Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
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E1231
CAS:1031195-19-3
E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma …
Formula:
C21H21N3O3
Purity:
98.45%
Color and Shape:
Solid
Molecular weight:
363.41
Ref: TM-T9106
| 1mg | 35.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 102.00 € | ||
| 25mg | 202.00 € | ||
| 50mg | 322.00 € | ||
| 100mg | 464.00 € | ||
| 500mg | 917.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
YK-3-237
CAS:1215281-19-8
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative
Formula:
C19H21BO7
Purity:
96.38%
Color and Shape:
Solid
Molecular weight:
372.18
Ref: TM-T9320
| 2mg | 40.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 176.00 € | ||
| 50mg | 301.00 € | ||
| 100mg | 526.00 € | ||
| 200mg | 676.00 € | ||
| 500mg | 1,054.00 € | ||
| 1mL*10mM (DMSO) | 67.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Scopolin
CAS:531-44-2
Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering …
Formula:
C16H18O9
Purity:
99.09% - ≥95%
Color and Shape:
Solid
Molecular weight:
354.31
Ref: TM-T3888
| 20mg | 107.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Agrimol B
CAS:55576-66-4
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
Formula:
C37H46O12
Purity:
99.89% - ≥95%
Color and Shape:
Solid
Molecular weight:
682.75
Ref: TM-T4S1173
| 5mg | 112.00 € | ||
| 10mg | 201.00 € | ||
| 25mg | 401.00 € | ||
| 50mg | 656.00 € | ||
| 100mg | 1,048.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
3-TYP
CAS:120241-79-4
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
Formula:
C7H6N4
Purity:
100% - 100.00%
Color and Shape:
Solid
Molecular weight:
146.15
Ref: TM-T4108
| 5mg | 56.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 256.00 € | ||
| 100mg | 460.00 € | ||
| 500mg | 1,040.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Tenovin-1
CAS:380315-80-0
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which …
Formula:
C20H23N3O2S
Purity:
99.44%
Color and Shape:
Solid
Molecular weight:
369.48
Ref: TM-T1919
| 10mg | 54.00 € | ||
| 25mg | 82.00 € | ||
| 50mg | 108.00 € | ||
| 100mg | 188.00 € | ||
| 1mL*10mM (DMSO) | 43.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Dihydrocoumarin
CAS:119-84-6
Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).
Formula:
C9H8O2
Purity:
99.19%
Color and Shape:
Leaflets Room Temperature (Ntp 1992)
Molecular weight:
148.16
Ref: TM-T2S0300
| 10g | 34.00 € | ||
| 1mL*10mM (DMSO) | 35.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
N-Caffeoyltryptophan
CAS:109163-69-1
N-Caffeoyltryptophan from coffee inhibits Sirt2 (IC50: 8.7μM) more effectively than Sirt1 (IC50: 34μM).
Formula:
C20H18N2O5
Purity:
99.50%
Color and Shape:
Solid
Molecular weight:
366.37
Ref: TM-TN7093
| 1mg | 104.00 € | ||
| 2mg | 145.00 € | ||
| 5mg | 226.00 € | ||
| 10mg | 335.00 € | ||
| 25mg | 555.00 € | ||
| 50mg | 791.00 € | ||
| 1mL*10mM (DMSO) | 245.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Gardenia yellow
CAS:94238-00-3
Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.
Formula:
C44H64O24
Purity:
98.24% - 98.82%
Color and Shape:
Orange Yellow To Reddish Yellow Powder
Molecular weight:
976.96
Ref: TM-T3S0175
| 25mg | 50.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Tenovin-6
CAS:1011557-82-6
Tenovin-6 is a p53 transcriptional activity agonist.
Formula:
C25H34N4O2S
Purity:
100% - 97.71%
Color and Shape:
Solid
Molecular weight:
454.63
Ref: TM-T1818
| 1mg | 42.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 76.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 154.00 € | ||
| 50mg | 227.00 € | ||
| 100mg | 384.00 € | ||
| 500mg | 915.00 € | ||
| 1mL*10mM (DMSO) | 79.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Selisistat
CAS:49843-98-3
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).
Formula:
C13H13ClN2O
Purity:
99% - 99.79%
Color and Shape:
Solid
Molecular weight:
248.71
Ref: TM-T6111
| 5mg | 55.00 € | ||
| 10mg | 61.00 € | ||
| 25mg | 96.00 € | ||
| 50mg | 143.00 € | ||
| 100mg | 236.00 € | ||
| 200mg | 353.00 € | ||
| 500mg | 570.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SRT1720 hydrochloride
CAS:1001645-58-4
SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows …
Formula:
C25H24ClN7OS
Purity:
98% - ≥95%
Color and Shape:
Solid
Molecular weight:
506.22
Ref: TM-T2412
| 1mg | 68.00 € | ||
| 2mg | 89.00 € | ||
| 5mg | 137.00 € | ||
| 10mg | 246.00 € | ||
| 25mg | 386.00 € | ||
| 50mg | 549.00 € | ||
| 100mg | 783.00 € | ||
| 200mg | 1,078.00 € | ||
| 500mg | 1,596.00 € | ||
| 1mL*10mM (DMSO) | 220.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
![SRT 1720 dihydrochloride[925434-55-5(free base)]](https://static.cymitquimica.com/products/TM/thumb/T5124.jpg)
SRT 1720 dihydrochloride[925434-55-5(free base)]
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent …
Formula:
C25H25Cl2N7OS
Purity:
98.43%
Color and Shape:
Solid
Molecular weight:
542.48
Ref: TM-T5124
| 1mg | 60.00 € | ||
| 2mg | 83.00 € | ||
| 5mg | 104.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 274.00 € | ||
| 50mg | 440.00 € | ||
| 100mg | 639.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MC2184
CAS:74901-20-5
MC2184 is the inhibitor of human recombinant SIRT1.
Formula:
C11H6N2O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
214.18
Ref: TM-T50080
| 1mg | 82.00 € | ||
| 5mg | 170.00 € | ||
| 10mg | 246.00 € | ||
| 25mg | 405.00 € | ||
| 50mg | 542.00 € | ||
| 100mg | 758.00 € | ||
| 200mg | 998.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ginkgolide C
CAS:15291-76-6
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the …
Formula:
C20H24O11
Purity:
99.71% - ≥98%
Color and Shape:
White Powder
Molecular weight:
440.4
Ref: TM-T2750
| 20mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SirReal2
CAS:709002-46-0
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
Formula:
C22H20N4OS2
Purity:
98.96% - 99.75%
Color and Shape:
Solid
Molecular weight:
420.55
Ref: TM-T6984
| 1mg | 39.00 € | ||
| 2mg | 50.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 105.00 € | ||
| 25mg | 194.00 € | ||
| 50mg | 307.00 € | ||
| 100mg | 493.00 € | ||
| 1mL*10mM (DMSO) | 91.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ganoderic acid D
CAS:108340-60-9
Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM …
Formula:
C30H42O7
Purity:
98% - 99.7%
Color and Shape:
Solid
Molecular weight:
514.65
Ref: TM-T5S1133
| 1mg | 46.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 135.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 114.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CAY10602
CAS:374922-43-7
CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.
Formula:
C22H15FN4O2S
Purity:
98.87%
Color and Shape:
Solid
Molecular weight:
418.44
Ref: TM-T4062
| 5mg | 51.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 170.00 € | ||
| 100mg | 302.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SIRT7 inhibitor 97491
CAS:1807758-81-1
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 …
Formula:
C15H12ClN3O
Purity:
99.79%
Color and Shape:
Solid
Molecular weight:
285.73
Ref: TM-T39233
| 1mg | 94.00 € | ||
| 5mg | 230.00 € | ||
| 10mg | 347.00 € | ||
| 25mg | 584.00 € | ||
| 50mg | 833.00 € | ||
| 100mg | 1,138.00 € | ||
| 1mL*10mM (DMSO) | 257.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Splitomicin
CAS:5690-03-9
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, …
Formula:
C13H10O2
Purity:
98.64% - 99.11%
Color and Shape:
Solid
Molecular weight:
198.22
Ref: TM-T6678
| 5mg | 48.00 € | ||
| 10mg | 63.00 € | ||
| 25mg | 115.00 € | ||
| 50mg | 173.00 € | ||
| 100mg | 326.00 € | ||
| 200mg | 472.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
