Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(136 products)
- CXCR(147 products)
- Cell wall(5 products)
- IL Receptor(113 products)
- IκB/IKK(61 products)
- LTR(3 products)
- MALT(23 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(445 products)
- NOD(17 products)
- NOS(63 products)
- Nrf2(78 products)
- PGE Synthase(31 products)
- ROS(69 products)
- TGF-beta/Smad(58 products)
- TLR(66 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3035 products of "Immunology and Inflammation"
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Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Formula:C22H20O12Color and Shape:SolidMolecular weight:476.39STING agonist-20
CAS:<p>STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.</p>Formula:C36H39N11O8Color and Shape:SolidMolecular weight:753.76MALT1-IN-11
CAS:<p>MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.</p>Formula:C20H16F4N8OColor and Shape:SolidMolecular weight:460.39TMC353121
CAS:<p>TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).</p>Formula:C32H42N6O3Purity:≥98%Color and Shape:SolidMolecular weight:558.71YM-I-26
CAS:<p>YM-I-26 is a selective inhibitor of the NLRP3 inflammasome. This compound enhances the phagocytic activity of β-amyloid in murine microglial BV2 cells and reduces the production of IL-1β and IL-10. YM-I-26 is useful for research into inflammation-related immunomodulatory activities.</p>Formula:C28H33ClN2O5S2Color and Shape:SolidMolecular weight:577.16COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Formula:C25H23N5O4S2Color and Shape:SolidMolecular weight:521.61Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Formula:C31H37ClFN5O5Color and Shape:SolidMolecular weight:614.11AIM4
CAS:<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Formula:C25H23Br2N5O4Color and Shape:SolidMolecular weight:617.289NOD1-IN-1
CAS:<p>NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.</p>Formula:C16H14ClN3O3Color and Shape:SolidMolecular weight:331.75G108
CAS:<p>G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.</p>Formula:C16H14Cl2N4O2Purity:99.13% - 99.75%Color and Shape:SolidMolecular weight:365.21NOTA-FAPI
CAS:<p>NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.</p>Formula:C36H47F2N9O8Purity:99.748%Color and Shape:SolidMolecular weight:771.81SLC7A11-IN-2
CAS:<p>SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.</p>Formula:C19H24N4O3Color and Shape:SolidMolecular weight:356.42α-Gracinoic acid
CAS:<p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>Formula:C29H42O4Color and Shape:SolidMolecular weight:454.64SP4206
CAS:<p>SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)</p>Formula:C30H37Cl2N7O6Purity:98%Color and Shape:SolidMolecular weight:662.56CD73-IN-18
CAS:<p>CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.</p>Formula:C20H17N5O3Color and Shape:SolidMolecular weight:375.38SARM1-IN-4
CAS:<p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>Formula:C13H17F2N3O2Color and Shape:SolidMolecular weight:285.29COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Formula:C19H14ClN5S2Color and Shape:SolidMolecular weight:411.93LHC-165
CAS:<p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>Formula:C29H32F2N3O7PPurity:98%Color and Shape:SolidMolecular weight:603.55SMW139
CAS:<p>SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.</p>Formula:C19H21ClF3NO2Color and Shape:SolidMolecular weight:387.824Antioxidant agent-3
<p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>Formula:C18H14O8Color and Shape:SolidMolecular weight:358.3Anti-inflammatory agent 102
CAS:<p>Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).</p>Formula:C16H16ClN3O3Color and Shape:SolidMolecular weight:333.77NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Formula:C18H15ClN2O4S3Color and Shape:SolidMolecular weight:454.97cGAS-IN-4
CAS:<p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>Formula:C19H18Cl2N4O3Color and Shape:SolidMolecular weight:421.277Cyclic-di-GMP sodium
<p>c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.</p>Formula:C20H24N10NaO14P2Color and Shape:SolidMolecular weight:713.08464MALT1-IN-5
CAS:<p>MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.</p>Formula:C17H17ClF2N6O3Color and Shape:SolidMolecular weight:426.80A-9758
CAS:<p>A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.</p>Formula:C25H23Cl2F3N2O3Purity:98%Color and Shape:SolidMolecular weight:527.36ABZI
CAS:<p>(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.</p>Formula:C23H24N6O3Molecular weight:432.48IRAK4-IN-12
<p>IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).</p>Formula:C24H31FN8OColor and Shape:SolidMolecular weight:466.55IRAK4-IN-15
CAS:<p>IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.</p>Formula:C25H29FN10Color and Shape:SolidMolecular weight:488.56Nrf2-ARE/hMAO-B/QR2 modulator 1
CAS:<p>Nrf2-ARE/hMAO-B/QR2 modulator 1 a resveratrol derivative activated the NRF2-ARE inhibit hMAO-B and QR2, promote hippocampal neurogenesis Alzheimer's disease .</p>Formula:C14H12N2O3Purity:98.5%Color and Shape:SolidMolecular weight:256.26COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formula:C31H32FN5O2SColor and Shape:SolidMolecular weight:557.68COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formula:C15H10ClIN2OColor and Shape:SolidMolecular weight:396.61FAPI-74
CAS:<p>FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.</p>Formula:C36H49N9O8Color and Shape:SolidMolecular weight:735.83Creatine ethyl ester
CAS:<p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>Formula:C6H13N3O2Color and Shape:SolidMolecular weight:159.186EGR-1-IN-3
CAS:<p>EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.</p>Formula:C31H31N3O6SColor and Shape:SolidMolecular weight:573.659Gardiquimod hydrochloride
CAS:<p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>Formula:C17H24ClN5OColor and Shape:SolidMolecular weight:349.858MSA-2 dimer
CAS:<p>MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.</p>Formula:C29H28O8S2Color and Shape:SolidMolecular weight:568.66Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formula:C18H15N5O2SColor and Shape:SolidMolecular weight:365.41WK692
CAS:<p>Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.</p>Formula:C26H28Br2N8O5Color and Shape:SolidMolecular weight:692.36AMC-04
CAS:<p>AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].</p>Formula:C26H28N2O3Color and Shape:SolidMolecular weight:416.51CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Formula:C6H6S3Color and Shape:SolidMolecular weight:174.307IACS-8779 disodium
CAS:<p>IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.</p>Formula:C21H23N9Na2O10P2S2Color and Shape:SolidMolecular weight:733.52mPGES1-IN-5
CAS:<p>mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.</p>Formula:C27H27N3OColor and Shape:SolidMolecular weight:409.52NLRP3-IN-6
<p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>Formula:C18H15ClN2O4S3Color and Shape:SolidMolecular weight:454.97RIPK1-IN-19
CAS:<p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>Formula:C28H25FN6O2Purity:98.81%Color and Shape:SolidMolecular weight:496.54NLRP3-IN-8
CAS:<p>NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 >100μM).</p>Formula:C23H20N2O6Color and Shape:SolidMolecular weight:420.41IRAK1/4/pan-FLT3 Kinase-IN-2
CAS:<p>IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.</p>Formula:C20H22F3N5OColor and Shape:SolidMolecular weight:405.42IRAK4-IN-31
CAS:<p>IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).</p>Formula:C27H33N5O5Color and Shape:SolidMolecular weight:507.58DEG-35
CAS:<p>DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).</p>Formula:C25H21N3O5Color and Shape:SolidMolecular weight:443.45AM679
CAS:<p>AM679: potent, selective FLAP inhibitor; IC50s—2.2 nM (FLAP), 0.6 nM (hLA), 154 nM (hWB); blocks leukotrienes in vivo; no significant CYP3A4 interaction.</p>Formula:C40H44N4O5SPurity:98%Color and Shape:SolidMolecular weight:692.87IKZF2-degrader 1
CAS:<p>IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.</p>Formula:C27H30FN7O3Color and Shape:SolidMolecular weight:519.57CD73-IN-19
CAS:<p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>Formula:C18H17N3O3SColor and Shape:SolidMolecular weight:355.411AhR agonist 8
CAS:<p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>Formula:C17H15FN4OColor and Shape:SolidMolecular weight:310.33TNFα activity modulator 3
CAS:<p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>Formula:C27H24F2N6O2Color and Shape:SolidMolecular weight:502.52NLRP3-IN-44
CAS:<p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>Formula:C25H30N4O3Color and Shape:SolidMolecular weight:434.53GTCpFE
CAS:<p>GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.</p>Formula:C22H20O8Color and Shape:SolidMolecular weight:412.39TBK1/IKKε-IN-1
CAS:<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Formula:C28H26N4O5Purity:98%Color and Shape:SolidMolecular weight:498.53COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formula:C22H23FN2O6S2Color and Shape:SolidMolecular weight:494.56Panaxcerol B
CAS:<p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>Formula:C27H46O9Color and Shape:SolidMolecular weight:514.65IL-17 modulator 1 disodium
CAS:<p>Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.</p>Formula:C28H37N6NaO6PColor and Shape:SolidMolecular weight:607.604SBI-0640726
CAS:<p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>Formula:C23H15ClN2O2Color and Shape:SolidMolecular weight:386.83IRAK4 modulator-1
CAS:<p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>Formula:C19H13ClN4O2Color and Shape:SolidMolecular weight:364.79TIM-3-IN-1
<p>TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.</p>Formula:C20H16ClN7O3SColor and Shape:SolidMolecular weight:469.9IKZF1-degrader-2
CAS:<p>IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].</p>Formula:C33H30FN5O5Color and Shape:SolidMolecular weight:595.62SB24011
CAS:<p>SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].</p>Formula:C34H38N4O7Color and Shape:SolidMolecular weight:614.696-Alkyne-F-araNAD
CAS:<p>6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).</p>Formula:C24H28FN7O13P2Color and Shape:SolidMolecular weight:703.464NF-κB-IN-6
<p>NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling</p>Formula:C14H20N2O3Color and Shape:SolidMolecular weight:264.32IRAK4 ligand-13
CAS:<p>IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.</p>Formula:C23H26N10Color and Shape:SolidMolecular weight:442.52BAA473
<p>BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.</p>Formula:C36H62O5Purity:98%Color and Shape:SolidMolecular weight:574.87Fexlamose
CAS:<p>Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).</p>Formula:C12H22O9S2Color and Shape:SolidMolecular weight:374.428Hypoxystat
CAS:<p>Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.</p>Formula:C21H21NO5Color and Shape:SolidMolecular weight:367.395IACS-8779
CAS:<p>IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.</p>Formula:C21H25N9O10P2S2Purity:98%Color and Shape:SolidMolecular weight:689.55STING agonist-42
CAS:<p>STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.</p>Formula:C17H8F2LiN5O3Color and Shape:SolidMolecular weight:375.22NLRP3-IN-4
<p>NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.</p>Formula:C22H22N2O5Color and Shape:SolidMolecular weight:394.42Balsalazide disodium
CAS:<p>Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.</p>Formula:C17H13N3Na2O6Color and Shape:SolidMolecular weight:401.281TE-11
CAS:<p>TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.</p>Formula:C16H13NOColor and Shape:SolidMolecular weight:235.28ALR-27
CAS:<p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>Formula:C19H22O3Color and Shape:SolidMolecular weight:298.38Itaconic acid prodrug-1
CAS:<p>Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.</p>Formula:C15H22O10Color and Shape:SolidMolecular weight:362.329K-14585
CAS:<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Formula:C51H56Cl2N8O4Color and Shape:SolidMolecular weight:915.95AS2690168 (free base)
CAS:<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formula:C17H13F3N4OColor and Shape:SolidMolecular weight:346.306FK-565
CAS:<p>FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.</p>Formula:C22H38N4O9Color and Shape:SolidMolecular weight:502.559mPGES1-IN-9
CAS:<p>mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.</p>Formula:C25H18N4OSColor and Shape:SolidMolecular weight:422.502Ambuic acid
CAS:<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formula:C19H26O6Color and Shape:SolidMolecular weight:350.41DPP4-In hydrochloride
CAS:<p>DPP4-In (hydrochloride) is an inhibitor of dipeptidyl peptidase 4 (DPP4) that effectively reduces the expression of DPP4.</p>Formula:C14H21ClN4O2Color and Shape:SolidMolecular weight:312.8STING agonist-21
CAS:<p>STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].</p>Formula:C17H11F6N5O2Color and Shape:SolidMolecular weight:431.29NIK-IN-2
CAS:<p>NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.</p>Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41NLRP3-IN-57
<p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>Formula:C44H60O7Color and Shape:SolidMolecular weight:700.94Indeno[1,2,3-cd]pyrene
CAS:<p>Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.</p>Formula:C22H12Color and Shape:SolidMolecular weight:276.33STING-IN-15
CAS:<p>STING-IN-15 (compound 66) is a potent STING inhibitor, effectively suppressing human and mouse STING with IC50 values of 116 nM and 96.3 nM, respectively. In the REX1 D18N mouse model, STING-IN-15 significantly reduces tissue damage and inflammation.</p>Formula:C20H14F2N4O3Color and Shape:SolidMolecular weight:396.354-Octylphenol
CAS:<p>4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.</p>Formula:C14H22OColor and Shape:SolidMolecular weight:206.32ROS inducer 9
CAS:<p>ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.</p>Formula:C26H26BrF4N3O3Color and Shape:SolidMolecular weight:584.401Darizmetinib
CAS:<p>Darizmetinib (HRX215) is an MKK4 inhibitor.</p>Formula:C21H17F2N5O3SPurity:98.03% - 99.57%Color and Shape:SolidMolecular weight:457.45UBS109
CAS:<p>UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.</p>Formula:C18H17N3OPurity:99.48%Color and Shape:SolidMolecular weight:291.35KI696
CAS:<p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>Formula:C28H30N4O6SPurity:99.74%Color and Shape:SolidMolecular weight:550.63AM103
CAS:<p>AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).</p>Formula:C36H38N3NaO4SPurity:99.75%Color and Shape:SolidMolecular weight:631.76Zharp1-211
CAS:<p>Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.</p>Formula:C24H25N5O4Purity:99.71%Color and Shape:SolidMolecular weight:447.49Dazostinag disodium
CAS:<p>Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.</p>Formula:C21H20F2N8Na2O10P2S2Purity:98.84% - 99.96%Color and Shape:SolidMolecular weight:754.48Antiproliferative agent-22
CAS:<p>Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.</p>Formula:C17H13N3O3Purity:99.20% - 99.27%Color and Shape:SolidMolecular weight:307.3Evixapodlin
CAS:<p>Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.</p>Formula:C34H36Cl2N8O4Purity:99.07%Color and Shape:SolidMolecular weight:691.61HOIPIN-8 sodium
CAS:<p>HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.</p>Formula:C23H15F2N4NaO3Purity:97.34%Color and Shape:SolidMolecular weight:456.38
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