mg | 71.00 € | ||
| 5mg | 106.00 € | ||
| 10mg | 162.00 € | ||
| 25mg | 276.00 € | ||
| 50mg | 423.00 € | ||
| 100mg | 609.00 € | ||
| 1mL*10mM (DMSO) | 111.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AK-7
CAS:420831-40-9
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models …
Formula:
C19H21BrN2O3S
Purity:
98.43%
Color and Shape:
Solid
Molecular weight:
437.35
Ref: TM-T5490
| 1mg | 36.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 74.00 € | ||
| 10mg | 103.00 € | ||
| 25mg | 183.00 € | ||
| 50mg | 323.00 € | ||
| 100mg | 529.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
4'-bromo-Resveratrol
CAS:1224713-90-9
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
Formula:
C14H11BrO2
Purity:
99.4%
Color and Shape:
Solid
Molecular weight:
291.14
Ref: TM-T21679
| 5mg | 75.00 € | ||
| 10mg | 108.00 € | ||
| 25mg | 217.00 € | ||
| 50mg | 354.00 € | ||
| 100mg | 568.00 € | ||
| 1mL*10mM (DMSO) | 83.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Fisetin
CAS:528-48-3
Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective …
Formula:
C15H10O6
Purity:
94.14% - 98.31%
Color and Shape:
Yellow To Brown Crystalline Powder
Molecular weight:
286.24
Ref: TM-T2879
| 100mg | 53.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Nicotinamide riboside chloride
CAS:23111-00-4
NR, also SRT647, is a B3 vitamin form; precursor to NAD+.
Formula:
C11H15ClN2O5
Purity:
98.92% - 99.86%
Color and Shape:
Solid
Molecular weight:
290.7
Ref: TM-T6220
| 1g | 142.00 € | ||
| 50mg | 37.00 € | ||
| 100mg | 52.00 € | ||
| 500mg | 95.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AK-1
CAS:330461-64-8
AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.
Formula:
C19H21N3O5S
Purity:
98.32% - 99.01%
Color and Shape:
Solid
Molecular weight:
403.45
Ref: TM-T5618
| 5mg | 35.00 € | ||
| 10mg | 49.00 € | ||
| 25mg | 93.00 € | ||
| 50mg | 159.00 € | ||
| 100mg | 231.00 € | ||
| 200mg | 342.00 € | ||
| 1mL*10mM (DMSO) | 36.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
