Immunology and Inflammation

<p>Bectumomab (IMMU-LL2) is a humanized IgG2a mAb targeting CD22, used in imaging and staging non-Hodgkin's lymphoma.</p>

<p>Dibenzothiophene, a sulfur PAH in petroleum, has 3 rings and keratolytic properties.</p>

<p>RH-EDA, a rhodamine-based turn-on fluorescent probe, detects hydroxyl radicals ([OH]) in living systems.</p>

<p>MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. It exhibits anti-inflammatory properties by suppressing the production of ROS and downregulating the expression of pro-inflammatory cytokines such as iNOS, IL-1β, and IL-6.</p>

<p>MS7829 is a first-class DUBTAC targeting cGAS, a critical component in the cGAS-STING pathway.</p>

<p>Perfluorohexane (AF-0150) is a perfluorocarbon (PFC)-based microbubble formulation for ultrasound contrast and is developmentally toxic.</p>

<p>NOD2 agonist 2 (compound 23) enhances antigen presentation in murine bone marrow-derived dendritic cells (BMDCs), highlighting its potential as a vaccine adjuvant.</p>

<p>Cugrastomig is a chimeric antibody of human and humanized IgG1κ-[scFv-heavy -κ]2 type, targeting PDCD1/LAG3.</p>

<p>CQ-16 is an orally active small molecule drug conjugate (SMDC) that targets prostate-specific membrane antigen (PSMA). It exhibits high selectivity in its antiproliferative activity between PSMA-positive and PSMA-negative prostate cells. Additionally, CQ-16 possesses PARP inhibitory activity (IC50=1 nM).</p>

<p>Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion protein combining a CD19-specific antibody domain with trimerized extracellular domains of human 4-1BBL,</p>

<p>TSR-033 is a human IgG4 antibody with high affinity for LAG-3 (lymphocyte activation gene-3), a co-receptor linked to diminished T cell activity, frequently co-</p>

<p>Antitumor agent-188 (compound C6) exhibits α-glucosidase inhibitory activity and anticancer properties. It induces excessive ROS production, thereby triggering oxidative stress.</p>

<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>

<p>NLRP3-IN-15: potent, selective NLRP3 inflammasome inhibitor; IC50 0.114 μM for IL-1β; for inflammation research.</p>

<p>Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle.</p>

<p>PSMA-ALB-56: radioactive, PSMA-targeted ligand, antitumor, combines glutamic urea, DOTA, albumin, with iodophenyl or tolyl fragments.</p>

<p>RS 09 TFA is a TLR4 agonist and LPS peptide analogue, promotes NF-κB nuclear translocation, induces inflammatory cytokine secretion in RAW264.7 macrophages.</p>

<p>CD19 CAR mRNA expresses a protein for use in CAR-CD19 T cell therapy, targeting B cell antigen for cancer treatment.</p>

<p>4-HNE, a marker of oxidative stress, arises from oxidized ω-6 fats like linoleic acid and shows cytotoxic and genotoxic effects.</p>

<p>BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.</p>

<p>Inflexuside B, an abietane diterpenoid derived from the aerial parts of Isodon inflexus, effectively inhibits lipopolysaccharide (LPS)-activated NO Synthase in</p>

<p>Guaiacol-d3 is a deuterated form of Guaiacol, which is a phenolic compound known for its ability to inhibit COX-2 expression and NF-κB activation in response to LPS stimulation, exhibiting anti-inflammatory properties.</p>

<p>NG-Hydroxy-L-arginine acetate (NOHA acetate) acts as a crucial physiological inhibitor of arginase, playing a vital role in the conversion of arginine to nitric oxide and citrulline via nitric oxide synthase.</p>

<p>CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and</p>

<p>PSMA-D5 exhibits a binding affinity for PSMA with a Ki of 0.21 nM and becomes useful for PSMA tracing following radiolabeling. When marked with [68Ga], PSMA-D5 contains a DOTA chelator, facilitating the convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. Additionally, [68Ga]-labeled PSMA-D5 demonstrates exceptional pharmacokinetic properties and significant tumor uptake in 22Rv1 tumors. This compound can be employed in the synthesis and research of radiolabeled conjugates (RDC).</p>

<p>Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's</p>

<p>4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole.</p>

<p>EX-A5758: novel nNOS-NOS1AP inhibitor, reduces pain &amp; enhances paclitaxel's anti-tumor effect.</p>

<p>AHR antagonist 5 free base is an orally active AHR antagonist and exhibits anticancer activity.Cost-effective and quality-assured.</p>

<p>Compound 2g (Anti-inflammatory agent 93) is an active compound that exhibits analgesic activity.</p>

<p>STING-IN-13 is a selective STING inhibitor that effectively suppresses downstream signaling of the STING pathway and STING-mediated inflammation. It exhibits low toxicity and is suitable for research related to STING-associated inflammatory and autoimmune diseases.</p>

<p>IL-6-IN-1 (Compound 22) inhibits the release of IL-6 with an IC50 of 1.065 μM and demonstrates anti-inflammatory activity in LPS-induced acute lung injury in mice.</p>

<p>Biotin-labeled Agatolimod (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, facilitates the assessment of cellular uptake and localization of</p>

<p>4'-hydroxy Flurbiprofen can be used in related research in the field of life sciences. Its product number is T35722 and CAS number is 52807-12-2.</p>

<p>Bermoprofen (AD-1590) is an anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers.</p>

<p>6'-O-Galloylsalidroside has antiviral activity and inhibits HIV.</p>

<p>PROTAC IRAK4 ligand-4, a Ligand for Target Protein for PROTAC (Ligand for Target Protein for PROTAC), exhibits anti-tumor activity and is utilized in synthesizing PROTAC IRAK4 degrader-12. This compound serves as a targeted ligand with specific applications in the development of cancer therapeutics.</p>

<p>TD139 is an inhaled small molecule inhibitor of galectin-3 (Gal-3) with potential anti-fibrotic activity. Cost-effective and quality-assured.</p>

<p>(Rac)-γ-Tocopherol (DMPBQ) is an isoform of Vitamin E that undergoes conversion to γ-Tocopherol through the action of tocopherol cyclase.</p>

<p>QKY-613 is a prodrug designed to enhance immune surveillance by targeting nucleic acid modification pathways. It selectively facilitates the incorporation of 6mdA (N6-methyl-deoxyadenosine) into viral DNA, boosting the DNA's phase separation potential and subsequently increasing cGAS activation levels to strengthen host immune surveillance. In mouse models of viral infection, QKY-613 significantly reduced mortality in aged mice. This compound holds promise for studying immune surveillance mechanisms based on nucleic acid modifications.</p>

<p>Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.</p>

<p>CRX-526, a TLR4 antagonist, protects against advanced diabetic nephropathy.</p>

<p>Pirenoxine is an agent with anti-cataractogenesis activity by interacting with calcium ions or selenite which could lead to the formation of lens cataract.</p>

<p>OVA Peptide(257-264) is an ovalbumin octamer Peptide expressed by class I MHC molecule h-2kb.</p>

<p>Pelgifatamab (BAY-2315497) is a prostate-specific membrane antigen (PSMA) antibody with potential anticancer activity that can be used to study prostate cancer.</p>

<p>CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =&gt;50 µM for TLR8 and TLR7, respectively.</p>

<p>Pepinh-MYD, a MyD88 inhibitor, incorporates both a domain sequence from MyD88 TIR and a protein transduction sequence to facilitate cell membrane penetration. This compound disrupts MyD88-mediated TLR signaling pathways, effectively inhibiting associated immune responses. Its design is particularly useful for investigating MyD88's function in viral infections.</p>

<p>2-Iminobiotin inhibits iNOS/nNOS; Ki: 21.8 μM (mouse iNOS), 37.5 μM (rat nNOS).</p>

<p>IACS-8803 Disodium, a potent cyclic dinucleotide STING agonist, exhibits strong systemic antitumor efficacy [1].</p>

<p>diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.</p>

<p>Compound Fr13590, with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13590 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Vadastuximab (Anti-Human CD33 Recombinant Antibody) is a humanized anti-CD33 monoclonal antibody for the study of acute myeloid leukemia (AML).</p>

<p>2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β; binds weaker than 2'3'-cGAMP but stronger than other CDNs.</p>

<p>SN50 is a cell-permeable inhibitor of NF-κB nuclear translocation that protects against ventilator-induced acute lung injury in rats.</p>

<p>(-)-10,11-Dihydroxyfarnesol, from Cryptomarasmius aucubae, inhibits NO production.</p>

<p>His-Pro is a dipeptide consisting of histidyl and proline.</p>

<p>Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.</p>

<p>Mifamurtide TFA: muramyl dipeptide analog, boosts immunity, activates macrophages/monocytes, potential osteosarcoma research.</p>

<p>PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies.</p>

<p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>

<p>AB-680: potent, reversible CD73 inhibitor, Ki=4.9 pM, &gt;10,000-fold selectivity vs CD39, anti-tumor.</p>

<p>β-Interleukin II is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH.</p>

<p>Icatolimab (JS-004) is a humanized antibody targeting BTLA/CD272 for the study of lymphomas and solid tumors.</p>

<p>Dithianon: broad-spectrum anthraquinone fungicide; sticks to leaves/fruits; controls various fungi in some produce.</p>

<p>Multinoside A is a useful organic compound for research related to life sciences. The catalog number is T124593 and the CAS number is 59262-54-3.</p>

<p>iNOs-IN-6 is an anti-inflammatory agent known for inhibiting the expression of NF-κB, iNOS, and MAPK with an IC50 ranging from 0.2 to 0.62 μM. Additionally, it decreases the levels of pro-inflammatory mediators, such as IL-6, TNF-α, and IL-1β, with an IC50 ranging from 0.4 to 0.69 μM.</p>

<p>HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.</p>

<p>TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.</p>

<p>Anti-Human MSLN Antibody (Clone HN1) is a humanised monoclonal antibody targeting MSLN (Mesothelin), , blocks the interaction between MSLN and CA125, cancer .</p>

<p>Greziprubart is a humanized IgG1κ monoclonal antibody that targets C5a, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>

<p>Eritoran Tetrasodium, a TLR4 receptor antagonist, is used potentially for the treatment of type 2 diabetes.</p>

<p>Septeremophilane E, from Septoria rudbeckiae fungus, inhibits NO production.</p>

<p>FITC-labeled ODN 2395 (sodium), a class C oligodeoxynucleotide and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and localization through</p>

<p>Siplizumab (MEDI-507), an IgG1 antibody targeting CD2, depletes T cells, may treat psoriasis.</p>

<p>CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.</p>

<p>Eramkafusp alfa is a human IgG1 antibody that targets the murine B lymphocyte antigen CD20, also known as MS4A1 [1].</p>

<p>STING agonist-25 is a non-nucleotide that activates STING, enhances immune response, and is active against SARS-CoV strains.</p>

<p>Timosaponin E2 is an anti-inflammatory agent that inhibits active oxygen production [1].</p>

<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>

<p>Compound 3 (diABZI-V/C-DBCO) functions as an efficient STING agonist. This compound acts by releasing diABZI-amine under the action of cathepsin B to activate STING, thereby inducing the production of interferon and other immune-activating molecules, which enhances the immune system's response to tumors. In THP1-Dual cells, the EC50 values for STING activation by diABZI-V/C-DBCO and diABZI-amine are 1.47 nM and 0.144 nM, respectively, and in primary mouse splenic cells, the EC50 values are 7.7 µM and 0.17 µM, respectively. diABZI-V/C-DBCO is useful for research in the field of cancer immunotherapy.</p>

<p>IACS-8803 diammonium, a potent cyclic dinucleotide STING agonist, demonstrates robust systemic antitumor efficacy [1].</p>

<p>Cbl-b-IN-28 (Compound B2) is an orally active Cbl-b inhibitor. It enhances the function of immune cells by promoting the secretion of cytokines like IL-2 and modulating the phosphorylation levels of key proteins in the T cell receptor signaling pathway. Cbl-b-IN-28 is applicable in cancer immunology research.</p>

<p>Hispaglabridin A, an effective antioxidant, inhibits lipid peroxidation [1].</p>

<p>M-5011: NSAID and immunomodulator for pain and inflammation; ED50 0.63mg/kg; reduces bone loss in arthritis; low ulcer risk.</p>

<p>Decylubiquinone (DUb) is a coenzyme Q10 analog with anticancer activity, inhibiting the growth and metastasis of breast cancer.</p>

<p>Ara-F-NAD+ sodium, an arabino analogue of NAD+, serves as a potent, reversible, and slow-binding inhibitor of the CD38 NADase [1] [2].</p>

<p>NLRP3-IN-45 (D6) serves as an inhibitor specifically targeting the NLRP3 inflammasome, demonstrated through its ability to curb the activity of IL-1β (IC 50 = 41.79 nM). It effectively prevents the activation of the NLRP3 inflammasome while sparing the initial stages of its activation process. Furthermore, NLRP3-IN-45 has been shown to selectively inhibit NLRP3 inflammasome activation in the LPS-induced acute lung injury (ALI) mouse model.</p>

<p>Decamethylene glycol, a reagent for studying modified oligonucleotides with anticancer effects, is also researched in myrrh and frankincense oil composition.</p>

<p>Axinelline A: COX inhibitor, IC50 of 2.22 μM (COX-2) &amp; 8.89 μM (COX-1), anti-inflammatory.</p>

<p>Anticancer agent 15 raises ROS, causing necroptosis in melanoma cells.</p>

<p>increases glucose stimulated insulin secretion and glucose metabolism</p>

<p>IL-17-IN-3 (compound 11) is an IL-17A inhibitor with an IC50 value of 35 nM. In a rat tolerance study, it showed no adverse reactions when administered at doses up to 300 mg/kg/day for four consecutive days.</p>

<p>Withangulatin A, a COX-2 inhibitor from Physalis angulata, has anti-tumor and anti-inflammatory effects.</p>

<p>Compound PDK0135, with CAS No. 253-52-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0135 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor.</p>

<p>CAY10614 is a TLR4 antagonist.</p>

<p>Olendalizumab (ALXN1007) is a humanized antibody targeting C5a for research on COVID-19-related inflammation.</p>

<p>Carboxy-PTIO rapidly scavenges NO, forming NO2, key in preventing hypotension and shock in rats.</p>

<p>Neuroprotective agent 5 (compound 28) acts as a brain-penetrating agent with anti-neuroinflammatory, antioxidant, and neuroprotective properties. It exhibits potent inhibition of nitric oxide (NO) with an EC50 of 0.49 μM and suppresses the release of pro-inflammatory mediators PGE2 and TNF-α. Additionally, it downregulates the expression of iNOS and COX-2 proteins, facilitating the polarization of BV-2 cells from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. Neuroprotective agent 5 also dose-dependently inhibits acetylcholinesterase (AChE) activity and the aggregation of Aβ42. This compound is useful for research into Alzheimer's disease.</p>

<p>BQ0413 exhibits high affinity for PSMA, with a dissociation constant (KD) of 89 pM. It demonstrates effective uptake and internalization, with an internalization rate of 44% in PC3-pip cells. After being labeled with [99mTc], BQ0413 can serve as an imaging agent for tumors.</p>